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K. Okumura · SciRah

Researcher profile · Semantic Scholar

K. Okumura

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K. Okumura — researcher profile on SciRah

h-index: 45
Works: 276
Citations: 6,658

Most-cited papers

Role for Cysteine Protease Cathepsins in Heart Disease: Focus on Biology and Mechanisms With Clinical Implication
Xian W. Cheng, G. Shi, M. Kuzuya, T. Sasaki +2 more
2012Circulation156 citations Open access
Semantic Scholar
Cysteine protease cathepsins in atherosclerosis-based vascular disease and its complications.
Xian W. Cheng, Zhe Huang, M. Kuzuya, K. Okumura +1 more
2011HYPERTENSION136 citations Open access
Semantic Scholar
Separating the mechanism-based and off-target actions of CETP-inhibitors using CETP gene polymorphisms
R. Sofat, A. Hingorani, L. Smeeth, S. Humphries +57 more
2009Circulation115 citations Open access
Semantic Scholar
Renal protective effects and the prevention of contrast-induced nephropathy by atrial natriuretic peptide.
S. Morikawa, T. Sone, H. Tsuboi, H. Mukawa +6 more
2009Journal of the American College of Cardiology108 citations Open access
Semantic Scholar
Isolation, Tissue Localization, and Cellular Characterization of Progenitors Derived from Adult Human Salivary Glands
Ayumi Sato, K. Okumura, S. Matsumoto, K. Hattori +3 more
2007Cloning and Stem Cells107 citations
Semantic Scholar
Exercise Training Stimulates Ischemia-Induced Neovascularization via Phosphatidylinositol 3-Kinase/Akt-Dependent Hypoxia-Induced Factor-1α Reactivation in Mice of Advanced Age
Xian W. Cheng, M. Kuzuya, Weon Kim, Hai-Zhen Song +9 more
2010Circulation95 citations Open access
Semantic Scholar
BH3 Mimetic Obatoclax Enhances TRAIL-Mediated Apoptosis in Human Pancreatic Cancer Cells
Shengbing Huang, K. Okumura, F. Sinicrope
2009Clinical Cancer Research91 citations Open access
Semantic Scholar
Induction of Noxa Sensitizes Human Colorectal Cancer Cells Expressing Mcl-1to the Small-Molecule Bcl-2/Bcl-xL Inhibitor, ABT-737
K. Okumura, Shengbing Huang, F. Sinicrope
2008Clinical Cancer Research89 citations Open access
Semantic Scholar
Cathepsin K-mediated notch1 activation contributes to neovascularization in response to hypoxia
Hai-Ying Jiang, Xian W. Cheng, G. Shi, Li-Na Hu +15 more
2014Nature Communications88 citations Open access
Semantic Scholar
Prognostic Impact of Bim, Puma, and Noxa Expression in Human Colon Carcinomas
F. Sinicrope, Rafaela Rego, K. Okumura, N. Foster +3 more
2008Clinical Cancer Research87 citations Open access
Semantic Scholar
Exenatide mitigated diet-induced vascular aging and atherosclerotic plaque growth in ApoE-deficient mice under chronic stress.
Guang Yang, Yan-Na Lei, A. Inoue, Li-Mei Piao +11 more
2017Atherosclerosis79 citations
Semantic Scholar
Impact of the high‐molecular‐weight form of adiponectin on endothelial function in healthy young men
M. Torigoe, H. Matsui, Y. Ogawa, Hisashi Murakami +5 more
2007Clinical Endocrinology71 citations
Semantic Scholar
Role of Bradykinin, Nitric Oxide, and Angiotensin II Type 2 Receptor in Imidapril-Induced Angiogenesis
Ping Li, T. Kondo, Y. Numaguchi, Koichi Kobayashi +4 more
2008HYPERTENSION70 citations Open access
Semantic Scholar
Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia‐Induced Neovascularization: The Role of Dipeptidyl Peptidase‐4/Glucagon‐Like Peptide‐1‐Adiponectin Axis
Li-Mei Piao, Guang-Xian Zhao, En-Bo Zhu, A. Inoue +12 more
2017Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease65 citations Open access
Semantic Scholar
Circulating cathepsin K as a potential novel biomarker of coronary artery disease.
Xian W. Cheng, R. Kikuchi, H. Ishii, D. Yoshikawa +7 more
2013Atherosclerosis62 citations
Semantic Scholar
Angiotensin Type 1 Receptor Blocker Reduces Intimal Neovascularization and Plaque Growth in Apolipoprotein E–Deficient Mice
Xian W. Cheng, Hai-Zhen Song, T. Sasaki, Li-Na Hu +6 more
2011HYPERTENSION59 citations Open access
Semantic Scholar
Production efficiency and telomere length of the cloned pigs following serial somatic cell nuclear transfer.
M. Kurome, H. Hisatomi, S. Matsumoto, R. Tomii +9 more
2008Journal of reproduction and development58 citations Open access
Semantic Scholar
Cardiovascular , Pulmonary and Renal Pathology Superoxide-Dependent Cathepsin Activation Is Associated with Hypertensive Myocardial Remodeling and Represents a Target for Angiotensin II Type 1 Receptor Blocker Treatment
Xian W. Cheng, T. Murohara, M. Kuzuya, H. Izawa +11 more
201056 citations
Semantic Scholar
Cathepsin K Activity Controls Injury-Related Vascular Repair in Mice
Li-Na Hu, Xian-Wu Cheng, Hai-Zhen Song, A. Inoue +6 more
2013HYPERTENSION55 citations Open access
Semantic Scholar
Folate in smokers.
K. Okumura, H. Tsukamoto
2011Clinica chimica acta; international journal of clinical chemistry50 citations
Semantic Scholar
AT1 blockade attenuates atherosclerotic plaque destabilization accompanied by the suppression of cathepsin S activity in apoE-deficient mice.
T. Sasaki, M. Kuzuya, Kae Nakamura, Xian W. Cheng +7 more
2010Atherosclerosis48 citations
Semantic Scholar
The effects of endothelial nitric oxide synthase gene polymorphisms on endothelial function and metabolic risk factors in healthy subjects: the significance of plasma adiponectin levels.
Akiko Imamura, Ryotaro Takahashi, Ryuichiro Murakami, Hiroki Kataoka +4 more
2008European Journal of Endocrinology47 citations
Semantic Scholar
Dipeptidyl Peptidase‐4 Regulates Hematopoietic Stem Cell Activation in Response to Chronic Stress
En-Bo Zhu, Li-Na Hu, Hong-Xian Wu, Li-Mei Piao +15 more
2017Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease45 citations Open access
Semantic Scholar
Pitavastatin, an HMG-CoA reductase inhibitor, ameliorates endothelial function in chronic smokers.
O. Yoshida, T. Kondo, Yasuko Kureishi-Bando, T. Sugiura +3 more
2010Circulation Journal45 citations Open access
Semantic Scholar
Pressure Overload-Induced Cardiomyopathy in Heterozygous Carrier Mice of Carnitine Transporter Gene Mutation
Ryotaro Takahashi, T. Asai, Hisashi Murakami, Ryuichiro Murakami +5 more
2007HYPERTENSION44 citations Open access
Semantic Scholar
Cathepsin S activity controls ischemia-induced neovascularization in mice.
Xiang Li, Xian W. Cheng, Li-Na Hu, Hong-Xian Wu +12 more
2015International Journal of Cardiology39 citations
Semantic Scholar
Capability of Tissue Stem Cells to Organize into Salivary Rudiments
K. Okumura, M. Shinohara, F. Endo
2012Stem Cells International36 citations Open access
Semantic Scholar
Catheter ablation for non-paroxysmal atrial fibrillation accompanied by heart failure with preserved ejection fraction: feasibility and benefits in functions and B-type natriuretic peptide.
R. Yamauchi, I. Morishima, K. Okumura, Y. Kanzaki +11 more
2021Europace35 citations
Semantic Scholar
Long-term administration of nifedipine attenuates cardiac remodeling and diastolic heart failure in hypertensive rats.
Takashi Yamada, K. Nagata, Xian W. Cheng, K. Obata +10 more
2009European Journal of Pharmacology34 citations
Semantic Scholar
High‐Normal Thyroid‐Stimulating Hormone Shows a Potential Causal Association With Arrhythmia Recurrence After Catheter Ablation of Atrial Fibrillation
I. Morishima, K. Okumura, Yasuhiro Morita, Y. Kanzaki +8 more
2018Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease33 citations Open access
Semantic Scholar
Ablation of Angiotensin IV Receptor Attenuates Hypofibrinolysis via PAI-1 Downregulation and Reduces Occlusive Arterial Thrombosis
Y. Numaguchi, M. Ishii, R. Kubota, Yasuhiro Morita +4 more
2009Arteriosclerosis, Thrombosis and Vascular Biology30 citations Open access
Semantic Scholar
Risk stratification of patients with prior myocardial infarction and advanced left ventricular dysfunction by gated myocardial perfusion SPECT imaging
I. Morishima, T. Sone, H. Tsuboi, H. Mukawa +9 more
2008Journal of Nuclear Cardiology30 citations
Semantic Scholar
Mechanisms With Clinical Implications for Atrial Fibrillation–Associated Remodeling: Cathepsin K Expression, Regulation, and Therapeutic Target and Biomarker
Masaya Fujita, Xian W. Cheng, Y. Inden, M. Shimano +10 more
2013Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease29 citations Open access
Semantic Scholar
Mechanism of Diastolic Stiffening of the Failing Myocardium and Its Prevention by Angiotensin Receptor and Calcium Channel Blockers
Xian W. Cheng, K. Okumura, M. Kuzuya, Zhe-Hu Jin +10 more
2009Journal of Cardiovascular Pharmacology28 citations Open access
Semantic Scholar
PLF‐1 (Proliferin‐1) Modulates Smooth Muscle Cell Proliferation and Development of Experimental Intimal Hyperplasia
Li-Na Hu, Zhe Huang, H. Ishii, Hong-Xian Wu +14 more
2019Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease26 citations Open access
Semantic Scholar
Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin
Xian W. Cheng, M. Kuzuya, T. Sasaki, A. Inoue +10 more
2011Journal of Hypertension26 citations Open access
Semantic Scholar
Angiotensin II type 1 receptor blockers prevent tumor necrosis factor-alpha-mediated endothelial nitric oxide synthase reduction and superoxide production in human umbilical vein endothelial cells.
Hiroki Kataoka, Ryuichiro Murakami, Y. Numaguchi, K. Okumura +1 more
2010European Journal of Pharmacology26 citations
Semantic Scholar
Mesenchymal stem cell-based gene therapy with prostacyclin synthase enhanced neovascularization in hindlimb ischemia.
M. Ishii, Y. Numaguchi, K. Okumura, R. Kubota +4 more
2009Atherosclerosis26 citations
Semantic Scholar
Low folate levels may be an atherogenic factor regardless of homocysteine levels in young healthy nonsmokers.
Akiko Imamura, Ryuichiro Murakami, Ryotaro Takahashi, Xian W. Cheng +3 more
2010Metabolism: Clinical and Experimental23 citations
Semantic Scholar
Production of Cloned Pigs from Salivary Gland-Derived Progenitor Cells
M. Kurome, R. Tomii, S. Ueno, K. Hiruma +7 more
2008Cloning and Stem Cells19 citations
Semantic Scholar
Ca2+ channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats
T. Nishizawa, Xian W. Cheng, Zhe-Hu Jin, K. Obata +10 more
2010Journal of Hypertension18 citations Open access
Semantic Scholar
Impact of basal inferolateral scar burden determined by automatic analysis of 99mTc-MIBI myocardial perfusion SPECT on the long-term prognosis of cardiac resynchronization therapy
I. Morishima, K. Okumura, H. Tsuboi, Yasuhiro Morita +8 more
2016Europace17 citations Open access
Semantic Scholar
Systemic immune-inflammation index as a predictor of prognosis after carotid artery stenting compared with C-reactive protein
S. Morikawa, K. Okumura, N. Inoue, Takashi Ogane +2 more
2023PLoS ONE15 citations Open access
Semantic Scholar
Very small low-density lipoprotein cholesterol level is a determinant of arterial stiffness in men with impaired glucose metabolism.
Ryotaro Takahashi, Akiko Imamura, M. Yoshikane, Masayuki Suzuki +6 more
2010Journal of atherosclerosis and thrombosis15 citations Open access
Semantic Scholar
New-onset atrial fibrillation may be a more important predictor of cardiac mortality in acute myocardial infarction patients than preexisting atrial fibrillation.
I. Morishima, Toshiro Tomomatsu, K. Okumura, T. Sone +6 more
2015International Journal of Cardiology14 citations
Semantic Scholar
Cholesterol and triglyceride concentrations in lipoproteins as related to carotid intima-media thickness.
Ryotaro Takahashi, Noriko Taguchi, Masayuki Suzuki, Xian W. Cheng +5 more
2012International Heart Journal13 citations Open access
Semantic Scholar
Differentiation capacity of endothelial progenitor cells correlates with endothelial function in healthy young men.
Manabu Miura, Y. Numaguchi, M. Ishii, R. Kubota +6 more
2009Circulation Journal13 citations Open access
Semantic Scholar
High serum concentrations of pentosidine, an advanced glycation end product, are associated with low normal value of ankle-brachial index in apparently healthy men.
Ryotaro Takahashi, Akiko Imamura, M. Yoshikane, Masayuki Suzuki +6 more
2011Metabolism: Clinical and Experimental12 citations
Semantic Scholar
Circulating malondialdehyde-modified low-density lipoprotein is strongly associated with very small low-density lipoprotein cholesterol concentrations in healthy men.
Ryotaro Takahashi, Akiko Imamura, M. Yoshikane, Masayuki Suzuki +5 more
2009Clinica chimica acta; international journal of clinical chemistry12 citations
Semantic Scholar
Microsomal triglyceride transfer protein gene polymorphism strongly influences circulating malondialdehyde-modified low-density lipoprotein.
K. Okumura, Akiko Imamura, Ryuichiro Murakami, Ryotaro Takahashi +3 more
2009Metabolism: Clinical and Experimental12 citations
Semantic Scholar

Frequent co-authors

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T. Murohara×39
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T. Murohara — researcher profile on SciRah
Xian W. Cheng×24
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Xian W. Cheng — researcher profile on SciRah
M. Kuzuya×19
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M. Kuzuya — researcher profile on SciRah
Y. Numaguchi×16
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Y. Numaguchi — researcher profile on SciRah

×12

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Li-Na Hu — researcher profile on SciRah

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A. Inoue — researcher profile on SciRah

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G. Shi — researcher profile on SciRah

Ryuichiro Murakami×11

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Ryuichiro Murakami — researcher profile on SciRah

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T. Sasaki — researcher profile on SciRah

Ryotaro Takahashi×9

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Ryotaro Takahashi — researcher profile on SciRah

Yasuhiro Morita×7

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Yasuhiro Morita — researcher profile on SciRah

Kyosuke Takeshita×7

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Kyosuke Takeshita — researcher profile on SciRah