K. Gaulton

Most-cited papers

1. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

   A. Mahajan, C. Spracklen, Wei-Hua Zhang, M. Ng +345 more

   2022Nature Genetics616 citations Open access

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2. Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis

   M. Udler, Jaegil Kim, Marcin von Grotthuss, S. Bonàs-Guarch +11 more

   2018PLoS Medicine476 citations Open access

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3. A single-cell atlas of chromatin accessibility in the human genome

   Kai Zhang, James D. Hocker, Michael Miller, Xiao-Meng Hou +8 more

   2021Cell432 citations Open access

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4. Interpreting type 1 diabetes risk with genetics and single cell epigenomics

   Joshua Chiou, Ryan J. Geusz, Mei-Lin Okino, Jee-Yun Han +12 more

   2021Nature381 citations Open access

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5. An atlas of dynamic chromatin landscapes in mouse fetal development

   David U. Gorkin, I. Barozzi, Yuan Zhao, Yan-Xiao Zhang +39 more

   2020Nature318 citations Open access

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6. Characterizing cis-regulatory elements using single-cell epigenomics

   Sebastian Preissl, K. Gaulton, B. Ren

   2022Nature reviews genetics224 citations

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7. An atlas of gene regulatory elements in adult mouse cerebrum

   Y. Li, Sebastian Preissl, Xiao-Meng Hou, Ziyang Zhang +24 more

   2021Nature196 citations Open access

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8. Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

   Allen Wang, Joshua Chiou, Olivier B. Poirion, J. Buchanan +23 more

   2020eLife156 citations Open access

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9. Single cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk

   Joshua Chiou, Chun Zeng, Zhang Cheng, Jee-Yun Han +16 more

   2021Nature Genetics149 citations Open access

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10. Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

    A. Morris, T. Le, Haojia Wu, A. Akbarov +68 more

    2019Nature Communications135 citations Open access

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11. Systematic Analysis of Transcription Factors Binding to Noncoding Variants

    Jian Yan, Yun-Jiang Qiu, André M. Ribeiro dos Santos, Yi-Meng Yin +14 more

    2021Nature131 citations Open access

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12. Cardiac cell type–specific gene regulatory programs and disease risk association

    James D. Hocker, Olivier B. Poirion, Fugui Zhu, J. Buchanan +14 more

    2020Science Advances127 citations Open access

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13. Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes

    Kirk Smith, A. Deutsch, Carolyn McGrail, Hyunkyung Kim +16 more

    2024Nature Medicine111 citations Open access

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14. The Type 2 Diabetes Knowledge Portal: an open access genetic resource dedicated to type 2 diabetes and related traits

    M. Costanzo, Marcin von Grotthuss, Jeffrey Massung, Dongkeun Jang +52 more

    2023Cell Metabolism99 citations Open access

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15. Deciphering the impact of genomic variation on function

    Jesse M. Heather A. Harinder Lea M. Gary C. Hannah Nidhi Engreitz Lawson Singh Starita Hon Carter Sahni Red, Jesse M. Heather A. Harinder Lea M. Gary C. Hannah Nidhi Engreitz Lawson Singh Starita Hon Carter Sahni Red, Jesse M. Engreitz, Heather A. Lawson +496 more

    2024Nature94 citations Open access

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16. Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk

    William W. Greenwald, Joshua Chiou, Jian Yan, Yun-Jiang Qiu +18 more

    2019Nature Communications94 citations Open access

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17. The long noncoding RNA ROCKI regulates inflammatory gene expression

    Qiong Zhang, T. Chao, Veena S Patil, Yue Qin +12 more

    2019EMBO Journal87 citations Open access

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18. Common DNA sequence variation influences 3-dimensional conformation of the human genome

    David U. Gorkin, Yun-Jiang Qiu, Ming Hu, K. Fletez-Brant +9 more

    2019Genome Biology76 citations Open access

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19. High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease

    Hyunkyung Kim, K. Westerman, Kirk Smith, Joshua Chiou +10 more

    2022Diabetologia70 citations Open access

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20. Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes

    Gao-Wei Wang, Joshua Chiou, Chun Zeng, Michael Miller +17 more

    2023Nature Genetics67 citations Open access

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21. Understanding cell fate acquisition in stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

    Han Zhu, Gao-Wei Wang, Kim-Vy Nguyen-Ngoc, Dongsu Kim +12 more

    2023Developmental Cell66 citations Open access

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22. Interpreting non-coding disease-associated human variants using single-cell epigenomics

    K. Gaulton, Sebastian Preissl, Bing Ren

    2023Nature reviews genetics65 citations Open access

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23. Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

    Ryan J. Geusz, Allen Wang, Dieter K. Lam, Nicholas K. Vinckier +11 more

    2021Nature Communications59 citations Open access

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24. An Integrated Map of Cell Type–Specific Gene Expression in Pancreatic Islets

    R. Elgamal, P. Kudtarkar, Rebecca Melton, Hannah M. Mummey +3 more

    2023Diabetes49 citations Open access

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25. ONECUT1 mutations and variants in diabetes

    A. Philippi, S. Heller, I. Costa, V. Senée +36 more

    2021Nature Medicine43 citations Open access

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26. Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits

    P. Benaglio, Agnieszka D'Antonio-Chronowska, Wubin Ma, Feng Yang +14 more

    2019Nature Genetics42 citations Open access

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27. Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

    J. Fernández-Tajes, K. Gaulton, M. van de Bunt, Jason M. Torres +5 more

    2018Genome Medicine42 citations Open access

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28. An integrated map of cell type-specific gene expression in pancreatic islets

    R. Elgamal, P. Kudtarkar, Rebecca Melton, Hannah M. Mummey +3 more

    2023bioRxiv41 citations Open access

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29. Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex immune trait variants using single nucleus ATAC-seq in peripheral blood

    P. Benaglio, Jacklyn M. Newsome, Jee-Yun Han, Joshua Chiou +8 more

    2023PLoS Genetics31 citations Open access

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30. Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

    Ryan J. Geusz, Allen Wang, Joshua Chiou, Joseph J. Lancman +10 more

    2020bioRxiv30 citations Open access

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31. Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes risk

    Joshua Chiou, Chun Zeng, Zhang Cheng, Jee-Yun Han +14 more

    2019bioRxiv25 citations Open access

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32. Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes

    Anthony Aylward, Mei-Lin Okino, P. Benaglio, Joshua Chiou +4 more

    2020bioRxiv24 citations Open access

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33. Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection

    Allen Wang, Joshua Chiou, Olivier B. Poirion, J. Buchanan +20 more

    2020bioRxiv24 citations Open access

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34. Single-cell multiome and spatial profiling reveals pancreas cell type–specific gene regulatory programs of type 1 diabetes progression

    Rebecca Melton, Sara Jimènez, Weston S Elison, Luca Tucciarone +19 more

    2025Science Advances23 citations Open access

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35. Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines

    P. Benaglio, Han Zhu, Mei-Lin Okino, Jian Yan +19 more

    2021bioRxiv23 citations Open access

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36. Nutrient regulation of the islet epigenome controls adaptive insulin secretion

    Matthew Wortham, Fenfen Liu, Johanna Y. Fleischman, M. Wallace +13 more

    2019bioRxiv22 citations Open access

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37. Author Correction: An atlas of dynamic chromatin landscapes in mouse fetal development

    David U. Gorkin, I. Barozzi, Yuan Zhao, Yan-Xiao Zhang +39 more

    2020Nature19 citations Open access

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38. The Cardiovascular Disease Knowledge Portal: A community resource for cardiovascular disease research

    Maria C. Costanzo, C. Roselli, Mackenzie Brandes, Marc P. Duby +18 more

    2023Circulation Genomic and Precision Medicine18 citations Open access

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39. Genetic Discovery and Risk Prediction for Type 1 Diabetes in Individuals Without High-Risk HLA-DR3/DR4 Haplotypes

    Carolyn McGrail, Joshua Chiou, R. Elgamal, A. Luckett +3 more

    2023medRxiv17 citations Open access

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40. The single-cell opioid responses in the context of HIV (SCORCH) consortium

    S. Ament, Rianne R. Campbell, M. Lobo, J. Receveur +73 more

    2024Molecular Psychiatry16 citations Open access

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41. Context-Dependent Roles of Mitochondrial LONP1 in Orchestrating the Balance between Airway Progenitor versus Progeny Cells

    Le Xu, Chunting Tan, Justinn Barr, N. Talaba +16 more

    2024Cell Stem Cell15 citations Open access

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42. Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes

    M. Qadir, R. Elgamal, Ke-Jing Song, P. Kudtarkar +6 more

    2024EMBO Journal15 citations Open access

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43. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings

    Teresa L. Mastracci, M. Apte, L. Amundadottir, Alexandra Alvarsson +30 more

    2023Diabetes15 citations Open access

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44. Author Correction: An atlas of dynamic chromatin landscapes in mouse fetal development

    David U. Gorkin, I. Barozzi, Yuan Zhao, Yan-Xiao Zhang +39 more

    2021Nature14 citations Open access

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45. Clustering of Type 2 Diabetes Genetic Loci by Multi-Trait Associations Identifies Disease Mechanisms and Subtypes

    M. Udler, Jaegil Kim, Marcin von Grotthuss, S. Bonàs-Guarch +12 more

    2018bioRxiv12 citations Open access

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46. Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex trait variants using single nucleus ATAC-seq

    P. Benaglio, Jacklyn M. Newsome, Jee-Yun Han, Joshua Chiou +6 more

    2020bioRxiv11 citations Open access

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47. A cell atlas of chromatin accessibility across 25 adult human tissues

    Kai Zhang, James D. Hocker, Michael Miller, Xiao-Meng Hou +8 more

    2021bioRxiv10 citations Open access

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48. Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes

    Theodore dos Santos, Xiao-Qing Dai, Robert C. Jones, A. Spigelman +16 more

    2025Journal of Clinical Investigation8 citations Open access

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49. Untangling the genetics of beta cell dysfunction and death in type 1 diabetes

    Catherine C. Robertson, R. Elgamal, Belle A. Henry-Kanarek, P. Arvan +8 more

    2024Molecular Metabolism8 citations Open access

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50. Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk

    Hannah M. Mummey, Weston S Elison, Katha Korgaonkar, R. Elgamal +11 more

    2024bioRxiv8 citations Open access

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