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J. C. Izpisúa Belmonte · SciRah

Researcher profile · Semantic Scholar

J. C. Izpisúa Belmonte

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J. C. Izpisúa Belmonte — researcher profile on SciRah

h-index: 66
Works: 236
Citations: 13K

Most-cited papers

Single-Cell Transcriptomic Atlas of Primate Ovarian Aging.
Si Wang, Yuxuan Zheng, Jing-Yi Li, Yang Yu +17 more
2020Cell495 citations Open access
Semantic Scholar
A Single-Cell Transcriptomic Atlas of Human Skin Aging.
Zhi-Ran Zou, X. Long, Qian Zhao, Yandong Zheng +14 more
2020Developmental Cell350 citations Open access
Semantic Scholar
Generation of human-PSC derived kidney organoids with patterned nephron segments and a de novo vascular network
J. Low, Pin Li, E. Chew, Bingrui Zhou +14 more
2019Cell Stem Cell302 citations Open access
Semantic Scholar
Universal DNA Methylation Age Across Mammalian Tissues
A. Lu, Z. Fei, A. Haghani, T. Robeck +184 more
2021bioRxiv257 citations Open access
Semantic Scholar
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice
Kristen C. Browder, P. Reddy, Mako Yamamoto, A. Haghani +23 more
2022Nature Aging233 citations
Semantic Scholar
Universal DNA methylation age across mammalian tissues
A. Lu, Z. Fei, A. Haghani, T. Robeck +184 more
2023Nature Aging230 citations Open access
Semantic Scholar
Organoids - Preclinical Models of Human Disease.
Mo Li, J. C. Izpisúa Belmonte
2019New England Journal of Medicine215 citations
Semantic Scholar
Metformin decelerates aging clock in male monkeys.
Yuanhan Yang, Xiao-Yong Lu, Ning Liu, Shuai Ma +40 more
2024Cell212 citations Open access
Semantic Scholar
Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice.
Yuta Takahashi, Mariana Morales Valencia, Yang Yu, Yasuo Ouchi +12 more
2023Cell169 citations Open access
Semantic Scholar
Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis
Li-Na Fu, Yuqiong Hu, Mo-Shi Song, Zun-Peng Liu +9 more
2019PLoS Biology163 citations Open access
Semantic Scholar
Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging.
Shuai Ma, Zhe-Jun Ji, Bin Zhang, Lingling Geng +43 more
2024Cell150 citations Open access
Semantic Scholar
In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche
Chao Wang, Rubén Rabadán-Ros, Paloma Martinez-Redondo, Zai-Jun Ma +11 more
2021Nature Communications119 citations Open access
Semantic Scholar
LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes
Francesco Della Valle, P. Reddy, Mako Yamamoto, Peng Liu +14 more
2022Science Translational Medicine110 citations
Semantic Scholar
FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration.
Pengze Yan, Qingqing Li, Lixia Wang, Ping Lu +14 more
2019Cell Stem Cell108 citations Open access
Semantic Scholar
APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation.
L. Arnaud, P. Benech, Louise Greetham, D. Stephan +10 more
2022Cell Reports99 citations Open access
Semantic Scholar
A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body
Shuhui Sun, Shuai Ma, Yu-Sheng Cai, Si Wang +14 more
2023Innovation (Cambridge (Mass.))97 citations Open access
Semantic Scholar
A stem cell aging framework, from mechanisms to interventions.
Beibei Liu, J. Qu, Wei-Qi Zhang, J. C. Izpisúa Belmonte +1 more
2022Cell Reports94 citations Open access
Semantic Scholar
Decoding aging-dependent regenerative decline across tissues at single-cell resolution.
Yu-Sheng Cai, M. Xiong, Zi-Juan Xin, Chengyu Liu +24 more
2023Cell Stem Cell82 citations Open access
Semantic Scholar
Systematic profiling reveals betaine as an exercise mimetic for geroprotection.
Lingling Geng, Jia-Le Ping, Ruo-Chen Wu, Haoteng Yan +65 more
2025Cell69 citations
Semantic Scholar
A single-cell transcriptomic atlas of primate pancreatic islet aging
Jing-Yi Li, Yuxuan Zheng, Pengze Yan, Mo-Shi Song +11 more
2020National Science Review67 citations Open access
Semantic Scholar
Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction
Keiichiro Suzuki, Mako Yamamoto, R. Hernández-Benítez, Zhe Li +23 more
2019Cell Research64 citations Open access
Semantic Scholar
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming.
Jinlong Lu, William B. Tu, Ronghui Li, Mingxi Weng +5 more
2025Cell55 citations
Semantic Scholar
Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging.
Hui Zhang, Jia-Ming Li, Yang Yu, Jie Ren +28 more
2023Cell Reports48 citations Open access
Semantic Scholar
Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
Hai-Song Liu, Rong-Hui Li, Hsin-Kai Liao, Zheying Min +8 more
2021Nature Communications43 citations Open access
Semantic Scholar
The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA.
Shijia Bi, Xiao-Yu Jiang, Qian-Zhao Ji, Ze-Hua Wang +16 more
2024Developmental Cell41 citations
Semantic Scholar
A prevalent neglect of environmental control in mammalian cell culture calls for best practices
S. Klein, Samhan M. Alsolami, Alexandra Steckbauer, Silvia Arossa +6 more
2021Nature Biomedical Engineering36 citations
Semantic Scholar
Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants
Timothy D. Arthur, Jennifer P. Nguyen, Benjamin A. Henson, Agnieszka D'Antonio-Chronowska +36 more
2025Cell Genomics35 citations Open access
Semantic Scholar
Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo.
Meng Liu, Chao Zhang, Xi-Ming Gong, Tian Zhang +26 more
2024Cell Stem Cell32 citations Open access
Semantic Scholar
Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging.
Hui Zhang, Jia-Ming Li, Yang Yu, Jie Ren +28 more
2023Cell Reports31 citations Open access
Semantic Scholar
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates.
Li-Xiao Liu, Zi-Kai Zheng, Wanbang You, Peng Yang +47 more
2026Cell Metabolism30 citations
Semantic Scholar
Genetic enhancement: an avenue to combat aging-related diseases
Yu-Sheng Cai, Zhe-Jun Ji, Si Wang, Wei-Qi Zhang +3 more
2022Life Medicine30 citations Open access
Semantic Scholar
Single-cell individual full-length mtDNA sequencing by iMiGseq uncovers unexpected heteroplasmy shifts in mtDNA editing
C. Bi, Lin Wang, Yong Fan, B. Yuan +12 more
2023Nucleic Acids Research28 citations Open access
Semantic Scholar
Simultaneous detection and mutation surveillance of SARS-CoV-2 and multiple respiratory viruses by rapid field-deployable sequencing
C. Bi, G. Ramos-Mandujano, Ye-Teng Tian, S. Hala +11 more
2021i Medicina27 citations Open access
Semantic Scholar
Modulation of the microhomology-mediated end joining pathway suppresses large deletions and enhances homology-directed repair following CRISPR-Cas9-induced DNA breaks
B. Yuan, C. Bi, Ye-Teng Tian, Jin-Cheng Wang +12 more
2022bioRxiv24 citations Open access
Semantic Scholar
Systematic profiling reveals betaine as an exercise mimetic for geroprotection.
Lingling Geng, Jia-Le Ping, Ruo-Chen Wu, Haoteng Yan +65 more
2025Cell23 citations
Semantic Scholar
Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland
Qiao-Ran Wang, Xuebao Wang, Beibei Liu, Shuai Ma +18 more
2024Nature Aging23 citations
Semantic Scholar
Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing
Fumiyuki Hatanaka, Keiichiro Suzuki, Kensaku Shojima, Jingting Yu +7 more
2023bioRxiv23 citations Open access
Semantic Scholar
Generation of RRMS and PPMS specific iPSCs as a platform for modeling Multiple Sclerosis.
Naresh Mutukula, Zhiqiu Man, Yuta Takahashi, Francisca Iniesta Martinez +9 more
2021Stem Cell Research21 citations Open access
Semantic Scholar
c-MYC Triggers Lipid Remodelling During Early Somatic Cell Reprogramming to Pluripotency
Javier Prieto, J. García-Cañaveras, Marian León, R. Sendra +4 more
2021Stem Cell Reviews and Reports21 citations Open access
Semantic Scholar
Reactivation of retrotransposable elements is associated with environmental stress and ageing
Francesco Della Valle, P. Reddy, Alain Aguirre Vazquez, J. C. Izpisúa Belmonte
2025Nature reviews genetics20 citations
Semantic Scholar
Extraembryonic Endoderm (XEN) Cells Capable of Contributing to Embryonic Chimeras Established from Pig Embryos
Chi-Hun Park, Y. Jeoung, K. Uh, Ki-Eun Park +12 more
2020Stem Cell Reports20 citations Open access
Semantic Scholar
Human iPSC-derived nephron progenitor cells treat acute kidney injury and chronic kidney disease in mouse models.
T. Araoka, Kosuke Toyohara, Makoto Ryosaka, Chihiro Inui +10 more
2025Science Translational Medicine19 citations
Semantic Scholar
Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing
B. Yuan, Xuan Zhou, Keiichiro Suzuki, G. Ramos-Mandujano +32 more
2022Nature Communications18 citations Open access
Semantic Scholar
Quantitative haplotype-resolved analysis of mitochondrial DNA heteroplasmy in Human single oocytes, blastoids, and pluripotent stem cells
C. Bi, Lin Wang, Yong Fan, B. Yuan +7 more
2023Nucleic Acids Research17 citations Open access
Semantic Scholar
The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming.
Shogo Sato, Tomoaki Hishida, Kenichiro Kinouchi, Fumiaki Hatanaka +8 more
2023Cell Reports14 citations Open access
Semantic Scholar
Vitamin C conveys geroprotection on primate ovaries.
Ying Jing, Hui-Fen Lu, Jing-Yi Li, Zan He +14 more
2025Cell Stem Cell13 citations
Semantic Scholar
Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice
R. Hernández-Benítez, Chao Wang, Lei Shi, Yasuo Ouchi +23 more
2024Cell Reports Medicine13 citations Open access
Semantic Scholar
LINE-1 RNA triggers matrix formation in bone cells via a PKR-mediated inflammatory response
Arianna Mangiavacchi, Gabriele Morelli, S. Reppe, Alfonso Saera-Vila +14 more
2024EMBO Journal13 citations Open access
Semantic Scholar
Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner
Jinghui Lei, Xiao-Yu Jiang, Dao-Yuan Huang, Ying Jing +10 more
2023Protein & Cell13 citations Open access
Semantic Scholar
Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo.
Tao Tan, Jun Wu, Chenyang Si, Shaoxing Dai +21 more
2021Cell13 citations Open access
Semantic Scholar

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