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K. McManus · SciRah

Researcher profile · Semantic Scholar

K. McManus

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K. McManus — researcher profile on SciRah

h-index: 29
Works: 95
Citations: 2,798

Most-cited papers

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers
T. Barber, K. McManus, K. Yuen, M. Reis +11 more
2008Proceedings of the National Academy of Sciences of the United States of America435 citations Open access
Semantic Scholar
ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells.
K. McManus, Michael J Hendzel
2005Molecular Biology of the Cell267 citations Open access
Semantic Scholar
Catalytic Function of the PR-Set7 Histone H4 Lysine 20 Monomethyltransferase Is Essential for Mitotic Entry and Genomic Stability*
Sabrina I. Houston, K. McManus, M. M. Adams, Jennifer K. Sims +3 more
2008Journal of Biological Chemistry151 citations Open access
Semantic Scholar
Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing
K. McManus, I. Barrett, Yasaman Nouhi, P. Hieter
2009Proceedings of the National Academy of Sciences of the United States of America137 citations Open access
Semantic Scholar
Predisposition to Cancer Caused by Genetic and Functional Defects of Mammalian Atad5
D. Bell, Nilabja Sikdar, Kyoo-young Lee, J. Price +30 more
2011PLoS Genetics92 citations Open access
Semantic Scholar
An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development
Derek M. van Pel, I. Barrett, Y. Shimizu, Babu V. Sajesh +4 more
2013PLoS Genetics86 citations Open access
Semantic Scholar
Quantitative Analysis of CBP- and P300-Induced Histone Acetylations In Vivo Using Native Chromatin
K. McManus, Michael J Hendzel
2003Molecular and Cellular Biology80 citations Open access
Semantic Scholar
The relationship between histone H3 phosphorylation and acetylation throughout the mammalian cell cycle.
K. McManus, Michael J Hendzel
2006Biochemistry and cell biology = Biochimie et biologie cellulaire75 citations
Semantic Scholar
Dynamic Changes in Histone H3 Lysine 9 Methylations
K. McManus, V. Biron, Ryan J. Heit, D. Underhill +1 more
2006Journal of Biological Chemistry68 citations Open access
Semantic Scholar
Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer
L. L. Thompson, Lucile M. Jeusset, Chloe C. Lepage, K. McManus
2017Cancers66 citations Open access
Semantic Scholar
Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes
Raghvendra Vishwakarma, K. McManus
2020Cancers65 citations Open access
Semantic Scholar
Regulation of chromatin structure via histone post-translational modification and the link to carcinogenesis
L. L. Thompson, Brent J. Guppy, Laryssa Sawchuk, J. Davie +1 more
2013Cancer Metastasis Review60 citations
Semantic Scholar
Proteasome Nuclear Activity Affects Chromosome Stability by Controlling the Turnover of Mms22, a Protein Important for DNA Repair
Shay Ben-Aroya, Neta Agmon, K. Yuen, Teresa Kwok +3 more
2010PLoS Genetics58 citations Open access
Semantic Scholar
Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer
Lucile M. Jeusset, K. McManus
2017Cancers55 citations Open access
Semantic Scholar
PROTACs: Current and Future Potential as a Precision Medicine Strategy to Combat Cancer
Kailee A. Rutherford, K. McManus
2024Molecular Cancer Therapeutics54 citations Open access
Semantic Scholar
Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer
Lucile M. Jeusset, K. McManus
2019Cells53 citations Open access
Semantic Scholar
Synthetic Lethal Targeting of Superoxide Dismutase 1 Selectively Kills RAD54B-Deficient Colorectal Cancer Cells
Babu V. Sajesh, Melanie L. Bailey, Zelda Lichtensztejn, P. Hieter +1 more
2013Genetics53 citations Open access
Semantic Scholar
Detecting Chromosome Instability in Cancer: Approaches to Resolve Cell-to-Cell Heterogeneity
Chloe C. Lepage, Claire R Morden, Michaela C L Palmer, M. Nachtigal +1 more
2019Cancers49 citations Open access
Semantic Scholar
The SCF Complex Is Essential to Maintain Genome and Chromosome Stability
L. L. Thompson, Kailee A. Rutherford, Chloe C. Lepage, K. McManus
2021International Journal of Molecular Sciences46 citations Open access
Semantic Scholar
The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samples
S. Penner-Goeke, Zelda Lichtensztejn, M. Neufeld, Jennifer L. Ali +3 more
2017PLoS Genetics44 citations Open access
Semantic Scholar
Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells
Babu V. Sajesh, K. McManus
2015OncoTarget44 citations Open access
Semantic Scholar
KIF11 silencing and inhibition induces chromosome instability that may contribute to cancer
Yasamin Asbaghi, L. L. Thompson, Zelda Lichtensztejn, K. McManus
2017Genes, Chromosomes and Cancer42 citations
Semantic Scholar
Synthetic Genetic Targeting of Genome Instability in Cancer
Babu V. Sajesh, Brent J. Guppy, K. McManus
2013Cancers42 citations Open access
Semantic Scholar
Sequencing of Candidate Chromosome Instability Genes in Endometrial Cancers Reveals Somatic Mutations in ESCO1, CHTF18, and MRE11A
J. Price, Lana M. Pollock, Meghan L. Rudd, Sarah K. Fogoros +14 more
2013PLoS ONE34 citations Open access
Semantic Scholar
Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes
Tarik R. Leylek, Lucile M. Jeusset, Zelda Lichtensztejn, K. McManus
2020Scientific Reports33 citations Open access
Semantic Scholar
Chromosome instability is prevalent and dynamic in high-grade serous ovarian cancer patient samples.
Claire R Morden, Ally C Farrell, Mirka Sliwowski, Zelda Lichtensztejn +3 more
2021Gynecologic Oncology32 citations Open access
Semantic Scholar
Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis
Allison K Baergen, Lucile M. Jeusset, Zelda Lichtensztejn, K. McManus
2019Cancers31 citations Open access
Semantic Scholar
Characterizing the Prevalence of Chromosome Instability in Interval Colorectal Cancer
Amy L. Cisyk, S. Penner-Goeke, Zelda Lichtensztejn, Z. Nugent +3 more
2015Neoplasia30 citations Open access
Semantic Scholar
Mitotic Accumulation of Dimethylated Lysine 79 of Histone H3 Is Important for Maintaining Genome Integrity During Mitosis in Human Cells
Brent J. Guppy, K. McManus
2014Genetics30 citations Open access
Semantic Scholar
Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer
Chloe C. Lepage, Michaela C L Palmer, Ally C Farrell, Nicole M. Neudorf +3 more
2021British Journal of Cancer29 citations Open access
Semantic Scholar
The synthetic lethal killing of RAD54B-deficient colorectal cancer cells by PARP1 inhibition is enhanced with SOD1 inhibition
Erin N McAndrew, Chloe C. Lepage, K. McManus
2016OncoTarget29 citations Open access
Semantic Scholar
A Novel Multiplexed, Image-Based Approach to Detect Phenotypes That Underlie Chromosome Instability in Human Cells
L. L. Thompson, K. McManus
2015PLoS ONE29 citations Open access
Semantic Scholar
An Automated, Single Cell Quantitative Imaging Microscopy Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability
Chloe C. Lepage, L. L. Thompson, B. Larson, K. McManus
2020Cells28 citations Open access
Semantic Scholar
The Transcriptional Regulator CBP Has Defined Spatial Associations within Interphase Nuclei
K. McManus, David A. Stephens, N. Adams, S. Islam +2 more
2006PLoS Comput. Biol.27 citations Open access
Semantic Scholar
Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers
Amy L. Cisyk, Z. Nugent, Robert H. Wightman, Harminder Singh +1 more
2018Neoplasia25 citations Open access
Semantic Scholar
Dynamic changes in histone H3 lysine 9 methylations. IDENTIFICATION OF A MITOSIS-SPECIFIC FUNCTION FOR DYNAMIC METHYLATION IN CHROMOSOME CONGRESSION AND SEGREGATION. VOLUME 281 (2006) PAGES 8888-8897
K. McManus, V. Biron, Ryan J. Heit, D. Underhill +1 more
200625 citations Open access
Semantic Scholar
Reduced RBX1 expression induces chromosome instability and promotes cellular transformation in high-grade serous ovarian cancer precursor cells.
Manisha Bungsy, Michaela C L Palmer, Lucile M. Jeusset, Nicole M. Neudorf +3 more
2020Cancer Letters23 citations Open access
Semantic Scholar
Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover
L. L. Thompson, Allison K Baergen, Zelda Lichtensztejn, K. McManus
2020Cancers23 citations Open access
Semantic Scholar
Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells
Babu V. Sajesh, Zelda Lichtensztejn, K. McManus
2013BMC Cancer23 citations Open access
Semantic Scholar
The enigmatic oncogene and tumor suppressor‐like properties of RAD54B: Insights into genome instability and cancer
Erin N McAndrew, K. McManus
2017Genes, Chromosomes and Cancer19 citations
Semantic Scholar
Characterizing and exploiting the many roles of aberrant H2B monoubiquitination in cancer pathogenesis.
Lucile M. Jeusset, K. McManus
2021Seminars in Cancer Biology18 citations Open access
Semantic Scholar
Establishing a Biological Profile for Interval Colorectal Cancers
Amy L. Cisyk, Harminder Singh, K. McManus
2014Digestive Diseases and Sciences18 citations
Semantic Scholar
Aberrant SKP1 Expression: Diverse Mechanisms Impacting Genome and Chromosome Stability
L. L. Thompson, Kailee A. Rutherford, Chloe C. Lepage, K. McManus
2022Frontiers in Cell and Developmental Biology16 citations Open access
Semantic Scholar
An amino acid substitution in the putative second extracellular loop of RBC band 3 accounts for the Froese blood group polymorphism
K. McManus, K. Lupe, G. Coghlan, T. Zelinski
2000Transfusion15 citations
Semantic Scholar
Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition
Brent J. Guppy, K. McManus
2017Cellular Oncology14 citations Open access
Semantic Scholar
Using quantitative imaging microscopy to define the target substrate specificities of histone post-translational-modifying enzymes.
K. McManus, Michael J Hendzel
2005Methods14 citations
Semantic Scholar
The ELO Blood Group Polymorphism Is Located in the Putative First Extracellular Loop of Human Erythrocyte Band 3
T. Zelinski, F. Punter, K. McManus, G. Coghlan
1998Vox Sanguinis12 citations
Semantic Scholar
Distinctive Swann Blood Group Genotypes: Molecular Investigations
T. Zelinski, A. Rusnak, K. McManus, G. Coghlan
2000Vox Sanguinis11 citations
Semantic Scholar
Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis
Lucile M. Jeusset, Brent J. Guppy, Zelda Lichtensztejn, Darin McDonald +1 more
2021Cancers10 citations Open access
Semantic Scholar
Correction: An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development
Derek M. van Pel, I. Barrett, Y. Shimizu, Babu V. Sajesh +4 more
2013PLoS Genetics10 citations Open access
Semantic Scholar

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