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Stephanie Federico · SciRah

Researcher profile · Semantic Scholar

Stephanie Federico

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Stephanie Federico — researcher profile on SciRah

h-index: 18
Works: 80
Citations: 917

Most-cited papers

The current status of pharmacotherapy for the treatment of Parkinson's disease: transition from single-target to multitarget therapy.
Siew Lee Cheong, Stephanie Federico, G. Spalluto, K. Klotz +1 more
2019Drug Discovery Today56 citations Open access
Semantic Scholar
Glycogen Synthase Kinase 3β Involvement in Neuroinflammation and Neurodegenerative Diseases.
T. Gianferrara, Eleonora Cescon, Ilenia Grieco, G. Spalluto +1 more
2022Current Medicinal Chemistry49 citations Open access
Semantic Scholar
Advances in Computational Techniques to Study GPCR-Ligand Recognition.
Antonella Ciancetta, Davide Sabbadin, Stephanie Federico, G. Spalluto +1 more
2015TIPS - Trends in Pharmacological Sciences45 citations Open access
Semantic Scholar
The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches
Siew Lee Cheong, Stephanie Federico, Gopalakrishnan Venkatesan, A. Mandel +4 more
2013Medicinal research reviews (Print)45 citations
Semantic Scholar
The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.
Siew Lee Cheong, A. Dolzhenko, Sonja Kachler, S. Paoletta +7 more
2010Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson's disease treatment
Yi-Ming Shao, Xiao-Hua Ma, P. Paira, Aaron Tan +10 more
2018PLoS ONE38 citations Open access
Semantic Scholar
Novel Fluorescent Antagonist as a Molecular Probe in A3 Adenosine Receptor Binding Assays Using Flow Cytometry
E. Kozma, T. S. Kumar, Stephanie Federico, Khai Phan +6 more
2012Biochemical Pharmacology33 citations Open access
Semantic Scholar
Fluorescent Ligands for Adenosine Receptors
E. Kozma, P. Jayasekara, L. Squarcialupi, S. Paoletta +4 more
2012Bioorganic & Medicinal Chemistry Letters31 citations Open access
Semantic Scholar
Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility.
Stephanie Federico, S. Paoletta, Siew Lee Cheong, G. Pastorin +8 more
2011Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand–receptor recognition process
G. Pastorin, Stephanie Federico, S. Paoletta, M. Corradino +7 more
2010Bioorganic & Medicinal Chemistry30 citations Open access
Semantic Scholar
A Triazolotriazine‐Based Dual GSK‐3β/CK‐1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition
S. Redenti, I. Marcovich, T. De Vita, Concepción Pérez +12 more
2019ChemMedChem29 citations Open access
Semantic Scholar
A novel conjugated agent between dopamine and an A2A adenosine receptor antagonist as a potential anti-Parkinson multitarget approach.
A. Dalpiaz, B. Cacciari, C. B. Vicentini, F. Bortolotti +6 more
2012Molecular Pharmaceutics27 citations
Semantic Scholar
Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites.
Lisa Michielan, C. Bolcato, Stephanie Federico, B. Cacciari +8 more
2009Bioorganic & Medicinal Chemistry25 citations Open access
Semantic Scholar
Adenosine Receptors in Neuroinflammation and Neurodegeneration
V. Salmaso, Silvia Menin, S. Moro, G. Spalluto +1 more
2025Cells23 citations Open access
Semantic Scholar
A Computational Workflow for the Identification of Novel Fragments Acting as Inhibitors of the Activity of Protein Kinase CK1δ
G. Bolcato, Eleonora Cescon, Matteo Pavan, Maicol Bissaro +5 more
2021International Journal of Molecular Sciences21 citations Open access
Semantic Scholar
5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors.
Stephanie Federico, Antonella Ciancetta, Nicola Porta, S. Redenti +5 more
2016European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Targeting Protein Kinase CK1δ with Riluzole: Could It Be One of the Possible Missing Bricks to Interpret Its Effect in the Treatment of ALS from a Molecular Point of View?
Maicol Bissaro, Stephanie Federico, V. Salmaso, M. Sturlese +2 more
2018ChemMedChem20 citations Open access
Semantic Scholar
Impact of protein–ligand solvation and desolvation on transition state thermodynamic properties of adenosine A2A ligand binding kinetics
Giuseppe Deganutti, A. Zhukov, Francesca Deflorian, Stephanie Federico +5 more
2017In Silico Pharmacology20 citations Open access
Semantic Scholar
Revisiting a Receptor-Based Pharmacophore Hypothesis for Human A2A Adenosine Receptor Antagonists
M. Bacilieri, Antonella Ciancetta, S. Paoletta, Stephanie Federico +8 more
2013Journal of Chemical Information and Modeling18 citations
Semantic Scholar
Therapeutic potential of A2 and A3 adenosine receptor: a review of novel patented ligands
Stephanie Federico, G. Spalluto
2012Expert Opinion on Therapeutic Patents17 citations
Semantic Scholar
Discovery of simplified N²-substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: efficient synthetic approaches, biological evaluations and molecular docking studies.
Gopalakrishnan Venkatesan, P. Paira, Siew Lee Cheong, K. VamsiKrishna +4 more
2014Bioorganic & Medicinal Chemistry16 citations Open access
Semantic Scholar
Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.
Stephanie Federico, Antonella Ciancetta, Davide Sabbadin, S. Paoletta +5 more
2012Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Riluzole–Rasagiline Hybrids: Toward the Development of Multi-Target-Directed Ligands for Amyotrophic Lateral Sclerosis
Claudia Albertini, A. Salerno, S. Atzeni, Elisa Uliassi +20 more
2022ACS Chemical Neuroscience15 citations Open access
Semantic Scholar
A2A Adenosine Receptor Antagonists as Therapeutic Candidates: Are They Still an Interesting Challenge?
B. Cacciari, G. Spalluto, Stephanie Federico
2018Mini-Reviews in Medical Chemistry15 citations Open access
Semantic Scholar
[1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A3 adenosine receptor subtype.
Stephanie Federico, Enrico Margiotta, V. Salmaso, G. Pastorin +4 more
2018European journal of medicinal chemistry15 citations Open access
Semantic Scholar
8-(2-Furyl)adenine derivatives as A₂A adenosine receptor ligands.
D. Dal Ben, M. Buccioni, C. Lambertucci, Ajiroghene Thomas +5 more
2013European journal of medicinal chemistry15 citations Open access
Semantic Scholar
“Dual Anta-Inhibitors” of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies
A. Spinaci, M. Buccioni, D. Catarzi, Chang Cui +14 more
2023Pharmaceuticals14 citations Open access
Semantic Scholar
Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and Structurally Simplified Analogs. Chemistry and SAR Profile as Adenosine Receptor Antagonists.
S. Redenti, Antonella Ciancetta, G. Pastorin, B. Cacciari +3 more
2016Current Topics in Medicinal Chemistry14 citations Open access
Semantic Scholar
Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study.
Stephanie Federico, Antonella Ciancetta, Nicola Porta, S. Redenti +5 more
2014Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems.
Ilenia Grieco, Maicol Bissaro, Davide Benedetto Tiz, Daniel I. Perez +10 more
2021European journal of medicinal chemistry13 citations Open access
Semantic Scholar
Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 δ Inhibitors.
Eleonora Cescon, G. Bolcato, Stephanie Federico, Maicol Bissaro +5 more
2020ACS Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Pyrazolo Derivatives as Potent Adenosine Receptor Antagonists: An Overview on the Structure-Activity Relationships
Siew Lee Cheong, Gopalakrishnan Venkatesan, P. Paira, R. Jothibasu +4 more
2011International Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Chemical Probes for the Adenosine Receptors
Stephanie Federico, L. Lassiani, G. Spalluto
2019Pharmaceuticals12 citations Open access
Semantic Scholar
Conjugable A3 adenosine receptor antagonists for the development of functionalized ligands and their use in fluorescent probes
Stephanie Federico, Enrico Margiotta, S. Moro, E. Kozma +3 more
2019European journal of medicinal chemistry11 citations Open access
Semantic Scholar
Does the combination of optimal substitutions at the C²-, N⁵- and N⁸-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A₃ adenosine receptors?
Siew Lee Cheong, A. Dolzhenko, S. Paoletta, E. Lee +7 more
2011Bioorganic & Medicinal Chemistry11 citations Open access
Semantic Scholar
Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists.
Siew Lee Cheong, Stephanie Federico, Gopalakrishnan Venkatesan, P. Paira +4 more
2011Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Human A3 adenosine receptor as versatile G protein-coupled receptor example to validate the receptor homology modeling technology.
Erika Morizzo, Stephanie Federico, G. Spalluto, S. Moro
2009Current pharmaceutical design10 citations
Semantic Scholar
Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example.
Stephanie Federico, Enrico Margiotta, S. Paoletta, Sonja Kachler +5 more
2019MedChemComm8 citations Open access
Semantic Scholar
A facile and novel synthesis of N(2)-, C(6)-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists.
Gopalakrishnan Venkatesan, P. Paira, Siew Lee Cheong, Stephanie Federico +3 more
2015European journal of medicinal chemistry8 citations Open access
Semantic Scholar
The Multifaceted Role of GPCRs in Amyotrophic Lateral Sclerosis: A New Therapeutic Perspective?
Davide Bassani, Matteo Pavan, Stephanie Federico, G. Spalluto +2 more
2022International Journal of Molecular Sciences7 citations Open access
Semantic Scholar
New 9-methyl-8-(4-hydroxyphenyl)adenine derivatives as A 1 adenosine receptor antagonists
C. Lambertucci, M. Buccioni, B. Cacciari, D. Dal Ben +6 more
20117 citations
Semantic Scholar
Receptor-driven identification of novel human A₃ adenosine receptor antagonists as potential therapeutic agents.
S. Paoletta, Stephanie Federico, G. Spalluto, S. Moro
2010Methods in Enzymology7 citations
Semantic Scholar
Targeting G Protein‐Coupled Receptors with Magnetic Carbon Nanotubes: The Case of the A3 Adenosine Receptor
F. Pineux, Stephanie Federico, K. Klotz, Sonja Kachler +6 more
2020ChemMedChem6 citations Open access
Semantic Scholar
Are Two Riboses Better Than One? The Case of the Recognition and Activation of Adenosine Receptors
T. Gianferrara, Matteo Pavan, Davide Bassani, F. Vincenzi +6 more
2023ChemMedChem5 citations Open access
Semantic Scholar
The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives
Stephanie Federico, S. Redenti, M. Sturlese, Antonella Ciancetta +5 more
2015PLoS ONE5 citations Open access
Semantic Scholar
7-Amino-[1,2,4]triazolo[1,5-a][1,3,5]triazines as CK1δ inhibitors: Exploring substitutions at the 2 and 5-positions.
Ilenia Grieco, Davide Bassani, Letizia Trevisan, V. Salmaso +8 more
2024Bioorganic chemistry (Print)4 citations Open access
Semantic Scholar
Functionalized ligands targeting G protein-coupled adenosine receptors.
Stephanie Federico, G. Spalluto
2019Future Medicinal Chemistry4 citations
Semantic Scholar
Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors
B. Cacciari, Pamela Crepaldi, Chun-Yang Cheng, E. Bossi +4 more
2019Medicinal chemistry4 citations Open access
Semantic Scholar
Gaucher Disease: A Glance from a Medicinal Chemistry Perspective.
Filippo Prencipe, Chiara Barzan, Chiara Savian, G. Spalluto +6 more
2024ChemMedChem3 citations Open access
Semantic Scholar
[1,2,4]Triazolo[1,5‐c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines
Stephanie Federico, Margherita Persico, Letizia Trevisan, Chiara Biasinutto +10 more
2023ChemMedChem3 citations Open access
Semantic Scholar

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