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A. Saunders · SciRah

Researcher profile · Semantic Scholar

A. Saunders

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A. Saunders — researcher profile on SciRah

h-index: 62
Works: 169
Citations: 36K

Most-cited papers

Patterns of brain activation in people at risk for Alzheimer's disease.
S. Bookheimer, M. Strojwas, M. Cohen, A. Saunders +3 more
2000New England Journal of Medicine1,308 citations Open access
Semantic Scholar
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
E. Reiman, Ke-Wei Chen, G. Alexander, R. Caselli +4 more
2003Proceedings of the National Academy of Sciences of the United States of America984 citations Open access
Semantic Scholar
Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways
J. Cogswell, James Ward, I. Taylor, M. Waters +11 more
2008Journal of Alzheimer's Disease927 citations
Semantic Scholar
Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease.
G. Small, L. Ercoli, D. Silverman, S.-C. Huang +16 more
2000Proceedings of the National Academy of Sciences of the United States of America766 citations Open access
Semantic Scholar
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.
Hao Li, S. Wetten, Li Li, P. S. St. Jean +44 more
2008Archives of Neurology542 citations
Semantic Scholar
Correlations between apolipoprotein E ε4 gene dose and brain-imaging measurements of regional hypometabolism
E. Reiman, K. Chen, G. Alexander, R. J. Caselli +4 more
2005370 citations Open access
Semantic Scholar
Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study
M. Gold, C. Alderton, M. Zvartau-Hind, S. Egginton +6 more
2010Dementia and Geriatric Cognitive Disorders358 citations Open access
Semantic Scholar
Analysis of European mitochondrial haplogroups with Alzheimer disease risk.
J. M. van der Walt, Y. Dementieva, E. Martin, W. Scott +12 more
2004Neuroscience Letters295 citations
Semantic Scholar
Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease.
Yi-Ju Li, S. A. Oliveira, Pu-Ting Xu, E. Martin +26 more
2003Human Molecular Genetics237 citations
Semantic Scholar
Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism.
E. Reiman, Ke-Wei Chen, G. Alexander, R. Caselli +4 more
2005Proceedings of the National Academy of Sciences of the United States of America220 citations
Semantic Scholar
Apolipoprotein E genotype and neurodevelopmental sequelae of infant cardiac surgery.
J. Gaynor, M. Gerdes, E. Zackai, J. Bernbaum +10 more
2003Journal of Thoracic and Cardiovascular Surgery206 citations Open access
Semantic Scholar
Identification of novel genes in late-onset Alzheimer's disease.
M. Pericak-Vance, J. Grubber, L. Bailey, Dale J. Hedges +11 more
2000Experimental Gerontology202 citations
Semantic Scholar
Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: two phase 3 studies.
Conn Harrington, S. Sawchak, Carl Chiang, J. Davies +7 more
2011Current Alzheimer Research186 citations
Semantic Scholar
Rosiglitazone Induces Mitochondrial Biogenesis in Mouse Brain
J. Strum, Ron Shehee, D. Virley, Jill C. Richardson +6 more
2007Journal of Alzheimer's Disease177 citations
Semantic Scholar
A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy
S. Schmidt, C. Klaver, A. Saunders, E. Postel +19 more
2002Ophthalmic Genetics156 citations
Semantic Scholar
Apolipoprotein E and Alzheimer Disease: An Update on Genetic and Functional Analyses
A. Saunders
2000Journal of Neuropathology and Experimental Neurology152 citations Open access
Semantic Scholar
A single-nucleotide polymorphism tagging set for human drug metabolism and transport
K. Ahmadi, M. Weale, Zhengyu Xue, N. Soranzo +10 more
2005Nature Genetics144 citations
Semantic Scholar
Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis.
S. Schmidt, L. Barcellos, K. Desombre, J. Rimmler +10 more
2002American Journal of Human Genetics124 citations Open access
Semantic Scholar
Correlations Between Apolipoprotein E ε4 Gene Dose and Whole Brain Atrophy Rates
Ke-Wei Chen, E. Reiman, G. Alexander, R. Caselli +8 more
2007114 citations
Semantic Scholar
Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22.
W. Scott, E. Hauser, D. Schmechel, K. Welsh-Bohmer +7 more
2003American Journal of Human Genetics106 citations Open access
Semantic Scholar
Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial.
D. Burns, R. Alexander, K. Welsh-Bohmer, Meredith Culp +14 more
2021Lancet Neurology98 citations
Semantic Scholar
The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection.
A. Saunders, Michael K. Trowers, Richard A. Shimkets, Stephen J. Blakemore +5 more
2000Biochimica et Biophysica Acta97 citations Open access
Semantic Scholar
A meta-analysis of genomic screens in multiple sclerosis. The Transatlantic Multiple Sclerosis Genetics Cooperative.
M. Pericak-Vance, J. Rimmler, A. Saunders, E. Martin +19 more
2001Multiple Sclerosis94 citations
Semantic Scholar
The Broad Impact of TOM40 on Neurodegenerative Diseases in Aging
W. Gottschalk, M. Lutz, Yu-Ting He, A. Saunders +3 more
2014Journal of Parkinson's Disease and Alzheimer's Disease88 citations Open access
Semantic Scholar
An α-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease
E. Rogaeva, S. Premkumar, J. Grubber, L. Serneels +26 more
1999Nature Genetics88 citations
Semantic Scholar
Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons
J. Brodbeck, Maureen E. Balestra, A. Saunders, A. Roses +2 more
2008Proceedings of the National Academy of Sciences of the United States of America86 citations Open access
Semantic Scholar
Preliminary Report on the Association of Apolipoprotein E Polymorphisms, with Postoperative Peak Serum Creatinine Concentrations in Cardiac Surgical Patients
S. Chew, M. Newman, W. White, P. Conlon +5 more
2000Anesthesiology84 citations Open access
Semantic Scholar
Apolipoprotein E is associated with age at onset of amyotrophic lateral sclerosis
Yi-Ju Li, M. Pericak-Vance, J. Haines, N. Siddique +10 more
2004Neurogenetics75 citations
Semantic Scholar
Using genetics to enable Alzheimer’s disease prevention studies
Donna G. Crenshaw, W. Gottschalk, M. Lutz, I. Grossman +6 more
2012Clinical pharmacology and therapy74 citations Open access
Semantic Scholar
Warning SINEs: Alu elements, evolution of the human brain, and the spectrum of neurological disease
P. Larsen, Kelsie E. Hunnicutt, Roxanne J. Larsen, A. Yoder +1 more
2018Chromosome Research73 citations Open access
Semantic Scholar
Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease
A. Roses, S. Sundseth, A. Saunders, W. Gottschalk +2 more
2016Alzheimer's & Dementia70 citations Open access
Semantic Scholar
Preclinical cognitive decline in late middle-aged asymptomatic apolipoprotein E-e4/4 homozygotes: a replication study.
R. Caselli, D. Osborne, E. Reiman, J. Hentz +6 more
2001Journal of Neurological Sciences68 citations
Semantic Scholar
The Relationship of APOE Genotype to Cognitive Functioning in Older African‐American and Caucasian Community Residents
G. Fillenbaum, L. Richard Landerman, D. Blazer, A. Saunders +2 more
2001Journal of The American Geriatrics Society68 citations
Semantic Scholar
The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease
P. Larsen, M. Lutz, Kelsie E. Hunnicutt, M. Mihovilovic +3 more
2017Alzheimer's & Dementia64 citations Open access
Semantic Scholar
Characterization of the Poly-T Variant in the TOMM40 Gene in Diverse Populations
Colton Linnertz, A. Saunders, M. Lutz, D. Crenshaw +10 more
2012PLoS ONE63 citations Open access
Semantic Scholar
Correlations between apolipoprotein E epsilon4 gene dose and whole brain atrophy rates.
Ke-Wei Chen, E. Reiman, G. Alexander, R. Caselli +8 more
2007American Journal of Psychiatry62 citations
Semantic Scholar
TOMM40′523 variant and cognitive decline in older persons with APOE ε3/3 genotype
Lei Yu, M. Lutz, Robert S. Wilson, D. Burns +6 more
2017Neurology60 citations Open access
Semantic Scholar
New applications of disease genetics and pharmacogenetics to drug development.
A. Roses, A. Saunders, M. Lutz, Nanyin Zhang +6 more
2014Current opinion in pharmacology (Print)59 citations Open access
Semantic Scholar
The Biological Foundation of the Genetic Association of TOMM40 with Late-onset Alzheimer’s disease
Kahli Zeitlow, Lefko Charlambous, Isaac Ng, Sonal Gagrani +6 more
2017Biochimica et Biophysica Acta - Molecular Basis of Disease56 citations Open access
Semantic Scholar
Reassessment of Pioglitazone for Alzheimer’s Disease
A. Saunders, D. Burns, W. Gottschalk
2021Frontiers in Neuroscience55 citations Open access
Semantic Scholar
APOE ε4-TOMM40 ‘523 haplotypes and the risk of Alzheimer’s disease in older Caucasian and African Americans
Lei Yu, M. Lutz, Robert S. Wilson, D. Burns +7 more
2017PLoS ONE51 citations Open access
Semantic Scholar
Novel STMN2 Variant Linked to Amyotrophic Lateral Sclerosis Risk and Clinical Phenotype
F. Theunissen, R. Anderton, F. Mastaglia, L. Flynn +15 more
2021Frontiers in Aging Neuroscience45 citations Open access
Semantic Scholar
Structural Variants May Be a Source of Missing Heritability in sALS
F. Theunissen, L. Flynn, R. Anderton, F. Mastaglia +8 more
2020Frontiers in Neuroscience45 citations Open access
Semantic Scholar
Reply to 'Haplotype block structure of the cytochrome P450 CYP2C gene cluster on chromosome 10'
K. Ahmadi, M. Weale, A. Roses, A. Saunders +1 more
2005Nature Genetics39 citations
Semantic Scholar
Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K).
J. Grubber, A. Saunders, Alison R. Crane-Gatherum, W. Scott +7 more
1999Neuroscience Letters39 citations
Semantic Scholar
Further evidence linking late-onset Alzheimer disease with chromosome 12.
W. K. Scott, J. M. Grubber, S. Abou-Donia, T. Church +6 more
1999Journal of the American Medical Association (JAMA)38 citations
Semantic Scholar
An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease.
E. Rogaeva, S. Premkumar, J. Grubber, L. Serneels +26 more
1999Nature Genetics38 citations
Semantic Scholar
The TOMMORROW study: Design of an Alzheimer's disease delay-of-onset clinical trial
D. Burns, Carl Chiang, K. Welsh-Bohmer, S. Brannan +14 more
2019Alzheimer's & Dementia37 citations Open access
Semantic Scholar
ApoE genotype-specific inhibition of apoptosiss⃞s⃞ The online version of this article (available at http://www.jlr.org) contains two supplemental figures. Published, JLR Papers in Press, May 16, 2003. DOI 10.1194/jlr.M300097-JLR200
R. Dekroon, M. Mihovilovic, Z. Goodger, Jennifer B. Robinette +3 more
2003Journal of Lipid Research36 citations Open access
Semantic Scholar
The discovery and early validation of novel plasma biomarkers in mild-to-moderate Alzheimer's disease patients responding to treatment with rosiglitazone.
E. L. Akuffo, John B. Davis, Steve M. Fox, I. Gloger +9 more
2008Biomarkers35 citations
Semantic Scholar

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