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Hiroyuki Watanabe · SciRah

Researcher profile · Semantic Scholar

Hiroyuki Watanabe

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Hiroyuki Watanabe — researcher profile on SciRah

h-index: 17
Works: 35
Citations: 4,190

Most-cited papers

Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
Hiroyuki Watanabe, J. Vriens, J. Prenen, G. Droogmans +2 more
2003Nature1,018 citations
Semantic Scholar
Heat-evoked Activation of TRPV4 Channels in a HEK293 Cell Expression System and in Native Mouse Aorta Endothelial Cells*
Hiroyuki Watanabe, J. Vriens, S. Suh, C. Benham +2 more
2002Journal of Biological Chemistry663 citations Open access
Semantic Scholar
Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4
J. Vriens, Hiroyuki Watanabe, Annelies Janssens, G. Droogmans +2 more
2003Proceedings of the National Academy of Sciences of the United States of America630 citations Open access
Semantic Scholar
Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives*
Hiroyuki Watanabe, John B. Davis, D. Smart, J. Jerman +10 more
2002Journal of Biological Chemistry602 citations Open access
Semantic Scholar
Molecular Determinants of Permeation through the Cation Channel TRPV4*
T. Voets, J. Prenen, J. Vriens, Hiroyuki Watanabe +5 more
2002Journal of Biological Chemistry309 citations Open access
Semantic Scholar
CaT1 and the Calcium Release-activated Calcium Channel Manifest Distinct Pore Properties*
T. Voets, J. Prenen, A. Fleig, R. Vennekens +6 more
2001Journal of Biological Chemistry243 citations Open access
Semantic Scholar
The TRPV4 channel: structure-function relationship and promiscuous gating behaviour
B. Nilius, Hiroyuki Watanabe, J. Vriens
2003Pflügers Archiv146 citations
Semantic Scholar
Modulation of TRPV4 gating by intra- and extracellular Ca2+.
Hiroyuki Watanabe, J. Vriens, Annelies Janssens, R. Wondergem +2 more
2003Cell Calcium122 citations
Semantic Scholar
Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and -2) in mice.
J. I. Mobarakeh, Kazuhiro Takahashi, S. Sakurada, S. Nishino +3 more
2005Peptides109 citations
Semantic Scholar
Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice
J. I. Mobarakeh, Kazuhiro Takahashi, S. Sakurada, S. Nishino +4 more
2005Pain51 citations
Semantic Scholar
Possible Involvement of Dynorphin A-(1–17) Release via μ1-Opioid Receptors in Spinal Antinociception by Endomorphin-2
H. Mizoguchi, Hiroyuki Watanabe, Takafumi Hayashi, Wataru Sakurada +4 more
2006Journal of Pharmacology and Experimental Therapeutics36 citations
Semantic Scholar
ATP and nitric oxide modulate a Ca2+-activated non-selective cation current in macrovascular endothelial cells
S. Suh, Hiroyuki Watanabe, G. Droogmans, B. Nilius
2002Pflügers Archiv32 citations
Semantic Scholar
Involvement of the histaminergic system in the nociceptin‐induced pain‐related behaviors in the mouse spinal cord
S. Sakurada, Hiroyuki Watanabe, H. Mizoguchi, A. Yonezawa +6 more
2004Pain29 citations
Semantic Scholar
Possible involvement of dynorphin A release via mu1-opioid receptor on supraspinal antinociception of endomorphin-2.
S. Sakurada, Toshiki Sawai, H. Mizoguchi, Hiroyuki Watanabe +6 more
2008Peptides22 citations
Semantic Scholar
Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors.
C. Watanabe, Tohru Orito, Hiroyuki Watanabe, H. Mizoguchi +6 more
2008European Journal of Pharmacology21 citations
Semantic Scholar
Intrathecal histamine induces spinally mediated behavioral responses through tachykinin NK1 receptors.
S. Sakurada, Tohru Orito, S. Furuta, Hiroyuki Watanabe +7 more
2003Pharmacology, Biochemistry and Behavior21 citations
Semantic Scholar
Endomorphin analogues containing D‐Pro2 discriminate different μ‐opioid receptor mediated antinociception in mice
S. Sakurada, Hiroyuki Watanabe, Takafumi Hayashi, M. Yuhki +4 more
2002British Journal of Pharmacology20 citations Open access
Semantic Scholar
A Tyr-W-MIF-1 Analog Containing D-Pro2 Acts as a Selective μ2-Opioid Receptor Antagonist in the Mouse
Hiroyuki Watanabe, Daisuke Nakayama, Kanenori Ito, C. Watanabe +8 more
2005Journal of Pharmacology and Experimental Therapeutics16 citations
Semantic Scholar
Involvement of endogenous opioid peptides in the antinociception induced by the novel dermorphin tetrapeptide analog amidino-TAPA.
H. Mizoguchi, C. Watanabe, Hiroyuki Watanabe, Kaori Moriyama +5 more
2007European Journal of Pharmacology13 citations
Semantic Scholar
The intracellular tyrosine residues of the ATP‐gated P2X1 ion channel are essential for its function
E. Tóth-Zsámboki, C. Oury, Hiroyuki Watanabe, B. Nilius +2 more
2002FEBS Letters13 citations Open access
Semantic Scholar
Contribution of spinal mu(1)-opioid receptors and dynorphin B to the antinociception induced by Tyr-d-Arg-Phe-Sar.
H. Mizoguchi, Kanenori Ito, Hiroyuki Watanabe, C. Watanabe +4 more
2006Peptides12 citations
Semantic Scholar
Involvement of 5-HT3 and 5-HT4 Receptors in the Regulation of Circadian Clock Gene Expression in Mouse Small Intestine
Natsumi Aoki, Hiroyuki Watanabe, K. Okada, Kazuyuki Aoki +4 more
20149 citations Open access
Semantic Scholar
Differential inhibitory effects of mu-opioids on substance P- and capsaicin-induced nociceptive behavior in mice.
Hiroyuki Watanabe, Daisuke Nakayama, M. Yuhki, Toshiki Sawai +8 more
2006Peptides9 citations
Semantic Scholar
Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecally.
H. Mizoguchi, T. Komatsu, Yoko Iwata, C. Watanabe +7 more
2011European Journal of Pharmacology7 citations
Semantic Scholar
Involvement of spinal mu1-opioid receptors on the Tyr-d-Arg-Phe-sarcosine-induced antinociception.
H. Mizoguchi, Daisuke Nakayama, Hiroyuki Watanabe, Kanenori Ito +6 more
2006European Journal of Pharmacology7 citations
Semantic Scholar
A Tyr-W-MIF-1 analog containing D-Pro2 discriminates among antinociception in mice mediated by different classes of mu-opioid receptors.
Daisuke Nakayama, C. Watanabe, Hiroyuki Watanabe, H. Mizoguchi +2 more
2007European Journal of Pharmacology5 citations
Semantic Scholar
Possible involvement of endogenous nociceptin/orphanin FQ in the pain-related behavioral responses induced by its own metabolite, nociceptin/orphanin FQ(14-17).
Hiroyuki Watanabe, H. Mizoguchi, Tohru Orito, S. Katsuyama +4 more
2007Peptides5 citations
Semantic Scholar
Differential involvement of mu 1-opioid receptors in dermorphin tetrapeptide analogues-induced antinociception.
H. Mizoguchi, M. Yuhki, Hiroyuki Watanabe, Takafumi Hayashi +4 more
2004European Journal of Pharmacology5 citations
Semantic Scholar
Antinociceptive mechanisms of [D-Arg2]-dermorphin tripeptide analogs.
S. Sakurada, K. Chaki, Hiroyuki Watanabe, N. Nakata +3 more
1992Journal of Pharmacology and Experimental Therapeutics5 citations
Semantic Scholar
Involvement of spinal release of α-neo-endorphin on the antinociceptive effect of TAPA.
H. Mizoguchi, T. Kon-no, Hiroyuki Watanabe, C. Watanabe +4 more
2013Peptides4 citations
Semantic Scholar
The involvement of spinal release of histamine on nociceptive behaviors induced by intrathecally administered spermine
H. Mizoguchi, C. Watanabe, Takafumi Hayashi, Yoko Iwata +7 more
2017European Journal of Pharmacology3 citations
Semantic Scholar
Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamine.
H. Mizoguchi, T. Komatsu, Yoko Iwata, C. Watanabe +7 more
2011Neuroscience Letters3 citations
Semantic Scholar
Involvement of 5-HT₃ and 5-HT₄ receptors in the regulation of circadian clock gene expression in mouse small intestine.
Natsumi Aoki, Hiroyuki Watanabe, K. Okada, Kazuyuki Aoki +4 more
2014Journal of Pharmacological Sciences1 citations
Semantic Scholar
Involvement of spinal δ-opioid receptor subtypes in stress-induced antinociception caused by repeated exposure to forced walking stress in mice
Takumi Sato, Hiroyuki Watanabe, S. Furuta, J. Terui +4 more
20030 citations
Semantic Scholar
The blocking properties of highly hydrophilic dihydropyridines on the L-type Ca channel of guinea-pig ventriclular myocytes
Hiroyuki Watanabe, T. Iijima
19950 citations Open access
Semantic Scholar

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S. Sakurada×22
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S. Sakurada — researcher profile on SciRah
T. Sakurada×19
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T. Sakurada — researcher profile on SciRah
H. Mizoguchi×16
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H. Mizoguchi — researcher profile on SciRah
C. Watanabe×12
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B. Nilius — researcher profile on SciRah

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A. Yonezawa — researcher profile on SciRah

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G. Droogmans×7

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