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S. Leiser · SciRah

Researcher profile · Semantic Scholar

S. Leiser

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S. Leiser — researcher profile on SciRah

h-index: 21
Works: 41
Citations: 2,108

Most-cited papers

Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome
Zhou Han, Chun-Ling Chen, A. Christiansen, Sophina Ji +8 more
2020Science Translational Medicine313 citations Open access
Semantic Scholar
A cog in cognition: how the alpha 7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits.
S. Leiser, M. Bowlby, T. Comery, J. Dunlop
2009Pharmacology and Therapeutics167 citations
Semantic Scholar
Responses of trigeminal ganglion neurons during natural whisking behaviors in the awake rat.
S. Leiser, K. Moxon
2007Neuron138 citations Open access
Semantic Scholar
Ceramic-based multisite electrode arrays for chronic single-neuron recording
K. Moxon, S. Leiser, G. Gerhardt, K. Barbee +1 more
2004IEEE Transactions on Biomedical Engineering136 citations
Semantic Scholar
Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function
E. Dale, A. Pehrson, Theepica Jeyarajah, Yan Li +4 more
2015CNS Spectrums135 citations Open access
Semantic Scholar
Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease.
Jon T. Brown, Jeannie Chin, S. Leiser, M. Pangalos +1 more
2011Neurobiology of Aging127 citations
Semantic Scholar
Aligning strategies for using EEG as a surrogate biomarker: a review of preclinical and clinical research.
S. Leiser, J. Dunlop, M. Bowlby, David M. Devilbiss
2011Biochemical Pharmacology126 citations
Semantic Scholar
Predator Stress Engages Corticotropin-releasing Factor and Opioid Systems to Alter the Operating Mode of Locus Coeruleus Norepinephrine Neurons
A. Curtis, S. Leiser, Kevin P. Snyder, R. Valentino
2011Neuropharmacology110 citations Open access
Semantic Scholar
Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine.
S. Leiser, Yan Li, A. Pehrson, E. Dale +2 more
2015ACS Chemical Neuroscience109 citations Open access
Semantic Scholar
Treatment of cognitive dysfunction in major depressive disorder--a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine.
A. Pehrson, S. Leiser, M. Gulinello, E. Dale +3 more
2015European Journal of Pharmacology99 citations Open access
Semantic Scholar
Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus
E. Dale, Hong Zhang, S. Leiser, Yixin Xiao +4 more
2014Journal of Psychopharmacology95 citations Open access
Semantic Scholar
Sodium Channel Cleavage Is Associated with Aberrant Neuronal Activity and Cognitive Deficits in a Mouse Model of Alzheimer's Disease
Brian F. Corbett, S. Leiser, H. Ling, R. Nagy +9 more
2013Journal of Neuroscience92 citations Open access
Semantic Scholar
Relationship between physiological response type (RA and SA) and vibrissal receptive field of neurons within the rat trigeminal ganglion.
S. Leiser, K. Moxon
2006Journal of Neurophysiology68 citations Open access
Semantic Scholar
Impact of state of arousal and stress neuropeptides on urodynamic function in freely moving rats.
D. Kiddoo, R. Valentino, S. Zderic, A. Ganesh +3 more
2006American Journal of Physiology. Regulatory Integrative and Comparative Physiology62 citations
Semantic Scholar
Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine – a quantitative EEG study in rats
S. Leiser, Alan L. Pehrson, P. Robichaud, C. Sánchez
2014British Journal of Pharmacology59 citations Open access
Semantic Scholar
Impact of overactive bladder on the brain: Central sequelae of a visceral pathology
E. Rickenbacher, Madelyn A Baez, L. Hale, S. Leiser +2 more
2008Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
Semantic Scholar
Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice
L. Cuddy, Dmitry Prokopenko, Eric P. Cunningham, Ross Brimberry +10 more
2020Science Translational Medicine43 citations
Semantic Scholar
Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism
S. Leiser, D. Iglesias-Bregna, L. Westrich, A. Pehrson +1 more
2015Journal of Psychopharmacology27 citations Open access
Semantic Scholar
Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex.
W. Theilmann, Birthe Gericke, Alina Schidlitzki, Syed Muhammad Muneeb Anjum +11 more
2020Neuropharmacology25 citations
Semantic Scholar
The 5‐HT6 receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep‐wake architecture
Maria Amat-Foraster, S. Leiser, K. Herrik, N. Richard +4 more
2017Neuropharmacology21 citations Open access
Semantic Scholar
Nicotine Receptor Subtype-Specific Effects on Auditory Evoked Oscillations and Potentials
R. Featherstone, J. Phillips, T. Thieu, R. Ehrlichman +6 more
2012PLoS ONE21 citations Open access
Semantic Scholar
Can pharmaco-electroencephalography help improve survival of central nervous system drugs in early clinical development?
F. J. Wilson, S. Leiser, M. Ivarsson, S. Christensen +1 more
2014Drug Discovery Today20 citations
Semantic Scholar
Inhibition of MEK-ERK Signaling Reduces Seizures in Two Mouse Models of Tuberous Sclerosis Complex
Lena H. Nguyen, S. Leiser, D. Song, D. Brunner +3 more
2022Epilepsy Research19 citations Open access
Semantic Scholar
Acute dosing of vortioxetine strengthens event-related brain activity associated with engagement of attention and cognitive functioning in rats.
Bettina Laursen, Cecilie H. Bundgaard, C. Graversen, M. Grupe +5 more
2017Brain Research9 citations
Semantic Scholar
Impact of the State of Arousal and Stress Neuropeptides on Urodynamic Function in the Freely Moving Rat
D. Kiddoo, R. Valentino, S. Zderic, A. Ganesh +3 more
20069 citations
Semantic Scholar
Evaluation of variation in preclinical electroencephalographic (EEG) spectral power across multiple laboratories and experiments: An EQIPD study
Tim P Ahuis, M. Smyk, Clément Laloux, Katharina Aulehner +15 more
2024PLoS ONE8 citations Open access
Semantic Scholar
Correction: Mantini et al., Evolutionarily Novel Functional Networks in the Human Brain?
Brian F. Corbett, S. Leiser, H. Ling, R. Nagy +20 more
2013Journal of Neuroscience8 citations Open access
Semantic Scholar
P.2.e.004 Vortioxetine (Lu AA21004) disinhibits pyramidal cell output and enhances theta rhythms and long-term plasticity in the hippocampus
E. Dale, Hong Zhang, S. Leiser, Y. Chao +3 more
20136 citations
Semantic Scholar
ACNP 59th Annual Meeting: Poster Session III
T. Hanania, M. Varney, E. Dugan, S. Leiser
2020Neuropsychopharmacology5 citations Open access
Semantic Scholar
P.2.b.005 The effects of the multimodal antidepressant Lu AA21004 on attention and vigilance measured as EEG activity in the rat
C. Sánchez, P. Robichaud, Alan L. Pehrson, S. Leiser
20125 citations
Semantic Scholar
P.2.a.015 Vortioxetine's reduced disruption of sleep–wake rhythms involves 5-HT3 receptor antagonism – a study in rats
S. Leiser, Deborah Iglesias-Bregna, C. Sánchez
20141 citations
Semantic Scholar
P.2.e.002 Vortioxetine (Lu AA21004), a multimodal antidepressant: differentiation from current antidepressants in animal models of depression
Arne Mørk, Alan L. Pehrson, C. Bétry, D. David +5 more
20131 citations
Semantic Scholar
DIFFERENTIAL GATING OF SOMATOSENSORY INPUT DURING ACTIVE AND PASSIVE STIMULATION
K. Moxon, S. Leiser, R. S. Markowitz, J. Chapin
20021 citations
Semantic Scholar
Idalopirdine, a 5-HT6 receptor antagonist in development for the treatment of mild-moderate Alzheimer’s disease: the scientific rationale
I. D. de Jong, K. Herrik, L. Helboe, M. A. Foraster +4 more
20160 citations
Semantic Scholar
P2‐319: The 5‐ht6 receptor antagonist idalopirdine in combination with donepezil potentiates theta and gamma eeg oscillations in the frontal cortex of the freely moving rat
S. Leiser, M. A. Foraster, Kjartan F. Herrik, J. Bastlund +1 more
20150 citations
Semantic Scholar
S 1 . 3 A re-evaluation of construct and predictive validity for rodent counterparts to the human MMN and P 300 event related potentials ( ERPs )
E. Christian, B. J. Farley, S. Leiser, J. Doherty +10 more
20110 citations
Semantic Scholar
Characterization of the alpha-7 nicotinic receptor agonist WYE-103914 in models relevant to schizophrenia and interaction with antipsychotics
K. Marquis, T. Comery, Rachel L Navarra, S. Leiser +11 more
20090 citations
Semantic Scholar
P1‐022: Cellular mechanisms underlying aberrant EEG activity and cognitive deficits in mouse models of Alzheimer's disease
P. Reinhart, S. Leiser, H. Ling, Jon T. Brown +6 more
20090 citations Open access
Semantic Scholar
Encoding of Tactile Responses in the Periphery of the Somatosensory System
S. Leiser, Karen A. Moxon
2005Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005.0 citations
Semantic Scholar
Fundamental properties of rapidly and slowly adapting cells in the trigeminal ganglion of the awake freely moving rat
S. Leiser
0 citations Open access
Semantic Scholar
Corrections
Brian F. Corbett, S. Leiser
1917The Lancet0 citations Open access
Semantic Scholar

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