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Xiaoyong Fu · SciRah

Researcher profile · Semantic Scholar

Xiaoyong Fu

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Xiaoyong Fu — researcher profile on SciRah

h-index: 25
Works: 61
Citations: 3,635

Most-cited papers

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo
K. Meerbrey, G. Hu, J. Kessler, K. Roarty +15 more
2011Proceedings of the National Academy of Sciences of the United States of America657 citations Open access
Semantic Scholar
Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast.
Jinglan Zhang, Xiaomin Shi, Yehua Li, Beom-Jun Kim +10 more
2008Molecules and Cells433 citations Open access
Semantic Scholar
Different mechanisms for resistance to trastuzumab versus lapatinib in HER2- positive breast cancers -- role of estrogen receptor and HER2 reactivation
Yen-chao Wang, Gladys Morrison, R. M. Gillihan, Jun Guo +10 more
2011Breast Cancer Research292 citations Open access
Semantic Scholar
Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer
C. Creighton, Xiaoyong Fu, Bryan T. Hennessy, Angelo J. Casa +10 more
2010Breast Cancer Research241 citations Open access
Semantic Scholar
An epigenomic approach to therapy for tamoxifen-resistant breast cancer
Qin Feng, Zheng Zhang, M. Shea, Chad J. Creighton +14 more
2014Cell Research182 citations Open access
Semantic Scholar
FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer
Xiaoyong Fu, R. Jeselsohn, Resel Pereira, E. F. Hollingsworth +23 more
2016Proceedings of the National Academy of Sciences of the United States of America147 citations Open access
Semantic Scholar
FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer
Xiaoyong Fu, Resel Pereira, C. de Angelis, J. Veeraraghavan +20 more
2019Proceedings of the National Academy of Sciences of the United States of America145 citations Open access
Semantic Scholar
Cancer Cells Resistant to Therapy Promote Cell Surface Relocalization of GRP78 Which Complexes with PI3K and Enhances PI(3,4,5)P3 Production
Yi Zhang, Chun-Chih Tseng, Yuan-Li Tsai, Xiaoyong Fu +2 more
2013PLoS ONE144 citations Open access
Semantic Scholar
Enhancer Reprogramming Driven by High-order Assemblies of Transcription Factors Promotes Phenotypic Plasticity and Breast Cancer Endocrine Resistance
Mingjun Bi, Zhao Zhang, Yi-Zhou Jiang, Pengya Xue +17 more
2020Nature Cell Biology124 citations Open access
Semantic Scholar
Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis
Yan-Ming Wu, Zhao Zhang, Mauro E. Cenciarini, Cecilia J. Proietti +16 more
2017Cancer Research110 citations Open access
Semantic Scholar
Upregulation of ER signaling as an adaptive mechanism of cell survival in HER2-positive breast tumors treated with anti-HER2 therapy
M. Giuliano, Huizhong Hu, Yen-chao Wang, Xiaoyong Fu +19 more
2015Clinical Cancer Research110 citations Open access
Semantic Scholar
Embryonic transcription factor SOX9 drives breast cancer endocrine resistance
R. Jeselsohn, M. Cornwell, Matthew Pun, Gilles Buchwalter +19 more
2017Proceedings of the National Academy of Sciences of the United States of America109 citations Open access
Semantic Scholar
RFWD3–Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage
Xiaoyong Fu, N. Yucer, Shang-Feng Liu, Mu-Yang Li +9 more
2010Proceedings of the National Academy of Sciences of the United States of America82 citations Open access
Semantic Scholar
Biology and therapeutic potential of PI3K signaling in ER+/HER2-negative breast cancer
Xiaoyong Fu, C. Osborne, R. Schiff
2013Breast81 citations Open access
Semantic Scholar
Activation of the interferon signaling pathway is associated with resistance to CDK4/6 inhibitors and immune checkpoint activation in ER-positive breast cancer
C. de Angelis, Xiaoyong Fu, M. Cataldo, A. Nardone +26 more
2021Clinical Cancer Research79 citations Open access
Semantic Scholar
Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase
Xiaoyong Fu, C. Creighton, N. Biswal, Vijetha Kumar +26 more
2014Breast Cancer Research77 citations Open access
Semantic Scholar
Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance
Yufan Zhou, D. Gerrard, Junbai Wang, Tian Li +9 more
2019Nature Communications76 citations Open access
Semantic Scholar
Pathway-Centric Integrative Analysis Identifies RRM2 as a Prognostic Marker in Breast Cancer Associated with Poor Survival and Tamoxifen Resistance
N. Putluri, S. Maity, Ramakrishna Kommangani, C. Creighton +17 more
2014Neoplasia76 citations Open access
Semantic Scholar
THERAPEUTIC POTENTIAL OF THE DUAL EGFR/HER2 INHIBITOR AZD8931 IN CIRCUMVENTING ENDOCRINE RESISTANCE
Gladys Morrison, Xiaoyong Fu, M. Shea, S. Nanda +6 more
2014Breast Cancer Research and Treatment63 citations Open access
Semantic Scholar
Targeting the mevalonate pathway to overcome acquired anti-HER2 treatment resistance in breast cancer
V. Sethunath, Huizhong Hu, C. de Angelis, J. Veeraraghavan +21 more
2019Molecular Cancer Research56 citations Open access
Semantic Scholar
The oral selective oestrogen receptor degrader (SERD) AZD9496 is comparable to fulvestrant in antagonising ER and circumventing endocrine resistance
A. Nardone, H. Weir, O. Delpuech, Henry Brown +15 more
2018British Journal of Cancer53 citations Open access
Semantic Scholar
Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance
L. Malorni, M. Giuliano, I. Migliaccio, Tao Wang +16 more
2016Molecular Cancer Research45 citations Open access
Semantic Scholar
NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer
R. Bhat, Hariprasad Thangavel, Noor M. Abdulkareem, S. Vasaikar +8 more
2022Scientific Reports27 citations Open access
Semantic Scholar
Integrated Molecular Analysis of Tamoxifen-Resistant Invasive Lobular Breast Cancer Cells Identifies MAPK and GRM/mGluR Signaling as Therapeutic Vulnerabilities
Hillary Stires, M. Heckler, Xiaoyong Fu, Li Zhao +9 more
2017Molecular and Cellular Endocrinology26 citations Open access
Semantic Scholar
GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer
R. Bhat, P. Yadav, D. Sahay, D. Bhargava +13 more
2018Breast Cancer Research and Treatment25 citations Open access
Semantic Scholar
SGK3 Is Associated with Estrogen Receptor Expression in Breast Cancer
Jun Xu, Ma Wan, Quanyuan He, Roland L. Jr Bassett +7 more
2012Breast Cancer Research and Treatment25 citations Open access
Semantic Scholar
Interferon Signaling in Estrogen Receptor-positive Breast Cancer: A Revitalized Topic.
Xiaoyong Fu, C. de Angelis, R. Schiff
2021Endocrinology24 citations
Semantic Scholar
Discovery, Structure-Activity Relationship and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP
Fang-Rui Wu, Y. Hua, S. Kaochar, S. Nie +12 more
2020Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
High FOXA1 Levels Induce ER Transcriptional Reprogramming and Promote a Pro-metastatic Secretome and Metastasis in Endocrine-resistant Breast Cancer
Xiaoyong Fu, Resel Pereira, C. Liu, C. de Angelis +18 more
2023Cell Reports23 citations Open access
Semantic Scholar
A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer
A. Nardone, X. Qiu, S. Spisák, Zsuzsanna Nagy +24 more
2022bioRxiv21 citations Open access
Semantic Scholar
Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity
F. Stossi, Radhika D. Dandekar, M. Mancini, G. Gu +10 more
2020Nucleic Acids Research19 citations Open access
Semantic Scholar
More on FOX News: FOXA1 on the horizon of estrogen receptor function and endocrine response
Xiaoyong Fu, Catherine Huang, R. Schiff
2011Breast Cancer Research14 citations Open access
Semantic Scholar
Molecular Mechanisms of Endocrine Resistance
Xiaoyong Fu, C. de Angelis, J. Veeraraghavan, C. Osborne +1 more
2018Estrogen Receptor and Breast Cancer8 citations
Semantic Scholar
MicroRNAs Add an Additional Layer to the Complexity of Cell Signaling
Jason I. Herschkowitz, Xiaoyong Fu
2011Science Signaling6 citations
Semantic Scholar
Abstract GS2-01: High levels of interferon-response gene signatures are associated withde novoand acquired resistance to CDK4/6 inhibitors in ER+ breast cancer
C. de Angelis, Xiaoyong Fu, M. Cataldo, A. Nardone +21 more
2020General Session Abstracts5 citations
Semantic Scholar
Pathway-Centric Integrative Analysis Identifies RRM2 as a Prognostic Marker in Breast Cancer Associated with Poor Survival and
N. Putluri, S. Maity, Ramakrishna Kommangani, C. Creighton +15 more
20145 citations
Semantic Scholar
Correction: Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer
C. de Angelis, Xiaoyong Fu, M. Cataldo, A. Nardone +26 more
2021Clinical Cancer Research2 citations Open access
Semantic Scholar
Author Correction: Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance
Yufan Zhou, D. Gerrard, Junbai Wang, Tian Li +9 more
2020Nature Communications2 citations Open access
Semantic Scholar
Coordinate Enhancer Reprogramming by GATA3 and AP1 Promotes Phenotypic Plasticity to Achieve Breast Cancer Endocrine Resistance
Mingjun Bi, Zhao Zhang, Pengya Xue, Karen Hernandez +14 more
20192 citations Open access
Semantic Scholar
Abstract PD8-03: A FOXA1/FRA1-centered transcriptional axis regulates interferon signaling in high FOXA1-associated endocrine-resistant and metastatic breast cancer
Xiaoyong Fu, Resel Pereira, L. Qin, C. de Angelis +9 more
2021Poster Spotlight Session Abstracts1 citations
Semantic Scholar
In vivo Longitudinal Imaging of RNAi Induced Endocrine Therapy Resistance in Breast Cancer
N. Biswal, Xiaoyong Fu, J. Jagtap, M. Shea +5 more
2019Journal of Biophotonics1 citations Open access
Semantic Scholar
Abstract SY01-01: Endocrine resistance in metastatic breast cancer: Mechanisms and new therapeutic strategies
R. Schiff, J. Veeraraghavan, Xiaoyong Fu
2018Experimental and Molecular Therapeutics1 citations
Semantic Scholar
Abstract PD6-2: FoxA1 gene amplification in ER+ breast cancer mediates endocrine resistance by increasing IL-8
Xiaoyong Fu, R. Jeselsohn, E. F. Hollingsworth, D. Lopez-Terrada +15 more
20151 citations
Semantic Scholar
Abstract P3-05-13: Overexpression of insulin receptor substrate 4 can mediate acquired resistance to lapatinib-containing regimens in HER2+ breast cancer cells
L. Qin, M. Hahn, Xiaoyong Fu, M. Shea +17 more
20151 citations
Semantic Scholar
Abstract PD10-03: PD10-03 Super-enhancer-oriented integrative bioinformatics identifies aberrant KLF4 signaling in endocrine-resistant breast cancer (BC)
C. Liu, L. Qin, Shanunak Sathe, S. Nanda +7 more
2023Cancer Research0 citations
Semantic Scholar
Abstract P2-03-10: DNA replication licensing is associated with resistance to CDK4/6 inhibitors in ER-positive breast cancer
S. Nanda, M. Shea, R. Schiff, C. Osborne +2 more
2023Cancer Research0 citations
Semantic Scholar
Abstract P1-13-17: Hyperactivation of the EGFR pathway is associated with resistance to tucatinib in HER2-positive breast cancer models
Fu-Tien Liao, T. Gordon, C. Liu, P. Selenica +14 more
2023Cancer Research0 citations
Semantic Scholar
Abstract PD1-05: Targeting the FRA1-dependent transcriptional nexus in high FOXA1-driven endocrine-resistant and metastatic breast cancer
C. Liu, L. Qin, C. de Angelis, S. Nanda +11 more
2022Cancer Research0 citations
Semantic Scholar
Abstract PS5-29: Insights into the molecular underpinnings of the mevalonate pathway-YAP/TAZ-driven anti-HER2 therapy resistance in HER2+ breast cancer (BC)
V. Sethunath, Xiaoyong Fu, P. Luna, S. Nanda +8 more
20210 citations
Semantic Scholar
Abstract 930: Production of functionally active recombinant FOXA1: The first step towards targeted drug discovery
Hariprasad Thangavel, Ying Zhu, K. Christensen, Xiaoyong Fu +3 more
2021Experimental and Molecular Therapeutics0 citations
Semantic Scholar

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