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G. Sasnauskas · SciRah

Researcher profile · Semantic Scholar

G. Sasnauskas

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G. Sasnauskas — researcher profile on SciRah

h-index: 22
Works: 77
Citations: 1,456

Most-cited papers

Structure of the tetrameric restriction endonuclease NgoMIV in complex with cleaved DNA
Markus Deibert, S. Gražulis, G. Sasnauskas, V. Šikšnys +1 more
2000Nature Structural Biology164 citations
Semantic Scholar
Novel Subtype of Type IIs Restriction Enzymes
Rimantas Šapranauskas, G. Sasnauskas, A. Lagunavičius, G. Vilkaitis +2 more
2000Journal of Biological Chemistry101 citations Open access
Semantic Scholar
TnpB structure reveals minimal functional core of Cas12 nuclease family
G. Sasnauskas, G. Tamulaitienė, G. Druteika, Arturo Carabias +6 more
2023Nature99 citations
Semantic Scholar
The Cfr10I restriction enzyme is functional as a tetramer.
V. Šikšnys, R. Skirgaila, G. Sasnauskas, Claus Urbanke +3 more
1999Journal of Molecular Biology91 citations
Semantic Scholar
Generation and characterization of new highly thermostable and processive M-MuLV reverse transcriptase variants.
Aurimas Baranauskas, S. Palikša, G. Alzbutas, Mindaugas Vaitkevicius +5 more
2012Protein engineering, design & selection : PEDS70 citations
Semantic Scholar
The metal-independent type IIs restriction enzyme BfiI is a dimer that binds two DNA sites but has only one catalytic centre.
A. Lagunavičius, G. Sasnauskas, S. Halford, V. Šikšnys
2003Journal of Molecular Biology69 citations
Semantic Scholar
Activation of Thoeris antiviral system via SIR2 effector filament assembly
G. Tamulaitienė, Dziugas Sabonis, G. Sasnauskas, Audronė Rukšėnaitė +6 more
2024Nature66 citations
Semantic Scholar
Crystal structure of the Bse634I restriction endonuclease: comparison of two enzymes recognizing the same DNA sequence.
S. Gražulis, Markus Deibert, R. Rimšelienė, R. Skirgaila +6 more
2002Nucleic Acids Research62 citations Open access
Semantic Scholar
How the BfiI restriction enzyme uses one active site to cut two DNA strands
G. Sasnauskas, S. Halford, V. Šikšnys
2003Proceedings of the National Academy of Sciences of the United States of America58 citations Open access
Semantic Scholar
HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation.
I. Songailienė, J. Juozapaitis, G. Tamulaitienė, Audronė Rukšėnaitė +4 more
2020Molecules and Cells52 citations Open access
Semantic Scholar
Conversion of the tetrameric restriction endonuclease Bse634I into a dimer: oligomeric structure-stability-function correlations.
M. Zaremba, G. Sasnauskas, C. Urbanke, V. Šikšnys
2005Journal of Molecular Biology43 citations
Semantic Scholar
Simultaneous binding of three recognition sites is necessary for a concerted plasmid DNA cleavage by EcoRII restriction endonuclease.
G. Tamulaitis, G. Sasnauskas, M. Mucke, V. Šikšnys
2006Journal of Molecular Biology34 citations
Semantic Scholar
Structural basis of DNA target recognition by the B3 domain of Arabidopsis epigenome reader VAL1
G. Sasnauskas, Kotryna Kauneckaitė, V. Šikšnys
2018Nucleic Acids Research33 citations Open access
Semantic Scholar
A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3′–5′ and 5′–3′ strands by rotating a single active site
G. Sasnauskas, L. Zakrys, M. Zaremba, R. Cosstick +3 more
2010Nucleic Acids Research33 citations Open access
Semantic Scholar
CRISPR adaptation from a structural perspective.
G. Sasnauskas, V. Šikšnys
2020Current Opinion in Structural Biology30 citations
Semantic Scholar
Tetrameric restriction enzymes: expansion to the GIY-YIG nuclease family
G. Gasiunas, G. Sasnauskas, G. Tamulaitis, C. Urbanke +2 more
2007Nucleic Acids Research30 citations Open access
Semantic Scholar
Plasmid DNA cleavage by MunI restriction enzyme: single-turnover and steady-state kinetic analysis.
G. Sasnauskas, A. Jeltsch, Alfred Pingoud, V. Šikšnys
1999Biochemistry30 citations
Semantic Scholar
DNA synapsis through transient tetramerization triggers cleavage by Ecl18kI restriction enzyme
M. Zaremba, Amelia Owsicka, G. Tamulaitis, G. Sasnauskas +7 more
2010Nucleic Acids Research27 citations Open access
Semantic Scholar
Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling
Irmantas Mogila, G. Tamulaitienė, Konstanty Keda, Albertas Timinskas +5 more
2023Science24 citations
Semantic Scholar
Activity and structure of EcoKMcrA
H. Czapinska, M. Kowalska, E. Zagorskaitė, E. Manakova +5 more
2018Nucleic Acids Research24 citations Open access
Semantic Scholar
Structural insight into the specificity of the B3 DNA-binding domains provided by the co-crystal structure of the C-terminal fragment of BfiI restriction enzyme
D. Golovenko, E. Manakova, L. Zakrys, M. Zaremba +3 more
2014Nucleic Acids Research23 citations Open access
Semantic Scholar
Target site cleavage by the monomeric restriction enzyme BcnI requires translocation to a random DNA sequence and a switch in enzyme orientation
G. Sasnauskas, Georgij Kostiuk, G. Tamulaitis, V. Šikšnys
2011Nucleic Acids Research23 citations Open access
Semantic Scholar
Site-specific DNA transesterification catalyzed by a restriction enzyme
G. Sasnauskas, B. Connolly, S. Halford, V. Šikšnys
2007Proceedings of the National Academy of Sciences of the United States of America22 citations Open access
Semantic Scholar
Innate programmable DNA binding by CRISPR-Cas12m effectors enable efficient base editing
Greta Bigelytė, Brigita Duchovska, Rimantė Žedaveinytė, G. Sasnauskas +10 more
2024Nucleic Acids Research21 citations Open access
Semantic Scholar
DNA recognition by Arabidopsis transcription factors ABI3 and NGA1
G. Sasnauskas, E. Manakova, Kęstutis Lapėnas, Kotryna Kauneckaitė +1 more
2018The FEBS Journal21 citations Open access
Semantic Scholar
Oligomeric structure diversity within the GIY-YIG nuclease family.
Elena M. Ibryashkina, G. Sasnauskas, A. Solonin, M. Zakharova +1 more
2009Journal of Molecular Biology19 citations
Semantic Scholar
Allosteric communication network in the tetrameric restriction endonuclease Bse634I.
M. Zaremba, G. Sasnauskas, C. Urbanke, V. Šikšnys
2006Journal of Molecular Biology18 citations
Semantic Scholar
DNA-Endonuclease Complex Dynamics by Simultaneous FRET and Fluorophore Intensity in Evanescent Field.
M. Tutkus, Tomas Marčiulionis, G. Sasnauskas, D. Rutkauskas
2017Biophysical Journal16 citations Open access
Semantic Scholar
Recognition of modified cytosine variants by the DNA‐binding domain of methyl‐directed endonuclease McrBC
E. Zagorskaitė, E. Manakova, G. Sasnauskas
2018FEBS Letters15 citations Open access
Semantic Scholar
The dynamics of the monomeric restriction endonuclease BcnI during its interaction with DNA
Georgij Kostiuk, Jasmina Dikić, Friedrich W. Schwarz, G. Sasnauskas +2 more
2017Nucleic Acids Research13 citations Open access
Semantic Scholar
Degenerate sequence recognition by the monomeric restriction enzyme: single mutation converts BcnI into a strand-specific nicking endonuclease
Georgij Kostiuk, G. Sasnauskas, G. Tamulaitienė, V. Šikšnys
2011Nucleic Acids Research13 citations Open access
Semantic Scholar
Prokaryotic Argonaute from Archaeoglobus fulgidus interacts with DNA as a homodimer
Edvardas Golovinas, D. Rutkauskas, E. Manakova, Marija Jankunec +3 more
2020Scientific Reports11 citations Open access
Semantic Scholar
Structure-guided sequence specificity engineering of the modification-dependent restriction endonuclease LpnPI
G. Sasnauskas, E. Zagorskaitė, Kotryna Kauneckaitė, G. Tamulaitienė +1 more
2015Nucleic Acids Research11 citations Open access
Semantic Scholar
Probing the dynamics of restriction endonuclease NgoMIV‐DNA interaction by single‐molecule FRET
M. Tutkus, G. Sasnauskas, D. Rutkauskas
2017Biopolymers10 citations
Semantic Scholar
Catalytic activity control of restriction endonuclease--triplex forming oligonucleotide conjugates.
A. Šilanskas, M. Zaremba, G. Sasnauskas, V. Šikšnys
2012Bioconjugate chemistry10 citations
Semantic Scholar
UbaLAI is a monomeric Type IIE restriction enzyme
G. Sasnauskas, G. Tamulaitienė, G. Tamulaitis, Jelena Calyseva +4 more
2017Nucleic Acids Research8 citations Open access
Semantic Scholar
Restriction enzyme Ecl18kI-induced DNA looping dynamics by single-molecule FRET.
D. Rutkauskas, Milda Petkelytė, Paulius Naujalis, G. Sasnauskas +3 more
2014Journal of Physical Chemistry B8 citations
Semantic Scholar
The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein
Elena Manakova, Edvardas Golovinas, Reda Pocevičiūtė, G. Sasnauskas +8 more
2024Nucleic Acids Research7 citations Open access
Semantic Scholar
Crystal structure of the EcoKMcrA N-terminal domain (NEco): recognition of modified cytosine bases without flipping
A. Slyvka, E. Zagorskaitė, H. Czapinska, G. Sasnauskas +1 more
2019Nucleic Acids Research7 citations Open access
Semantic Scholar
Chemical Display of Pyrimidine Bases Flipped Out by Modification-Dependent Restriction Endonucleases of MspJI and PvuRts1I Families
E. Zagorskaitė, G. Sasnauskas
2014PLoS ONE6 citations Open access
Semantic Scholar
Domain organization and functional analysis of type IIS restriction endonuclease Eco31I.
A. Jakubauskas, G. Sasnauskas, Jolanta Giedriene, A. Janulaitis
2008Biochemistry6 citations
Semantic Scholar
Deoxydinucleotides activate the bacterial anti-phage defense system ApeA
J. Juozapaitis, A. Šilanskas, Audronė Rukšėnaitė, Ema Ežerskytė +7 more
2026bioRxiv4 citations Open access
Semantic Scholar
Off-target detection of CRISPR-Cas9 nuclease in vitro with CROFT-Seq
P. Toliusis, A. Grybauskas, Tomas Šinkūnas, Tautvydas Karvelis +2 more
2025bioRxiv4 citations Open access
Semantic Scholar
Structural basis for sequence-specific recognition of guide and target strands by the Archaeoglobus fulgidus Argonaute protein
E. Manakova, Edvardas Golovinas, Reda Pocevičiūtė, G. Sasnauskas +3 more
2023Scientific Reports4 citations Open access
Semantic Scholar
Structural and mechanistic insights into the sequential dsDNA cleavage by SpCas12f1
J. Madariaga-Marcos, Marius Baltramonaitis, Selgar Henkel-Heinecke, Dominik J. Kauert +7 more
2025Nucleic Acids Research3 citations Open access
Semantic Scholar
smFRET Detection of Cis and Trans DNA Interactions by the BfiI Restriction Endonuclease
Šaru̅nė Ivanovaitė, Justė Paksaitė, A. Kopu̅stas, Giedrė Karzaitė +6 more
2023Journal of Physical Chemistry B3 citations Open access
Semantic Scholar
The link between restriction endonuclease fidelity and oligomeric state: A study with Bse634I
M. Zaremba, G. Sasnauskas, V. Šikšnys
2012FEBS Letters3 citations
Semantic Scholar
Template-directed addition of nucleosides to DNA by the BfiI restriction enzyme
G. Sasnauskas, B. Connolly, S. Halford, V. Šikšnys
2008Nucleic Acids Research3 citations Open access
Semantic Scholar
Lemon balm-derived nanovesicles restore mitochondrial functions and reduce cytokine production in skin fibroblasts under pro-inflammatory conditions.
G. Kulkovienė, M. Uldukytė, Sofiya Haluts, Emilija Mikalauskienė +5 more
2026European Journal of Pharmaceutical Sciences2 citations Open access
Semantic Scholar
Viral SSB-bound ssDNA activates the bacterial anti-phage defense system DARNA
Rugilė Puteikienė, Christopher N. Vassallo, A. Šilanskas, J. Juozapaitis +3 more
2026bioRxiv2 citations Open access
Semantic Scholar

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