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Sarit Larisch · SciRah

Researcher profile · Semantic Scholar

Sarit Larisch

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Sarit Larisch — researcher profile on SciRah

h-index: 24
Works: 51
Citations: 2,170

Most-cited papers

The Sept4 septin locus is required for sperm terminal differentiation in mice.
H. Kissel, M. Georgescu, Sarit Larisch, K. Manova +2 more
2005Developmental Cell301 citations Open access
Semantic Scholar
A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif
Sarit Larisch, Y. Yi, R. Lotan, H. Kerner +14 more
2000Nature Cell Biology260 citations
Semantic Scholar
The mitochondrial ARTS protein promotes apoptosis through targeting XIAP
Y. Gottfried, Asaf Rotem, R. Lotan, H. Steller +1 more
2004EMBO Journal183 citations Open access
Semantic Scholar
Inhibiting the inhibitors: Targeting anti-apoptotic proteins in cancer and therapy resistance.
Nir Shahar, Sarit Larisch
2020Drug resistance updates153 citations
Semantic Scholar
High glucose-induced replicative senescence: point of no return and effect of telomerase.
S. Blazer, E. Khankin, Y. Segev, R. Ofir +5 more
2002Biochemical and Biophysical Research Communications - BBRC104 citations
Semantic Scholar
Targeting XIAP for Promoting Cancer Cell Death—The Story of ARTS and SMAC
Ruqaia Abbas, Sarit Larisch
2020Cells100 citations Open access
Semantic Scholar
Sept4/ARTS is required for stem cell apoptosis and tumor suppression.
M. García-Fernández, H. Kissel, Samara Brown, Travis Gorenc +4 more
2010Genes & Development87 citations Open access
Semantic Scholar
Degradation of Bcl-2 by XIAP and ARTS promotes apoptosis
N. Edison, Yael Curtz, Nicole Paland, Dana Mamriev +8 more
2017Cell Reports82 citations Open access
Semantic Scholar
Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients
R. Elhasid, D. Sahar, Ayellet Merling, Yifat Zivony +5 more
2004Oncogene74 citations
Semantic Scholar
Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System
Ruqaia Abbas, Sarit Larisch
2021Cells64 citations Open access
Semantic Scholar
Hypoxia predisposes neonatal rat ventricular myocytes to apoptosis induced by activation of the Fas (CD95/Apo-1) receptor: Fas activation and apoptosis in hypoxic myocytes.
G. Yaniv, M. Shilkrut, R. Lotan, G. Berke +2 more
2002Cardiovascular Research59 citations
Semantic Scholar
The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo
N. Edison, Dotan Zuri, I. Maniv, Bavat Bornstein +6 more
2011Cell Death and Differentiation58 citations Open access
Semantic Scholar
Ripoptosome: a novel IAP-regulated cell death-signalling platform.
G. Imre, Sarit Larisch, K. Rajalingam
2011Journal of Molecular Cell Biology55 citations Open access
Semantic Scholar
p53 induces ARTS to promote mitochondrial apoptosis
Q. Hao, Jia-Xiang Chen, Jun-Ming Liao, Yingdan Huang +5 more
2020Cell Death and Disease45 citations Open access
Semantic Scholar
PAX8 activates a p53-p21-dependent pro-proliferative effect in high grade serous ovarian carcinoma
Dima Ghannam-Shahbari, Eyal Jacob, R. Kakun, Tanya Wasserman +11 more
2018Oncogene45 citations
Semantic Scholar
Regulation of the Proapoptotic ARTS Protein by Ubiquitin-mediated Degradation*
R. Lotan, Asaf Rotem, H. Gonen, J. Finberg +4 more
2005Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Parkin Promotes Degradation of the Mitochondrial Pro-Apoptotic ARTS Protein
S. Kemeny, D. Dery, Y. Loboda, Marshall Rovner +4 more
2012PLoS ONE36 citations Open access
Semantic Scholar
ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists
Bavat Bornstein, Y. Gottfried, N. Edison, A. Shekhtman +3 more
2011Apoptosis36 citations
Semantic Scholar
Mitochondrial damage: A target for new therapeutic horizons
J. Soustiel, Sarit Larisch
2011Neurotherapeutics35 citations Open access
Semantic Scholar
Role of Melanoma Inhibitor of Apoptosis (ML-IAP) Protein, a Member of the Baculoviral IAP Repeat (BIR) Domain Family, in the Regulation of C-RAF Kinase and Cell Migration*
Tripat Kaur Oberoi-Khanuja, C. Karreman, Sarit Larisch, U. Rapp +1 more
2012Journal of Biological Chemistry33 citations Open access
Semantic Scholar
Article in press-uncorrected proof Review ARTS , the unusual septin : structural and functional aspects
Yael Mandel-Gutfreund, I. Kosti, Sarit Larisch
201133 citations
Semantic Scholar
Parkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTS
Inna Bendikov-Bar, D. Rapaport, Sarit Larisch, M. Horowitz
2014Orphanet Journal of Rare Diseases29 citations Open access
Semantic Scholar
Peptides Mimicking the Unique ARTS-XIAP Binding Site Promote Apoptotic Cell Death in Cultured Cancer Cells
N. Edison, T. Reingewertz, Y. Gottfried, T. Lev +6 more
2012Clinical Cancer Research28 citations Open access
Semantic Scholar
A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2
Dana Mamriev, Ruqaia Abbas, Franca-Maria Klingler, J. Kagan +6 more
2020Cell Death and Disease26 citations Open access
Semantic Scholar
Mechanism of the Interaction between the Intrinsically Disordered C-Terminus of the Pro-Apoptotic ARTS Protein and the Bir3 Domain of XIAP
T. Reingewertz, D. Shalev, S. Sukenik, O. Blatt +4 more
2011PLoS ONE22 citations Open access
Semantic Scholar
The ARTS Connection: Role of ARTS in Apoptosis and Cancer
Sarit Larisch
2004Cell Cycle22 citations Open access
Semantic Scholar
Expression of the pro‐apoptotic protein ARTS in astrocytic tumors
Y. Gottfried, Eugene Voldavsky, Lena Yodko, E. Sabo +2 more
2004Cancer21 citations
Semantic Scholar
The pro-apoptotic ARTS protein induces neutrophil apoptosis, efferocytosis, and macrophage reprogramming to promote resolution of inflammation
N. Maimon, Zohar Zvi Zamir, P. Kalkar, Orly Zeytuni-Timor +3 more
2020Apoptosis19 citations
Semantic Scholar
Hydrogen peroxide predisposes neonatal rat ventricular myocytes to Fas-mediated apoptosis.
G. Yaniv, M. Shilkrut, Sarit Larisch, O. Binah
2005Biochemical and Biophysical Research Communications - BBRC19 citations
Semantic Scholar
X-linked Inhibitor of Apoptosis Protein promotes the degradation of its antagonist, the pro-apoptotic ARTS protein.
Bavat Bornstein, N. Edison, Y. Gottfried, T. Lev +4 more
2012International Journal of Biochemistry and Cell Biology17 citations
Semantic Scholar
The Fas Receptor—1,4,5‐IP3 Cascade: A Potential Target for Treating Heart Failure and Arrhythmias
O. Binah, M. Shilkrut, G. Yaniv, Sarit Larisch
2004Annals of the New York Academy of Sciences16 citations
Semantic Scholar
Tyrosine kinases inhibitors block Fas-mediated deleterious effects in normoxic and hypoxic ventricular myocytes.
M. Shilkrut, G. Yaniv, R. Asleh, A. Levy +2 more
2003Journal of Molecular and Cellular Cardiology16 citations
Semantic Scholar
The pro-apoptotic ARTS/Sept4 protein is significantly reduced in post-mortem brains from schizophrenic patients.
Y. Gottfried, Asaf Rotem, E. Klein, Sarit Larisch
2007Schizophrenia Research14 citations
Semantic Scholar
ARTS-based anticancer therapy: taking aim at cancer stem cells.
R. Elhasid, Sarit Larisch
2011Future Oncology9 citations
Semantic Scholar
Chemical Tomography of Cancer Organoids and Cyto‐Proteo‐Genomic Development Stages Through Chemical Communication Signals
Arnab Maity, Vivian Darsa Maidantchik, Keren Weidenfeld, Sarit Larisch +2 more
2025Advances in Materials8 citations Open access
Semantic Scholar
ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP
Ruqaia Abbas, Oliver Hartmann, Dorin Theodora Asiss, R. Abbas +6 more
2024Apoptosis5 citations Open access
Semantic Scholar
IFN-β and ARTS deficiency promote the generation of hyper-efferocytic Ly6C+ macrophages in resolving inflammation in male mice
Orly Zeituni-Timor, Soaad Soboh, Ahmad Zaid, Hiba Yaseen +7 more
2025Communications Biology4 citations Open access
Semantic Scholar
International conference on Cell Death in Cancer and Toxicology 2018 (CDCT-2018)
K. Ansari, P. Arany, E. Arama, Sarit Larisch +2 more
2018Cell Communication and Signaling4 citations Open access
Semantic Scholar
Septins and Apoptosis
Marie-Jeanne Carp, Sarit Larisch
20084 citations
Semantic Scholar
Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma
Z. Choo, Xiaoying Koh, M. Wong, Ruth Minothini Ashokan +7 more
2023Cancer Research Communications3 citations Open access
Semantic Scholar
Erratum: Mitochondrial proapoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients (Oncogene (2004) 23 (5468-5475) doi:10.1038/sj.onc.1207725)
R. Elhasid, D. Sahar, Ayellet Merling, Yifat Zivony +5 more
20043 citations Open access
Semantic Scholar
Mitochondrial proapoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients
R. Elhasid, D. Sahar, Ayellet Merling, Yifat Zivony +5 more
2004Oncogene3 citations Open access
Semantic Scholar
Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP
Dana Mamriev, Sarit Larisch
2018Molecular & Cellular Oncology2 citations Open access
Semantic Scholar
CED-3 caspase promotes dismantling but not onset of non-apoptotic linker cell death in C. elegans
Olya Yarychkivska, L. Kutscher, Betty Ortiz Bido, J. Kagan +7 more
2025bioRxiv1 citations Open access
Semantic Scholar
Corrigendum: Sept4/ARTS is required for stem cell apoptosis and tumor suppression
M. García-Fernández, H. Kissel, Samara Brown, Travis Gorenc +4 more
2025Genes & Development0 citations Open access
Semantic Scholar
The “ARTS” of Cell Death in Service of Life: How Do We Force Cancer Cells to Commit Suicide?
Sarit Larisch
2021Frontiers for Young Minds0 citations Open access
Semantic Scholar
A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2
Dana Mamriev, Ruqaia Abbas, Franca-Maria Klingler, J. Kagan +6 more
2020Cell Death and Disease0 citations Open access
Semantic Scholar
The pro-apoptotic ARTS protein induces neutrophil apoptosis, efferocytosis, and macrophage reprogramming to promote resolution of inflammation
N. Maimon, Zohar Zvi Zamir, P. Kalkar, Orly Zeytuni-Timor +3 more
2020Apoptosis0 citations
Semantic Scholar
Abstract GMM-045: PAX8 PLAYS AN ESSENTIAL ROLE IN HIGH GRADE SEROUS OVARIAN CANCER VIA ACTIVATION OF MUTANT P53 AND MISLOCALIZED P21
Dima Ghannam, Eyal Jacob, R. Kakun, Tanya Wasserman +11 more
2019Genomics and Molecular Mechanisms of Ovarian Cancer0 citations
Semantic Scholar
1 Cancer Therapy : Preclinical 2 Peptides Mimicking the Unique ARTS-XIAP Binding Site 3 Promote Apoptotic Cell Death in Cultured Cancer Cells 4 5
N. Edison, T. Reingewertz, Y. Gottfried, T. Lev +6 more
20120 citations
Semantic Scholar

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Y. Gottfried×10
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Y. Gottfried — researcher profile on SciRah
J. Kagan×7
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H. Steller×6
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Asaf Rotem×6
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N. Edison — researcher profile on SciRah

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T. Lev — researcher profile on SciRah

Ruqaia Abbas×5

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Ruqaia Abbas — researcher profile on SciRah

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Dana Mamriev — researcher profile on SciRah

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R. Lotan — researcher profile on SciRah

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R. Elhasid — researcher profile on SciRah

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G. Yaniv — researcher profile on SciRah

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M. Shilkrut — researcher profile on SciRah