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E. Rozners · SciRah

Researcher profile · Semantic Scholar

E. Rozners

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E. Rozners — researcher profile on SciRah

h-index: 26
Works: 125
Citations: 2,457

Most-cited papers

Unique Gene-silencing and Structural Properties of 2′-F Modified siRNAs
M. Manoharan, A. Akinc, R. Pandey, June Qin +11 more
2011Angewandte Chemie190 citations Open access
Semantic Scholar
Unexpected origins of the enhanced pairing affinity of 2′-fluoro-modified RNA
P. Pallan, E. Greene, P. A. Jicman, R. Pandey +3 more
2010Nucleic Acids Research180 citations Open access
Semantic Scholar
Short Peptide Nucleic Acids Bind Strongly to Homopurine Tract of Double Helical RNA at pH 5.5
Ming Li, Thomas T. Zengeya, E. Rozners
2010Journal of the American Chemical Society113 citations Open access
Semantic Scholar
Triple Helical Recognition of RNA Using 2-Aminopyridine-Modified PNA at Physiologically Relevant Conditions
Thomas T. Zengeya, Pankaj Gupta, E. Rozners
2012Angewandte Chemie91 citations Open access
Semantic Scholar
2′-Fluoro RNA Shows Increased Watson-Crick H-Bonding Strength and Stacking relative to RNA: Evidence from NMR and Thermodynamic Data
A. Patra, Michael Paolillo, K. Charissé, M. Manoharan +2 more
2012Angewandte Chemie88 citations Open access
Semantic Scholar
Chemical Modifications of CRISPR RNAs to Improve Gene Editing Activity and Specificity
E. Rozners
2022Journal of the American Chemical Society74 citations Open access
Semantic Scholar
Triple Helical Recognition of Pyrimidine Inversions in Polypurine Tracts of RNA by Nucleobase-modified PNA
Pankaj Gupta, Thomas T. Zengeya, E. Rozners
2011Chemical Communications63 citations Open access
Semantic Scholar
Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs
Daniel Mutisya, C. Selvam, Benjamin D Lunstad, P. Pallan +4 more
2014Nucleic Acids Research60 citations Open access
Semantic Scholar
Nucleobase-Modified PNA Suppresses Translation by Forming a Triple Helix with a Hairpin Structure in mRNA In Vitro and in Cells.
T. Endoh, Dziyana Hnedzko, E. Rozners, N. Sugimoto
2016Angewandte Chemie57 citations
Semantic Scholar
Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications
N. Brodyagin, M. Katkevics, Venubabu Kotikam, Christopher A. Ryan +1 more
2021Beilstein Journal of Organic Chemistry56 citations Open access
Semantic Scholar
Recognition of Double Stranded RNA by Guanidine-Modified Peptide Nucleic Acids (GPNA)
Pankaj Gupta, Oluwatoyosi Muse, E. Rozners
2011Biochemistry55 citations Open access
Semantic Scholar
Recent Advances in Chemical Modification of Peptide Nucleic Acids
E. Rozners
2012Journal of Nucleic Acids51 citations Open access
Semantic Scholar
Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme
Feng Li, P. Pallan, Martin A. Maier, K. G. Rajeev +8 more
2007Nucleic Acids Research47 citations Open access
Semantic Scholar
Amides Are Excellent Mimics of Phosphate Linkages in RNA
C. Selvam, Siji Thomas, Jason R. Abbott, S. Kennedy +1 more
2011Angewandte Chemie46 citations Open access
Semantic Scholar
Sequence-selective recognition of double-stranded RNA and enhanced cellular uptake of cationic nucleobase and backbone-modified peptide nucleic acids
Dziyana Hnedzko, D. McGee, Yannis Karamitas, E. Rozners
2017RNA: A publication of the RNA Society45 citations Open access
Semantic Scholar
Sequence Selective Recognition of Double-Stranded RNA at Physiologically Relevant Conditions Using PNA-Peptide Conjugates
Oluwatoyosi Muse, Thomas T. Zengeya, Juddy Mwaura, Dziyana Hnedzko +3 more
2013ACS Chemical Biology43 citations Open access
Semantic Scholar
Asymmetric synthesis of trans-3,4-dialkyl-gamma-butyrolactones via an acyl-Claisen and iodolactonization route.
Qun Xu, E. Rozners
2005Organic Letters40 citations
Semantic Scholar
Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs
Daniel Mutisya, Travis Hardcastle, Samwel K. Cheruiyot, P. Pallan +5 more
2017Nucleic Acids Research38 citations Open access
Semantic Scholar
Identification of Tau Stem Loop RNA Stabilizers
C. P. Donahue, Jake Ni, E. Rozners, M. Glicksman +1 more
2007Journal of biomolecular screening36 citations Open access
Semantic Scholar
Carbohydrate Chemistry for RNA Interference: Synthesis and Properties of RNA Analogues Modified in Sugar-Phosphate Backbone
E. Rozners
200628 citations
Semantic Scholar
Amide-Modified RNA: Using Protein Backbone to Modulate Function of Short Interfering RNAs
Venubabu Kotikam, E. Rozners
2020Accounts of Chemical Research27 citations Open access
Semantic Scholar
Synthetic, Structural, and RNA Binding Studies on 2-Aminopyridine-Modified Triplex-Forming Peptide Nucleic Acids.
Venubabu Kotikam, S. Kennedy, J. A. MacKay, E. Rozners
2019Chemistry27 citations
Semantic Scholar
A Single Amide Linkage in the Passenger Strand Suppresses Its Activity and Enhances Guide Strand Targeting of siRNAs
Travis Hardcastle, I. Novosjolova, Venubabu Kotikam, Samwel K. Cheruiyot +6 more
2018ACS Chemical Biology26 citations Open access
Semantic Scholar
Synthesis and properties of triazole-linked RNA
Daniel Mutisya, C. Selvam, S. Kennedy, E. Rozners
2011Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Effects of non‐catalytic, distal amino acid residues on activity of E. coli DinB (DNA polymerase IV)
J. Walsh, Ramya Parasuram, Pradyumna R. Rajput, E. Rozners +2 more
2012Environmental and Molecular Mutagenesis24 citations Open access
Semantic Scholar
Synthesis, Biophysical Studies and RNA Interference Activity of RNA Having Three Consecutive Amide Linkages
Paul Tanui, S. Kennedy, Benjamin D Lunstad, Amanda Haas +2 more
2014Organic and biomolecular chemistry23 citations Open access
Semantic Scholar
2-Aminopyridine Nucleobase Improves Triple Helical Recognition of RNA and DNA when Used Instead of Pseudoisocytosine in Peptide Nucleic Acids
Christopher A. Ryan, N. Brodyagin, Justin Lok, E. Rozners
2021Biochemistry20 citations Open access
Semantic Scholar
PNA containing isocytidine nucleobase: synthesis and recognition of double helical RNA
Thomas T. Zengeya, Ming Li, E. Rozners
2011Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Interplay of Structure, Hydration and Thermal Stability in Formacetal Modified Oligonucleotides: RNA May Tolerate Nonionic Modifications Better than DNA
A. Kolarovič, E. Schweizer, E. Greene, M. Gironda +3 more
2009Journal of the American Chemical Society20 citations Open access
Semantic Scholar
Fluorescent 2‐Aminopyridine Nucleobases for Triplex‐Forming Peptide Nucleic Acids
Samwel K. Cheruiyot, E. Rozners
2016ChemBioChem19 citations
Semantic Scholar
Synthesis and RNA binding properties of extended nucleobases for triplex-forming peptide nucleic acids.
Ilze Kumpiņa, N. Brodyagin, J. A. MacKay, S. Kennedy +2 more
2019Journal of Organic Chemistry18 citations
Semantic Scholar
Using Triple Helix Forming Peptide Nucleic Acids for Sequence-selective Recognition of Double-stranded RNA
Dziyana Hnedzko, Samwel K. Cheruiyot, E. Rozners
2014Current Protocols in Nucleic Acid Chemistry17 citations Open access
Semantic Scholar
Triple-Helical Binding of Peptide Nucleic Acid Inhibits Maturation of Endogenous MicroRNA-197
T. Endoh, N. Brodyagin, Dziyana Hnedzko, N. Sugimoto +1 more
2021ACS Chemical Biology16 citations Open access
Semantic Scholar
Triplex-forming peptide nucleic acid modified with 2-aminopyridine as a new tool for detection of A-to-I editing.
C. Annoni, T. Endoh, Dziyana Hnedzko, E. Rozners +1 more
2016Chemical Communications16 citations
Semantic Scholar
Discrimination against major groove adducts by Y-family polymerases of the DinB subfamily.
J. Walsh, Paul Ippoliti, Erin A. Ronayne, E. Rozners +1 more
2013DNA Repair16 citations
Semantic Scholar
Triplex-forming peptide nucleic acids as emerging ligands to modulate structure and function of complex RNAs
M. Katkevics, James A MacKay, E. Rozners
2024Chemical Communications14 citations
Semantic Scholar
Synthesis and properties of peptide nucleic acid labeled at the N-terminus with HiLyte Fluor 488 fluorescent dye
Dziyana Hnedzko, D. McGee, E. Rozners
2016Bioorganic & Medicinal Chemistry14 citations Open access
Semantic Scholar
Triplex-Forming Peptide Nucleic Acid Controls Dynamic Conformations of RNA Bulges
Christopher A. Ryan, Md Motiar Rahman, Vipin Kumar, E. Rozners
2023Journal of the American Chemical Society13 citations Open access
Semantic Scholar
Oligoribonucleotide Analogues Containing a Mixed Backbone of Phosphodiester and Formacetal Internucleoside Linkages, Together with Vicinal 2′‐O‐Methyl Groups
E. Rozners, Dace Katkevica, R. Strömberg
2007ChemBioChem13 citations
Semantic Scholar
Toward amide-modified RNA: synthesis of 3'-aminomethyl-5'-carboxy-3',5'-dideoxy nucleosides.
Qun Xu, Dace Katkevica, E. Rozners
2006Journal of Organic Chemistry13 citations
Semantic Scholar
Amide Modifications in the Seed Region of the Guide Strand Improve the On-Target Specificity of Short Interfering RNA
Michael Richter, Julien A Viel, Venubabu Kotikam, Praveen K. Gajula +3 more
2022ACS Chemical Biology12 citations Open access
Semantic Scholar
Pyridazine Nucleobase in Triplex-Forming PNA Improves Recognition of Cytosine Interruptions of Polypurine Tracts in RNA
N. Brodyagin, Ilze Kumpiņa, Justin Applegate, M. Katkevics +1 more
2021ACS Chemical Biology12 citations Open access
Semantic Scholar
Sequence selective recognition of double-stranded RNA using triple helix-forming peptide nucleic acids.
Thomas T. Zengeya, Pankaj Gupta, E. Rozners
2014Methods in molecular biology11 citations
Semantic Scholar
Triplex-Forming Peptide Nucleic Acids with Extended Backbones
Vipin Kumar, N. Brodyagin, E. Rozners
2020ChemBioChem10 citations Open access
Semantic Scholar
Concurrent Hydrogenation of Three Functional Groups Enables Synthesis of C3´-Homologated Nucleoside Amino Acids
Venubabu Kotikam, E. Rozners
2017Organic Letters10 citations Open access
Semantic Scholar
Monomers for preparation of amide linked RNA: Synthesis of C3’-homologated nucleoside amino acids from d-xylose
Paul Tanui, M. Kullberg, Ni Song, Yashodhan Chivate +1 more
2010Tetrahedron10 citations Open access
Semantic Scholar
Nucleobase and Linker Modification for Triple‐Helical Recognition of Pyrimidines in RNA Using Peptide Nucleic Acids
Ilze Kumpiņa, Vladislavs Baskevics, Khoi Nguyen, M. Katkevics +1 more
2023ChemBioChem9 citations Open access
Semantic Scholar
Synthesis and Biological Activity of Short Interfering RNAs Having Several Consecutive Amide Internucleoside Linkages
Venubabu Kotikam, Julien A Viel, E. Rozners
2019Chemistry9 citations Open access
Semantic Scholar
Determination of Nucleic Acid Hydration Using Osmotic Stress
E. Rozners
2010Current Protocols in Nucleic Acid Chemistry9 citations Open access
Semantic Scholar
Amide Internucleoside Linkages Are Well Tolerated in Protospacer Adjacent Motif-Distal Region of CRISPR RNAs
Venubabu Kotikam, Praveen K. Gajula, Lamorna Coyle, E. Rozners
2022ACS Chemical Biology8 citations Open access
Semantic Scholar

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M. Egli×8
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Venubabu Kotikam×8
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Dziyana Hnedzko×7
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S. Kennedy×7
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Thomas T. Zengeya×6

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N. Brodyagin×6

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M. Katkevics×5

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M. Manoharan×4

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Daniel Mutisya×4

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