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M. Merrins · SciRah

Researcher profile · Semantic Scholar

M. Merrins

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M. Merrins — researcher profile on SciRah

h-index: 29
Works: 94
Citations: 2,735

Most-cited papers

Decreased consumption of branched chain amino acids improves metabolic health
L. Fontana, Nicole E. Cummings, S. A. Arriola Apelo, J. Neuman +20 more
2016Cell Reports441 citations Open access
Semantic Scholar
Restoration of metabolic health by decreased consumption of branched‐chain amino acids
Nicole E. Cummings, Elizabeth M. Williams, Ildikó Kasza, E. Konon +16 more
2017Journal of Physiology316 citations Open access
Semantic Scholar
β Cell tone is defined by proglucagon peptides through cAMP signaling.
M. Capozzi, B. Svendsen, S. Encisco, Sophie L. Lewandowski +9 more
2019JCI Insight212 citations Open access
Semantic Scholar
Pyruvate kinase controls signal strength in the insulin secretory pathway
Sophie L. Lewandowski, R. Cardone, Hannah R. Foster, Thuong Ho +15 more
2020bioRxiv119 citations Open access
Semantic Scholar
Protein-bound NAD(P)H Lifetime is Sensitive to Multiple Fates of Glucose Carbon
Joe T. Sharick, Peter F. Favreau, A. Gillette, Sophia M. Sdao +2 more
2018Scientific Reports115 citations Open access
Semantic Scholar
GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells
K. El, S. Gray, M. Capozzi, E. Knuth +11 more
2021Science Advances111 citations Open access
Semantic Scholar
Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring.
E. Alejandro, B. Gregg, Taylor Wallen, Doga Kumusoglu +7 more
2014Journal of Clinical Investigation103 citations Open access
Semantic Scholar
Metabolic Cycles and Signals for Insulin Secretion
M. Merrins, B. Corkey, R. Kibbey, M. Prentki
2022Cell Metabolism99 citations Open access
Semantic Scholar
Direct Measurements of Oscillatory Glycolysis in Pancreatic Islet β-Cells Using Novel Fluorescence Resonance Energy Transfer (FRET) Biosensors for Pyruvate Kinase M2 Activity*♦
M. Merrins, A. Van Dyke, A. Mapp, M. Rizzo +1 more
2013Journal of Biological Chemistry84 citations Open access
Semantic Scholar
Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity
T. Gregg, Chetan Poudel, B. Schmidt, R. Dhillon +10 more
2016Diabetes72 citations Open access
Semantic Scholar
Phase Analysis of Metabolic Oscillations and Membrane Potential in Pancreatic Islet β-Cells.
M. Merrins, Chetan Poudel, Joseph P. McKenna, Joon Ha +3 more
2016Biophysical Journal71 citations Open access
Semantic Scholar
Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health
Abudukadier Abulizi, R. Cardone, R. Stark, Sophie L. Lewandowski +14 more
2020Cell Metabolism65 citations Open access
Semantic Scholar
Metabolic oscillations in pancreatic islets depend on the intracellular Ca2+ level but not Ca2+ oscillations.
M. Merrins, Bernard Fendler, Min Zhang, A. Sherman +2 more
2010Biophysical Journal56 citations Open access
Semantic Scholar
Glucose Metabolism, Islet Architecture, and Genetic Homogeneity in Imprinting of [Ca2+]i and Insulin Rhythms in Mouse Islets
Craig S. Nunemaker, John F. Dishinger, S. Dula, R. Wu +5 more
2009PLoS ONE51 citations Open access
Semantic Scholar
What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?
B. Corkey, J. Deeney, M. Merrins
2021Diabetes44 citations Open access
Semantic Scholar
Pancreatic and Duodenal Homeobox Protein 1 (Pdx-1) Maintains Endoplasmic Reticulum Calcium Levels through Transcriptional Regulation of Sarco-endoplasmic Reticulum Calcium ATPase 2b (SERCA2b) in the Islet β Cell*
Justin S. Johnson, Tatsuyoshi Kono, Xin Tong, Wataru R. Yamamoto +5 more
2014Journal of Biological Chemistry44 citations Open access
Semantic Scholar
In Vivo Deletion of &bgr;-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption
Thomas G. Hennings, D. Chopra, Elizabeth R. De Leon, Halena R. VanDeusen +3 more
2018Endocrinology41 citations Open access
Semantic Scholar
Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes
R. Hernandez, Stephen A. Graves, T. Gregg, Halena R. VanDeusen +11 more
2017Diabetes39 citations Open access
Semantic Scholar
Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E2 Signaling and Enhances Diabetic β-Cell Function
J. Neuman, Michael D Schaid, Allison L. Brill, Rachel J. Fenske +10 more
2017Diabetes39 citations Open access
Semantic Scholar
Ca2+ Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity.
Joseph P. McKenna, Joon Ha, M. Merrins, L. Satin +2 more
2016Biophysical Journal39 citations Open access
Semantic Scholar
Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells
Weiwei Xu, M. M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sá +31 more
2023Cell Reports36 citations Open access
Semantic Scholar
Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets
A. D. de Souza, Jiayin Tang, A. Yadev, Samuel T. Saghafi +4 more
2020Scientific Reports36 citations Open access
Semantic Scholar
Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and Diabetes*
So Yoon Kim, Ji-Hyeon Lee, M. Merrins, O. Gavrilova +4 more
2017Journal of Biological Chemistry36 citations Open access
Semantic Scholar
A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice
Thuong Ho, E. Potapenko, D. Davis, M. Merrins
2022bioRxiv35 citations Open access
Semantic Scholar
Sleeve gastrectomy rapidly enhances islet function independently of body weight.
J. Douros, Jingjing Niu, Sophia M. Sdao, T. Gregg +11 more
2019JCI Insight35 citations Open access
Semantic Scholar
Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at complex I in pancreatic β-cells
T. Gregg, Sophia M. Sdao, R. Dhillon, Jarred W. Rensvold +4 more
2019Journal of Biological Chemistry35 citations Open access
Semantic Scholar
RhoC GTPase Is a Potent Regulator of Glutamine Metabolism and N-Acetylaspartate Production in Inflammatory Breast Cancer Cells*
Michelle L. Wynn, J. Yates, C. Evans, L. V. Van Wassenhove +10 more
2016Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase Modulates Oscillations of Pancreatic Islet Metabolism
M. Merrins, R. Bertram, A. Sherman, L. Satin
2012PLoS ONE32 citations Open access
Semantic Scholar
β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel
Hannah R. Foster, Thuong Ho, E. Potapenko, Sophia M. Sdao +8 more
2022eLife31 citations Open access
Semantic Scholar
LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells
Federica Cuozzo, Katrina Viloria, Ali H. Shilleh, Daniela Nasteska +29 more
2024Cell Reports28 citations Open access
Semantic Scholar
Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model!
M. Merrins, R. Kibbey
2024Diabetes27 citations Open access
Semantic Scholar
Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells
Melissa T Adams, JaeAnn M. Dwulet, J. Briggs, Christopher A. Reissaus +12 more
2021eLife25 citations Open access
Semantic Scholar
Calcium and Metabolic Oscillations in Pancreatic Islets: Who’s Driving the Bus?*
Margaret Watts, Bernard Fendler, M. Merrins, L. Satin +2 more
2014SIAM Journal on Applied Dynamical Systems23 citations Open access
Semantic Scholar
β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice
Hao-Peng Lin, Nancy Smith, A. Spigelman, Kunimasa Suzuki +10 more
2021Diabetes18 citations Open access
Semantic Scholar
Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice
Elizabeth R. De Leon, Jacqueline A. Brinkman, Rachel J. Fenske, T. Gregg +7 more
2018Scientific Reports16 citations Open access
Semantic Scholar
Pancreatic and Duodenal Homeobox Protein 1 (Pdx-1) Maintains Endoplasmic Reticulum Calcium Levels Through Transcriptional Regulation of Sarco-endoplasmic Reticulum Calcium ATPase 2b (SERCA2b) in the Islet β Cell*
Justin S. Johnson, Tatsuyoshi Kono, Xin Tong, Wataru R. Yamamoto +6 more
201415 citations
Semantic Scholar
CDK2 limits the highly energetic secretory program of mature β cells by restricting PEP cycle-dependent KATP channel closure
Sophia M. Sdao, Thuong Ho, C. Poudel, Hannah R. Foster +6 more
2021Cell Reports14 citations Open access
Semantic Scholar
Temporal plasticity of insulin and incretin secretion and insulin sensitivity following sleeve gastrectomy contribute to sustained improvements in glucose control
J. Douros, Jingjing Niu, Sophia M. Sdao, T. Gregg +4 more
2019Molecular Metabolism13 citations Open access
Semantic Scholar
Intra-islet α-cell Gs signaling promotes glucagon release
Liu Liu, K. El, Diptadip Dattaroy, Luiz F Barella +13 more
2024Nature Communications11 citations Open access
Semantic Scholar
Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet Ca2+ oscillations
Er-Li Jin, J. Briggs, Richard K. P. Benninger, M. Merrins
2025eLife9 citations Open access
Semantic Scholar
β Cell Gαs signaling is critical for physiological and pharmacological enhancement of insulin secretion
M. Capozzi, David Bouslov, Ashot Sargsyan, Michelle Y Chan +20 more
2025Journal of Clinical Investigation9 citations Open access
Semantic Scholar
β Cell–specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses
Christopher H. Emfinger, Eleonora de Klerk, K. Schueler, M. Rabaglia +18 more
2022JCI Insight6 citations Open access
Semantic Scholar
b-Cell tone is defined by proglucagon peptides through cyclic AMP signaling
M. Capozzi, D. D'Alessio, J. Campbell, B. Svendsen +9 more
20196 citations
Semantic Scholar
Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary (cid:2) -Cell Dysfunction to Progressive Depletion of (cid:2) -Cell Mass and Diabetes *
So Yoon Kim, Jihee Lee, M. Merrins, O. Gavrilova +4 more
20176 citations
Semantic Scholar
Leucine suppresses α-cell cAMP and glucagon secretion via a combination of cell-intrinsic and islet paracrine signaling.
E. Knuth, Hannah R. Foster, Er-Li Jin, Maia H. Ekstrand +2 more
2024Diabetes5 citations Open access
Semantic Scholar
Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations
Christopher H. Emfinger, Lauren E. Clark, B. Yandell, K. Schueler +6 more
2023bioRxiv4 citations Open access
Semantic Scholar
What the BTBR/J mouse has taught us about diabetes and diabetic complications
Mark P. Keller, K. Hudkins, Anath Shalev, Sushant Bhatnagar +6 more
2023iScience4 citations Open access
Semantic Scholar
Islet Architecture Controls Synchronous β Cell Response to Glucose in the Intact Mouse Pancreas in vivo
Melissa T Adams, Christopher A. Reissaus, Joseph M. Szulczewski, JaeAnn M. Dwulet +9 more
2019Social Science Research Network4 citations Open access
Semantic Scholar
Synchronized β cell response to glucose is lost concomitant with loss of islet architecture in Robo deficient islets of Langerhans in vivo
Melissa T Adams, Christopher A. Reissaus, JaeAnn M. Dwulet, Er-Li Jin +10 more
2019bioRxiv4 citations Open access
Semantic Scholar
EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance
Michael D Schaid, J. Harrington, Grant Kelly, Sophia M. Sdao +2 more
2023Islets3 citations Open access
Semantic Scholar

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