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J. Gross · SciRah

Researcher profile · Semantic Scholar

J. Gross

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J. Gross — researcher profile on SciRah

h-index: 14
Works: 26
Citations: 697

Most-cited papers

Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).
H. Deng, H. O'keefe, C. Davie, Kenneth E. Lind +21 more
2012Journal of Medicinal Chemistry128 citations Open access
Semantic Scholar
Toward a structural understanding of the dehydratase mechanism.
S. Allard, K. Beis, M. Giraud, A. Hegeman +8 more
2002Structure99 citations Open access
Semantic Scholar
Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.
R. K. Thalji, J. McAtee, S. Belyanskaya, M. Brandt +24 more
2013Bioorganic & Medicinal Chemistry Letters68 citations Open access
Semantic Scholar
Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode.
M. Kranz, Michael D. Wall, B. Evans, Afjal H Miah +8 more
2009Bioorganic & Medicinal Chemistry67 citations Open access
Semantic Scholar
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
Carl A. Machutta, Christopher S. Kollmann, K. Lind, Xiaopeng Bai +61 more
2017Nature Communications60 citations Open access
Semantic Scholar
Characterization of enzymatic processes by rapid mix-quench mass spectrometry: the case of dTDP-glucose 4,6-dehydratase.
J. Gross, A. Hegeman, Martha M. Vestling, Perry A. Frey
2000Biochemistry43 citations
Semantic Scholar
Kinetic mechanism of nicotinic acid phosphoribosyltransferase: implications for energy coupling.
J. Gross, M. Rajavel, C. Grubmeyer
1998Biochemistry43 citations
Semantic Scholar
Concerted and stepwise dehydration mechanisms observed in wild-type and mutated Escherichia coli dTDP-glucose 4,6-dehydratase.
A. Hegeman, J. Gross, P. Frey
2002Biochemistry32 citations
Semantic Scholar
Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: identification and preliminary characterization of functional amino acid residues at the active site.
A. Hegeman, J. Gross, Perry A. Frey
2001Biochemistry32 citations
Semantic Scholar
Dehydration is catalyzed by glutamate-136 and aspartic acid-135 active site residues in Escherichia coli dTDP-glucose 4,6-dehydratase.
J. Gross, A. Hegeman, B. Gerratana, P. Frey
2001Biochemistry24 citations
Semantic Scholar
Integration of Lead Discovery Tactics and the Evolution of the Lead Discovery Toolbox
Melanie V. Leveridge, C. Chung, J. Gross, C. Phelps +1 more
2018SLAS discovery : advancing life sciences R & D21 citations Open access
Semantic Scholar
Electrochemical Properties of Some Biologically Active Quinone Derivatives: Furanquinones, Pyridoquinones, and Diplamine, a Cytotoxic Pyridoacridine Alkaloid
P. W. Crawford, J. Gross, K. Lawson, C.-C. Cheng +5 more
199721 citations Open access
Semantic Scholar
The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.
Ian Holmes, S. Gaines, S. Watson, Olivier Lorthioir +12 more
2009Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1′ modifications for the exploration of the S1′ subsite
D. N. Deaton, K. Graham, J. Gross, A. Miller
2008Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite
D. N. Deaton, Enoch N. Gao, K. Graham, J. Gross +2 more
2007Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Rapid mix-quench MALDI-TOF mass spectrometry for analysis of enzymatic systems.
J. Gross, P. Frey
2002Methods in Enzymology7 citations
Semantic Scholar
Electrochemistry and Spectroscopy of Sulfate Complexes of (Tetraphenylporphyrinato)manganese
K. Lawson, J. Gross, P. W. Crawford
20043 citations
Semantic Scholar
Quaternary pyridinium salts from olefins, pyridine and chlorine or bromine
D. H. Wheeler, J. Gross
19653 citations
Semantic Scholar
Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai +61 more
2018Nature Communications2 citations Open access
Semantic Scholar
Development of a high-content imaging assay for screening compound aggregation.
Yong Jiang, A. Hoffman, Geoffrey T. Quinque, W. Bonnette +3 more
2018Analytical Biochemistry1 citations
Semantic Scholar
Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition.
B. Lawhorn, Tritin Tran, V. Hong, L. Morgan +12 more
2017Bioorganic & Medicinal Chemistry Letters0 citations Open access
Semantic Scholar
MMP12 complex with a beta hydroxy carboxylic acid
Ian Holmes, S. Gaines, S. Watson, Olivier Lorthioir +12 more
20090 citations
Semantic Scholar
The crystal structure of dTDP-D-glucose 4,6-dehydratase (RmlB) from Streptococcus suis with dTDP-D-glucose bound
S. Allard, K. Beis, M. Giraud, A. Hegeman +6 more
20020 citations
Semantic Scholar
The crystal structure of dTDP-D-glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar Typhimurium with dTDP-D-glucose bound
S. Allard, K. Beis, M. Giraud, A. Hegeman +6 more
20020 citations
Semantic Scholar
The crystal structure of dTDP-D-glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar Typhimurium with thymidine diphosphate bound
S. Allard, K. Beis, M. Giraud, A. Hegeman +6 more
20020 citations
Semantic Scholar
The crystal structure of dTDP-D-glucose 4,6-dehydratase (RmlB) from Streptococcus suis with thymidine diphosphate bound
S. Allard, K. Beis, M. Giraud, A. Hegeman +6 more
20020 citations
Semantic Scholar

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