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P. Malherbe · SciRah

Researcher profile · Semantic Scholar

P. Malherbe

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P. Malherbe — researcher profile on SciRah

h-index: 37
Works: 87
Citations: 5,332

Most-cited papers

The effect of subunit composition of rat brain GABAA receptors on channel function.
E. Sigel, R. Baur, G. Trube, H. Möhler +1 more
1990Neuron586 citations
Semantic Scholar
Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.
G. Fischer, V. Mutel, G. Trube, P. Malherbe +4 more
1997Journal of Pharmacology and Experimental Therapeutics494 citations
Semantic Scholar
Comparative molecular neuroanatomy of cloned GABAA receptor subunits in the rat CNS
E. Persohn, P. Malherbe, J. Richards
1992The Journal of comparative neurology365 citations
Semantic Scholar
Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity
R. Porter, G. Jaeschke, W. Spooren, T. Ballard +10 more
2005Journal of Pharmacology and Experimental Therapeutics304 citations Open access
Semantic Scholar
Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site
F. Knoflach, V. Mutel, S. Jolidon, J. Kew +4 more
2001Proceedings of the National Academy of Sciences of the United States of America234 citations Open access
Semantic Scholar
Molecular cloning and functional characterization of human vesicular glutamate transporter 3
S. Takamori, P. Malherbe, C. Broger, R. Jahn
2002EMBO Reports224 citations Open access
Semantic Scholar
PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation
J. Richards, G. Higgins, A. Ouagazzal, L. Ozmen +10 more
2003Journal of Neuroscience197 citations Open access
Semantic Scholar
Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry.
J. Saura, Z. Bleuel, J. Ulrich, A. Mendelowitsch +5 more
1996Neuroscience164 citations
Semantic Scholar
Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine.
P. Malherbe, N. Kratochwil, Marie-Thérèse Zenner, J. Piussi +4 more
2003Molecular Pharmacology148 citations
Semantic Scholar
Mutational Analysis and Molecular Modeling of the Allosteric Binding Site of a Novel, Selective, Noncompetitive Antagonist of the Metabotropic Glutamate 1 Receptor*
P. Malherbe, N. Kratochwil, F. Knoflach, Marie-Thérèse Zenner +5 more
2003Journal of Biological Chemistry131 citations Open access
Semantic Scholar
Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion than Antagonism of Either Receptor Alone
Stephen R. Morairty, F. Revel, P. Malherbe, J. Moreau +4 more
2012PLoS ONE129 citations Open access
Semantic Scholar
Recombinant GABAA receptor function and ethanol
E. Sigel, R. Baur, P. Malherbe
1993FEBS Letters108 citations Open access
Semantic Scholar
Activation of protein kinase C results in down‐modulation of different recombinant GABAA‐channels
E. Sigel, R. Baur, P. Malherbe
1991FEBS Letters108 citations
Semantic Scholar
Characterization of (R,S)‐5,7‐di‐tert‐butyl‐3‐hydroxy‐3‐trifluoromethyl‐3H‐benzofuran‐2‐one as a positive allosteric modulator of GABAB receptors
P. Malherbe, R. Masciadri, R. Norcross, F. Knoflach +12 more
2008British Journal of Pharmacology100 citations Open access
Semantic Scholar
Pharmacological characterization of the novel nonpeptide orphanin FQ/nociceptin receptor agonist Ro 64-6198: rapid and reversible desensitization of the ORL1 receptor in vitro and lack of tolerance in vivo.
F. Dautzenberg, J. Wichmann, J. Higelin, G. Py-Lang +4 more
2001Journal of Pharmacology and Experimental Therapeutics97 citations
Semantic Scholar
Biochemical and behavioural characterization of EMPA, a novel high‐affinity, selective antagonist for the OX2 receptor
P. Malherbe, E. Borroni, L. Gobbi, H. Knust +6 more
2009British Journal of Pharmacology96 citations Open access
Semantic Scholar
GABAA-receptor expressed from rat brain α- and β-subunit cDNAs displays potentiation by benzodiazepine receptor ligands
P. Malherbe, A. Draguhn, G. Multhaup, K. Beyreuther +1 more
199094 citations
Semantic Scholar
The rat β1 ‐subunit of the GABAA receptor forms a picrotoxin‐sensitive anion channel open in the absence of GABA
E. Sigel, R. Baur, P. Malherbe, H. Möhler
1989FEBS Letters86 citations Open access
Semantic Scholar
Biochemical and Electrophysiological Characterization of Almorexant, a Dual Orexin 1 Receptor (OX1)/Orexin 2 Receptor (OX2) Antagonist: Comparison with Selective OX1 and OX2 Antagonists
P. Malherbe, E. Borroni, E. Pinard, J. Wettstein +1 more
2009Molecular Pharmacology85 citations
Semantic Scholar
Cloning and Functional Expression of a Soluble Form of Kynurenine/α -Aminoadipate Aminotransferase from Rat Kidney *
R. Buchli, D. Alberati-Giani, P. Malherbe, C. Köhler +2 more
1995Journal of Biological Chemistry79 citations Open access
Semantic Scholar
Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors.
C. Schweitzer, C. Kratzeisen, G. Adam, K. Lundstrom +6 more
2000Neuropharmacology77 citations
Semantic Scholar
Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP
P. Malherbe, N. Kratochwil, A. Mühlemann, Marie-Thérèse Zenner +5 more
2006Journal of Neurochemistry71 citations
Semantic Scholar
Characterization of [3H]Quisqualate Binding to Recombinant Rat Metabotropic Glutamate 1a and 5a Receptors and to Rat and Human Brain Sections
V. Mutel, G. J. Ellis, G. Adam, Sylvie Chaboz +9 more
2000Journal of Neurochemistry63 citations Open access
Semantic Scholar
Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors.
A. Mühlemann, N. Ward, N. Kratochwil, C. Diener +5 more
2006European Journal of Pharmacology62 citations
Semantic Scholar
Identification of essential residues involved in the glutamate binding pocket of the group II metabotropic glutamate receptor.
P. Malherbe, F. Knoflach, C. Broger, Serge Ohresser +5 more
2001Molecular Pharmacology62 citations
Semantic Scholar
Identification of Critical Residues in the Amino Terminal Domain of the Human NR2B Subunit Involved in the RO 25-6981 Binding Pocket
P. Malherbe, V. Mutel, C. Broger, F. Perin-Dureau +4 more
2003Journal of Pharmacology and Experimental Therapeutics58 citations
Semantic Scholar
An Automated System for the Analysis of G Protein-Coupled Receptor Transmembrane Binding Pockets: Alignment, Receptor-Based Pharmacophores, and Their Application
N. Kratochwil, P. Malherbe, L. Lindemann, M. Ebeling +5 more
2005Journal of Chemical Information and Modeling57 citations
Semantic Scholar
Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain
P. Malherbe, D. Alberati-Giani, C. Köhler, A. Cesura
1995FEBS Letters55 citations Open access
Semantic Scholar
Mapping the Binding Pocket of Dual Antagonist Almorexant to Human Orexin 1 and Orexin 2 Receptors: Comparison with the Selective OX1 Antagonist SB-674042 and the Selective OX2 Antagonist N-Ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA)
P. Malherbe, O. Roche, A. Marcuz, C. Kratzeisen +2 more
2010Molecular Pharmacology53 citations
Semantic Scholar
Distribution and abundance of metabotropic glutamate receptor subtype 2 in rat brain revealed by [3H]LY354740 binding in vitro and quantitative radioautography: Correlation with the sites of synthesis, expression, and agonist stimulation of [35S]GTPγs binding
G. Richards, Jürg Messer, P. Malherbe, R. Pink +5 more
200553 citations
Semantic Scholar
Expression of Functional Membrane‐Bound and Soluble Catechol‐O‐Methyltransferase in Escherichia coli and a Mammalian Cell Line
P. Malherbe, B. Bertocci, P. Caspers, G. Zürcher +1 more
1992Journal of Neurochemistry50 citations
Semantic Scholar
Cloning and functional expression of human kynurenine 3‐monooxygenase
D. Alberati-Giani, A. Cesura, C. Broger, W. D. Warren +2 more
1997FEBS Letters46 citations Open access
Semantic Scholar
Isolation and expression of a cDNA clone encoding human kynureninase.
Dsniela Alberati-Giani, R. Buchli, P. Malherbe, C. Broger +4 more
1996European Journal of Biochemistry45 citations Open access
Semantic Scholar
Characterisation of wild‐type and mutant forms of human monoamine oxidase A and B expressed in a mammalian cell line
Jürgen Gottowik, Andrea M. Cesura, P. Malherbe, G. Lang +1 more
1993FEBS Letters45 citations
Semantic Scholar
The positive allosteric modulator of the GABA(B) receptor, rac-BHFF, suppresses alcohol self-administration.
P. Maccioni, A. Thomas, M. Carai, G. Gessa +2 more
2010Drug and Alcohol Dependence42 citations
Semantic Scholar
Identification and characterization of a novel splice variant of the metabotropic glutamate receptor 5 gene in human hippocampus and cerebellum.
P. Malherbe, J. Kew, J. Richards, F. Knoflach +5 more
2002Brain Research. Molecular Brain Research37 citations
Semantic Scholar
Structure/function relationships of mitochondrial monoamine oxidase A and B chimeric forms.
J. Gottowik, P. Malherbe, G. Lang, M. da Prada +1 more
1995European Journal of Biochemistry37 citations Open access
Semantic Scholar
Tachykinin neurokinin 3 receptor antagonists: a patent review (2005 – 2010)
P. Malherbe, T. Ballard, H. Ratni
2011Expert Opinion on Therapeutic Patents36 citations
Semantic Scholar
Effect of the umami peptides on the ligand binding and function of rat mGlu4a receptor might implicate this receptor in the monosodium glutamate taste transduction
K. Monastyrskaia, K. Lundstrom, Doris Plahl, G. Acuña +3 more
1999British Journal of Pharmacology34 citations Open access
Semantic Scholar
Reduction of alcohol intake by the positive allosteric modulator of the GABA(B) receptor, rac-BHFF, in alcohol-preferring rats.
B. Loi, P. Maccioni, C. Lobina, M. Carai +4 more
2013Alcohol33 citations
Semantic Scholar
Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7
Christoph Ullmer, S. Zoffmann, Bernd Bohrmann, Hugues Matile +3 more
2012British Journal of Pharmacology33 citations Open access
Semantic Scholar
Inhibition of alcohol self-administration by positive allosteric modulators of the GABAB receptor in rats: lack of tolerance and potentiation of baclofen
P. Maccioni, Daniela Vargiolu, A. Thomas, P. Malherbe +5 more
2014Psychopharmacology32 citations
Semantic Scholar
Cloning and Characterization of a Soluble Kynurenine Aminotransferase from Rat Brain: Identity with Kidney Cysteine Conjugate β‐Lyase
D. Alberati-Giani, P. Malherbe, C. Köhler, G. Lang +3 more
199532 citations
Semantic Scholar
Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis.
Andrea Cesura, J. Gottowik, H. Lahm, G. Lang +4 more
1996European Journal of Biochemistry31 citations Open access
Semantic Scholar
Me-Talnetant and Osanetant Interact within Overlapping but Not Identical Binding Pockets in the Human Tachykinin Neurokinin 3 Receptor Transmembrane Domains
P. Malherbe, C. Bissantz, A. Marcuz, C. Kratzeisen +5 more
2008Molecular Pharmacology29 citations
Semantic Scholar
Localization of GABAA receptor subunit mRNAs in the rat locus coeruleus.
J. M. Luque, P. Malherbe, J. Richards
1994Brain Research. Molecular Brain Research29 citations
Semantic Scholar
Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology.
J. Richards, J. Saura, J. M. Luque, A. Cesura +4 more
1998Journal of neural transmission. Supplementum27 citations
Semantic Scholar
Lazabemide for the treatment of Alzheimer's disease: rationale and therapeutic perspectives.
A. Cesura, E. Borroni, J. Gottowik, C. Kuhn +3 more
1999Advances in neurology20 citations
Semantic Scholar
G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.
N. Kratochwil, S. Gatti McArthur, M. Hoener, L. Lindemann +15 more
2011Current Topics in Medicinal Chemistry18 citations
Semantic Scholar
cDNA Cloning and Molecular Characterization of Human Brain Metalloprotease MP100
G. Huber, A. Thompson, F. Grüninger, H. Mechler +3 more
199918 citations
Semantic Scholar

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