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R. Thaler · SciRah

Researcher profile · Semantic Scholar

R. Thaler

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R. Thaler — researcher profile on SciRah

h-index: 29
Works: 110
Citations: 2,476

Most-cited papers

Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2*
A. Dudakovic, Emily T. Camilleri, Fuhua Xu, Scott M. Riester +13 more
2015Journal of Biological Chemistry162 citations Open access
Semantic Scholar
Homocysteine Suppresses the Expression of the Collagen Cross-linker Lysyl Oxidase Involving IL-6, Fli1, and Epigenetic DNA Methylation*
R. Thaler, M. Agsten, S. Spitzer, E. Paschalis +3 more
2010Journal of Biological Chemistry119 citations Open access
Semantic Scholar
Vitamin C epigenetically controls osteogenesis and bone mineralization
R. Thaler, Farzaneh Khani, Ines Sturmlechner, S. S. Dehghani +15 more
2022Nature Communications106 citations Open access
Semantic Scholar
Biological Functions of Chromobox (CBX) Proteins in Stem Cell Self-Renewal, Lineage-Commitment, Cancer and Development.
A. VanWijnen, Leila Bagheri, Amr A. Badreldin, A. N. Larson +4 more
2020Bone103 citations
Semantic Scholar
Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells
H. Karlic, R. Thaler, C. Gerner, T. Grunt +3 more
2015Cancer Genetics99 citations Open access
Semantic Scholar
Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice*
A. Dudakovic, Emily T. Camilleri, Scott M. Riester, Christopher R. Paradise +12 more
2016Journal of Biological Chemistry92 citations Open access
Semantic Scholar
DMSO is a strong inducer of DNA hydroxymethylation in pre-osteoblastic MC3T3-E1 cells
R. Thaler, S. Spitzer, H. Karlic, K. Klaushofer +1 more
2012Epigenetics87 citations Open access
Semantic Scholar
Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice
A. Dudakovic, Emily T. Camilleri, Christopher R. Paradise, R. Samsonraj +14 more
2018Journal of Biological Chemistry79 citations Open access
Semantic Scholar
Proteomic Analysis of Exosomes and Exosome‐Free Conditioned Media From Human Osteosarcoma Cell Lines Reveals Secretion of Proteins Related to Tumor Progression
Sofía Jerez, Héctor F Araya, R. Thaler, M. Charlesworth +7 more
2016Journal of Cellular Biochemistry78 citations Open access
Semantic Scholar
Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate*
R. Thaler, A. Maurizi, P. Roschger, I. Sturmlechner +11 more
2016Journal of Biological Chemistry66 citations Open access
Semantic Scholar
Multi-Disciplinary Antimicrobial Strategies for Improving Orthopaedic Implants to Prevent Prosthetic Joint Infections in Hip and Knee
M. Getzlaf, Eric A. Lewallen, H. Kremers, Dakota L. Jones +6 more
2015Journal of Orthopaedic Research65 citations Open access
Semantic Scholar
Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2
A. Dudakovic, R. Samsonraj, Christopher R. Paradise, Catalina Galeano-Garces +14 more
2020Journal of Biological Chemistry63 citations Open access
Semantic Scholar
Wnt/β‐Catenin Signaling Activates Expression of the Bone‐Related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types
Oscar A. Vega, Claudia M. J. Lucero, Héctor F Araya, Sofía Jerez +9 more
2017Journal of Cellular Biochemistry58 citations Open access
Semantic Scholar
T3 affects expression of collagen I and collagen cross-linking in bone cell cultures
F. Varga, M. Rumpler, R. Zoehrer, C. Turecek +4 more
2010Biochemical and Biophysical Research Communications - BBRC58 citations Open access
Semantic Scholar
Extracellular vesicles from osteosarcoma cell lines contain miRNAs associated with cell adhesion and apoptosis.
Sofía Jerez, Héctor F Araya, Daniel Hevia, Carlos E Irarrázaval +3 more
2019Gene55 citations Open access
Semantic Scholar
Molecular Pathology of Human Knee Arthrofibrosis Defined by RNA Sequencing
B. Bayram, A. K. Limberg, C. Salib, Jacob W. Bettencourt +10 more
2020Genomics50 citations Open access
Semantic Scholar
Differential effects of homocysteine and beta aminopropionitrile on preosteoblastic MC3T3-E1 cells.
R. Thaler, S. Spitzer, M. Rumpler, N. Fratzl-Zelman +3 more
2010Bone50 citations
Semantic Scholar
Local Cellular Responses to Titanium Dioxide from Orthopedic Implants
Jie J. Yao, Eric A. Lewallen, William H. Trousdale, Wei Xu +6 more
2017BioResearch Open Access49 citations Open access
Semantic Scholar
Improved Post-Thaw Function and Epigenetic Changes in Mesenchymal Stromal Cells Cryopreserved Using Multicomponent Osmolyte Solutions
K. Pollock, R. Samsonraj, A. Dudakovic, R. Thaler +5 more
2017Stem Cells and Development48 citations Open access
Semantic Scholar
The cancer‐related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis
F. Villanueva, Héctor F Araya, P. Briceño, Nelson Varela +13 more
2019Journal of Cellular Physiology43 citations Open access
Semantic Scholar
Multiple pharmacological inhibitors targeting the epigenetic suppressor Enhancer of Zeste Homolog 2 (EZH2) accelerate osteoblast differentiation
M. Galvan, Christopher R. Paradise, Eva Kubrova, Sofía Jerez +4 more
2021Bone38 citations Open access
Semantic Scholar
In vivo assessment of high-molecular-weight polyethylene core suture tape for intra-articular ligament reconstruction: an animal study.
Endre Søreide, J. Denbeigh, Eric A. Lewallen, R. Thaler +7 more
2019The Bone & Joint Journal31 citations
Semantic Scholar
Acute‐phase protein serum amyloid A3 is a novel paracrine coupling factor that controls bone homeostasis
R. Thaler, I. Sturmlechner, S. Spitzer, Scott M. Riester +5 more
2015The FASEB Journal30 citations Open access
Semantic Scholar
Surface Roughness of Titanium Orthopedic Implants Alters the Biological Phenotype of Human Mesenchymal Stromal Cells
Eric A. Lewallen, William H. Trousdale, R. Thaler, Jie J. Yao +10 more
2021Tissue Engineering. Part A29 citations Open access
Semantic Scholar
Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing
A. Dudakovic, Martina Gluscevic, Christopher R. Paradise, Halil Dudakovic +10 more
2017Gene29 citations Open access
Semantic Scholar
Histone H4 methyltransferase Suv420h2 maintains fidelity of osteoblast differentiation
Khani Farzaneh, R. Thaler, Christopher R. Paradise, David R. Deyle +6 more
2016Journal of Cellular Biochemistry29 citations Open access
Semantic Scholar
In Vivo Survival of Mesenchymal Stromal Cell-Enhanced Decellularized Nerve Grafts for Segmental Peripheral Nerve Reconstruction.
N. Rbia, L. Bulstra, R. Thaler, S. Hovius +2 more
2019Journal of Hand Surgery-American Volume28 citations
Semantic Scholar
Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis
Busra Isik, R. Thaler, Busra B. Goksu, S. Conley +14 more
2021Stem cell research & therapeutics27 citations Open access
Semantic Scholar
Control of bone development by P2X and P2Y receptors expressed in mesenchymal and hematopoietic cells
L. Lenertz, Cory J Baughman, N. Waldschmidt, R. Thaler +1 more
2015Gene27 citations Open access
Semantic Scholar
The role of epigenetics in the regulation of apoptosis in myelodysplastic syndromes and acute myeloid leukemia.
H. Karlic, H. Herrmann, F. Varga, R. Thaler +7 more
2014Critical reviews in oncology/hematology27 citations
Semantic Scholar
Homocysteine induces serum amyloid A3 in osteoblasts via unlocking RGD‐motifs in collagen
R. Thaler, J. Zwerina, M. Rumpler, S. Spitzer +4 more
2013The FASEB Journal27 citations
Semantic Scholar
Osteogenic potential of human adipose-tissue derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium
Eric A. Lewallen, Dakota L. Jones, A. Dudakovic, R. Thaler +8 more
2016Gene25 citations Open access
Semantic Scholar
Extra-cellular matrix suppresses expression of the apoptosis mediator Fas by epigenetic DNA methylation
R. Thaler, H. Karlic, S. Spitzer, K. Klaushofer +1 more
2010Apoptosis25 citations
Semantic Scholar
Gene expression profiles of differentiated and undifferentiated adipose derived mesenchymal stem cells dynamically seeded onto a processed nerve allograft.
F. Mathot, N. Rbia, R. Thaler, A. Bishop +2 more
2020Gene24 citations
Semantic Scholar
Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells
R. Thaler, S. Spitzer, H. Karlic, C. Berger +2 more
2013Biochemical Pharmacology24 citations Open access
Semantic Scholar
Intra-articular celecoxib improves knee extension regardless of surgical release in a rabbit model of arthrofibrosis
William H. Trousdale, A. K. Limberg, N. Reina, C. Salib +7 more
2022Bone & Joint Research23 citations Open access
Semantic Scholar
Inhibition of Ezh2 redistributes bivalent domains within transcriptional regulators associated with WNT and Hedgehog pathways in osteoblasts
Margarita E. Carrasco, R. Thaler, Gino Nardocci, A. Dudakovic +1 more
2023Journal of Biological Chemistry21 citations Open access
Semantic Scholar
The epigenetic reader Brd4 is required for osteoblast differentiation
Christopher R. Paradise, M. Galvan, Eva Kubrova, Sierra Bowden +6 more
2019Journal of Cellular Physiology21 citations Open access
Semantic Scholar
Mospd1, a new player in mesenchymal versus epidermal cell differentiation
R. Thaler, M. Rumpler, S. Spitzer, K. Klaushofer +1 more
2011Journal of Cellular Physiology21 citations
Semantic Scholar
Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogramming
M. Afarideh, R. Thaler, Farzaneh Khani, Hui Tang +10 more
2020Epigenetics20 citations Open access
Semantic Scholar
The lysine methyltransferases SET and MYND domain containing 2 (Smyd2) and Enhancer of Zeste 2 (Ezh2) co-regulate osteoblast proliferation and mineralization.
P. Dashti, J. van de Peppel, R. Thaler, Christopher R. Paradise +6 more
2022Gene17 citations Open access
Semantic Scholar
Mitotic inheritance of mRNA facilitates translational activation of the osteogenic-lineage commitment factor Runx2 in progeny of osteoblastic cells
Nelson Varela, Alejandra Aranguiz, C. Lizama, Hugo Sepúlveda +7 more
2015Journal of Cellular Physiology17 citations Open access
Semantic Scholar
Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2
Héctor F Araya, Hugo Sepúlveda, C. Lizama, Oscar A. Vega +14 more
2018Journal of Cellular Biochemistry16 citations Open access
Semantic Scholar
Molecular pathology of adverse local tissue reaction caused by metal-on-metal implants defined by RNA-seq
C. Salib, Eric A. Lewallen, Christopher R. Paradise, M. Tibbo +15 more
2018Genomics16 citations Open access
Semantic Scholar
Mitogen‐activated protein kinase 2 regulates physiological and pathological bone turnover
Tobias Braun, Johannes Lepper, Gisela Ruiz Heiland, W. Hofstetter +9 more
2013Journal of Bone and Mineral Research16 citations Open access
Semantic Scholar
Brd4 is required for chondrocyte differentiation and endochondral ossification
Christopher R. Paradise, M. Galvan, Oksana Pichurin, Sofía Jerez +7 more
2021Bone15 citations Open access
Semantic Scholar
Introducing Human Adipose-Derived Mesenchymal Stem Cells to Avance® Nerve Grafts and NeuraGen® Nerve Guides
F. Mathot, N. Rbia, R. Thaler, A. Bishop +2 more
2020Journal of Plastic, Reconstructive & Aesthetic Surgery14 citations Open access
Semantic Scholar
Gene expression profiles of human adipose-derived mesenchymal stem cells dynamically seeded on clinically available processed nerve allografts and collagen nerve guides
F. Mathot, N. Rbia, R. Thaler, A. Dietz +3 more
2021Neural Regeneration Research13 citations Open access
Semantic Scholar
Human Outgrowth Knee Fibroblasts from Patients Undergoing Total Knee Arthroplasty Exhibit a Unique Gene Expression Profile and Undergo Myofibroblastogenesis upon TGFβ1 Stimulation
B. Bayram, R. Thaler, Jacob W. Bettencourt, A. K. Limberg +8 more
2022Journal of Cellular Biochemistry12 citations Open access
Semantic Scholar
Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells
Logan M. Glasstetter, Tomiwa S. Oderinde, Mohit Mirchandani, K. S. Rajagopalan +10 more
2023Stem cell research & therapeutics11 citations Open access
Semantic Scholar

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