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Lei Zhang · SciRah

Researcher profile · Semantic Scholar

Lei Zhang

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Lei Zhang — researcher profile on SciRah

h-index: 21
Works: 114
Citations: 2,168

Most-cited papers

Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke.
Pengfei Yang, Yong-Wei Zhang, Lei Zhang, Yong-Xin Zhang +55 more
2020New England Journal of Medicine699 citations Open access
Semantic Scholar
Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials.
C. Majoie, F. Cavalcante, J. Gralla, Pengfei Yang +43 more
2023The Lancet175 citations Open access
Semantic Scholar
Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis.
J. Kaesmacher, F. Cavalcante, M. Kappelhof, K. Treurniet +30 more
2024Journal of the American Medical Association (JAMA)115 citations Open access
Semantic Scholar
Direct Intra-arterial thrombectomy in order to Revascularize AIS patients with large vessel occlusion Efficiently in Chinese Tertiary hospitals: A Multicenter randomized clinical Trial (DIRECT-MT)—Protocol
Pengfei Yang, K. Treurniet, Lei Zhang, Yong-Wei Zhang +11 more
2019International Journal of Stroke46 citations
Semantic Scholar
Predictors and outcome of early neurological deterioration after endovascular thrombectomy: a secondary analysis of the DIRECT-MT trial
Miao-Yi Zhang, P. Xing, Jie Tang, Lang-feng Shi +8 more
2022Journal of NeuroInterventional Surgery38 citations
Semantic Scholar
Balloon guide catheters for endovascular thrombectomy in patients with acute ischaemic stroke due to large-vessel occlusion in China (PROTECT-MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial.
Jian-Min Liu, Yu Zhou, Lei Zhang, Zifu Li +127 more
2024The Lancet37 citations
Semantic Scholar
Exosomes containing miR‐451a is involved in the protective effect of cerebral ischemic preconditioning against cerebral ischemia and reperfusion injury
He Li, Yin Luo, P. Liu, Pei Liu +9 more
2021CNS Neuroscience & Therapeutics35 citations Open access
Semantic Scholar
Antioxidants and the risk of stroke: results from NHANES and two-sample Mendelian randomization study
Rundong Chen, Hanchen Liu, Guanghao Zhang, Qian Zhang +12 more
2024European Journal of Medical Research26 citations Open access
Semantic Scholar
Endovascular Treatment of Acute Ischemic Stroke Due to Intracranial Atherosclerotic Large Vessel Occlusion
He Li, Yong-Xin Zhang, Lei Zhang, Zifu Li +5 more
2019Clinical Neuroradiology25 citations
Semantic Scholar
The functions of exosomes targeting astrocytes and astrocyte-derived exosomes targeting other cell types
Hongye Xu, He Li, Ping Zhang, Yuan Gao +8 more
2023Neural Regeneration Research23 citations Open access
Semantic Scholar
Single-Cell RNA-Sequencing Analyses Revealed Heterogeneity and Dynamic Changes of Metabolic Pathways in Astrocytes at the Acute Phase of Ischemic Stroke
Hongyu Ma, Yu Zhou, Zifu Li, Luojiang Zhu +14 more
2022Oxidative Medicine and Cellular Longevity22 citations Open access
Semantic Scholar
Glia-derived exosomes: Promising therapeutic targets.
He Li, Yin Luo, Luojiang Zhu, W. Hua +9 more
2019Life Science22 citations
Semantic Scholar
Association of Intravenous Alteplase, Early Reperfusion, and Clinical Outcome in Patients With Large Vessel Occlusion Stroke: Post Hoc Analysis of the Randomized DIRECT-MT Trial
Yu Zhou, Lei Zhang, J. Ospel, M. Goyal +15 more
2022Stroke21 citations Open access
Semantic Scholar
Differences in Safety and Efficacy of Endovascular Treatment for Acute Ischemic Stroke
Wen-Jin Yang, Yong-Xin Zhang, Zifu Li, Lei Zhang +10 more
2020Clinical Neuroradiology21 citations
Semantic Scholar
Hemodynamic assessment for intracranial atherosclerosis from angiographic images: a clinical validation study
Pengfei Yang, Shu Wan, Jun Wang, Yu-Meng Hu +14 more
2023Journal of NeuroInterventional Surgery20 citations
Semantic Scholar
CT Hyperdense Artery Sign and the Effect of Alteplase in Endovascular Thrombectomy after Acute Stroke.
Yu Zhou, Y. Jing, J. Ospel, M. Goyal +18 more
2022Radiology20 citations
Semantic Scholar
Effect of Occlusion Site on the Safety and Efficacy of Intravenous Alteplase Before Endovascular Thrombectomy: A Prespecified Subgroup Analysis of DIRECT-MT
Yu Zhou, P. Xing, Zifu Li, Xiaoxi Zhang +20 more
2021Stroke19 citations Open access
Semantic Scholar
Risk factors for hyperperfusion-induced intracranial hemorrhage after carotid artery stenting in patients with symptomatic severe carotid stenosis evaluation
Lei Zhang, Dong-Wei Dai, Zifu Li, Guoli Duan +6 more
2018Journal of NeuroInterventional Surgery18 citations
Semantic Scholar
Intracranial Hemorrhage in Patients With Stroke After Endovascular Treatment With or Without IV Alteplase: An Individual Participant Data Meta-Analysis.
Yu Zhou, Lei Zhang, F. Cavalcante, Kentaro Suzuki +20 more
2025JAMA Neurology17 citations Open access
Semantic Scholar
Impact of leukoaraiosis in patients with acute ischemic stroke treated with thrombectomy: a post hoc analysis of the DIRECT-MT trial
Tingyu Yi, Yong-Xin Zhang, Wen-Huo Chen, Yan-Min Wu +10 more
2022Journal of NeuroInterventional Surgery16 citations
Semantic Scholar
AKG Attenuates Cerebral Ischemia-Reperfusion Injury through c-Fos/IL-10/Stat3 Signaling Pathway
W. Hua, Xiaoxi Zhang, Hai-Shuang Tang, Chen Li +16 more
2022Oxidative Medicine and Cellular Longevity16 citations Open access
Semantic Scholar
Effect of baseline infarct size on endovascular thrombectomy with or without intravenous alteplase in stroke patients: A subgroup analysis of a randomized trial (DIRECT‐MT)
Zhen-Yu Jia, Yong-Xin Zhang, Yue-Zhou Cao, Lin-Bo Zhao +12 more
2022European Journal of Neurology14 citations
Semantic Scholar
Current knowledge of large vascular occlusion due to intracranial atherosclerosis: focusing on early diagnosis
He Li, Peng Liu, Pei Liu, W. Hua +9 more
2020Chinese Neurosurgical Journal14 citations Open access
Semantic Scholar
Asymptomatic Hemorrhagic Events and Functional Outcomes in Acute Stroke
Rundong Chen, W. Hua, Yi-Lei Zhang, Yong-Xin Zhang +6 more
2025JAMA Network Open13 citations Open access
Semantic Scholar
Higher Baseline Cortical Score Predicts Good Outcome in Patients With Low Alberta Stroke Program Early Computed Tomography Score Treated with Endovascular Treatment.
P. Xing, Yong-Wei Zhang, Lei Zhang, Zifu Li +10 more
2020Neurosurgery13 citations
Semantic Scholar
The “distal-to-proximal” strategy for the treatment of posterior circulation tandem occlusions: a single-centre experience
P. Xing, Yong-Wei Zhang, Zifu Li, Lei Zhang +10 more
2020Neuroradiology13 citations
Semantic Scholar
Predictors of recurrence and complications for the endovascular treatment of unruptured middle cerebral artery aneurysm: A high-volume center experience over 12 years.
Guoli Duan, Yuhang Zhang, Hong-Wei Yin, Yi-na Wu +15 more
2023European Journal of Radiology11 citations
Semantic Scholar
Association between blood pressure and different antihypertensive drugs with outcome after ischemic stroke: A Mendelian randomization study
Hanchen Liu, Xiaoxi Zhang, Yu Zhou, Thanh N. Nguyen +18 more
2023International Journal of Stroke11 citations
Semantic Scholar
Early diagnosis of intracranial atherosclerotic large vascular occlusion: A prediction model based on DIRECT-MT data
He Li, Hong Y. Ma, Lei Zhang, Pei Liu +8 more
2022Frontiers in Neurology11 citations Open access
Semantic Scholar
Fine-tuning of microglia polarization prevents diabetes-associated cerebral atherosclerosis
Xu-Cheng Zhu, P. Xing, Ping Zhang, Min-min Zhang +14 more
2022Frontiers in Immunology11 citations Open access
Semantic Scholar
Endovascular Treatment for Acute Basilar Artery Occlusion: A Comparison of Arteriosclerotic, Embolic and Tandem Lesions
Wen-Jin Yang, Lei Zhang, Zifu Li, Yong-Xin Zhang +10 more
2021Cardiovascular and Interventional Radiology11 citations
Semantic Scholar
Intracranial hemorrhage in large vessel occlusion patients receiving endovascular thrombectomy with or without intravenous alteplase: a secondary analysis of the DIRECT-MT trial
Xiaowei Hu, Yu Zhou, J. Ospel, Feirong Yao +14 more
2022Journal of NeuroInterventional Surgery10 citations Open access
Semantic Scholar
Impact of renal impairment on short-term outcomes following endovascular thrombectomy for acute ischemic stroke: A systematic review and meta-analysis
J. Jeon, Chih-Hao Chen, Fon-Yih Tsuang, Jian-Min Liu +9 more
2021International Journal of Stroke10 citations
Semantic Scholar
Stent angioplasty for acute intracranial atherosclerotic occlusion after failed thrombectomy: a single institution series of 55 patients.
Ming-Tao Feng, Hong-Jian Zhang, Yong-Xin Zhang, P. Xing +8 more
2019World Neurosurgery9 citations
Semantic Scholar
Hemodynamic evaluation of symptomatic and asymptomatic intracranial atherosclerotic stenosis using cerebral angiographic images: an exploratory study
Jia-Yan Li, Li-Jun Wang, Yong-Xin Zhang, Xuan Zhu +14 more
2025Journal of NeuroInterventional Surgery8 citations
Semantic Scholar
Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke
Zifu Li, Tianxiang Gao, Jing Wang, Xiao-Xi Zhang +4 more
2024Journal of Neurochemistry8 citations
Semantic Scholar
Association between basal ganglia infarction and hemorrhagic transformation after mechanical thrombectomy in acute ischemic stroke: insights from the DIRECT-MT trial
Rundong Chen, W. Hua, Yi-Lei Zhang, Yong-Xin Zhang +5 more
2024Journal of NeuroInterventional Surgery8 citations
Semantic Scholar
Predictors of malignant middle cerebral artery infarction after endovascular thrombectomy: results of DIRECT-MT trial
Xiao-Quan Xu, Guang-Quan Zhang, Zhen-Yu Jia, Lin-Bo Zhao +13 more
2022European Radiology8 citations
Semantic Scholar
The second randomized controlled ENhanced Control of Hypertension ANd Thrombectomy strokE stuDy (ENCHANTED2): Protocol and progress
Li-Li Song, Pengfei Yang, Yong-Wei Zhang, Xiaoxi Zhang +22 more
2022International Journal of Stroke8 citations Open access
Semantic Scholar
Endovascular Recanalization for Acute Internal Carotid Artery Terminus Occlusion: A Subgroup Analysis From the Direct-MT Trial
Ying-Ying Zhang, Lei Zhang, Yong-Wei Zhang, Zifu Li +7 more
2022Neurosurgery8 citations Open access
Semantic Scholar
Efficacy and Safety of a Novel Thrombectomy Device in Patients With Acute Ischemic Stroke: A Randomized Controlled Trial
Yong-Xin Zhang, W. Hua, Zifu Li, Ya Peng +25 more
2021Frontiers in Neurology8 citations Open access
Semantic Scholar
Interaction of brain imaging features and effects of intensive blood pressure lowering after endovascular treatment for acute ischaemic stroke: the pre-specified secondary analyses of ENCHANTED2/MT trial
Xiao-Xi Zhang, Xin-Wen Ren, Yong-Xin Zhang, Yong-Wei Zhang +26 more
2025EClinicalMedicine7 citations Open access
Semantic Scholar
Acute ischemic stroke with or without asymptomatic intracranial hemorrhage after endovascular treatment: a propensity-score matching study
Xiao-Xi Zhang, F. Shen, Luo Rui, Hanchen Liu +10 more
2024Journal of NeuroInterventional Surgery7 citations
Semantic Scholar
The Efficacy and Safety of Tirofiban Use in Endovascular Thrombectomy for Intravenous Thrombolysis Applicable Patients with Large Vessel Occlusion Stroke—a Post Hoc Analysis from the Direct-MT Trial
Ying-Ying Zhang, Ping Zhang, Anyang Tao, Xinliang Wang +9 more
2023Cardiovascular and Interventional Radiology7 citations Open access
Semantic Scholar
Thrombus migration in patients with acute ischaemic stroke undergoing endovascular thrombectomy
Ze-Feng Tan, Lei Zhang, Li'an Huang, Hong'yu Qiao +15 more
2023Stroke and vascular neurology7 citations Open access
Semantic Scholar
Impact of anesthesia modalities on functional outcome of mechanical thrombectomy in patients with acute ischemic stroke: a subgroup analysis of DIRECT-MT trial
Zifu Li, Hongyu Ma, Bin-Ben Li, Lei Zhang +13 more
2023European Journal of Medical Research7 citations Open access
Semantic Scholar
The Diagnostic Value of Whole Blood lncRNA NR_120420 for Acute Ischemic Stroke
Chun-ou Tian, Zifu Li, Sisi Li, Lei Zhang +4 more
2022Oxidative Medicine and Cellular Longevity7 citations Open access
Semantic Scholar
Acute Carotid Stenting for Tandem Lesions in Patients Randomized to Endovascular Treatment With or Without Thrombolysis: Results From the IRIS Individual Participant Data Meta-Analysis.
F. Cavalcante, K. Treurniet, J. Kaesmacher, M. Kappelhof +26 more
2025Stroke6 citations Open access
Semantic Scholar
Diagnostic accuracy of hemodynamic assessment of intracranial atherosclerotic stenosis from a single angiographic view: a validation study
Jian-Ping Xiang, Lei Zhang, Chenbin Rong, Rong Zou +10 more
2024Journal of NeuroInterventional Surgery6 citations
Semantic Scholar
Patient-Reported Anxiety/Depression After Endovascular Thrombectomy: A post-hoc Analysis of Direct-MT Trial
Ping Zhang, Hong-Jian Shen, Lei Chen, Xueling Zhu +12 more
2022Frontiers in Neurology6 citations Open access
Semantic Scholar

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