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Clint D. J. Tavares · SciRah

Researcher profile · Semantic Scholar

Clint D. J. Tavares

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Clint D. J. Tavares — researcher profile on SciRah

h-index: 13
Works: 31
Citations: 530

Most-cited papers

Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer
İ. Tekedereli, S. Alpay, Clint D. J. Tavares, Zehra E. Cobanoglu +6 more
2012PLoS ONE112 citations Open access
Semantic Scholar
Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.
Ramakrishna Edupuganti, Qiantao Wang, Clint D. J. Tavares, Catrina A Chitjian +4 more
2014Bioorganic & Medicinal Chemistry65 citations Open access
Semantic Scholar
Calcium/Calmodulin Stimulates the Autophosphorylation of Elongation Factor 2 Kinase on Thr-348 and Ser-500 to Regulate its Activity and Calcium Dependence
Clint D. J. Tavares, J. O'Brien, O. Abramczyk, Ashwini K. Devkota +10 more
2012Biochemistry63 citations Open access
Semantic Scholar
Investigating the Kinetic Mechanism of Inhibition of Elongation Factor 2 Kinase (eEF-2K) by NH125: Evidence for a Common in vitro Artifact
Ashwini K. Devkota, Clint D. J. Tavares, Mangalika Warthaka, O. Abramczyk +5 more
2012Biochemistry60 citations Open access
Semantic Scholar
The Molecular Mechanism of Eukaryotic Elongation Factor 2 Kinase Activation*
Clint D. J. Tavares, S. Ferguson, D. H. Giles, Qiantao Wang +6 more
2014Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Purification and Characterization of Tagless Recombinant Human Elongation Factor 2 Kinase (eEF-2K) Expressed in Escherichia coli
O. Abramczyk, Clint D. J. Tavares, Ashwini K. Devkota, A. Ryazanov +4 more
2011Protein Expression and Purification30 citations Open access
Semantic Scholar
High-Throughput Screens for eEF-2 Kinase
Ashwini K. Devkota, Mangalika Warthaka, Ramakrishna Edupuganti, Clint D. J. Tavares +4 more
2014Journal of biomolecular screening26 citations Open access
Semantic Scholar
Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo
Tamer S. Kaoud, W. Johnson, N. Ebelt, A. Piserchio +16 more
2019Nature Communications25 citations Open access
Semantic Scholar
Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth.
Jiney Jose, Clint D. J. Tavares, N. Ebelt, A. Lodi +9 more
2017ACS Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin
Kwangwoon Lee, Sébastien Alphonse, A. Piserchio, Clint D. J. Tavares +4 more
2016Structure23 citations Open access
Semantic Scholar
Signal Integration at Elongation Factor 2 Kinase
Clint D. J. Tavares, D. H. Giles, G. Stancu, Catrina A Chitjian +5 more
2016Journal of Biological Chemistry20 citations Open access
Semantic Scholar
Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis
Qiantao Wang, Ramakrishna Edupuganti, Clint D. J. Tavares, K. Dalby +1 more
2015Frontiers in Molecular Biosciences20 citations Open access
Semantic Scholar
Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine.
Mangalika Warthaka, Charles H. Adelmann, Tamer S. Kaoud, Ramakrishna Edupuganti +9 more
2015ACS Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening.
Clint D. J. Tavares, Ashwini K. Devkota, K. Dalby, E. Cho
2016Methods in molecular biology4 citations
Semantic Scholar
Corrigendum to “Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli” [Protein Expression and Purification 79 (2011) 237–244] (S1046592811001197) (10.1016/j.pep.2011.05.005))
O. Abramczyk, Clint D. J. Tavares, Ashwini K. Devkota, A. Ryazanov +4 more
20122 citations
Semantic Scholar
Ser500 phosphorylation acts as a conformational switch to prime eEF-2K for activation
Amanda L. Bohanon, Luke S. Browning, A. Piserchio, Kimberly J. Long +6 more
2025Journal of Biological Chemistry1 citations Open access
Semantic Scholar
TRPM7 kinase domain rather than the channel regulates breast cancer cell migration and tumor metastasis
Tamer S. Kaoud, Xuemei Xie, R. Mangieri, Jihyun Park +9 more
2017The FASEB Journal1 citations Open access
Semantic Scholar
Abstract 3743 An intrinsically disordered regulatory loop integrates Ser500 phosphorylation and calmodulin binding to tune eEF-2K activation under stress
K. Dalby, Luke Browning, Amanda M. Bohanon, A. Piserchio +5 more
2026Journal of Biological Chemistry0 citations Open access
Semantic Scholar
Ser500 phosphorylation acts as a conformational switch to prime eEF-2K for activation
Amanda L. Bohanon, Luke S. Browning, R. Sammons, A. Piserchio +4 more
2025bioRxiv0 citations Open access
Semantic Scholar
Structure of calmodulin in a complex with a peptide derived from a calmodulin-dependent kinase
S. Alphonse, Kwangwoon Lee, A. Piserchio, Clint D. J. Tavares +4 more
20160 citations
Semantic Scholar
Abstract A17: TRPM7 kinase domain is involved in breast tumor cell metastasis
Tamer S. Kaoud, Xuemei Xie, Jihyun Park, Clint D. J. Tavares +5 more
20160 citations
Semantic Scholar
Structural Basis for the Re cognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin Graphical
Kwangwoo Lee, Sébastien Alphonse, A. Piserchio, Clint D. J. Tavares +4 more
20160 citations
Semantic Scholar
Abstract 3569: Inhibition of the TRPM7 kinase domain inhibits breast cancer cell migration and invasion and tumor metastasis
Tamer S. Kaoud, Xuemei Xie, Jihyun Park, Clint D. J. Tavares +6 more
20150 citations
Semantic Scholar
Targeting the transient receptor potential‐melastatin‐like 7 (Trpm7) kinase domain with the first inhibitor, inhibited breast cancer cell migration, invasion and tumor metastasis.
Tamer S. Kaoud, Xuemei Xie, Jihyun Park, Clint D. J. Tavares +6 more
20150 citations
Semantic Scholar
Modulation of eukaryotic elongation factor 2 kinase activity via phosphorylation on Ser‐500 (773.1)
Clint D. J. Tavares, Tamer S. Kaoud, S. Ferguson, Rebecca M. Wellmann +4 more
20140 citations
Semantic Scholar
Abstract 5462: Antiproliferative and cytotoxic activities of 5-(nonyloxy)tryptamine derivatives in breast cancer cells
Clint D. J. Tavares, Jiney Jose, Ashwini K. Devkota, Jihyun Park +3 more
20140 citations
Semantic Scholar
Abstract 513: Investigating stress-response pathways in pancreatic cancer cells using novel PERK inhibitors
Jihyun Park, Qiantao Wang, Tamer S. Kaoud, Clint D. J. Tavares +3 more
20140 citations
Semantic Scholar
Regulation of elongation factor 2 kinase (eEF-2K) by phosphorylation
Clint D. J. Tavares
20140 citations
Semantic Scholar
Abstract 2722: Suppression of breast cancer cell migration by novel inhibitors that target transient receptor potential-melastatin-like 7 (Trpm7) kinase activity
Tamer S. Kaoud, Jihyun Park, Clint D. J. Tavares, S. Mitra +3 more
20140 citations
Semantic Scholar
Abstract 2222: Analysis of the autophosphorylation-induced calcium-independent activity of human elongation factor 2 kinase (eEF-2K) - a therapeutic target for breast cancer.
Clint D. J. Tavares, S. Ferguson, Rebecca M. Wellmann, Tamer S. Kaoud +4 more
20130 citations
Semantic Scholar
Abstract 4551: Identification of TRPM7 kinase inhibitors.
Tamer S. Kaoud, Jihyun Park, S. Mitra, Clint D. J. Tavares +2 more
20130 citations
Semantic Scholar

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K. Dalby×26
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K. Dalby — researcher profile on SciRah
Tamer S. Kaoud×17
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Tamer S. Kaoud — researcher profile on SciRah
Ashwini K. Devkota×8
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A. Piserchio×7

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Peng-Yu Y. Ren×6

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Mangalika Warthaka×6

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