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R. Struthers · SciRah

Researcher profile · Semantic Scholar

R. Struthers

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R. Struthers — researcher profile on SciRah

h-index: 26
Works: 78
Citations: 2,034

Most-cited papers

Differential Desensitization, Receptor Phosphorylation, β-Arrestin Recruitment, and ERK1/2 Activation by the Two Endogenous Ligands for the CC Chemokine Receptor 7*
T. Kohout, Shelby L. Nicholas, S. Perry, G. Reinhart +2 more
2004Journal of Biological Chemistry363 citations Open access
Semantic Scholar
Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor.
Chen Chen, Dongpei Wu, Zhiqian Guo, Q. Xie +15 more
2008Journal of Medicinal Chemistry114 citations Open access
Semantic Scholar
Suppression of gonadotropins and estradiol in premenopausal women by oral administration of the nonpeptide gonadotropin-releasing hormone antagonist elagolix.
R. Struthers, A. Nicholls, J. Grundy, Ta-Kung Chen +3 more
2009Journal of Clinical Endocrinology and Metabolism70 citations Open access
Semantic Scholar
Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide Gonadotropin-Releasing Hormone Antagonist Elagolix
R. Struthers, A. Nicholls, J. Grundy, Ta-Kung Chen +3 more
200970 citations
Semantic Scholar
Distinct Conformations of the Corticotropin Releasing Factor Type 1 Receptor Adopted following Agonist and Antagonist Binding Are Differentially Regulated*
S. Perry, Sachiko Junger, T. Kohout, S. Hoare +3 more
2005Journal of Biological Chemistry58 citations Open access
Semantic Scholar
Non-peptide gonadotropin-releasing hormone receptor antagonists.
S. Betz, Yun-Fei Zhu, Chen Chen, R. Struthers
2008Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization.
F. Tucci, Yun-Fei Zhu, R. Struthers, Zhiqian Guo +12 more
2005Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Progress towards the development of non-peptide orally-active gonadotropin-releasing hormone (GnRH) antagonists: therapeutic implications.
R. Millar, Y.-F. Zhu, C. Chen, R. Struthers
2000British Medical Bulletin44 citations
Semantic Scholar
Activin inhibits binding of transcription factor Pit-1 to the growth hormone promoter.
R. Struthers, Dana Gaddy-Kurten, W. Vale
1992Proceedings of the National Academy of Sciences of the United States of America42 citations Open access
Semantic Scholar
Design of biologically active, conformationally constrained GnRH antagonists
R. Struthers, Genzo Tanaka, S. Koerber, T. Šolmajer +5 more
1990Proteins: Structure, Function, and Bioinformatics39 citations
Semantic Scholar
Partial retro-inverso analogues of somatostatin: pairwise modifications at residues 7 and 8 and at residues 8 and 9.
P. Pallai, R. Struthers, M. Goodman, Luis Moroder +2 more
1985Biochemistry39 citations
Semantic Scholar
Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902.
R. Struthers, Q. Xie, Susan K. Sullivan, G. Reinhart +10 more
2007Endocrinology38 citations
Semantic Scholar
Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure-activity relationships and insurmountable antagonism.
Susan K. Sullivan, S. Hoare, Beth A. Fleck, Yun-Fei Zhu +3 more
2006Biochemical Pharmacology38 citations
Semantic Scholar
Overlapping, nonidentical binding sites of different classes of nonpeptide antagonists for the human gonadotropin-releasing hormone receptor.
S. Betz, G. Reinhart, F. Lio, Chen Chen +1 more
2006Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
The N-terminal domain of CCL21 reconstitutes high affinity binding, G protein activation, and chemotactic activity, to the C-terminal domain of CCL19.
T. Ott, F. Lio, D. Olshefski, Xin-Jun Liu +2 more
2006Biochemical and Biophysical Research Communications - BBRC34 citations
Semantic Scholar
Determinants of high-affinity binding and receptor activation in the N-terminus of CCL-19 (MIP-3 beta).
T. Ott, F. Lio, D. Olshefski, X.-J. Liu +2 more
2004Biochemistry34 citations
Semantic Scholar
Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist
Jian Zhao, Shi-Miao Wang, S. Markison, S. H. Kim +10 more
2022ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor.
Joseph Pontillo, Zhiqian Guo, Dongpei Wu, R. Struthers +1 more
2005Bioorganic & Medicinal Chemistry Letters32 citations
Semantic Scholar
Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers
A. Madan, S. Markison, S. Betz, A. Krasner +4 more
2022Pituitary31 citations Open access
Semantic Scholar
Nuclear magnetic resonance analysis and conformational characterization of a cyclic decapeptide antagonist of gonadotropin-releasing hormone.
Edmund L. Baniak, Jean E. Rivier, R. Struthers, Arnold T. Hagler +1 more
1987Biochemistry31 citations
Semantic Scholar
Suppression of serum luteinizing hormone in postmenopausal women by an orally administered nonpeptide antagonist of the gonadotropin-releasing hormone receptor (NBI-42902).
R. Struthers, Ta-Kung Chen, B. Campbell, R. Jimenez +3 more
2006Journal of Clinical Endocrinology and Metabolism30 citations Open access
Semantic Scholar
Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.
Yun-Fei Zhu, Zhiqian Guo, T. Gross, Yinghong Gao +8 more
2003Journal of Medicinal Chemistry30 citations Open access
Semantic Scholar
Approaches to the synthesis of retro-inverso peptides.
P. Pallai, S. Richman, R. Struthers, M. Goodman
2009International journal of peptide & protein research29 citations
Semantic Scholar
ACROBAT Edge: Safety and Efficacy of Switching Injected SRLs to Oral Paltusotine in Patients With Acromegaly
M. Gadelha, M. Gordon, M. Doknic, E. Mezősi +10 more
2022Journal of Clinical Endocrinology and Metabolism28 citations Open access
Semantic Scholar
Identification of CC Chemokine Receptor 7 Residues Important for Receptor Activation*
T. Ott, A. Pahuja, Sarah A. Nickolls, D. Alleva +1 more
2004Journal of Biological Chemistry28 citations Open access
Semantic Scholar
Regulation of the atrial natriuretic peptide receptor on a smooth muscle cell.
Richard J. Hughes, R. Struthers, A. Fong, P. Insel
1987American Journal of Physiology28 citations
Semantic Scholar
3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor.
F. Tucci, Yun-Fei Zhu, Zhiqian Guo, T. Gross +12 more
2004Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Design of Peptide Analogs: Theoretical Simulation of Conformation, Energetics, and Dynamics
R. Struthers, A. Hagler, Jean E. Rivier
198426 citations
Semantic Scholar
Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidine-2,4-dione derivatives as potent GnRH receptor antagonists.
Zhiqian Guo, Yongsheng Chen, Dongpei Wu, Yun-Fei Zhu +4 more
2003Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists.
Yun-Fei Zhu, R. Struthers, Patrick J. Connors, Yinghong Gao +6 more
2002Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonists.
F. Tucci, Yun-Fei Zhu, Zhiqian Guo, T. Gross +6 more
2002Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Consensus bioactive conformation of cyclic GnRH antagonists defined by NMR and molecular modeling.
S. Koerber, Josep Rizo, R. Struthers, Jean E. Rivier
2000Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Identification of 1-arylmethyl-3- (2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists.
Yun-Fei Zhu, T. Gross, Zhiqian Guo, Patrick J. Connors +7 more
2003Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor.
F. Tucci, Yun-Fei Zhu, Zhiqian Guo, T. Gross +5 more
2003Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Design, synthesis and structure-activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.
T. Gross, Yun-Fei Zhu, J. Saunders, Keith M. Wilcoxen +6 more
2002Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Species Selectivity of Nonpeptide Antagonists of the Gonadotropinreleasing Hormone Receptor Is Determined by Residues in Extracellular Loops II and III and the Amino Terminus*
G. Reinhart, Q. Xie, Xin-Jun Liu, Yun-Fei Zhu +3 more
2004Journal of Biological Chemistry22 citations Open access
Semantic Scholar
Synthesis and initial structure-activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.
K. Wilcoxen, Yun-Fei Zhu, Patrick J. Connors, J. Saunders +5 more
2002Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists.
Zhiqian Guo, Dongpei Wu, Yun-Fei Zhu, F. Tucci +5 more
2005Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
A novel synthesis of 2-arylpyrrolo[1,2-a]pyrimid-7-ones and their structure-activity relationships as potent GnRH receptor antagonists.
Yun-Fei Zhu, K. Wilcoxen, J. Saunders, Zhiqian Guo +8 more
2002Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties.
C. Regan, Zhiqian Guo, Yongsheng Chen, Charles Q. Huang +13 more
2008Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Design of potent dicyclic (4-10/5-8) gonadotropin releasing hormone (GnRH) antagonists.
Jean E. Rivier, R. Struthers, John Porter, S. Lahrichi +6 more
2000Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Atropisomeric property of 1-(2,6-difluorobenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil.
F. Tucci, T. Hu, M. Mesleh, A. Bokser +7 more
2005Chirality17 citations
Semantic Scholar
Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists.
Zhiqian Guo, Yun-Fei Zhu, F. Tucci, Yinghong Gao +6 more
2003Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Nucleotide regulation of growth hormone-releasing factor binding to rat pituitary receptors.
R. Struthers, M. Perrin, W. Vale
1989Endocrinology17 citations
Semantic Scholar
Trapping of a Nonpeptide Ligand by the Extracellular Domains of the Gonadotropin-Releasing Hormone Receptor Results in Insurmountable Antagonism
T. Kohout, Q. Xie, Shelby Reijmers, Kenneth J. Finn +3 more
2007Molecular Pharmacology16 citations
Semantic Scholar
Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists.
M. Rowbottom, F. Tucci, Yun-Fei Zhu, Zhiqian Guo +6 more
2004Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Design of monocyclic (1-3) and dicyclic (1-3/4-10) gonadotropin releasing hormone (GnRH) antagonists.
Jean E. Rivier, J. Porter, L. Cervini, S. Lahrichi +4 more
2000Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Design of potent dicyclic (1-5/4-10) gonadotropin releasing hormone (GnRH) antagonists.
Jean E. Rivier, Guang-Cheng Jiang, R. Struthers, S. Koerber +5 more
2000Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist.
S. H. Kim, Sangdon Han, Jian Zhao, Shi-Miao Wang +9 more
2024ACS Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Allosteric and orthosteric binding modes of two nonpeptide human gonadotropin-releasing hormone receptor antagonists.
Susan K. Sullivan, Michael S. Brown, Yinghong Gao, Colin J. Loweth +4 more
2006Biochemistry14 citations
Semantic Scholar

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Yun-Fei Zhu — researcher profile on SciRah
G. Reinhart×18
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Chen Chen×18
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Chen Chen — researcher profile on SciRah
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J. Saunders — researcher profile on SciRah

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