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Jia-Heng Tan · SciRah

Researcher profile · Semantic Scholar

Jia-Heng Tan

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Jia-Heng Tan — researcher profile on SciRah

h-index: 43
Works: 182
Citations: 5,829

Most-cited papers

Tracking the Dynamic Folding and Unfolding of RNA G-Quadruplexes in Live Cells.
Xiu-Cai Chen, Shuo-Bin Chen, Jing Dai, Jia Yuan +3 more
2018Angewandte Chemie163 citations
Semantic Scholar
Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe.
Shuo-Bin Chen, Ming-Hao Hu, Guo-Cai Liu, Jin Wang +4 more
2016Journal of the American Chemical Society123 citations
Semantic Scholar
Conformation Selective Antibody Enables Genome Profiling and Leads to Discovery of Parallel G-Quadruplex in Human Telomeres.
Hui-Yun Liu, Qi Zhao, Tian-Peng Zhang, Yue Wu +12 more
2016Cell Chemical Biology113 citations Open access
Semantic Scholar
Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex.
Ming-Hao Hu, Yu-Qing Wang, Ze-Yi Yu, L. Hu +4 more
2018Journal of Medicinal Chemistry94 citations
Semantic Scholar
Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole
Ming-Hao Hu, Shuo-Bin Chen, Bo Wang, Tian-Miao Ou +3 more
2016Nucleic Acids Research92 citations Open access
Semantic Scholar
Identification of G-Quadruplex-Binding Protein from the Exploration of RGG Motif/G-Quadruplex Interactions.
Zhou-Li Huang, Jing Dai, Wen-Hua Luo, Xianggui Wang +3 more
2018Journal of the American Chemical Society81 citations
Semantic Scholar
Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry.
De-Ying Zeng, Guotao Kuang, Shi-Ke Wang, Wang Peng +9 more
2017Journal of Medicinal Chemistry73 citations
Semantic Scholar
Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis.
Xiu-Cai Chen, Gui-Xue Tang, Wen-Hua Luo, Wen Shao +5 more
2021Journal of the American Chemical Society61 citations
Semantic Scholar
Design, synthesis, and biological evaluation of 2-arylethenylquinoline derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Xiao-Qin Wang, Chun-Li Xia, Shuo-Bin Chen, Jia-Heng Tan +5 more
2015European journal of medicinal chemistry54 citations
Semantic Scholar
A colorimetric and fluorescent turn-on probe for carbon monoxide and imaging in living cells
Zhong-yong Xu, Jin-Wu Yan, Jing Li, Pei-Fen Yao +2 more
201652 citations Open access
Semantic Scholar
Revealing Mitochondrion-Lysosome Dynamic Interactions and pH Variations in Live Cells with a pH-Sensitive Fluorescent Probe.
Jian Wang, Jia-Tong Yan, Shu Zeng, Wen Shao +5 more
2023Analytical Chemistry51 citations
Semantic Scholar
New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
Hui-Yun Liu, Ai-Chun Chen, Qi-Kun Yin, Zeng Li +11 more
2017Journal of Medicinal Chemistry51 citations
Semantic Scholar
Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents
Tong Che, Yu-Qing Wang, Zhou-Li Huang, Jia-Heng Tan +2 more
2018Molecules46 citations Open access
Semantic Scholar
Development of a Smart Fluorescent Sensor That Specifically Recognizes the c-MYC G-Quadruplex.
Ming-Hao Hu, Jingwei Zhou, Wen-Hua Luo, Shuo-Bin Chen +3 more
2019Analytical Chemistry44 citations
Semantic Scholar
Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex.
Shan Chan, Jin-Wu Yan, Yu-Qing Wang, Tong Che +8 more
2017Journal of Medicinal Chemistry44 citations Open access
Semantic Scholar
Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair.
Qi-Kun Yin, Chen-xi Wang, Yu-Qing Wang, Qian-Liang Guo +8 more
2019Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation.
Bing Shu, Jiaojiao Cao, Guotao Kuang, Jun Qiu +9 more
2018Chemical Communications43 citations
Semantic Scholar
Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors.
Peng-Hui Li, P. Zeng, Shuo-Bin Chen, Pei-Fen Yao +7 more
2016Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response.
Tong Che, Shuo-Bin Chen, Jia-Li Tu, Bo Wang +9 more
2018Journal of Medicinal Chemistry40 citations
Semantic Scholar
Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction.
Yu-Qing Wang, Zhou-Li Huang, Shuo-Bin Chen, Chen-xi Wang +7 more
2017Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes.
Yong Rao, Hong Liu, Lin Gao, Hong Yu +6 more
2015Bioorganic & Medicinal Chemistry40 citations
Semantic Scholar
Construction of a TICT-AIE-Integrated Unimolecular Platform for Imaging Lipid Droplet-Mitochondrion Interactions in Live Cells and In Vivo.
Shu Zeng, Wen Shao, Ze-Yi Yu, Lan Fang +6 more
2022ACS Sensors39 citations
Semantic Scholar
Design, Synthesis and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom's Syndrome Protein (BLM) Helicase, Trigger DNA damage at the Telomere Region and Synergize with PARP Inhibitors.
Chen-xi Wang, Zi-Lin Zhang, Qi-Kun Yin, Jia-Li Tu +11 more
2020Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Recent advances in fluorescent probes for G-quadruplex nucleic acids.
Jia Yuan, Wen Shao, Shuo-Bin Chen, Zhi-Shu Huang +1 more
2020Biochemical and Biophysical Research Communications - BBRC35 citations
Semantic Scholar
Development of a colorimetric and NIR fluorescent dual probe for carbon monoxide
Jin-Wu Yan, Jia-Ying Zhu, Qi-feng Tan, Lin-Fu Zhou +4 more
201635 citations
Semantic Scholar
A colorimetric and fluorescent dual probe for palladium in aqueous medium and live cell imaging.
Jin-Wu Yan, Xiao-lin Wang, Qi-feng Tan, Pei-Fen Yao +2 more
2016In Analysis34 citations
Semantic Scholar
Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule
Shan Chan, Jing Lin, Jin-Qiang Hou, Hui-Yun Liu +7 more
2015Nucleic Acids Research32 citations Open access
Semantic Scholar
Design, Synthesis, and Evaluation of Novel p-(Methylthio)styryl Substituted Quindoline Derivatives as Neuroblastoma RAS (NRAS) Repressors via Specific Stabilizing the RNA G-Quadruplex.
Wang Peng, Zhi-Yin Sun, Qi Zhang, Sui-Qi Cheng +7 more
2018Journal of Medicinal Chemistry29 citations
Semantic Scholar
A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology
Ming-Hao Hu, Xiao Chen, Shuo-Bin Chen, Tian-Miao Ou +4 more
2015Scientific Reports29 citations Open access
Semantic Scholar
Synthesis and evaluation of 7-substituted-5,6-dihydrobenzo[c]acridine derivatives as new c-KIT promoter G-quadruplex binding ligands.
Qian-Liang Guo, Hua-Fei Su, Ning Wang, Sheng-Rong Liao +5 more
2017European journal of medicinal chemistry28 citations
Semantic Scholar
Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole.
Ming-Hao Hu, Shuo-Bin Chen, Yu-Qing Wang, You-Mei Zeng +5 more
2016Biosensors & bioelectronics28 citations
Semantic Scholar
Design, synthesis and biological evaluation of 4-anilinoquinazoline derivatives as new c-myc G-quadruplex ligands.
Yin-Zhi Jiang, Ai-Chun Chen, Guotao Kuang, Shi-Ke Wang +4 more
2016European journal of medicinal chemistry28 citations
Semantic Scholar
Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment.
Yong Rao, Hong Liu, Lin Gao, Hong Yu +8 more
2015Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Development and Characterization of Benzoselenazole Derivatives as Potent and Selective c-MYC Transcription Inhibitors.
Tian-Ying Wu, Xiu-Cai Chen, Gui-Xue Tang, Wen Shao +4 more
2023Journal of Medicinal Chemistry27 citations
Semantic Scholar
An RNA G-Quadruplex Structure within the ADAR 5'UTR Interacts with DHX36 Helicase to Regulate Translation.
Kaixin Lyu, Shuo-Bin Chen, E. Chow, Hai-Zhou Zhao +6 more
2022Angewandte Chemie27 citations Open access
Semantic Scholar
A novel HSF1 activator ameliorates non‐alcoholic steatohepatitis by stimulating mitochondrial adaptive oxidation
Yong Rao, Chan Li, Yu-Tao Hu, Yao-Hao Xu +12 more
2021British Journal of Pharmacology26 citations Open access
Semantic Scholar
Interaction of Quindoline derivative with telomeric repeat-containing RNA induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2.
Yan Zhang, De-Ying Zeng, Jiaojiao Cao, Mingxue Wang +7 more
2017Biochimica et Biophysica Acta - General Subjects26 citations
Semantic Scholar
Dimeric aryl-substituted imidazoles may inhibit ALT cancer by targeting the multimeric G-quadruplex in telomere.
Ming-Hao Hu, Xiaojie Lin, Bin Liu, Jia-Heng Tan
2019European journal of medicinal chemistry24 citations
Semantic Scholar
Development of an engineered carbazole/thiazole orange conjugating probe for G-quadruplexes
Ming-Hao Hu, Ruizhi Guo, Shuo-Bin Chen, Zhi-Shu Huang +1 more
201724 citations
Semantic Scholar
Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer.
Xingpeng Jiang, Fang-Hai Tu, Li-Yuan Wei, Bo-Zheng Wang +10 more
2022Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex.
Tian-Ying Wu, Qiong Huang, Zhi-Shu Huang, Ming-Hao Hu +1 more
2020Bioorganic chemistry (Print)23 citations
Semantic Scholar
Selective targeting of parallel G-quadruplex structure using L-RNA aptamer
Danyang Ji, Jia-Hao Yuan, Shuo-Bin Chen, Jia-Heng Tan +1 more
2023Nucleic Acids Research22 citations Open access
Semantic Scholar
Development of a highly sensitive fluorescent light-up probe for G-quadruplexes.
Ming-Hao Hu, Shuo-Bin Chen, Rui-Jun Guo, Tian-Miao Ou +2 more
2015In Analysis22 citations
Semantic Scholar
Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c-MYC Transcription Repressors Targeting the Promoter G-Quadruplex.
Mao-lin Li, Jing-Mei Yuan, Haoxuan Yuan, Bi-Han Wu +8 more
2022Journal of Medicinal Chemistry20 citations
Semantic Scholar
Tracking Stress Granule Dynamics in Live Cells and In Vivo with a Small Molecule.
Wen Shao, Shu Zeng, Ze-Yi Yu, Gui-Xue Tang +4 more
2021Analytical Chemistry19 citations
Semantic Scholar
Discovery of Small Molecules for Repressing Cap-Independent Translation of Human Vascular Endothelial Growth Factor (hVEGF) as Novel Antitumor Agents.
Shi-Ke Wang, Yue Wu, Xiao-Qin Wang, Guotao Kuang +6 more
2017Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
A simple structural modification to thiazole orange to improve the selective detection of G-quadruplexes
Ruizhi Guo, Jin-Wu Yan, Shuo-Bin Chen, L. Gu +2 more
201619 citations
Semantic Scholar
Tuning the selectivity of a commercial cyanine nucleic acid dye for preferential sensing of hybrid telomeric G-quadruplex DNA
Yu-Qing Wang, Ming-Hao Hu, Ruizhi Guo, Shuo-Bin Chen +2 more
2018Sensors and Actuators B: Chemical18 citations
Semantic Scholar
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.
Chun-Li Xia, Ning Wang, Qian-Liang Guo, Zhen-Quan Liu +7 more
2017European journal of medicinal chemistry18 citations Open access
Semantic Scholar
Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5'-UTR RNA G-Quadruplexes.
Mao-Lin Li, Le-Tian Dai, Zhuo-Yu Gao, Jia-Tong Yan +5 more
2024Journal of Medicinal Chemistry16 citations
Semantic Scholar

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Shuo-Bin Chen×32
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