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O. Burren · SciRah

Researcher profile · Semantic Scholar

O. Burren

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O. Burren — researcher profile on SciRah

h-index: 33
Works: 74
Citations: 9,450

Most-cited papers

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
J. Todd, N. Walker, J. Cooper, D. Smyth +36 more
2007Nature Genetics1,543 citations Open access
Semantic Scholar
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
B. Javierre, O. Burren, S. Wilder, Roman Kreuzhuber +24 more
2017917 citations
Semantic Scholar
Genome-wide association study of copy number variation in 16,000 cases of eight common diseases and 3,000 shared controls
Nick Craddock, M. Hurles, Niall J. Cardin, R. Pearson +213 more
2010Nature706 citations Open access
Semantic Scholar
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
D. Smyth, J. Cooper, Rebecca Bailey, Sarah F. Field +10 more
2006Nature Genetics678 citations
Semantic Scholar
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers
S. Onengut-Gumuscu, Wei-Min Chen, O. Burren, Nicholas J. Cooper +22 more
2015Nature Genetics672 citations Open access
Semantic Scholar
Rare variant contribution to human disease in 281,104 UK Biobank exomes
Quan-Li Wang, R. Dhindsa, K. Carss, A. Harper +55 more
2021Nature545 citations Open access
Semantic Scholar
Widespread seasonal gene expression reveals annual differences in human immunity and physiology
X. C. Dopico, Marina Evangelou, R. Ferreira, Hui Guo +11 more
2015Nature Communications504 citations Open access
Semantic Scholar
Whole-genome sequencing of patients with rare diseases in a national health system
E. Turro, W. Astle, K. Megy, S. Gräf +59 more
2020Nature502 citations Open access
Semantic Scholar
Inherited Variation in Vitamin D Genes Is Associated With Predisposition to Autoimmune Disease Type 1 Diabetes
J. Cooper, D. Smyth, N. Walker, Helen E. Stevens +11 more
2011Diabetes293 citations Open access
Semantic Scholar
A type I interferon transcriptional signature precedes autoimmunity in children genetically at-risk of type 1 diabetes
R. Ferreira, Hui Guo, Richard M. R. Coulson, D. Smyth +17 more
2014Diabetes292 citations Open access
Semantic Scholar
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
C. Dendrou, V. Plagnol, E. Fung, Jen-Nie H. M. Yang +15 more
2009Nature Genetics291 citations Open access
Semantic Scholar
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability
K. Hunt, Vanisha Mistry, N. Bockett, T. Ahmad +33 more
2013Nature211 citations Open access
Semantic Scholar
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
B. Javierre, O. Burren, S. Wilder, Roman Kreuzhuber +35 more
2016Cell208 citations Open access
Semantic Scholar
Whole genome sequencing of a sporadic primary immunodeficiency cohort
James E. D. Thaventhiran, H. Allen, O. Burren, W. Rae +55 more
2020Nature189 citations Open access
Semantic Scholar
Seven newly identified loci for autoimmune thyroid disease
J. Cooper, M. Simmonds, N. Walker, O. Burren +8 more
2012Human Molecular Genetics156 citations Open access
Semantic Scholar
Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases
Hui Guo, M. Fortune, O. Burren, E. Schofield +2 more
2015Human Molecular Genetics149 citations Open access
Semantic Scholar
Statistical Colocalization of Genetic Risk Variants for Related Autoimmune Diseases in the Context of Common Controls
M. Fortune, Hui Guo, O. Burren, E. Schofield +9 more
2015Nature Genetics137 citations Open access
Semantic Scholar
Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations
Tiziana Lorenzini, M. Fliegauf, N. Klammer, N. Frede +234 more
2020Journal of Allergy and Clinical Immunology123 citations Open access
Semantic Scholar
Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants
Benjamin B. Sun, Joshua Chiou, M. Traylor, C. Benner +44 more
2022bioRxiv119 citations Open access
Semantic Scholar
Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene
L. Davison, C. Wallace, J. Cooper, Nathan F. Cope +21 more
2011Human Molecular Genetics117 citations Open access
Semantic Scholar
Chromosome contacts in activated T cells identify autoimmune disease candidate genes
O. Burren, Arcadio Rubio García, B. Javierre, Daniel B. Rainbow +19 more
2017Genome Biology92 citations Open access
Semantic Scholar
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data
A. Romagnoni, S. Jégou, K. van Steen, G. Wainrib +341 more
2019Scientific Reports88 citations Open access
Semantic Scholar
T1DBase: update 2011, organization and presentation of large-scale data sets for type 1 diabetes research
O. Burren, E. Adlem, P. Achuthan, Mikkel B. Christensen +2 more
2010Nucleic Acids Res.80 citations Open access
Semantic Scholar
Gene-gene interactions in the NOD mouse model of type 1 diabetes.
W. Ridgway, L. Peterson, J. Todd, Daniel B. Rainbow +3 more
2008Advances in Immunology77 citations
Semantic Scholar
T1DBase: integration and presentation of complex data for type 1 diabetes research
E. Hulbert, L. Smink, E. Adlem, James E. Allen +16 more
2006Nucleic Acids Res.75 citations Open access
Semantic Scholar
CHiCP: a web-based tool for the integrative and interactive visualization of promoter capture Hi-C datasets
E. Schofield, T. Carver, P. Achuthan, P. Freire-Pritchett +3 more
2016Bioinform.72 citations Open access
Semantic Scholar
Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping
C. Wallace, Antony J. Cutler, N. Pontikos, M. Pekalski +14 more
2015bioRxiv63 citations Open access
Semantic Scholar
Genetic Epidemiology Research Article a Method for Gene-based Pathway Analysis Using Genomewide Association Study Summary Statistics Reveals Nine New Type 1 Diabetes Associations
Marina Evangelou, D. Smyth, M. Fortune, O. Burren +8 more
63 citations
Semantic Scholar
T1DBase, a community web-based resource for type 1 diabetes research
L. Smink, E. Helton, B. Healy, C. Cavnor +17 more
2004Nucleic Acids Res.61 citations Open access
Semantic Scholar
Approaches and advances in the genetic causes of autoimmune disease and their implications
J. Inshaw, Antony J. Cutler, O. Burren, M. Stefana +1 more
2018Nature Immunology55 citations Open access
Semantic Scholar
Resolving mechanisms of immune‐mediated disease in primary CD4 T cells
C. Bourges, A. Groff, O. Burren, C. Gerhardinger +9 more
2020bioRxiv37 citations Open access
Semantic Scholar
Evidence that Cd101 is an autoimmune diabetes gene in NOD mice
Daniel B. Rainbow, C. Moule, Heather I Fraser, Jan Clark +18 more
2011Journal of Immunology37 citations Open access
Semantic Scholar
A minimal role for synonymous variation in human disease
R. Dhindsa, Quan-Li Wang, D. Vitsios, O. Burren +6 more
2022bioRxiv34 citations Open access
Semantic Scholar
Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing
Daniel B. Rainbow, Xin Yang, O. Burren, M. Pekalski +8 more
2015European Journal of Immunology25 citations Open access
Semantic Scholar
Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes
Nicholas J. Cooper, Corina J. Shtir, D. Smyth, Hui Guo +11 more
2014Human Molecular Genetics23 citations Open access
Semantic Scholar
Type 1 diabetes genome-wide association analysis with imputation identifies five new risk regions
Nicholas J. Cooper, C. Wallace, O. Burren, Antony J. Cutler +2 more
2017bioRxiv22 citations Open access
Semantic Scholar
Fine mapping chromatin contacts in capture Hi-C data
C. Eijsbouts, O. Burren, P. Newcombe, C. Wallace
2018BMC Genomics21 citations Open access
Semantic Scholar
T1DBase: integration and presentation of complex data for type 1 diabetes research
E. Hulbert, L. Smink, E. Adlem, James E. Allen +17 more
2007Nucleic Acids Research20 citations Open access
Semantic Scholar
Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases
O. Burren, G. Reales, Limy Wong, J. Bowes +7 more
2020Genome Medicine17 citations Open access
Semantic Scholar
VSEAMS: a pipeline for variant set enrichment analysis using summary GWAS data identifies IKZF3, BATF and ESRRA as key transcription factors in type 1 diabetes
O. Burren, Hui Guo, C. Wallace
2014Bioinform.17 citations Open access
Semantic Scholar
The effects of pathogenic and likely pathogenic variants for inherited hemostasis disorders in 140 214 UK Biobank participants
L. Stefanucci, Janine H. Collins, Matthew C. Sims, Inigo Barrio‐Hernandez +31 more
2023Blood16 citations Open access
Semantic Scholar
Development of an integrated genome informatics, data management and workflow infrastructure: A toolbox for the study of complex disease genetics
O. Burren, B. Healy, Alex C. Lam, Helen Schuilenburg +15 more
2004Human Genomics16 citations Open access
Semantic Scholar
A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples
N. Pontikos, D. Smyth, Helen Schuilenburg, J. Howson +13 more
2014BMC Genomics14 citations Open access
Semantic Scholar
Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes
Hidenori Taniguchi, C. Lowe, J. Cooper, D. Smyth +9 more
2006BMC Genetics14 citations Open access
Semantic Scholar
Sequencing and association analysis of the type 1 diabetes – linked region on chromosome 10p12-q11
S. Nejentsev, L. Smink, D. Smyth, Rebecca Bailey +19 more
2007BMC Genetics10 citations Open access
Semantic Scholar
Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene
Lisa M. Maier, R. Twells, J. Howson, Alex C. Lam +18 more
2003Genes and Immunity10 citations Open access
Semantic Scholar
Influences of rare protein-coding genetic variants on the human plasma proteome in 50,829 UK Biobank participants
R. Dhindsa, O. Burren, Benjamin B. Sun, B. Prins +21 more
2022bioRxiv9 citations Open access
Semantic Scholar
A rare IL2RA haplotype identifies SNP rs61839660 as causal for autoimmunity
Daniel B. Rainbow, M. Pekalski, Antony J. Cutler, O. Burren +4 more
2017bioRxiv8 citations Open access
Semantic Scholar
No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes.
F. Payne, D. Smyth, Rebecca Pask, J. Cooper +17 more
2005Biochemical and Biophysical Research Communications - BBRC8 citations
Semantic Scholar
Prevalence of CFTR variants in PID patients with bronchiectasis - an important modifying co-factor.
Dylan Lawless, H. Allen, James E. D. Thaventhiran, S. Goddard +5 more
2023Journal of Allergy and Clinical Immunology7 citations Open access
Semantic Scholar

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