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A. Nykänen · SciRah

Researcher profile · Semantic Scholar

A. Nykänen

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A. Nykänen — researcher profile on SciRah

h-index: 37
Works: 245
Citations: 7,247

Most-cited papers

Hybrid Supramolecular and Colloidal Hydrogels that Bridge Multiple Length Scales
Emma-Rose Janeček, Jason R. McKee, C. S. Y. Tan, A. Nykänen +4 more
2015Angewandte Chemie70 citations Open access
Semantic Scholar
Successful 3-day lung preservation using a cyclic normothermic ex vivo lung perfusion strategy
Aadil Ali, A. Nykänen, E. Beroncal, E. Brambate +14 more
2022EBioMedicine49 citations Open access
Semantic Scholar
Ischemia–Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts
A. Dashkevich, A. Raissadati, S. Syrjälä, G. Zarkada +9 more
2016American Journal of Transplantation45 citations Open access
Semantic Scholar
Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release.
S. Nummelin, Ville Liljeström, Eve Saarikoski, J. Ropponen +7 more
2015Chemistry44 citations Open access
Semantic Scholar
VEGF Pathways in the Lymphatics of Healthy and Diseased Heart
A. Dashkevich, C. Hagl, F. Beyersdorf, A. Nykänen +1 more
2016Microcirculation37 citations
Semantic Scholar
Efficacy and safety of the Lotus Valve System for treatment of patients with severe aortic valve stenosis and intermediate surgical risk: Results from the Nordic Lotus-TAVR registry.
O. de Backer, Matthias Götberg, L. Ihlberg, Erik J. S. Packer +9 more
2016International Journal of Cardiology35 citations
Semantic Scholar
Donor Simvastatin Treatment in Heart Transplantation: A Randomized and Blinded Clinical Trial.
A. Nykänen, E. Holmström, R. Tuuminen, R. Krebs +8 more
2019Circulation31 citations Open access
Semantic Scholar
Creating superior lungs for transplantation with next-generation gene therapy during ex vivo lung perfusion.
A. Nykänen, S. Keshavjee, Ming-Yao Liu
2024The Journal of Heart and Lung Transplantation29 citations Open access
Semantic Scholar
Engineered mesenchymal stromal cell therapy during human lung ex vivo lung perfusion is compromised by acidic lung microenvironment
A. Nykänen, A. Mariscal, A. Duong, C. Estrada +17 more
2021Molecular Therapy: Methods & Clinical Development29 citations Open access
Semantic Scholar
Incidence and impact of chronic lung allograft dysfunction after lung transplantation – single-center 14-year experience
A. Nykänen, P. Raivio, L. Peräkylä, C. Stark +4 more
2020Scandinavian Cardiovascular Journal24 citations Open access
Semantic Scholar
Modular synthesis of self-assembling Janus-dendrimers and facile preparation of drug-loaded dendrimersomes.
S. Nummelin, M. Selin, Sacha Legrand, J. Ropponen +6 more
2017Nanoscale23 citations Open access
Semantic Scholar
Severe primary graft dysfunction of the heart transplant is associated with increased plasma and intragraft proinflammatory cytokine expression.
E. Holmström, S. Syrjälä, K. Dhaygude, R. Tuuminen +3 more
2023The Journal of Heart and Lung Transplantation16 citations Open access
Semantic Scholar
Platelet-derived Growth Factor-B Protects Rat Cardiac Allografts From Ischemia-reperfusion Injury
R. Tuuminen, A. Dashkevich, M. A. Keränen, A. Raissadati +7 more
2016Transplantation14 citations
Semantic Scholar
Lung Transplant Immunomodulation with Genetically Engineered Mesenchymal Stromal Cells—Therapeutic Window for Interleukin-10
A. Nykänen, A. Mariscal, A. Duong, Aadil Ali +18 more
2024Cells11 citations Open access
Semantic Scholar
Epitranscriptomics of Ischemic Heart Disease—The IHD-EPITRAN Study Design and Objectives
Vilbert Sikorski, P. Karjalainen, D. Blokhina, Kati Oksaharju +35 more
2021International Journal of Molecular Sciences10 citations Open access
Semantic Scholar
Mesenchymal Stromal Cell Therapy in Lung Transplantation
A. Nykänen, Ming Liu, S. Keshavjee
2023Bioengineering9 citations Open access
Semantic Scholar
Plasma proteome of brain-dead organ donors predicts heart transplant outcome.
Janja Lukac, K. Dhaygude, M. Saraswat, S. Joenväärä +6 more
2021The Journal of Heart and Lung Transplantation9 citations Open access
Semantic Scholar
Alpha 1 Antitrypsin Treatment during Human Ex Vivo Lung Perfusion Improves Lung Function by Protecting Lung Endothelium.
A. Mariscal, A. Nykänen, J. Tikkanen, A. Ali +8 more
2020The Journal of Heart and Lung Transplantation8 citations
Semantic Scholar
Near-infrared fluorescence imaging during ex vivo lung perfusion: Noninvasive real-time evaluation of regional lung perfusion and edema.
A. Nykänen, A. Mariscal, Aadil Ali, O. Hough +4 more
2022Journal of Thoracic and Cardiovascular Surgery7 citations Open access
Semantic Scholar
Chronic lung allograft dysfunction subtype analysis by computed tomography volumetry
L. Peräkylä, P. Raivio, R. Kesavuori, A. Piilonen +3 more
2021Clinical Transplantation7 citations
Semantic Scholar
Pseudo heparin resistance after pulmonary endarterectomy: Role of thrombus production of Factor VIII.
A. Nykänen, R. Selby, K. McRae, Yi-Dan Zhao +4 more
2021Seminars in Thoracic and Cardiovascular Surgery7 citations Open access
Semantic Scholar
Hypoxia-inducible factor controls immunoregulatory properties of myeloid cells in mouse cardiac allografts – an experimental study
M. A. Keränen, A. Raissadati, A. Nykänen, A. Dashkevich +5 more
2018Transplant International7 citations Open access
Semantic Scholar
Donor Plasma VEGF-A as a Biomarker for Myocardial Injury and Primary Graft Dysfunction After Heart Transplantation.
E. Holmström, S. Syrjälä, K. Dhaygude, R. Tuuminen +4 more
2024The Journal of Heart and Lung Transplantation6 citations Open access
Semantic Scholar
Access Site Complications in Thoracic Endovascular Aortic Repair.
S. Dahlbacka, A. Nykänen, Tatu Juvonen, M. Jormalainen
2023Journal of Vascular Surgery6 citations Open access
Semantic Scholar
Transition from BOS to RAS impairs prognosis after lung transplantation—CLAD subtype analysis by CT volumetry
L. Peräkylä, A. Nykänen, A. Piilonen, R. Kesavuori +2 more
2022PLoS ONE6 citations Open access
Semantic Scholar
Successful Transplantation of Porcine Lungs Following 3 Days of Preservation Using a Modified Cold Static Method Paired with Intermittent Normothermic Ex Vivo Lung Perfusion (EVLP).
Aadil Ali, A. Nykänen, E. Brambate, A. Mariscal +12 more
2020The Journal of Heart and Lung Transplantation6 citations
Semantic Scholar
Characterization of Polyaniline-Based Blends, Composites, and Nanocomposites
J. Araujo, E. S. Lopes, R. D. de Castro, C. A. Senna +7 more
20185 citations
Semantic Scholar
Extracellular Vesicles in Lung Donor Plasma: Potential Indicators of Donor Organ Quality.
S. Joo, K. Dhaygude, R. Krebs, E. Holmström +14 more
2025Journal of Thoracic and Cardiovascular Surgery4 citations Open access
Semantic Scholar
Transcriptomic Landscape of Circulating Extracellular Vesicles in Heart Transplant Ischemia–Reperfusion
S. Joo, K. Dhaygude, Sofie Westerberg, R. Krebs +5 more
2023Genes4 citations Open access
Semantic Scholar
Upregulation of Coagulation Factor VIII and Fibrinogen After Pulmonary Endarterectomy in Patients with Chronic Thromboembolic Pulmonary Hypertension
Lasse Myllylahti, J. Ropponen, Mikko Lax, R. Lassila +1 more
2023Clinical and applied thrombosis/hemostasis4 citations Open access
Semantic Scholar
Donor Simvastatin Treatment in Liver Transplantation: Post Hoc Analysis of a Randomized Placebo-controlled Trial With Long-term Follow-up.
F. Åberg, A. Nykänen, I. Helanterä, K. Lemström
2023Transplantation4 citations Open access
Semantic Scholar
Monogenic gene variants in lung transplant recipients with usual interstitial pneumonia
C. Stark, J. Koskenvuo, A. Nykänen, E. Seppälä +3 more
2022ERJ Open Research4 citations Open access
Semantic Scholar
Increased myeloid cell hypoxia-inducible factor-1 delays obliterative airway disease in the mouse.
J. Ropponen, M. A. Keränen, A. Raissadati, A. Nykänen +3 more
2016The Journal of Heart and Lung Transplantation4 citations
Semantic Scholar
Donor Simvastatin Treatment in Heart Transplantation: 5-y Results of SIMVA Trial
E. Holmström, S. Syrjälä, K. Dhaygude, R. Krebs +4 more
2025Transplantation3 citations Open access
Semantic Scholar
Addition of Dialysis to Ex-Vivo Lung Perfusion Maintains Homeostasis and Stability of Donor Lungs: A Pilot Study.
O. Hough, X. Gao, C. Yang, M. Takahashi +8 more
2020The Journal of Heart and Lung Transplantation3 citations
Semantic Scholar
Donor Simvastatin Treatment in Heart Transplantation: 5-Year Results of a Randomized Clinical Trial
S. O. Syrjala, E. Holmstrom, K. Dhaygude, J. Lommi +2 more
2023The Journal of Heart and Lung Transplantation2 citations Open access
Semantic Scholar
Addition of Dialysis to Ex-Vivo Lung Perfusion Maintains Homeostasis and Stability of Donor Lungs: A Proof of Concept Study
O. Hough, X. Gao, Chengliang Yang, M. Takahashi +11 more
20212 citations Open access
Semantic Scholar
Outcome of patients receiving a continuous flow left ventricular assist device – a retrospective single center study
J. Kišš, C. Stark, A. Nykänen, K. Lemström
2020Scandinavian Cardiovascular Journal2 citations Open access
Semantic Scholar
Engineered Mesenchymal Stromal Cell Therapy during Pig Ex Vivo Lung Perfusion and Transplant
A. Nykänen, A. Mariscal, M. Takahashi, A. Duong +13 more
2019The Journal of Heart and Lung Transplantation2 citations
Semantic Scholar
The Impact of Deceased Donor Simvastatin Treatment on Kidney Transplant Outcomes - Results of a Double-Blinded, Randomized Controlled Trial
E. Holmström, I. Helanterä, R. Krebs, S. Syrjälä +3 more
2018Transplantation2 citations
Semantic Scholar
Metabolic changes and plasma glycine predict the risk of acute cellular rejection in heart transplantation
K. Dhaygude, Richard S. Krebs, R. Krebs, S. Joo +6 more
2026JTCVS Open1 citations Open access
Semantic Scholar
Bridging to a delayed pulmonary endarterectomy in massive acute-on-chronic pulmonary thromboembolism: a case report
M. Lehtinen, J. Ropponen, R. Kesavuori, E. Wilkman +2 more
2025Journal of Cardiothoracic Surgery1 citations Open access
Semantic Scholar
Donor and Recipient Cytokine Profiles Predict Acute Rejection and Graft-Related Survival After Heart Transplantation
E. Holmström, S. Syrjälä, K. Dhaygude, R. Tuuminen +3 more
2022The Journal of Heart and Lung Transplantation1 citations Open access
Semantic Scholar
Reconstruction of Donor Anomalous Pulmonary Vein During Lung Transplantation.
A. Nykänen, P. Raivio
2021Annals of Thoracic Surgery1 citations Open access
Semantic Scholar
Engineered Mesenchymal Stromal Cell Therapy during Human Lung Ex Vivo Lung Perfusion is Affected by Lung Acidosis.
A. Nykänen, A. Mariscal, C. Estrada, A. Duong +15 more
2020The Journal of Heart and Lung Transplantation1 citations
Semantic Scholar
Plasma Protein Signature during Ischemia-Reperfusion Injury in Clinical Heart Transplantation.
J. Lukác, S. Syrjälä, M. Saraswat, S. Joenväärä +6 more
2020The Journal of Heart and Lung Transplantation1 citations
Semantic Scholar
Evaluation of Lung Quality by Near-Infrared Fluorescent Imaging during Ex Vivo Lung Perfusion.
A. Nykänen, A. Mariscal, A. Ali, Man-Yin Chen +5 more
2020The Journal of Heart and Lung Transplantation1 citations
Semantic Scholar
Donor Simvastatin Treatment Alters Protein Expression in the Recipient after Heart Transplantation: ISHLT 38th Annual Meeting and Scientific Sessions
J. Lukác, E. Holmström, S. Joenväärä, M. Saraswat +5 more
20181 citations
Semantic Scholar
(164) - Effect of Donor Simvastatin Treatment on Cardiac Allograft Ischemia-Reperfusion Injury - 30-Day Analysis of a Randomized Prospective Single-Center Clinical Trial
A. Nykänen, E. Holmström, S. Syrjälä, J. Jokinen +2 more
20171 citations
Semantic Scholar
Vascular Endothelial Growth Factor-B Overexpressing Hearts Are Not Protected From Transplant-Associated Ischemia-Reperfusion Injury.
A. Raissadati, R. Tuuminen, A. Dashkevich, M. Bry +9 more
2016Experimental and Clinical Transplantation1 citations
Semantic Scholar

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