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B. Hyman · SciRah

Researcher profile · Semantic Scholar

B. Hyman

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B. Hyman — researcher profile on SciRah

h-index: 193
Works: 1,184
Citations: 186K

Most-cited papers

Characterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer’s disease and related dementias
Methasit Jaisa-aad, C. Muñoz-Castro, Molly A. Healey, B. Hyman +1 more
2024Acta Neuropathologica62 citations
Semantic Scholar
APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease
Rosemary J. Jackson, Megan S. Keiser, Jonah C. Meltzer, Dustin P. Fykstra +15 more
2024Molecular Therapy59 citations Open access
Semantic Scholar
Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer’s disease
Ana Rita Agra Almeida Quadros, Zhao-Zhi Li, Xue Wang, I. S. Ndayambaje +26 more
2024Acta Neuropathologica58 citations Open access
Semantic Scholar
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia
Christine Marques, Aaron Held, Katherine Dorfman, J. Sung +10 more
2024Acta Neuropathologica51 citations Open access
Semantic Scholar
Common mouse models of tauopathy reflect early but not late human disease
K. Wenger, A. Viode, Christoph N. Schlaffner, Patrick van Zalm +12 more
2023Molecular Neurodegeneration47 citations Open access
Semantic Scholar
Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer’s pathology
T. Zwang, Eric del Sastre, Nina Wolf, Nancy Ruiz-Uribe +9 more
2024Cell Reports37 citations Open access
Semantic Scholar
Alzheimer’s disease patient-derived high molecular weight tau impairs bursting in hippocampal neurons
Samuel S. Harris, Robert Ellingford, J. Hartmann, Debanjan Dasgupta +15 more
2025Cell35 citations Open access
Semantic Scholar
Pathways to personalized medicine—Embracing heterogeneity for progress in clinical therapeutics research in Alzheimer's disease
S. E. Arnold, B. Hyman, Rebecca A. Betensky, H. Dodge
2024Alzheimer's & Dementia34 citations Open access
Semantic Scholar
Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease
Annie G. Bryant, Zhao-Zhi Li, Rojashree Jayakumar, A. Serrano-Pozo +12 more
2023Journal of Neuroscience32 citations Open access
Semantic Scholar
Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer’s Disease
Annie G. Bryant, Zhao-Zhi Li, Rojashree Jayakumar, A. Serrano-Pozo +12 more
2023bioRxiv24 citations Open access
Semantic Scholar
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease
F. Rajabli, Penelope H. Benchek, G. Tosto, Nicholas A. Kushch +282 more
2025Genome Biology22 citations Open access
Semantic Scholar
Lewy body dementia: Overcoming barriers and identifying solutions
Kanishka Agarwal, Wendi Backler, E. Bayram, L. Bloom +29 more
2024Alzheimer's & Dementia20 citations Open access
Semantic Scholar
SORL1 is a receptor for tau that promotes tau seeding
Joanna M. Cooper, Aurelien Lathuiliere, En-Ming J. Su, Yu-Yu Song +9 more
2024Journal of Biological Chemistry18 citations Open access
Semantic Scholar
Amyloid-β predominant Alzheimer’s disease neuropathologic change
Gabor G. Kovacs, Y. Katsumata, Xian Wu, K. Z. Aung +216 more
2024Brain : a journal of neurology18 citations Open access
Semantic Scholar
Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tau
A. Wachter, Maya E. Woodbury, Sylvia Lombardo, A. Abdourahman +25 more
2024Acta Neuropathologica18 citations Open access
Semantic Scholar
Molecular features of human pathological tau distinguish tauopathy-associated dementias
Mukesh Kumar, Christoph N. Schlaffner, Shao-Jun Tang, Maaike A Beuvink +27 more
2026Cell17 citations Open access
Semantic Scholar
Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer’s disease
Zachary T. Hoglund, Nancy Ruiz-Uribe, Eric del Sastre, Benjamin Woost +5 more
2024Acta Neuropathologica17 citations Open access
Semantic Scholar
In vivo cortical diffusion imaging relates to Alzheimer’s disease neuropathology
M. Torso, Gerard R. Ridgway, Michele Valotti, I. Hardingham +39 more
2023Alzheimer's Research & Therapy15 citations Open access
Semantic Scholar
Tau, synapse loss and gliosis progress in an Alzheimer’s mouse model after amyloid-β immunotherapy
Lindsay A. Welikovitch, Anastasie Mate de Gerando, Anita Khasnavis, Harshil Bhavsar +5 more
2024Brain13 citations Open access
Semantic Scholar
Toxic effects of mutant huntingtin in axons are mediated by its proline-rich domain.
S. Brady, Nichole A. Mesnard-Hoaglin, Mercedes Priego, Joanna Dziechciowska +11 more
2023Brain : a journal of neurology13 citations Open access
Semantic Scholar
Oligodendroglia vulnerability in the human dorsal striatum in Parkinson’s disease
Juan M. Barba-Reyes, L. Harder, Sergio Marco Salas, Methasit Jaisa-aad +7 more
2025bioRxiv12 citations Open access
Semantic Scholar
The structural line between prion and “prion-like”: Insights from prion protein and tau
Calina Glynn, Jose A. Rodriguez, B. Hyman
2024Current Opinion in Neurobiology12 citations Open access
Semantic Scholar
Cell-death pathways and tau-associated neuronal vulnerability in Alzheimer’s disease
G. Lin, S. Chancellor, T. Kwon, Maya E. Woodbury +22 more
2025Cell Reports11 citations Open access
Semantic Scholar
α-Synuclein purification significantly impacts seed amplification assay performance and consistency
Z. Al-Azzawi, N. R. G. Silver, Surabhi Mehra, Simeng Niu +9 more
2025bioRxiv10 citations Open access
Semantic Scholar
Consensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias
Céline Atahualpa Najaf Sven J. Manon Kayenat Fahri Benjam Bellenguez Castillo Morales Amin van der Lee Munta, C. Bellenguez, Atahualpa Castillo Morales, N. Amin +496 more
2026Nature Genetics9 citations Open access
Semantic Scholar
β-Amyloid species production and tau phosphorylation in iPSC-neurons with reference to neuropathologically characterized matched donor brains
Derek H. Oakley, Mirra Chung, Sara Abrha, B. Hyman +1 more
2024Journal of Neuropathology and Experimental Neurology9 citations Open access
Semantic Scholar
Utility of cortical tissue analysis in normal pressure hydrocephalus.
A. Greenberg, Kedous Y. Mekbib, Neel H. Mehta, E. Kiziltug +11 more
2024Cerebral Cortex9 citations
Semantic Scholar
Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer’s disease
Bo-Wen Jin, K. Brown, Denis Smirnov, Samuel M Naik +12 more
2025bioRxiv8 citations
Semantic Scholar
The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo
Samuel S. Harris, Rikesh M. Rajani, Jana Zünkler, Robert Ellingford +15 more
2025Cell Reports8 citations Open access
Semantic Scholar
Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model
C. Davies, J. Tulloch, E. Yip, L. Currie +7 more
2023Brain and Neuroscience Advances8 citations Open access
Semantic Scholar
Cases of familial idiopathic normal pressure hydrocephalus implicate genetic factors in disease pathogenesis.
A. Greenberg, Neel H. Mehta, Kedous Y. Mekbib, E. Kiziltug +8 more
2023Cerebral Cortex8 citations
Semantic Scholar
Tau biology, biomarkers, and therapeutics
Bess Frost, H. Kolb, A. Algeciras-Schimnich, T. Betthauser +21 more
2025Alzheimer's & Dementia7 citations Open access
Semantic Scholar
Distinct inflammatory profiles in young‐onset versus late‐onset Alzheimer's disease
Simrika Thapa, Chloe Anastassiadis, Anna Vasilevskaya, Foad Taghdiri +12 more
2025Alzheimer's & Dementia5 citations Open access
Semantic Scholar
X-chromosome-wide association study for Alzheimer’s disease
J. Le Borgne, L. Gomez, S. Heikkinen, N. Amin +168 more
2024Molecular Psychiatry5 citations Open access
Semantic Scholar
Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains
Lindsay A. Welikovitch, Simon Dujardin, Amy R. Dunn, Analiese R. Fernandes +4 more
2023iScience5 citations Open access
Semantic Scholar
Dysregulation of neuroproteasomes by ApoE isoforms drives endogenous Tau aggregation
V. Paradise, M. Sabu, J. Bafia, N. Sharif +15 more
2023bioRxiv5 citations Open access
Semantic Scholar
Arc mediates intercellular tau transmission via extracellular vesicles
Mitali Tyagi, Eric de Hoog, Matthew Grega, Kaelan R. Sullivan +8 more
2026Cell4 citations Open access
Semantic Scholar
Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner
V. Paradise, Kalin D. Konrad-Vicario, C. Nguyen, Nyle A. Sharif +14 more
2026Nature Neuroscience4 citations Open access
Semantic Scholar
Relationship between cerebral small vessel disease and proteinopathies in the medial temporal lobe
V. Perosa, J. Oltmer, F. Bax, Maarten L. van den Berg +9 more
2025Acta Neuropathologica Communications4 citations Open access
Semantic Scholar
Dynamic conformational ensembles of soluble Tau encode neuronal toxicity prior to aggregation
F. Georgescauld, Sonia Okekenwa, Tanner Boyd, Cameron Donahue +7 more
2026bioRxiv2 citations
Semantic Scholar
Molecular polymorphism of tau aggregates in Pick’s disease
Ji-Liang Liu, Theresa Connors Stewart, Derek H. Oakley, B. Hyman +3 more
2025Neurobiology of Disease2 citations Open access
Semantic Scholar
Seed-competent tau oligomers’ activity correlates with the rate of progression in sporadic Alzheimer’s disease patients
Romain Perbet, Anne E. Wiedmer, Noe Quitot, Harshil Bhavsar +7 more
2025Journal of Alzheimer's Disease2 citations
Semantic Scholar
Brain MRI signatures across sex and CSF Alzheimer’s disease biomarkers
You Cheng, Yingnan He, Karthik Gopinath, Benjamin Billot +9 more
2025Brain Communications2 citations Open access
Semantic Scholar
In situ seeding assay: A novel technique for direct tissue localization of bioactive tau.
Romain Perbet, Anastasie Mate de Gerando, Calina Glynn, Cameron Donahue +5 more
2024Journal of Neuropathology and Experimental Neurology2 citations Open access
Semantic Scholar
Cyclic Multiplex Fluorescent Immunohistochemistry Protocol to Phenotype Glial Cells in Human Formalin-Fixed Paraffin-Embedded Brain Sections
C. Muñoz-Castro, Ayush Noori, B. Hyman, A. Serrano-Pozo
2023Methods in molecular biology2 citations Open access
Semantic Scholar
Scanning X-ray microdiffraction studies of protein accumulation and tissue loss in thin sections of human brain tissue in Alzheimer’s disease
Prakash Nepal, Abdullah Al Bashit, Theresa Connors Stewart, Derek H. Oakley +3 more
2026Research Square1 citations Open access
Semantic Scholar
Neuropathological study of the effects of aducanumab anti-Aβ immunotherapy on patients with Alzheimer’s disease
Lindsay A. Welikovitch, Derek H. Oakley, Rachel E. Bennett, A. Serrano-Pozo +18 more
2026Acta Neuropathologica1 citations Open access
Semantic Scholar
Amyloid plaques drive state-dependent long-range circuit reorganization in the hippocampus
Z. Zhao, J. Locascio, H. Li, N. Gowravaram +5 more
2026bioRxiv1 citations
Semantic Scholar
Alzheimer’s disease pathology degrades an NMDA receptor-dependent spontaneous-activity pattern in cortico-hippocampal circuits
Robert Ellingford, Samuel S. Harris, Marten Kehring, Rikesh M. Rajani +18 more
2026Neuron1 citations Open access
Semantic Scholar
Improving Neuropathological Reconstruction Fidelity via AI Slice Imputation
Marina Crespo Aguirre, John Williams-Ramirez, Dina Zemlyanker, Xiaoling Hu +12 more
2026Research Square1 citations Open access
Semantic Scholar

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