R. Hohlfeld

Most-cited papers

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice
K. Berer, L. Gerdes, Egle Cekanaviciute, Xiao-Ming Jia +10 more
2017Proceedings of the National Academy of Sciences of the United States of America837 citations Open access
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Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course
Xiaoping Zhou, Ryan Baumann, Xiaohui Gao, Myra Mendoza +39 more
2022Cell296 citations Open access
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Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society
N. Melzer, T. Ruck, P. Fuhr, R. Gold +9 more
2016Journal of Neurology269 citations Open access
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The role of B cells in Multiple Sclerosis and related disorders
G. Comi, A. Bar-Or, H. Lassmann, A. Uccelli +5 more
2020Annals of Neurology243 citations Open access
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Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study
L. Kappos, R. Fox, Michel Burcklen, M. Freedman +13 more
2021JAMA Neurology198 citations Open access
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The role of the gut microbiota in multiple sclerosis
J. Correale, R. Hohlfeld, S. Baranzini
2022Nature Reviews Neurology194 citations
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Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis
M. Spadaro, L. Gerdes, M. Krumbholz, B. Ertl-Wagner +9 more
2016Neurology: Neuroimmunology & Neuroinflammation189 citations Open access
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Features of Human CD3+CD20+ T Cells
E. Schuh, K. Berer, M. Mulazzani, K. Feil +12 more
2016Journal of Immunology184 citations Open access
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The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets.
R. Hohlfeld, K. Dornmair, E. Meinl, H. Wekerle
2016Lancet Neurology183 citations
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Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein
M. Spadaro, S. Winklmeier, E. Beltrán, C. Macrini +19 more
2018Annals of Neurology180 citations
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Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins
S. Brändle, B. Obermeier, M. Senel, J. Bruder +9 more
2016Proceedings of the National Academy of Sciences of the United States of America177 citations Open access
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The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research.
R. Hohlfeld, K. Dornmair, E. Meinl, H. Wekerle
2016Lancet Neurology173 citations
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Histopathology and clinical course of MOG-antibody-associated encephalomyelitis
M. Spadaro, L. Gerdes, M. C. Mayer, B. Ertl-Wagner +10 more
2015Annals of Clinical and Translational Neurology170 citations Open access
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Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation
C. Gross, A. Schulte-Mecklenbeck, Anna Rünzi, T. Kuhlmann +13 more
2016Proceedings of the National Academy of Sciences of the United States of America167 citations Open access
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Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives
L. Yshii, R. Hohlfeld, R. Liblau
2017Nature Reviews Neurology156 citations
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Long-term effects of fingolimod in multiple sclerosis
L. Kappos, P. O'Connor, E. Radue, C. Polman +7 more
2015Neurology118 citations Open access
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CTLA4 as Immunological Checkpoint in the Development of Multiple Sclerosis
L. Gerdes, K. Held, E. Beltrán, C. Berking +8 more
2016Annals of Neurology115 citations Open access
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Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis.
E. Beltrán, L. Gerdes, Julie Hansen, Andrea Flierl-Hecht +7 more
2019Journal of Clinical Investigation113 citations Open access
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Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid
M. Wuhrer, M. Selman, L. McDonnell, T. Kümpfel +6 more
2015Journal of Neuroinflammation107 citations Open access
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The immunoregulator soluble TACI is released by ADAM10 and reflects B-cell activation in autoimmunity
F. Hoffmann, Peer-Hendrik Kuhn, S. Laurent, S. Hauck +15 more
2014Journal of Immunology103 citations Open access
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Risks and risk management in modern multiple sclerosis immunotherapeutic treatment
L. Klotz, J. Havla, N. Schwab, R. Hohlfeld +3 more
2019Therapeutic Advances in Neurological Disorders99 citations Open access
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Cerebrospinal Fluid JC Virus Antibody Index for Diagnosis of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy
C. Warnke, G. Von Geldern, P. Markwerth, T. Dehmel +20 more
2014Annals of Neurology93 citations Open access
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Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis
T. Schneider-Hohendorf, L. Gerdes, B. Pignolet, R. Gittelman +24 more
2022Journal of Experimental Medicine81 citations Open access
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Myelin-oligodendrocyte-glycoprotein (MOG) autoantibodies as potential markers of severe optic neuritis and subclinical retinal axonal degeneration
J. Havla, T. Kümpfel, R. Schinner, M. Spadaro +4 more
2016Journal of Neurology81 citations
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Fingolimod induces neuroprotective factors in human astrocytes
F. Hoffmann, J. Hofereiter, H. Rübsamen, Johannes Melms +9 more
2015Journal of Neuroinflammation79 citations Open access
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Twin study reveals non-heritable immune perturbations in multiple sclerosis
F. Ingelfinger, L. Gerdes, V. Kavaka, Sinduya Krishnarajah +17 more
2022Nature77 citations Open access
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Natalizumab exerts a suppressive effect on surrogates of B cell function in blood and CSF
C. Warnke, M. Stettner, V. Lehmensiek, T. Dehmel +19 more
2015Multiple Sclerosis76 citations Open access
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Guidelines on dermatomyositis – excerpt from the interdisciplinary S2k guidelines on myositis syndromes by the German Society of Neurology
C. Sunderkötter, A. Nast, M. Worm, R. Dengler +11 more
2016Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG70 citations Open access
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PML risk stratification using anti-JCV antibody index and L-selectin
N. Schwab, T. Schneider-Hohendorf, B. Pignolet, M. Spadaro +22 more
2016Multiple Sclerosis69 citations Open access
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First manifestation of multiple sclerosis after immunization with the Pfizer-BioNTech COVID-19 vaccine
J. Havla, Yannick Schultz, H. Zimmermann, R. Hohlfeld +2 more
2021Journal of Neurology65 citations Open access
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DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis
N. Souren, L. Gerdes, P. Lutsik, G. Gasparoni +7 more
2019Nature Communications58 citations Open access
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Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study
F. C. Oertel, O. Outteryck, B. Knier, H. Zimmermann +12 more
2019Journal of Neuroinflammation55 citations Open access
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Features of MOG required for recognition by patients with MOG antibody-associated disorders.
C. Macrini, R. Gerhards, S. Winklmeier, L. Bergmann +10 more
2021Brain : a journal of neurology53 citations Open access
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Identification of circulating MOG-specific B cells in patients with MOG antibodies
S. Winklmeier, Miriam Schlüter, M. Spadaro, F. Thaler +12 more
2019Neurology: Neuroimmunology & Neuroinflammation53 citations Open access
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αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell–related features
K. Held, Latika Bhonsle-Deeng, K. Siewert, W. Sato +13 more
2015Neurology: Neuroimmunology & Neuroinflammation51 citations Open access
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Expanding spectrum of neurologic manifestations in patients with NLRP3 low-penetrance mutations
E. Schuh, P. Lohse, B. Ertl-Wagner, M. Witt +5 more
2015Neurology: Neuroimmunology & Neuroinflammation51 citations Open access
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Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity
P. Ostkamp, A. Salmen, B. Pignolet, Dennis Görlich +42 more
2020Proceedings of the National Academy of Sciences of the United States of America48 citations Open access
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Immune signatures of prodromal multiple sclerosis in monozygotic twins
L. Gerdes, C. Janoschka, M. Eveslage, Bianca Mannig +14 more
2020Proceedings of the National Academy of Sciences of the United States of America42 citations Open access
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Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement
E. Schuh, A. Musumeci, F. Thaler, S. Laurent +4 more
2017Journal of Immunology41 citations
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Household paired design reduces variance and increases power in multi-city gut microbiome study in multiple sclerosis
Xiao-Yuan Zhou, Sneha Singh, Ryan Baumann, Patrick Barba +31 more
2020Multiple Sclerosis39 citations Open access
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Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy
Nikolaos I. Kyratsous, Isabel J. Bauer, Guo-Kun Zhang, M. Pešić +11 more
2017Proceedings of the National Academy of Sciences of the United States of America39 citations Open access
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Recurrence of disease activity during pregnancy after cessation of fingolimod in multiple sclerosis
I. Meinl, J. Havla, R. Hohlfeld, T. Kümpfel
2018Multiple Sclerosis38 citations Open access
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Facing the urgency of therapies for progressive MS — a Progressive MS Alliance proposal
F. Dangond, Alexis A. Donnelly, R. Hohlfeld, C. Lubetzki +11 more
2021Nature Reviews Neurology33 citations
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Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis
S. Brändle, M. Cerina, Susanne Weber, K. Held +17 more
2021Proceedings of the National Academy of Sciences of the United States of America28 citations Open access
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Abundant glutamic acid decarboxylase (GAD)‐reactive B cells in gad‐antibody–associated neurological disorders
F. Thaler, A. Thaller, Michelle Biljecki, E. Schuh +9 more
2019Annals of Neurology26 citations
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Communication of CD8+ T cells with mononuclear phagocytes in multiple sclerosis
Matea Konjevic Sabolek, K. Held, E. Beltrán, Anna G. Niedl +4 more
2019Annals of Clinical and Translational Neurology23 citations Open access
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An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis
A. Bracher, C. Alcalá, J. Ferrer, N. Melzer +4 more
2020Annals of Clinical and Translational Neurology22 citations Open access
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Dynamic Contrast-Enhanced Magnetic Resonance Imaging Suggests Normal Perfusion in Normal-Appearing White Matter in Multiple Sclerosis
M. Ingrisch, S. Sourbron, Sina Herberich, M. Schneider +4 more
2016Investigative Radiology22 citations Open access
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Managing Risks with Immune Therapies in Multiple Sclerosis
Moritz Förster, Patrick Küry, O. Aktas, C. Warnke +5 more
2019Drug Safety21 citations
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T-cell receptor repertoire of human peripheral CD161hiTRAV1-2+ MAIT cells revealed by next generation sequencing and single cell analysis.
K. Held, E. Beltrán, M. Moser, R. Hohlfeld +1 more
2015Human Immunology21 citations
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