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I. S. Cohen · SciRah

Researcher profile · Semantic Scholar

I. S. Cohen

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I. S. Cohen — researcher profile on SciRah

h-index: 52
Works: 175
Citations: 10K

Most-cited papers

Mesenchymal Stem Cells Support Migration, Extracellular Matrix Invasion, Proliferation, and Survival of Endothelial Cells In Vitro
I. Potapova, G. Gaudette, P. Brink, R. B. Robinson +3 more
2007Stem Cells320 citations
Semantic Scholar
Xenografted Adult Human Mesenchymal Stem Cells Provide a Platform for Sustained Biological Pacemaker Function in Canine Heart
A. Plotnikov, Iryna N. Shlapakova, M. Szabolcs, P. Danilo +9 more
2007Circulation206 citations Open access
Semantic Scholar
Stimulating Cardiac Muscle by Light: Cardiac Optogenetics by Cell Delivery
Z. Jia, V. Valiunas, Zongju Lu, H. Bien +6 more
2011Circulation: Arrhythmia and Electrophysiology192 citations Open access
Semantic Scholar
Culturing of Human Mesenchymal Stem Cells as Three-dimensional Aggregates Induces Functional Expression of CXCR4 That Regulates Adhesion to Endothelial Cells*
I. Potapova, P. Brink, I. S. Cohen, S. Doronin
2008Journal of Biological Chemistry174 citations Open access
Semantic Scholar
Computational Optogenetics: Empirically-Derived Voltage- and Light-Sensitive Channelrhodopsin-2 Model
John C. Williams, Jian-Jin Xu, Zhongju Lu, Aleksandra Klimas +4 more
2013PLoS Comput. Biol.163 citations Open access
Semantic Scholar
Suppression of Phosphoinositide 3-Kinase Signaling and Alteration of Multiple Ion Currents in Drug-Induced Long QT Syndrome
Zhongju Lu, Chia-Yen C. Wu, Ya-Ping Jiang, L. Ballou +3 more
2012Science Translational Medicine160 citations Open access
Semantic Scholar
The road to biological pacing
M. Rosen, R. B. Robinson, P. Brink, I. S. Cohen
2011Nature Reviews Cardiology133 citations
Semantic Scholar
Epicardial border zone overexpression of skeletal muscle sodium channel, SkM1, normalizes activation, preserves conduction and suppresses ventricular arrhythmia: an in silico, in vivo, in vitro study
David H. Lau, C. Clausen, E. Sosunov, Iryna N. Shlapakova +12 more
2008Circulation96 citations Open access
Semantic Scholar
Decreased l-Type Ca2+ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3-Kinase Signaling
Zhongju Lu, Ya-Ping Jiang, Xin-Hua Xu, L. Ballou +2 more
2007Diabetes90 citations Open access
Semantic Scholar
Loss of Cardiac Phosphoinositide 3-kinase p110α Results in Contractile Dysfunction: Lu et al PI3K p110α Regulates Myocyte Contractility
Zhongju Lu, Ya-Ping Jiang, Wei Wang, Xin-Hua Xu +5 more
2009Circulation89 citations Open access
Semantic Scholar
Increased Persistent Sodium Current Due to Decreased PI3K Signaling Contributes to QT Prolongation in the Diabetic Heart
Zhongju Lu, Ya-Ping Jiang, Chia-Yen C. Wu, L. Ballou +5 more
2013Diabetes88 citations Open access
Semantic Scholar
HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockade.
A. Plotnikov, A. Bucchi, Iryna N. Shlapakova, P. Danilo +4 more
2008Heart Rhythm80 citations Open access
Semantic Scholar
Control of Cardiac Repolarization by Phosphoinositide 3-kinase Signaling to Ion Channels
L. Ballou, R. Lin, I. S. Cohen
2015Circulation Research78 citations Open access
Semantic Scholar
Enhanced recovery of mechanical function in the canine heart by seeding an extracellular matrix patch with mesenchymal stem cells committed to a cardiac lineage.
I. Potapova, S. Doronin, D. J. Kelly, A. B. Rosen +8 more
2008American Journal of Physiology. Heart and Circulatory Physiology76 citations Open access
Semantic Scholar
Induced Pluripotent Stem Cell–Derived Cardiomyocytes Provide In Vivo Biological Pacemaker Function
S. Chauveau, E. P. Anyukhovsky, M. Ben-Ari, Shulamit Naor +11 more
2017Circulation: Arrhythmia and Electrophysiology72 citations Open access
Semantic Scholar
The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium.
S. Badylak, Paul V. Kochupura, I. S. Cohen, S. Doronin +5 more
2006Cell Transplantation72 citations
Semantic Scholar
Can gap junctions deliver?
P. Brink, V. Valiunas, C. Gordon, M. Rosen +1 more
2012Biochimica et Biophysica Acta71 citations Open access
Semantic Scholar
Restoration of defective L-type Ca2+ current in cardiac myocytes of type 2 diabetic db/db mice by Akt and PKC-Ι
Zhongju Lu, L. Ballou, Ya-Ping Jiang, I. S. Cohen +1 more
2011Journal of Cardiovascular Pharmacology68 citations Open access
Semantic Scholar
HCN2/SkM1 Gene Transfer Into Canine Left Bundle Branch Induces Stable, Autonomically Responsive Biological Pacing at Physiological Heart Rates
G. J. Boink, Lian Duan, B. Nearing, Iryna N. Shlapakova +10 more
2013Journal of the American College of Cardiology65 citations Open access
Semantic Scholar
Increased Myocyte Content and Mechanical Function Within a Tissue-Engineered Myocardial Patch Following Implantation
D. J. Kelly, A. B. Rosen, A. J. Schuldt, Paul V. Kochupura +7 more
2009Tissue Engineering. Part A58 citations Open access
Semantic Scholar
PI3Ks Maintain the Structural Integrity of T-Tubules in Cardiac Myocytes
Chia-Yen C. Wu, Z. Jia, Wei Wang, L. Ballou +7 more
2011PLoS ONE52 citations Open access
Semantic Scholar
The Ca2+-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2
G. J. Boink, B. Nearing, Iryna N. Shlapakova, Lian Duan +8 more
2012Circulation49 citations Open access
Semantic Scholar
Intracellular ATP binding is required to activate the slowly activating K+ channel IKs
Yang Li, Junyuan Gao, Zhongju Lu, Kelli McFarland +4 more
2013Proceedings of the National Academy of Sciences of the United States of America47 citations Open access
Semantic Scholar
Biological pacemakers in canines exhibit positive chronotropic response to emotional arousal.
Iryna N. Shlapakova, B. Nearing, David H. Lau, G. J. Boink +6 more
2010Heart Rhythm40 citations
Semantic Scholar
Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium.
L. Protas, Dun Wen, Z. Jia, Jia Lu +7 more
2009Cardiovascular Research33 citations Open access
Semantic Scholar
Biological pacemakers based on If
M. Rosen, P. Brink, I. S. Cohen, R. B. Robinson
2007Medical and Biological Engineering and Computing33 citations
Semantic Scholar
Expression of skeletal muscle sodium channel (Nav1.4) or connexin32 prevents reperfusion arrhythmias in murine heart.
E. P. Anyukhovsky, E. Sosunov, Yelena N. Kryukova, Kevin A Prestia +5 more
2011Cardiovascular Research32 citations Open access
Semantic Scholar
Repairing damaged myocardium: Evaluating cells used for cardiac regeneration
A. J. Schuldt, M. Rosen, G. Gaudette, I. S. Cohen
2008Current Treatment Options in Cardiovascular Medicine32 citations
Semantic Scholar
A comparison of two cellular delivery mechanisms for small interfering RNA
V. Valiunas, Hong-Zhang Wang, Ling Li, C. Gordon +3 more
2015Physiological Reports31 citations Open access
Semantic Scholar
Stem Cell Based Biological Pacemakers From Proof of Principle to Therapy: a Review
S. Chauveau, P. Brink, I. S. Cohen
2014Cytotherapy31 citations Open access
Semantic Scholar
Cardiac pacing: from biological to electronic ... to biological?
M. Rosen, P. Brink, I. S. Cohen, R. B. Robinson
2008Circulation: Arrhythmia and Electrophysiology30 citations
Semantic Scholar
A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation
Yongfeng Liu, Xian-Jin Xu, Junyuan Gao, Moawiah M. Naffaa +14 more
2020Communications Biology26 citations Open access
Semantic Scholar
Cardiac Expression of Skeletal Muscle Sodium Channels Increases Longitudinal Conduction Velocity in the Canine One Week Myocardial Infarction
R. Coronel, David H. Lau, E. Sosunov, M. Janse +11 more
2010Heart Rhythm26 citations Open access
Semantic Scholar
Defining the factors that affect solute permeation of gap junction channels
V. Valiunas, I. S. Cohen, P. Brink
2017Biochimica et Biophysica Acta - Biomembranes22 citations Open access
Semantic Scholar
Arrhythmia / Electrophysiology Ca 2-Stimulated Adenylyl Cyclase AC 1 Generates Efficient Biological Pacing as Single Gene Therapy and in Combination With HCN 2
G. J. Boink, B. Nearing, Iryna N. Shlapakova, Lian Duan +8 more
201217 citations
Semantic Scholar
SkM1 and Cx32 improve conduction in canine myocardial infarcts yet only SkM1 is antiarrhythmic.
G. J. Boink, David H. Lau, Iryna N. Shlapakova, E. Sosunov +14 more
2012Cardiovascular Research17 citations Open access
Semantic Scholar
Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling
R. Lin, Zhongju Lu, E. P. Anyukhovsky, Ya-Ping Jiang +5 more
2019The Journal of General Physiology16 citations Open access
Semantic Scholar
Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration
Xiaoliang Qiu, S. Chauveau, E. P. Anyukhovsky, Tania Rahim +10 more
2016Circulation: Arrhythmia and Electrophysiology15 citations Open access
Semantic Scholar
Improving cardiac conduction with a skeletal muscle sodium channel by gene and cell therapy
Jia Lu, Hong-Zhan Wang, Z. Jia, J. Zuckerman +7 more
2012Journal of Cardiovascular Pharmacology15 citations Open access
Semantic Scholar
Acquired Long QT Syndrome and Phosphoinositide 3-kinase
I. S. Cohen, R. Lin, L. Ballou
2017Trends in cardiovascular medicine14 citations Open access
Semantic Scholar
A Transmural Gradient in the Cardiac Na/K Pump Generates a Transmural Gradient in Na/Ca Exchange
Wei Wang, Junyuan Gao, E. Entcheva, I. S. Cohen +2 more
2010Journal of Membrane Biology14 citations Open access
Semantic Scholar
Von willebrand factor increases endothelial cell adhesiveness for human mesenchymal stem cells by activating p38 mitogen-activated protein kinase
I. Potapova, I. S. Cohen, S. Doronin
2010Stem cell research & therapeutics14 citations Open access
Semantic Scholar
A Caveat Emptor for myocardial regeneration: mechanical without electrical recovery will not suffice.
I. S. Cohen, A. B. Rosen, G. Gaudette
2007Journal of Molecular and Cellular Cardiology14 citations Open access
Semantic Scholar
The effects of the histone deacetylase inhibitor 4-phenylbutyrate on gap junction conductance and permeability
Joshua Kaufman, C. Gordon, R. Bergamaschi, Hong-Zhan Wang +3 more
2013Frontiers in Pharmacology13 citations Open access
Semantic Scholar
Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects
Yangyang Lin, S. Grinter, Zhongju Lu, Xian-Jin Xu +16 more
2021Proceedings of the National Academy of Sciences of the United States of America10 citations Open access
Semantic Scholar
Pressure-overload-induced angiotensin-mediated early remodeling in mouse heart
Jeremy Kim, Ya-Ping Jiang, I. S. Cohen, R. Lin +1 more
2017PLoS ONE10 citations Open access
Semantic Scholar
Microtubules and angiotensin II receptors contribute to modulation of repolarization induced by ventricular pacing
Nazira Özgen, Zhongju Lu, G. J. Boink, David H. Lau +5 more
2012Heart Rhythm10 citations Open access
Semantic Scholar
Strategies for regeneration of heart muscle.
J. Guyette, I. S. Cohen, G. Gaudette
2010Critical Reviews in Eukaryotic Gene Expression10 citations
Semantic Scholar
Regenerative therapies in electrophysiology and pacing
M. Rosen, P. Brink, I. S. Cohen, P. Danilo +3 more
2008Journal of interventional cardiac electrophysiology9 citations Open access
Semantic Scholar
Autocrine A2 in the T-system of ventricular myocytes creates transmural gradients in ion transport: a mechanism to match contraction with load?
Junyuan Gao, X. Sun, I. Potapova, I. S. Cohen +2 more
2014Biophysical Journal8 citations Open access
Semantic Scholar

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M. Rosen×23
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M. Rosen — researcher profile on SciRah
P. Brink×19
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P. Brink — researcher profile on SciRah
R. B. Robinson×18
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R. B. Robinson — researcher profile on SciRah
Zhongju Lu×13
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P. Danilo — researcher profile on SciRah

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R. Lin — researcher profile on SciRah

Iryna N. Shlapakova×10

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Iryna N. Shlapakova — researcher profile on SciRah

Ya-Ping Jiang×10

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L. Ballou — researcher profile on SciRah

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I. Potapova — researcher profile on SciRah

E. P. Anyukhovsky×8

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E. P. Anyukhovsky — researcher profile on SciRah

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G. Gaudette — researcher profile on SciRah