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R. Reynolds · SciRah

Researcher profile · Semantic Scholar

R. Reynolds

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R. Reynolds — researcher profile on SciRah

h-index: 38
Works: 139
Citations: 4,558

Most-cited papers

Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives.
Lainne E. Seitz, W. J. Suling, R. Reynolds
2002Journal of Medicinal Chemistry404 citations
Semantic Scholar
Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against Mycobacterium tuberculosis in a Series of In Vitro and In Vivo Models
A. Lenaerts, Veronica Gruppo, Karen S Marietta, Christine M. Johnson +5 more
2005Antimicrobial Agents and Chemotherapy311 citations Open access
Semantic Scholar
EthA, a Common Activator of Thiocarbamide-Containing Drugs Acting on Different Mycobacterial Targets
L. Dover, A. Alahari, Paul Gratraud, J. Gomes +4 more
2007Antimicrobial Agents and Chemotherapy142 citations Open access
Semantic Scholar
Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria
A. Alahari, X. Trivelli, Y. Guérardel, L. Dover +5 more
2007PLoS ONE135 citations Open access
Semantic Scholar
The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds.
S. Waddell, R. Stabler, K. Laing, L. Kremer +2 more
2004Tuberculosis130 citations Open access
Semantic Scholar
Silibinin Inhibits Wnt/β-catenin Signaling by Suppressing Wnt Co-receptor LRP6 Expression in Human Prostate and Breast Cancer Cells
Wenyan Lu, Cui-Hong Lin, Taj D. King, Hong-Hong Chen +2 more
2012Cellular Signalling125 citations Open access
Semantic Scholar
Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches.
A. Leung, E. White, L. Ross, R. Reynolds +2 more
2004Journal of Molecular Biology122 citations
Semantic Scholar
Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets
A. Clark, Krishna Dole, Anna Coulon-Spektor, Andrew M. Mcnutt +4 more
2015Journal of Chemical Information and Modeling114 citations Open access
Semantic Scholar
2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ.
E. White, W. J. Suling, L. Ross, Lainne E. Seitz +1 more
2002Journal of Antimicrobial Chemotherapy110 citations
Semantic Scholar
Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery
T. Lane, Daniel P. Russo, Kimberley M. Zorn, A. Clark +6 more
2018Molecular Pharmaceutics102 citations Open access
Semantic Scholar
A Novel Sulindac Derivative That Does Not Inhibit Cyclooxygenases but Potently Inhibits Colon Tumor Cell Growth and Induces Apoptosis with Antitumor Activity
G. Piazza, A. Keeton, Heather N. Tinsley, Bernard D. Gary +10 more
2009Cancer Prevention Research97 citations Open access
Semantic Scholar
Bayesian Models Leveraging Bioactivity and Cytotoxicity Information for Drug Discovery
S. Ekins, R. Reynolds, Hiyun Kim, Mi-Sun Koo +8 more
2013Chemistry and Biology95 citations Open access
Semantic Scholar
Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by PDE5 inhibition, elevation of cGMP, and activation of PKG
Heather N. Tinsley, Bernard D. Gary, A. Keeton, Wei Zhang +3 more
2009Molecular Cancer Therapeutics95 citations Open access
Semantic Scholar
Antimycobacterial agents. 1. Thio analogues of purine.
A. Pathak, V. Pathak, Lainne E. Seitz, W. J. Suling +1 more
2004Journal of Medicinal Chemistry82 citations
Semantic Scholar
Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100.
D. Marciani, R. Reynolds, A. Pathak, Kyra Finley-Woodman +1 more
2003Vaccine74 citations
Semantic Scholar
Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation.
R. Reynolds, S. R. Campbell, R. Fairchild, R. Kisliuk +9 more
2007Journal of Medicinal Chemistry71 citations Open access
Semantic Scholar
Synthesis and biological evaluation of trehalose analogs as potential inhibitors of mycobacterial cell wall biosynthesis.
J. D. Rose, J. Maddry, R. Comber, W. J. Suling +2 more
2002Carbohydrate Research60 citations
Semantic Scholar
Studies on (β,1→5) and (β,1→6) linked octyl Galf disaccharides as substrates for mycobacterial galactosyltransferase activity
A. Pathak, V. Pathak, Lainne E. Seitz, J. Maddry +4 more
200158 citations
Semantic Scholar
NSAIDs: Old Drugs Reveal New Anticancer Targets
G. Piazza, A. Keeton, Heather N. Tinsley, J. Whitt +5 more
2010Pharmaceuticals56 citations Open access
Semantic Scholar
Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis
A. Alahari, L. Alibaud, X. Trivelli, Radhika Gupta +5 more
2009Molecular Microbiology52 citations Open access
Semantic Scholar
Binding Mode Analysis of 2,4-diamino-5-methyl-5-deaza-6-substituted Pteridines with Mycobacterium tuberculosis and Human Dihydrofolate Reductases
E. D. da Cunha, Teodorico C. Ramalho, R. Reynolds
2008Journal of Biomolecular Structure and Dynamics50 citations
Semantic Scholar
Are Bigger Datasets Better for Machine Learning? Fusing Single-Point and Dual-event Dose Response Data For Mycobacterium tuberculosis
S. Ekins, J. Freundlich, R. Reynolds
2014Journal of Chemical Information and Modeling44 citations Open access
Semantic Scholar
Looking Back to the Future: Predicting in Vivo Efficacy of Small Molecules versus Mycobacterium tuberculosis
S. Ekins, R. Pottorf, R. Reynolds, A. Williams +2 more
2014Journal of Chemical Information and Modeling44 citations Open access
Semantic Scholar
Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis.
V. Usha, S. Gurcha, A. Lovering, A. Lloyd +3 more
2011Microbiology40 citations Open access
Semantic Scholar
Thiosemicarbazole (Thiacetazone-Like) Compound with Activity against Mycobacterium avium in Mice
L. Bermudez, R. Reynolds, P. Kolonoski, P. Aralar +2 more
2003Antimicrobial Agents and Chemotherapy40 citations Open access
Semantic Scholar
Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis.
L. Alderwick, L. Dover, N. Veerapen, S. Gurcha +5 more
2008Protein Expression and Purification39 citations
Semantic Scholar
Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis.
Veemal Bhowruth, Alistair K. Brown, R. Reynolds, G. Coxon +3 more
2006Bioorganic & Medicinal Chemistry Letters39 citations
Semantic Scholar
Studies on n-Octyl-5-(α-d-arabinofuranosyl)-β-d-galactofuranosides for Mycobacterial Glycosyltransferase Activity
A. Pathak, V. Pathak, W. J. Suling, S. Gurcha +4 more
200238 citations Open access
Semantic Scholar
SRI-286, a Thiosemicarbazole, in Combination with Mefloquine and Moxifloxacin for Treatment of Murine Mycobacterium avium Complex Disease
L. Bermudez, P. Kolonoski, L. Seitz, M. Petrofsky +3 more
2004Antimicrobial Agents and Chemotherapy35 citations Open access
Semantic Scholar
Identification of shikimate kinase inhibitors among anti-Mycobacterium tuberculosis compounds by LC-MS.
Johayra Simithy, N. Reeve, J. Hobrath, R. Reynolds +1 more
2014Tuberculosis32 citations
Semantic Scholar
Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target
S. Gurcha, V. Usha, Jonathan A. G. Cox, K. Fütterer +12 more
2014PLoS ONE32 citations Open access
Semantic Scholar
EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR.
V. Molle, R. Reynolds, L. Alderwick, G. Besra +3 more
2008Biochemical Journal31 citations Open access
Semantic Scholar
Molecule Property Analyses of Active Compounds for Mycobacterium Tuberculosis
V. Makarov, E. Salina, R. Reynolds, Phyo Phyo Zin +1 more
2020Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
Fusing Dual-Event Datasets for Mycobacterium Tuberculosis Machine Learning Models and their Evaluation
S. Ekins, J. Freundlich, R. Reynolds
2013Journal of Chemical Information and Modeling29 citations Open access
Semantic Scholar
A novel quinoline derivative that inhibits mycobacterial FtsZ
Bini Mathew, L. Ross, R. Reynolds
2013Tuberculosis29 citations Open access
Semantic Scholar
Synthesis and PreliminaryIn Vitro Evaluation of Antimycobacterial Activity of New Pyrrolo[1,2-a]quinoxaline-carboxylic Acid Hydrazide Derivatives
J. Guillon, R. Reynolds, J. Léger, Marie-Aude Guie +3 more
2004Journal of Enzyme Inhibition and Medicinal Chemistry29 citations Open access
Semantic Scholar
Identification of Novel Mt-Guab2 Inhibitor Series Active against M. tuberculosis
V. Usha, J. Hobrath, S. Gurcha, R. Reynolds +1 more
2012PLoS ONE28 citations Open access
Semantic Scholar
Identification of DOT1L Inhibitors by Structure-Based Virtual Screening Adapted from a Nucleoside-Focused Library
Garrett S. Gibbons, Amarraj Chakraborty, Sierrah M. Grigsby, Afoma C. Umeano +10 more
2020European journal of medicinal chemistry26 citations Open access
Semantic Scholar
Programs to facilitate tuberculosis drug discovery: the tuberculosis antimicrobial acquisition and coordinating facility.
R. Goldman, B. E. Laughon, R. Reynolds, J. Secrist +5 more
2007Infectious Diseases - Drug Targets26 citations
Semantic Scholar
Diverse amide analogs of sulindac for cancer treatment and prevention
Bini Mathew, J. Hobrath, M. Connelly, R. K. Guy +1 more
2017Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis.
A. Pathak, V. Pathak, J. M. Riordan, S. Gurcha +2 more
2004Carbohydrate Research23 citations
Semantic Scholar
Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis
A. Pathak, V. Pathak, M. Kulshrestha, D. Kinnaird +4 more
200322 citations
Semantic Scholar
ChemInform Abstract: A Facile Method for Deprotection of Trityl Ethers Using Column Chromatography.
A. Pathak, V. Pathak, Lainne E. Seitz, K. Tiwari +2 more
200122 citations
Semantic Scholar
6-Oxo and 6-Thio Purine Analogs as Antimycobacterial Agents
A. Pathak, V. Pathak, Lainne E. Seitz, W. J. Suling +1 more
2013Bioorganic & Medicinal Chemistry19 citations Open access
Semantic Scholar
Synthesis of Deoxygenated (α 1→5)-Linked Arabinofuranose Disaccharides as Substrates and Inhibitors of Arabinosyltransferases of Mycobacterium tuberculosis
A. Pathak, V. Pathak, W. J. Suling, J. Riordan +3 more
2008Bioorganic & Medicinal Chemistry19 citations Open access
Semantic Scholar
Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens
Bini Mathew, J. Hobrath, Wenyan Lu, Yong-He Li +1 more
2017Medicinal Chemistry Research16 citations Open access
Semantic Scholar
Oxazole and thiazole analogs of sulindac for cancer prevention
Bini Mathew, J. Hobrath, M. Connelly, R. Guy +1 more
2018Future Medicinal Chemistry15 citations Open access
Semantic Scholar
Parallel Solution-Phase Synthesis and General Biological Activity of a Uridine Antibiotic Analog Library
O. Moukha-Chafiq, R. Reynolds
2014ACS Combinatorial Science15 citations Open access
Semantic Scholar
Synthesis of a fluorescent arabinofuranosyl disaccharide: a probe for arabinosyltransferase activity in Mycobacterium tuberculosis
A. Pathak, V. Pathak, N. Bansal, J. Maddry +1 more
200115 citations
Semantic Scholar
Degradation of Quillaja saponaria Molina saponins: loss of the protective effects of a herpes simplex virus 1 subunit vaccine.
D. Marciani, R. Ptak, Thomas G. Voss, R. Reynolds +4 more
2002International Immunopharmacology14 citations
Semantic Scholar

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G. Besra — researcher profile on SciRah
A. Pathak×12
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A. Pathak — researcher profile on SciRah
V. Pathak×10
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V. Pathak — researcher profile on SciRah
W. J. Suling×9
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W. J. Suling — researcher profile on SciRah

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S. Gurcha — researcher profile on SciRah

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Bini Mathew — researcher profile on SciRah

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Lainne E. Seitz×6

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Lainne E. Seitz — researcher profile on SciRah

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J. Freundlich — researcher profile on SciRah

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J. Maddry — researcher profile on SciRah