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Shelley D. Copley · SciRah

Researcher profile · Semantic Scholar

Shelley D. Copley

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Shelley D. Copley — researcher profile on SciRah

h-index: 35
Works: 93
Citations: 4,373

Most-cited papers

Enzymes with extra talents: moonlighting functions and catalytic promiscuity.
Shelley D. Copley
2003Current Opinion in Chemical Biology484 citations
Semantic Scholar
Evolution of Efficient Pathways for Degradation of Anthropogenic Chemicals
Shelley D. Copley
2009Nature Chemical Biology207 citations Open access
Semantic Scholar
Shining a light on enzyme promiscuity.
Shelley D. Copley
2017Current Opinion in Structural Biology175 citations
Semantic Scholar
The origin of the RNA world: co-evolution of genes and metabolism.
Shelley D. Copley, Eric Smith, H. Morowitz
2007Bioorganic chemistry (Print)170 citations
Semantic Scholar
An Evolutionary Biochemist’s Perspective on Promiscuity
Shelley D. Copley
2015TIBS -Trends in Biochemical Sciences. Regular ed162 citations Open access
Semantic Scholar
Genome Shuffling Improves Degradation of the Anthropogenic Pesticide Pentachlorophenol by Sphingobium chlorophenolicum ATCC 39723
Minghua Dai, Shelley D. Copley
2004Applied and Environmental Microbiology159 citations Open access
Semantic Scholar
Divergence of function in the thioredoxin fold suprafamily: evidence for evolution of peroxiredoxins from a thioredoxin-like ancestor.
Shelley D. Copley, W. R. Novak, P. Babbitt
2004Biochemistry147 citations
Semantic Scholar
Lateral gene transfer and parallel evolution in the history of glutathione biosynthesis genes
Shelley D. Copley, J. K. Dhillon
2002Genome Biology143 citations Open access
Semantic Scholar
A mechanism for the association of amino acids with their codons and the origin of the genetic code.
Shelley D. Copley, Eric Smith, H. Morowitz
2005Proceedings of the National Academy of Sciences of the United States of America135 citations Open access
Semantic Scholar
Evolution of new enzymes by gene duplication and divergence
Shelley D. Copley
2020The FEBS Journal130 citations Open access
Semantic Scholar
The conformational equilibrium of chorismate in solution: implications for the mechanism of the non-enzymic and the enzyme-catalyzed rearrangement of chorismate to prephenate
Shelley D. Copley, J. Knowles
1987128 citations
Semantic Scholar
Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5′-phosphate synthesis
J. Kim, Jamie P. Kershner, Yehor Y. Novikov, R. Shoemaker +1 more
2010Molecular Systems Biology124 citations Open access
Semantic Scholar
Recruitment of a double bond isomerase to serve as a reductive dehalogenase during biodegradation of pentachlorophenol.
K. Anandarajah, P. Kiefer, B. Donohoe, Shelley D. Copley
2000Biochemistry104 citations
Semantic Scholar
Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme
JohnCarlo Kristofich, A. Morgenthaler, W. Kinney, C. Ebmeier +4 more
2018PLoS Genetics89 citations Open access
Semantic Scholar
The Whole Genome Sequence of Sphingobium chlorophenolicum L-1: Insights into the Evolution of the Pentachlorophenol Degradation Pathway
Shelley D. Copley, J. Rokicki, Pernilla Turner, H. Daligault +2 more
2011Genome Biology and Evolution84 citations Open access
Semantic Scholar
The mechanism of the chorismate mutase reaction
William Guilford, Shelley D. Copley, J. Knowles
198782 citations
Semantic Scholar
Evidence that pcpA encodes 2,6-dichlorohydroquinone dioxygenase, the ring cleavage enzyme required for pentachlorophenol degradation in Sphingomonas chlorophenolica strain ATCC 39723.
Ling Xu, K. Resing, Sherry L. Lawson, Patricia C. Babbitt +1 more
1999Biochemistry79 citations
Semantic Scholar
Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network
J. Kim, Shelley D. Copley
2012Proceedings of the National Academy of Sciences of the United States of America78 citations Open access
Semantic Scholar
A Previously Unrecognized Step in Pentachlorophenol Degradation in Sphingobium chlorophenolicum Is Catalyzed by Tetrachlorobenzoquinone Reductase (PcpD)
Minghua Dai, J. B. Rogers, J. Warner, Shelley D. Copley
2003Journal of Bacteriology78 citations Open access
Semantic Scholar
An Evolutionary Perspective on Protein Moonlighting
Shelley D. Copley
2014Biochemical Society Transactions73 citations Open access
Semantic Scholar
A compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities
S. Y. McLoughlin, Shelley D. Copley
2008Proceedings of the National Academy of Sciences of the United States of America73 citations Open access
Semantic Scholar
Toward a Systems Biology Perspective on Enzyme Evolution*
Shelley D. Copley
2011Journal of Biological Chemistry72 citations Open access
Semantic Scholar
Reactivity landscape of pyruvate under simulated hydrothermal vent conditions
Yehor Y. Novikov, Shelley D. Copley
2013Proceedings of the National Academy of Sciences of the United States of America71 citations Open access
Semantic Scholar
Differential Effects of a Mutation on the Normal and Promiscuous Activities of Orthologs: Implications for Natural and Directed Evolution
Akhil Khanal, Sean Yu McLoughlin, Jamie P. Kershner, Shelley D. Copley
2014Molecular biology and evolution70 citations Open access
Semantic Scholar
Why metabolic enzymes are essential or nonessential for growth of Escherichia coli K12 on glucose.
J. Kim, Shelley D. Copley
2007Biochemistry68 citations
Semantic Scholar
The uncatalyzed Claisen rearrangement of chorismate to prephenate prefers a transition state of chair-like geometry
Shelley D. Copley, J. Knowles
198568 citations
Semantic Scholar
The Nature of Life: Classical and Contemporary Perspectives from Philosophy and Science: The possibility of alternative microbial life on Earth
Carol E. Cleland, Shelley D. Copley
201067 citations
Semantic Scholar
A versatile and highly efficient method for scarless genome editing in Escherichia coli and Salmonella enterica
J. Kim, A. Webb, Jamie P. Kershner, Stephen Blaskowski +1 more
2014BMC Biotechnology66 citations Open access
Semantic Scholar
Exploration of the relationship between tetrachlorohydroquinone dehalogenase and the glutathione S-transferase superfamily.
Darla L. Mccarthy, S. Navarrete, W. Willett, Patricia C. Babbitt +1 more
1996Biochemistry65 citations
Semantic Scholar
In vivo levels of chlorinated hydroquinones in a pentachlorophenol-degrading bacterium
Darla L. Mccarthy, Alejandro A. Claude, Shelley D. Copley
1997Applied and Environmental Microbiology55 citations Open access
Semantic Scholar
Visualization of protoplast fusion and quantitation of recombination in fused protoplasts of auxotrophic strains of Escherichia coli.
Minghua Dai, S. Ziesman, T. Ratcliffe, R. Gill +1 more
2005Metabolic Engineering53 citations
Semantic Scholar
Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol
I. Yadid, J. Rudolph, Klara Hlouchova, Shelley D. Copley
2013Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
Pentachlorophenol hydroxylase, a poorly functioning enzyme required for degradation of pentachlorophenol by Sphingobium chlorophenolicum
Klara Hlouchova, J. Rudolph, J. Pietari, L. Behlen +1 more
2012Biochemistry43 citations Open access
Semantic Scholar
Pre-steady-state kinetic studies of the reductive dehalogenation catalyzed by tetrachlorohydroquinone dehalogenase.
J. Warner, Shelley D. Copley
2007Biochemistry42 citations
Semantic Scholar
Diverse mechanistic approaches to difficult chemical transformations: microbial dehalogenation of chlorinated aromatic compounds.
Shelley D. Copley
1997Chemistry and Biology39 citations Open access
Semantic Scholar
Successful aerobic bioremediation of groundwater contaminated with higher chlorinated phenols by indigenous degrader bacteria.
A. Mikkonen, Kati Yläranta, M. Tiirola, L. Dutra +5 more
2018Water Research33 citations Open access
Semantic Scholar
Hidden resources in the Escherichia coli genome restore PLP synthesis and robust growth after deletion of the essential gene pdxB
J. Kim, J. Flood, Michael Kristofich, Cyrus Gidfar +8 more
2019Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
Semantic Scholar
Characterization of the initial steps in the reductive dehalogenation catalyzed by tetrachlorohydroquinone dehalogenase.
P. Kiefer, Shelley D. Copley
2002Biochemistry31 citations
Semantic Scholar
How to recruit a promiscuous enzyme to serve a new function
Shelley D. Copley, M. Newton, Karl A. Widney
2022Biochemistry30 citations Open access
Semantic Scholar
Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme A hydrolase.
R. J. Kovachy, Shelley D. Copley, R. Allen
1983Journal of Biological Chemistry28 citations Open access
Semantic Scholar
A surprising effect of leaving group on the nucleophilic aromatic substitution reaction catalyzed by 4-chlorobenzoyl-CoA dehalogenase
G. P. Crooks, Shelley D. Copley
199327 citations
Semantic Scholar
A Synonymous Mutation Upstream of the Gene Encoding a Weak-Link Enzyme Causes an Ultrasensitive Response in Growth Rate
Jamie P. Kershner, Sean Yu McLoughlin, J. Kim, A. Morgenthaler +3 more
2016Journal of Bacteriology26 citations Open access
Semantic Scholar
EXPLORATION OF POSSIBLE MECHANISMS FOR 4-CHLOROBENZOYL COA DEHALOGENASE : EVIDENCE FOR AN ARYL-ENZYME INTERMEDIATE
G. P. Crooks, Ling Xu, R. Barkley, Shelley D. Copley
199526 citations
Semantic Scholar
A mechanistic investigation of the thiol-disulfide exchange step in the reductive dehalogenation catalyzed by tetrachlorohydroquinone dehalogenase.
J. Warner, Sherry L. Lawson, Shelley D. Copley
2005Biochemistry25 citations
Semantic Scholar
Identification of a Covalent Intermediate between Glutathione and Cysteine13 Formed during Catalysis by Tetrachlorohydroquinone Dehalogenase
Darla L. Mccarthy, Donna F. Louie, Shelley D. Copley
199725 citations
Semantic Scholar
Enzymic Dehalogenation of 4-Chlorobenzoyl Coenzyme A in Acinetobacter sp. Strain 4-CB1
Shelley D. Copley, G. P. Crooks
1992Applied and Environmental Microbiology25 citations Open access
Semantic Scholar
Setting the stage for evolution of a new enzyme
Shelley D. Copley
2021Current Opinion in Structural Biology24 citations Open access
Semantic Scholar
The reaction catalyzed by tetrachlorohydroquinone dehalogenase does not involve nucleophilic aromatic substitution.
P. Kiefer, Darla L. Mccarthy, Shelley D. Copley
2002Biochemistry24 citations
Semantic Scholar
The physical basis and practical consequences of biological promiscuity
Shelley D. Copley
2020Physical Biology23 citations Open access
Semantic Scholar
Multiple turnovers of the nicotino-enzyme PdxB require α-keto acids as co-substrates
J. Rudolph, J. Kim, Shelley D. Copley
2010Biochemistry22 citations Open access
Semantic Scholar

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