Xiaolei Zhang

Most-cited papers

1. Solvent-induced protein precipitation for drug target discovery on proteomic scale.

   Xiaolei Zhang, Qi Wang, Yanan Li, Cheng-Fei Ruan +3 more

   2019Analytical Chemistry104 citations

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2. A peptide-centric local stability assay enables proteome-scale identification of the protein targets and binding regions of diverse ligands

   Ke-Jia Li, Shi-Jie Chen, Ke-Yun Wang, Yan Wang +16 more

   2024Nature Methods78 citations

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3. Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth

   Zhenlong Yu, Jian Gao, Xiaolei Zhang, Yulin Peng +12 more

   2022Signal Transduction and Targeted Therapy57 citations Open access

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4. Matrix Thermal Shift Assay for Fast Construction of Multidimensional Ligand-Target Space.

   Cheng-Fei Ruan, Yan Wang, Xiaolei Zhang, Jiawen Lyu +5 more

   2022Analytical Chemistry38 citations

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5. Precipitate-Supported Thermal Proteome Profiling Coupled with Deep Learning for Comprehensive Screening of Drug Target Proteins.

   Cheng-Fei Ruan, Wanshan Ning, Z. Liu, Xiaolei Zhang +5 more

   2022ACS Chemical Biology32 citations

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6. Highly effective identification of drug targets at the proteome level by pH-dependent protein precipitation

   Xiaolei Zhang, Keyun Wang, Si-Jin Wu, Cheng-Fei Ruan +8 more

   2022Chemical Science25 citations Open access

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7. Mechanical stress induced protein precipitation method for drug target screening.

   Jiawen Lyu, Yan Wang, Cheng-Fei Ruan, Xiaolei Zhang +2 more

   2021Analytica Chimica Acta23 citations

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8. Profiling of Endogenous Intact N-linked and O-linked Glycopeptides from Human Serum by Using an Integrated Platform.

   Shuyue Wang, Hong-Qiang Qin, Jia-Wei Mao, Zheng Fang +4 more

   2020Journal of Proteome Research17 citations

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9. Microparticle assisted precipitation screening method for robust drug target identification.

   Jiawen Lyu, Cheng-Fei Ruan, Xiaolei Zhang, Yan Wang +2 more

   2020Analytical Chemistry16 citations

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10. A Simplified Thermal Proteome Profiling Approach to Screen Protein Targets of a Ligand

    Xiaolei Zhang, Cheng-Fei Ruan, He Zhu, Ke-Jia Li +4 more

    2020Proteomics13 citations

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11. The Introduction of Detergents in Thermal Proteome Profiling Requires Lowering the Applied Temperatures for Efficient Target Protein Identification

    Yuying Ye, Ke-Jia Li, Yanni Ma, Xiaolei Zhang +4 more

    2023Molecules10 citations Open access

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12. Integrated Protein Solubility Shift Assays for Comprehensive Drug Target Identification on a Proteome-Wide Scale.

    Xiaolei Zhang, Cheng-Fei Ruan, Yan Wang, Keyun Wang +3 more

    2023Analytical Chemistry10 citations

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13. Proteome-Wide Deconvolution of Drug Targets and Binding Sites by Lysine Reactivity Profiling.

    Cheng-Fei Ruan, Jiahua Zhou, Zhouxian Li, Ke-Jia Li +3 more

    2022Analytical Chemistry10 citations

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14. Solvent-Induced Protein Precipitation for Drug Target Discovery.

    Xiaolei Zhang, Lianghai Hu, Ming-Liang Ye

    2023Methods in molecular biology7 citations

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15. Probing the methotrexate-protein interactions by proteomics and thermostability assay for drug resistance study.

    Wenbo Zhang, Xiaoying Li, Xiaolei Zhang, Yan Dong +1 more

    2021Analytical Methods5 citations

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16. TIPP: A Novel Iodoacetamide Reaction-Induced Protein Precipitation Approach for Proteome-Wide Ligand-Target Identification.

    Yan-Ni Ma, Jiahua Zhou, Bangtong Guan, Xiaolei Zhang +4 more

    2026Analytical Chemistry3 citations

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17. Solvent-induced partial cellular fixation decodes proteome-wide drug targets and downstream pathways in living cells

    Ting Yu, Yan Wang, Ke-Yun Wang, Zheng Fang +4 more

    2025Nature Communications3 citations Open access

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18. Polyphenol Tannin‐Induced Protein Precipitation for Drug Target Discovery by Chemical Proteomics

    Yujun Gao, Xiaolei Zhang, Ming-Liang Ye, Lianghai Hu

    2024ChemistrySelect2 citations

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19. 矩阵热转移技术鉴定有机酸类代谢物的结合蛋白质

    Ke-Jia Li, Yuying Ye, Xiaolei Zhang, Jiahua Zhou +2 more

    2024Se pu = Chinese journal of chromatography1 citations Open access

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20. Author Correction: A peptide-centric local stability assay enables proteome-scale identification of the protein targets and binding regions of diverse ligands

    Ke-Jia Li, Shi-Jie Chen, Ke-Yun Wang, Yan Wang +16 more

    2026Nature Methods0 citations Open access

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21. Detergent-Free Nuclear–Cytoplasmic Fractionation Enables Spatially Resolved PELSA for Enhanced Nuclear Drug Target Identification

    Danni Cai, Kun Zou, Jia-Yi Wang, Hai-Yang Zhu +7 more

    2026bioRxiv0 citations

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22. Sequential denaturation and protein precipitation assay (SDPP) improves the sensitivity for ligand target identification at the proteome level.

    Yan-Ni Ma, Xiaolei Zhang, Longrun Shi, Jia-Yang Yan +2 more

    2025Analytica Chimica Acta0 citations

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23. A peptide-centric local stability assay to unveil protein targets of diverse ligands

    Ke-Jia Li, Shi-Jie Chen, Keyun Wang, Yan Wang +13 more

    2023bioRxiv0 citations Open access

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24. Recent advances of chemical proteomics for protein drug target screening

    评 述 生物质谱专辑, Xiaolei Zhang, Zhang Wen-bo, Lianghai Hu

    20180 citations

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25. Recent advances of chemical proteomics for protein drug target screening

    Xiaolei Zhang, Wenbo Zhang, Liang-Hai Hu

    20170 citations Open access

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