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David H. Spencer · SciRah

Researcher profile · Semantic Scholar

David H. Spencer

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David H. Spencer — researcher profile on SciRah

h-index: 28
Works: 84
Citations: 9,406

Most-cited papers

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
T. Ley, Christopher B. Miller, L. Ding, Benjamin J. Raphael +96 more
2013New England Journal of Medicine4,643 citations Open access
Semantic Scholar
CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer
M. Griffith, N. Spies, K. Krysiak, Joshua F. McMichael +41 more
2017Nature Genetics604 citations Open access
Semantic Scholar
Clonal dynamics of haematopoiesis across the human lifespan
E. Mitchell, Michael Spencer-Chapman, Nicholas Williams, K. Dawson +25 more
2021Nature455 citations Open access
Semantic Scholar
The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits WT DNMT3A by Blocking its Ability to Form Active Tetramers
D. Russler-Germain, David H. Spencer, Margaret A. Young, T. Lamprecht +7 more
2014Cancer Cell448 citations Open access
Semantic Scholar
Functional heterogeneity of genetically defined subclones in acute myeloid leukemia
J. Klco, David H. Spencer, Christopher A. Miller, M. Griffith +14 more
2014Cancer Cell386 citations Open access
Semantic Scholar
Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia
J. Klco, Christopher A. Miller, M. Griffith, A. Petti +32 more
2015Journal of the American Medical Association (JAMA)330 citations Open access
Semantic Scholar
Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers
E. Duncavage, M. Schroeder, Michele O'Laughlin, Roxanne Wilson +23 more
2021New England Journal of Medicine231 citations Open access
Semantic Scholar
Clinical next‐generation sequencing in patients with non–small cell lung cancer
I. Hagemann, S. Devarakonda, Christina M. Lockwood, David H. Spencer +14 more
2015Cancer214 citations
Semantic Scholar
CpG island hypermethylation mediated by DNMT3A is a consequence of AML progression
David H. Spencer, D. Russler-Germain, Shamika Ketkar, Nichole M. Helton +15 more
2017Cell199 citations Open access
Semantic Scholar
Comparison of clinical targeted next-generation sequence data from formalin-fixed and fresh-frozen tissue specimens.
David H. Spencer, Jennifer K Sehn, H. Abel, M. Watson +2 more
2013Journal of Molecular Diagnostics195 citations Open access
Semantic Scholar
Validation of a next-generation sequencing assay for clinical molecular oncology.
C. Cottrell, H. Al-Kateb, Andrew J. Bredemeyer, E. Duncavage +28 more
2014Journal of Molecular Diagnostics188 citations Open access
Semantic Scholar
Genomic impact of transient low-dose decitabine treatment on primary AML cells.
J. Klco, David H. Spencer, T. Lamprecht, S. Sarkaria +12 more
2013Blood152 citations Open access
Semantic Scholar
Detection of FLT3 internal tandem duplication in targeted, short-read-length, next-generation sequencing data.
David H. Spencer, H. Abel, Christina M. Lockwood, J. Payton +5 more
2013Journal of Molecular Diagnostics141 citations Open access
Semantic Scholar
Performance of common analysis methods for detecting low-frequency single nucleotide variants in targeted next-generation sequence data.
David H. Spencer, M. Tyagi, Francesco Vallania, Andrew J. Bredemeyer +3 more
2014Journal of Molecular Diagnostics137 citations Open access
Semantic Scholar
Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells
David H. Spencer, Margaret A. Young, T. Lamprecht, Nichole M. Helton +9 more
2015Leukemia132 citations Open access
Semantic Scholar
Inflammatory Cytokines Promote Clonal Hematopoiesis with Specific Mutations in Ulcerative Colitis Patients
Christine R. C. Zhang, D. Nix, Martin H. Gregory, Matthew A. Ciorba +4 more
2019Experimental Hematology123 citations Open access
Semantic Scholar
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia
M. Berrien-Elliott, J. Foltz, D. Russler-Germain, C. Neal +36 more
2022Science Translational Medicine105 citations Open access
Semantic Scholar
Validation and implementation of the GeneXpert MRSA/SA blood culture assay in a pediatric setting.
David H. Spencer, P. Sellenriek, C. Burnham
2011American Journal of Clinical Pathology70 citations Open access
Semantic Scholar
Red cell transfusion decreases hemoglobin A1c in patients with diabetes.
David H. Spencer, B. Grossman, M. Scott
2011Clinical Chemistry63 citations Open access
Semantic Scholar
Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens
G. Linette, M. Becker-Hapak, Zachary L. Skidmore, M. L. Baroja +15 more
2019Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
Semantic Scholar
Expression profiling of snoRNAs in normal hematopoiesis and AML.
Wayne A. Warner, David H. Spencer, Maria C Trissal, B. S. White +3 more
2018Blood Advances51 citations Open access
Semantic Scholar
Heterozygous Variants of CLPB are a Cause of Severe Congenital Neutropenia.
J. Warren, Ryan R. Cupo, Peeradol Wattanasirakul, David H. Spencer +10 more
2021Blood42 citations Open access
Semantic Scholar
Failure to Detect Mutations in U2AF1 due to Changes in the GRCh38 Reference Sequence
Christopher A. Miller, Jason R. Walker, T. L. Jensen, William F. Hooper +7 more
2021bioRxiv41 citations Open access
Semantic Scholar
Occult Specimen Contamination in Routine Clinical Next-Generation Sequencing Testing.
Jennifer K Sehn, David H. Spencer, J. Pfeifer, Andrew J. Bredemeyer +3 more
2015American Journal of Clinical Pathology37 citations Open access
Semantic Scholar
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes
F. Ferraro, Christopher A. Miller, Keegan A Christensen, Nichole M. Helton +23 more
2021Proceedings of the National Academy of Sciences of the United States of America36 citations Open access
Semantic Scholar
Remethylation of Dnmt3a−/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing
Shamika Ketkar, A. Verdoni, Amanda M. Smith, C. Bangert +14 more
2020Proceedings of the National Academy of Sciences of the United States of America30 citations Open access
Semantic Scholar
Focal disruption of DNA methylation dynamics at enhancers in IDH mutant AML cells
Elisabeth R. Wilson, Nichole M. Helton, S. Heath, R. Fulton +9 more
2021Leukemia29 citations Open access
Semantic Scholar
Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells
R. Ghasemi, H. Struthers, Elisabeth R. Wilson, David H. Spencer
2020bioRxiv28 citations Open access
Semantic Scholar
Genomic landscape of TP53-mutated myeloid malignancies
H. Abel, K. Oetjen, C. A. Miller, S. M. Ramakrishnan +16 more
2023medRxiv25 citations Open access
Semantic Scholar
Clinical whole‐genome sequencing in cancer diagnosis
Y. Hou, Julie A. Neidich, E. Duncavage, David H. Spencer +1 more
2022Human Mutation22 citations
Semantic Scholar
Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.
Andrew J. Menssen, Ajay Khanna, Christopher A. Miller, Sridhar Nonavinkere Srivatsan +20 more
2022Blood Cancer Discovery21 citations Open access
Semantic Scholar
Clinical genomicist workstation.
Mukesh K. Sharma, Joshua Phillips, Saurabh Agarwal, Wesley S. Wiggins +30 more
2013AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science20 citations
Semantic Scholar
DNMT3A Overgrowth Syndrome is associated with the development of hematopoietic malignancies in children and young adults.
M. A. Ferris, Amanda M. Smith, S. Heath, E. Duncavage +14 more
2021Blood19 citations Open access
Semantic Scholar
Direct-to-consumer genetic testing: reliable or risky?
David H. Spencer, Christina M. Lockwood, E. Topol, James P. Evans +3 more
2011Clinical Chemistry19 citations
Semantic Scholar
Functional Characterization of Biallelic RTTN Variants Identified in an Infant with Microcephaly, Simplified Gyral Pattern, Pontocerebellar Hypoplasia, and Seizures
J. Wambach, D. Wegner, Ping Yang, M. Shinawi +10 more
2018Pediatric Research17 citations Open access
Semantic Scholar
Comprehensive discovery of non-coding RNAs in acute myeloid leukemia cell transcriptomes
Jin Zhang, M. Griffith, Christopher A. Miller, O. Griffith +19 more
2017Experimental Hematology11 citations Open access
Semantic Scholar
CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer
M. Griffith, N. Spies, K. Krysiak, Adam C. Coffman +36 more
2016bioRxiv11 citations Open access
Semantic Scholar
Single Nucleotide Variant Detection Using Next Generation Sequencing
David H. Spencer, Bin Zhang, J. Pfeifer
201511 citations
Semantic Scholar
KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress
Nancy Issa, Hassan Bjeije, Elisabeth R. Wilson, A. Krishnan +12 more
2023Leukemia10 citations Open access
Semantic Scholar
Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia
Erica K. Barnell, Kenneth F. Newcomer, Zachary L. Skidmore, K. Krysiak +21 more
2021JCO Precision Oncology10 citations Open access
Semantic Scholar
Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing
Michael J. Slade, R. Ghasemi, M. O'Laughlin, Tasha Burton +6 more
2023JCO Precision Oncology9 citations Open access
Semantic Scholar
Sequencing of Tumor DNA to Guide Cancer Risk Assessment and Therapy.
David H. Spencer, T. Ley
2018Journal of the American Medical Association (JAMA)9 citations
Semantic Scholar
DNMT3AR882-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3AR882C OCI-AML3 leukemia cell line
David Y. Chen, Matthew J. Christopher, Nichole M. Helton, I. Ferguson +2 more
2018Blood Cancer Journal9 citations Open access
Semantic Scholar
Evaluation of Breast Implant-associated Anaplastic Large Cell Lymphoma With Whole Exome and Genome Sequencing.
Neha Akkad, R. Kodgule, E. Duncavage, N. Mehta-Shah +4 more
2022Aesthetic surgery journal8 citations
Semantic Scholar
Tumor suppressor function of WT1 in acute promyelocytic leukemia
Matthew J. Christopher, C. Katerndahl, Hayley R. LeBlanc, Tyler T Elmendorf +10 more
2021Haematologica7 citations Open access
Semantic Scholar
Characterization of WU-CART-007, an Allogeneic CD7-Targeted CAR-T Cell Therapy for T-Cell Malignancies
Thomas A. Leedom, A. Hamil, S. Pouyanfard, J. Govero +12 more
2021Blood6 citations Open access
Semantic Scholar
Whole-Genome Bisulfite Sequencing of Primary AML Cells with the DNMT3A R882H Mutation Identifies Regions of Focal Hypomethylation That Are Associated with Open Chromatin
David H. Spencer, Bilal Al-Khalil, D. Russler-Germain, T. Lamprecht +6 more
20144 citations
Semantic Scholar
Comprehensive Analysis Of HOX Gene Expression and DNA Methylation From 189 Primary AMLs Demonstrates Canonical Patterns Associated With Hematopoietic Stem/Progenitors and Recurrent AML Mutations
David H. Spencer, Margaret A. Young, J. Klco, T. Ley
20133 citations
Semantic Scholar
Extended Genetic Testing in Severe Congenital Neutropenia May Identify Mutations That Inform Therapy
D. Link, V. Makaryan, David H. Spencer, Jun Xia +2 more
2018Blood2 citations Open access
Semantic Scholar
Adverse Outcomes in Acute Myeloid Leukemia Are Associated with Tumor Cell-Mediated Immunosuppression
F. Ferraro, Christopher A. Miller, Keegan A Christensen, Nichole M. Helton +22 more
2021Blood1 citations Open access
Semantic Scholar

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