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G. Tzimas · SciRah

Researcher profile · Semantic Scholar

G. Tzimas

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G. Tzimas — researcher profile on SciRah

h-index: 17
Works: 25
Citations: 799

Most-cited papers

Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption.
T. Arnhold, G. Tzimas, W. Wittfoht, Sabine Luise Plonait +1 more
1996Life Science92 citations
Semantic Scholar
Comparative teratology and transplacental pharmacokinetics of all-trans-retinoic acid, 13-cis-retinoic acid, and retinyl palmitate following daily administrations in rats.
M. Collins, G. Tzimas, H. Hummler, H. Burgin +1 more
1994Toxicology and Applied Pharmacology74 citations
Semantic Scholar
Endogenous status of retinoids and their cytosolic binding proteins in limb buds of chick vs mouse embryos.
W. J. Scott, Rosemarie Walter, G. Tzimas, J. O. Sass +2 more
1994Developmental Biology68 citations
Semantic Scholar
Human Uterine Leiomyomata Express Higher Levels of Peroxisome Proliferator-activated Receptor γ, Retinoid X Receptor α, and all-trans Retinoic Acid Than Myometrium
J. Tsibris, K. Porter, A. Jazayeri, G. Tzimas +6 more
199955 citations
Semantic Scholar
The role of metabolism and toxicokinetics in retinoid teratogenesis.
G. Tzimas, H. Nau
2001Current pharmaceutical design53 citations
Semantic Scholar
Identification of 9,13-dicis-retinoic acid as a major plasma metabolite of 9-cis-retinoic acid and limited transfer of 9-cis-retinoic acid and 9,13-dicis-retinoic acid to the mouse and rat embryos.
G. Tzimas, J. O. Sass, W. Wittfoht, M. Elmazar +2 more
1994Drug Metabolism And Disposition51 citations
Semantic Scholar
The area under the concentration-time curve of all-trans-retinoic acid is the most suitable pharmacokinetic correlate to the embryotoxicity of this retinoid in the rat.
G. Tzimas, R. Thiel, I. Chahoud, H. Nau
1997Toxicology and Applied Pharmacology50 citations
Semantic Scholar
Antiepileptic drugs alter endogenous retinoid concentrations: a possible mechanism of teratogenesis of anticonvulsant therapy.
H. Nau, G. Tzimas, M. Mondry, C. Plum +1 more
1995Life Science46 citations
Semantic Scholar
Modulation of myb gene expression in sponges by retinoic acid.
H. Biesalski, G. Doepner, G. Tzimas, V. Gamulin +4 more
1992Oncogene45 citations
Semantic Scholar
Embryotoxic doses of vitamin A to rabbits result in low plasma but high embryonic concentrations of all-trans-retinoic acid: risk of vitamin A exposure in humans.
G. Tzimas, Michael D. Collins, H. Burgin, H. Hummler +1 more
1996Journal of NutriLife39 citations Open access
Semantic Scholar
Single versus multiple dose administration of all-trans-retinoic acid during organogenesis: differential metabolism and transplacental kinetics in rat and rabbit.
Michael D. Collins, G. Tzimas, H. Burgin, H. Hummler +1 more
1995Toxicology and Applied Pharmacology32 citations
Semantic Scholar
Developmental stage-associated differences in the transplacental distribution of 13-cis- and all-trans-retinoic acid as well as their glucuronides in rats and mice.
G. Tzimas, M. Collins, H. Nau
1995Toxicology and Applied Pharmacology29 citations
Semantic Scholar
Human uterine leiomyomata express higher levels of peroxisome proliferator-activated receptor gamma, retinoid X receptor alpha, and all-trans retinoic acid than myometrium.
J. Tsibris, K. Porter, A. Jazayeri, G. Tzimas +6 more
1999Cancer Research23 citations
Semantic Scholar
Retinoid teratogenicity in the macaque: Verification of dosing regimen
A. Hendrickx, G. Tzimas, R. Korte, H. Hummler
1998Journal of medical primatology20 citations
Semantic Scholar
Retinoid metabolism and transplacental pharmacokinetics in the cynomolgus monkey following a nonteratogenic dosing regimen with all-trans-retinoic acid.
G. Tzimas, H. Nau, A. Hendrickx, P. E. Peterson +1 more
1996Teratology19 citations
Semantic Scholar
9-Cis-retinoyl-β-glucuronide is a major metabolite of 9-Cis-retinoic acid
J. Sass, G. Tzimas, H. Nau
199419 citations
Semantic Scholar
The high sensitivity of the rabbit to the teratogenic effects of 13-cis-retinoic acid (isotretinoin) is a consequence of prolonged exposure of the embryo to 13-cis-retinoic acid and 13-cis-4-oxo-retinoic acid, and not of isomerization to all-trans-retinoic acid
G. Tzimas, H. Burgin, M. Collins, H. Hummler +1 more
2007Archives of Toxicology18 citations
Semantic Scholar
Identification of 14-hydroxy-4,14-retro-retinol as an in vivo metabolite of vitamin A.
G. Tzimas, M. Collins, H. Nau
1996Biochimica et Biophysica Acta16 citations
Semantic Scholar
Vitamin A teratogenicity and risk assessment in the macaque retinoid model.
G. Tzimas, H. Nau
2001Reproductive Toxicology14 citations
Semantic Scholar
Metabolism of retinaldehyde isomers in pregnant rats: 13-cis- and all-trans-retinaldehyde, but not 9-cis-retinaldehyde, yield very similar patterns of retinoid metabolites.
J. O. Sass, G. Tzimas, M. Elmazar, H. Nau
1999Drug Metabolism And Disposition13 citations
Semantic Scholar
Distribution of endogenous retinoids, retinoid binding proteins (RBP, CRABPI) and nuclear retinoid X receptor beta (RXRbeta) in the porcine embryo.
F. Schweigert, C. Siegling, G. Tzimas, J. Seeger +1 more
2002Reproduction, nutrition, development10 citations Open access
Semantic Scholar
9,13-Dicis-retinoic acid as an isomerization product of 9-cis-retinoic acid.
J. O. Sass, G. Tzimas, H. Nau
1997Drug Metabolism And Disposition7 citations
Semantic Scholar
9-cis-retinoyl-beta-D-glucuronide is a major metabolite of 9-cis-retinoic acid.
J. Sass, G. Tzimas, H. Nau
1994Life Science6 citations
Semantic Scholar
Proximate retinoid teratogens.
G. Tzimas, J. Sass, R. Rühl, M. Foerster +5 more
19944 citations
Semantic Scholar
Nutrient Metabolism Embryotoxic Doses of Vitamin A to Rabbits Result in Low Plasma but High Embryonic Concentrations of All-Â£rans-RetinoicAcid: Risk of Vitamin A Exposure in Humans1'2'3
G. Tzimas, M. Collins, Hans HÃœMMLERf
20060 citations
Semantic Scholar

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