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O. Issinger · SciRah

Researcher profile · Semantic Scholar

O. Issinger

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O. Issinger — researcher profile on SciRah

h-index: 44
Works: 199
Citations: 6,653

Most-cited papers

Disruption of the Regulatory β Subunit of Protein Kinase CK2 in Mice Leads to a Cell-Autonomous Defect and Early Embryonic Lethality
T. Buchou, M. Vernet, O. Blond, Hans H. Jensen +5 more
2003Molecular and Cellular Biology282 citations Open access
Semantic Scholar
Protein kinase CK2 in human diseases.
B. Guerra, O. Issinger
2008Current Medicinal Chemistry261 citations
Semantic Scholar
The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules.
J. Raaf, E. Brunstein, O. Issinger, K. Niefind
2008Chemistry and Biology87 citations Open access
Semantic Scholar
Protein Kinase CK2 in Health and Disease
K. Niefind, J. Raaf, O. Issinger
2009Cellular and Molecular Life Sciences84 citations Open access
Semantic Scholar
Enhancing cisplatin sensitivity in MCF-7 human breast cancer cells by down-regulation of Bcl-2 and cyclin D1.
C. Yde, O. Issinger
2006International Journal of Oncology83 citations Open access
Semantic Scholar
Protein kinase CK2: from structures to insights
K. Niefind, J. Raaf, O. Issinger
2009Cellular and Molecular Life Sciences79 citations Open access
Semantic Scholar
Evolved to be active: sulfate ions define substrate recognition sites of CK2alpha and emphasise its exceptional role within the CMGC family of eukaryotic protein kinases.
K. Niefind, C. Yde, I. Ermakova, O. Issinger
2007Journal of Molecular Biology65 citations
Semantic Scholar
Profiling of signaling molecules in four different human prostate carcinoma cell lines before and after induction of apoptosis.
I. Skjøth, O. Issinger
2006International Journal of Oncology60 citations
Semantic Scholar
The interaction of CK2α and CK2β, the subunits of protein kinase CK2, requires CK2β in a preformed conformation and is enthalpically driven
J. Raaf, E. Brunstein, O. Issinger, K. Niefind
2008Protein Science58 citations Open access
Semantic Scholar
Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells
B. Olsen, O. Issinger, Barbara Guerra
2010Oncogene57 citations
Semantic Scholar
Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
C. Yde, I. Ermakova, O. Issinger, K. Niefind
2005Journal of Molecular Biology57 citations
Semantic Scholar
The catalytic subunit of human protein kinase CK2 structurally deviates from its maize homologue in complex with the nucleotide competitive inhibitor emodin.
J. Raaf, Karsten Klopffleisch, O. Issinger, K. Niefind
2008Journal of Molecular Biology55 citations
Semantic Scholar
Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT.
C. Yde, T. Frogne, A. Lykkesfeldt, I. Fichtner +2 more
2007Cancer Letters54 citations
Semantic Scholar
Structure of the human protein kinase CK2 catalytic subunit CK2α' and interaction thermodynamics with the regulatory subunit CK2β.
N. Bischoff, B. Olsen, J. Raaf, M. Bretner +2 more
2011Journal of Molecular Biology53 citations
Semantic Scholar
Conformational plasticity of the catalytic subunit of protein kinase CK2 and its consequences for regulation and drug design.
K. Niefind, O. Issinger
2010Biochimica et Biophysica Acta49 citations
Semantic Scholar
Synthesis of a new class of pyrrolo[3,4-h]quinazolines with antimitotic activity.
V. Spanò, A. Montalbano, A. Carbone, B. Parrino +10 more
2014European journal of medicinal chemistry47 citations
Semantic Scholar
First structure of protein kinase CK2 catalytic subunit with an effective CK2β-competitive ligand.
J. Raaf, B. Guerra, I. Neundorf, B. Bopp +4 more
2013ACS Chemical Biology44 citations
Semantic Scholar
Phytochemicals in cancer and their effect on the PI3K/AKT-mediated cellular signalling.
O. Issinger, B. Guerra
2021Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie43 citations Open access
Semantic Scholar
A subnanomolar fluorescent probe for protein kinase CK2 interaction studies.
E. Enkvist, Kaido Viht, N. Bischoff, Jürgen Vahter +5 more
2012Organic and biomolecular chemistry41 citations
Semantic Scholar
Primary and secondary interactions between CK2α and CK2β lead to ring-like structures in the crystals of the CK2 holoenzyme
K. Niefind, O. Issinger
2005Molecular and Cellular Biochemistry41 citations
Semantic Scholar
The Yin and Yang of redox regulation
L. Olsen, O. Issinger, B. Guerra
2013Redox Report40 citations Open access
Semantic Scholar
Protein kinase CK2 is required for the recruitment of 53BP1 to sites of DNA double-strand break induced by radiomimetic drugs.
B. Guerra, Kuniyoshi Iwabuchi, O. Issinger
2014Cancer Letters38 citations
Semantic Scholar
First inactive conformation of CK2 alpha, the catalytic subunit of protein kinase CK2.
J. Raaf, O. Issinger, K. Niefind
2009Journal of Molecular Biology35 citations Open access
Semantic Scholar
Resorufin: a lead for a new protein kinase CK2 inhibitor
I. Sandholt, B. Olsen, B. Guerra, O. Issinger
2009Anti-Cancer Drugs35 citations
Semantic Scholar
Biochemical characterization of CK2α and α′ paralogues and their derived holoenzymes: evidence for the existence of a heterotrimeric CK2α′-holoenzyme forming trimeric complexes
B. Olsen, Tine L. Rasmussen, K. Niefind, O. Issinger
2008Molecular and Cellular Biochemistry32 citations
Semantic Scholar
Acetoxymethyl Ester of Tetrabromobenzimidazole-Peptoid Conjugate for Inhibition of Protein Kinase CK2 in Living Cells.
Kaido Viht, Siiri Saaver, Jürgen Vahter, E. Enkvist +6 more
2015Bioconjugate chemistry31 citations
Semantic Scholar
Protein kinase CK2 inhibition is associated with the destabilization of HIF-1α in human cancer cells.
B. Guerra, Tine Rasmussen, A. Schnitzler, Hans H. Jensen +5 more
2015Cancer Letters31 citations
Semantic Scholar
Interaction between CK2α and CK2β, the subunits of protein kinase CK2: thermodynamic contributions of key residues on the CK2α surface.
J. Raaf, N. Bischoff, Karsten Klopffleisch, E. Brunstein +5 more
2011Biochemistry30 citations
Semantic Scholar
Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death
C. Yde, M. Gyrd-Hansen, A. Lykkesfeldt, O. Issinger +1 more
2007Molecular Cancer Therapeutics30 citations Open access
Semantic Scholar
Natural Compounds and Derivatives as Ser/Thr Protein Kinase Modulators and Inhibitors
B. Guerra, O. Issinger
2019Pharmaceuticals28 citations Open access
Semantic Scholar
Purification and characterization of the CK2α'-based holoenzyme, an isozyme of CK2α : A comparative analysis
B. Olsen, B. Boldyreff, K. Niefind, O. Issinger
200627 citations
Semantic Scholar
Knocking out the regulatory beta subunit of protein kinase CK2 in mice: Gene dosage effects in ES cells and embryos
O. Blond, Hans H. Jensen, T. Buchou, C. Cochet +2 more
2005Molecular and Cellular Biochemistry26 citations
Semantic Scholar
Delivery of proteins encapsulated in chitosan-tripolyphosphate nanoparticles to human skin melanoma cells.
Mai Bay Stie, H. S. Thoke, O. Issinger, Jennifer Hochscherf +2 more
2019Colloids and Surfaces B: Biointerfaces25 citations Open access
Semantic Scholar
The kinase inhibitor D11 induces caspase-mediated cell death in cancer cells resistant to chemotherapeutic treatment
B. Guerra, M. Fischer, S. Schaefer, O. Issinger
2015Journal of experimental & clinical cancer research : CR25 citations Open access
Semantic Scholar
A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2α Complex Structures.
B. Guerra, N. Bischoff, V. Bdzhola, S. Yarmoluk +3 more
2015ACS Chemical Biology24 citations
Semantic Scholar
Identification of a novel potent, selective and cell permeable inhibitor of protein kinase CK2 from the NIH/NCI Diversity Set Library
B. Guerra, Jennifer Hochscherf, Nina Jensen, O. Issinger
2015Molecular and Cellular Biochemistry24 citations
Semantic Scholar
The protein kinase CK2(Andante) holoenzyme structure supports proposed models of autoregulation and trans-autophosphorylation.
A. Schnitzler, B. Olsen, O. Issinger, K. Niefind
2014Journal of Molecular Biology23 citations
Semantic Scholar
Biochemical characterization of the recombinant human Drosophila homologues Timekeeper and Andante involved in the Drosophila circadian oscillator
Tine L. Rasmussen, I. Skjøth, Hans H. Jensen, K. Niefind +2 more
2005Molecular and Cellular Biochemistry23 citations
Semantic Scholar
Role of Protein Kinase CK2 in Aberrant Lipid Metabolism in Cancer
B. Guerra, O. Issinger
2020Pharmaceuticals22 citations Open access
Semantic Scholar
Development of a high-throughput screening-compatible assay to identify inhibitors of the CK2α/CK2β interaction.
Jennifer Hochscherf, D. Lindenblatt, Michaela Steinkrüger, Eungyoung Yoo +8 more
2015Analytical Biochemistry21 citations
Semantic Scholar
Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias.
Karsten Klopffleisch, O. Issinger, K. Niefind
2012Acta Crystallographica Section D: Biological Crystallography21 citations
Semantic Scholar
Enzymatic activity with an incomplete catalytic spine: insights from a comparative structural analysis of human CK2α and its paralogous isoform CK2α′
N. Bischoff, J. Raaf, B. Olsen, M. Bretner +2 more
2011Molecular and Cellular Biochemistry20 citations
Semantic Scholar
Structural basis of the constitutive activity of protein kinase CK2.
B. Olsen, B. Guerra, K. Niefind, O. Issinger
2010Methods in Enzymology20 citations
Semantic Scholar
Purification and characterization of recombinant protein kinase CK2 from Zea mays expressed in Escherichia coli.
M. Riera, M. Pagés, O. Issinger, B. Guerra
2003Protein Expression and Purification20 citations
Semantic Scholar
Nuclear localization of the CK2α-subunit correlates with poor prognosis in Clear Cell Renal Cell Carcinoma
M. Rabjerg, B. Guerra, A. Oliván-Viguera, M. Nedergaard +4 more
201719 citations
Semantic Scholar
Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases.
R. Ekambaram, E. Enkvist, G. B. Manoharan, Mihkel Ugandi +5 more
2014Chemical Communications19 citations Open access
Semantic Scholar
BID, an interaction partner of protein kinase CK2α
B. Olsen, J. Petersen, O. Issinger
2006Biological chemistry18 citations
Semantic Scholar
Phosphorylation of the regulatory β‐subunit of protein kinase CK2 by checkpoint kinase Chk1: identification of the in vitro CK2β phosphorylation site
L. P. Kristensen, M. Larsen, P. Højrup, O. Issinger +1 more
200418 citations Open access
Semantic Scholar
Protein Kinase CK2 Cellular Function in Normal and Disease States
K. Ahmed, O. Issinger, R. Szyszka
2015Advances in Biochemistry in Health and Disease15 citations
Semantic Scholar
Evidence for aggregation of protein kinase CK2 in the cell: a novel strategy for studying CK2 holoenzyme interaction by BRET2
Gerda M. Hübner, J. N. Larsen, B. Guerra, K. Niefind +2 more
2014Molecular and Cellular Biochemistry15 citations
Semantic Scholar

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