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B. Dymock · SciRah

Researcher profile · Semantic Scholar

B. Dymock

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B. Dymock — researcher profile on SciRah

h-index: 36
Works: 120
Citations: 4,791

Most-cited papers

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.
S. Eccles, A. Massey, F. Raynaud, S. Sharp +33 more
2008Cancer Research470 citations Open access
Semantic Scholar
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
Paul A. Brough, W. Aherne, X. Barril, Jenifer Borgognoni +33 more
2007Journal of Medicinal Chemistry429 citations Open access
Semantic Scholar
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.
L. Wright, X. Barril, B. Dymock, L. Sheridan +13 more
2004Chemistry and Biology243 citations Open access
Semantic Scholar
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
B. Dymock, X. Barril, Paul A. Brough, J. Cansfield +9 more
2005Journal of Medicinal Chemistry212 citations Open access
Semantic Scholar
SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies
S. Hart, Kee C. Goh, V. Novotny-Diermayr, C.-Y. Hu +14 more
2011Leukemia187 citations Open access
Semantic Scholar
Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor for the treatment of myelofibrosis and lympho
A. William, Angeline Lee, Stephanie E. Blanchard, A. Poulsen +15 more
2011Journal of Medicinal Chemistry175 citations Open access
Semantic Scholar
Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone.
Paul A. Brough, X. Barril, Jenifer Borgognoni, P. Chène +29 more
2009Journal of Medicinal Chemistry172 citations Open access
Semantic Scholar
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues
S. Sharp, C. Prodromou, K. Boxall, M. Powers +24 more
2007Molecular Cancer Therapeutics130 citations Open access
Semantic Scholar
Design and Characterization of Libraries of Molecular Fragments for Use in NMR Screening against Protein Targets
N. Baurin, F. Aboul-ela, X. Barril, B. Davis +7 more
2004Journal of Chemical Information and Modeling120 citations
Semantic Scholar
TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties
Kee C. Goh, V. Novotny-Diermayr, S. Hart, L. Ong +12 more
2012Leukemia114 citations
Semantic Scholar
AI is a viable alternative to high throughput screening: a 318-target study
Izhar Wallach, Denzil Bernard, Kong Nguyen, Gregory Ho +496 more
2024Scientific Reports112 citations Open access
Semantic Scholar
GYY4137, a novel water-soluble, H2S-releasing molecule.
P. Rose, B. Dymock, P. Moore
2015Methods in Enzymology104 citations Open access
Semantic Scholar
Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.
Hai-Shan Wang, Nie-Fang Yu, Di-Zhong Chen, Ken Lee +23 more
2011Journal of Medicinal Chemistry88 citations Open access
Semantic Scholar
Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat.
Lianbin Yao, N. Mustafa, E. Tan, A. Poulsen +8 more
2017Journal of Medicinal Chemistry86 citations Open access
Semantic Scholar
Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.
E. G. Yang, N. Mustafa, E. Tan, A. Poulsen +4 more
2016Journal of Medicinal Chemistry81 citations Open access
Semantic Scholar
Hydrogen Sulfide Is an Endogenous Regulator of Aging in Caenorhabditis elegans
Bedoor Qabazard, Ling-Xia Li, J. Gruber, M. T. Peh +10 more
2014Antioxidants and Redox Signaling81 citations Open access
Semantic Scholar
Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-
A. William, Angeline Lee, Kee C. Goh, Stephanie E. Blanchard +13 more
2012Journal of Medicinal Chemistry81 citations Open access
Semantic Scholar
Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity.
W. Feng, Xin-Yi Teo, Wisna Novera, P. M. Ramanujulu +5 more
2015Journal of Medicinal Chemistry76 citations
Semantic Scholar
3-(5-Chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone.
Paul A. Brough, X. Barril, M. Beswick, B. Dymock +6 more
2005Bioorganic & Medicinal Chemistry Letters76 citations Open access
Semantic Scholar
4-Amino derivatives of the Hsp90 inhibitor CCT018159.
X. Barril, M. Beswick, A. Collier, M. Drysdale +10 more
2006Bioorganic & Medicinal Chemistry Letters75 citations Open access
Semantic Scholar
VS-5584, a Novel and Highly Selective PI3K/mTOR Kinase Inhibitor for the Treatment of Cancer
S. Hart, V. Novotny-Diermayr, Kee C. Goh, Meredith Williams +18 more
2012Molecular Cancer Therapeutics73 citations Open access
Semantic Scholar
Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
M. Kitagawa, Pei-Ju Liao, Kyung Hee Lee, Jasmine Wong +15 more
2017Nature Communications72 citations Open access
Semantic Scholar
Hydrogen Sulfide Promotes Adipogenesis in 3T3L1 Cells
C. Tsai, M. T. Peh, W. Feng, B. Dymock +1 more
2015PLoS ONE71 citations Open access
Semantic Scholar
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity.
S. East, C. White, Oliver Barker, S. Barker +21 more
2009Bioorganic & Medicinal Chemistry Letters69 citations
Semantic Scholar
A fluorescence polarization assay for inhibitors of Hsp90.
R. Howes, X. Barril, B. Dymock, K. Grant +11 more
2006Analytical Biochemistry69 citations
Semantic Scholar
A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo.
C. Huang, W. Feng, M. T. Peh, K. Peh +2 more
2016Pharmacological Research64 citations
Semantic Scholar
New patented histone deacetylase inhibitors
Hai-Shan Wang, B. Dymock
2009Expert Opinion on Therapeutic Patents60 citations
Semantic Scholar
Inhibitors of JAK2 and JAK3: an update on the patent literature 2010 – 2012
B. Dymock, Shang-See Cheng
2013Expert Opinion on Therapeutic Patents46 citations
Semantic Scholar
Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthr
A. William, Angeline Lee, A. Poulsen, Kee C. Goh +13 more
2012Journal of Medicinal Chemistry44 citations Open access
Semantic Scholar
Inhibitors of HSP90 and other chaperones for the treatment of cancer
B. Dymock, M. Drysdale, E. Mcdonald, P. Workman
200441 citations
Semantic Scholar
Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3)
A. Poulsen, A. William, Stephanie E. Blanchard, Angeline Lee +6 more
2012Journal of Computer-Aided Molecular Design40 citations
Semantic Scholar
Antioxidants inhibit neuronal toxicity in Parkinson's disease‐linked LRRK2
D. Angeles, P. Ho, B. Dymock, K. Lim +2 more
2016Annals of Clinical and Translational Neurology37 citations Open access
Semantic Scholar
Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors
N. Smith, A. Hayes, K. James, B. Nutley +6 more
2006Molecular Cancer Therapeutics34 citations
Semantic Scholar
Structure-based design of nitrogen-linked macrocyclic kinase inhibitors leading to the clinical candidate SB1317/TG02, a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3)
A. Poulsen, A. William, Stephanie E. Blanchard, H. Nagaraj +8 more
2012Journal of Molecular Modeling33 citations
Semantic Scholar
SB1578, a Novel Inhibitor of JAK2, FLT3, and c-Fms for the Treatment of Rheumatoid Arthritis
Babita Madan, Kee C. Goh, S. Hart, A. William +4 more
2012Journal of Immunology33 citations Open access
Semantic Scholar
Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat.
Yu-Yi Chu-Farseeva, N. Mustafa, A. Poulsen, E. Tan +3 more
2018European journal of medicinal chemistry32 citations Open access
Semantic Scholar
Intracellular Hyper-Acidification Potentiated by Hydrogen Sulfide Mediates Invasive and Therapy Resistant Cancer Cell Death
Z. Lee, Xin-Yi Teo, Z. Song, D. Nin +6 more
2017Frontiers in Pharmacology32 citations Open access
Semantic Scholar
Selective JAK inhibitors.
B. Dymock, E. G. Yang, Yu-Yi Chu-Farseeva, Lianbin Yao
2014Future Medicinal Chemistry32 citations
Semantic Scholar
Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome
W. Moreira, Sridhar Santhanakrishnan, B. Dymock, T. Dick
2017Frontiers in Microbiology29 citations Open access
Semantic Scholar
Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome
W. Moreira, Sridhar Santhanakrishnan, Grace J. Y. Ngan, Choon Bing Low +4 more
2017Antimicrobial Agents and Chemotherapy29 citations Open access
Semantic Scholar
Predicting chemotherapeutic drug combinations through gene network profiling
Thi Thuy Trang Nguyen, J. Chua, K. Seah, S. Koo +10 more
2016Scientific Reports27 citations Open access
Semantic Scholar
Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.
M. Ermann, Doris Riether, E. Walker, Innocent Mushi +14 more
2008Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75NTR Induces Melanoma Cell Death and Reduces Tumor Growth.
Eddy T. H. Goh, Zhi Lin, B. Ahn, V. Lopes-Rodrigues +6 more
2018Cell Chemical Biology25 citations Open access
Semantic Scholar
Fragment-Based Whole Cell Screen Delivers Hits against M. tuberculosis and Non-tuberculous Mycobacteria
W. Moreira, Ji Lim, S. Y. Yeo, P. M. Ramanujulu +2 more
2016Frontiers in Microbiology24 citations Open access
Semantic Scholar
Structure and Ligand-Based Design of mTOR and PI3-Kinase Inhibitors Leading to the Clinical Candidates VS-5584 (SB2343) and SB2602
A. Poulsen, H. Nagaraj, Angeline Lee, Stephanie E. Blanchard +7 more
2014Journal of Chemical Information and Modeling24 citations
Semantic Scholar
Recently discovered EZH2 and EHMT2 (G9a) inhibitors.
Uttara Soumyanarayanan, B. Dymock
2016Future Medicinal Chemistry22 citations
Semantic Scholar
Intranasal administration of a stapled relaxin‐3 mimetic has anxiolytic‐ and antidepressant‐like activity in rats
Subhi Marwari, A. Poulsen, N. Shih, R. Lakshminarayanan +4 more
2019British Journal of Pharmacology21 citations Open access
Semantic Scholar
Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90).
Lianbin Yao, S. Ohlson, B. Dymock
2018Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK‐mTOR signalling
K. Seah, Jian Yun Loh, Thi Thuy Trang Nguyen, Hwei Ling Tan +7 more
2018Experimental Cell Research21 citations
Semantic Scholar
Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors.
A. Poulsen, Meredith Williams, H. Nagaraj, A. William +4 more
2012Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar

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