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T. Kryza · SciRah

Researcher profile · Semantic Scholar

T. Kryza

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T. Kryza — researcher profile on SciRah

h-index: 17
Works: 45
Citations: 812

Most-cited papers

The kallikrein-related peptidase family: Dysregulation and functions during cancer progression.
T. Kryza, M. L. Silva, D. Loessner, N. Heuzé-Vourc'h +1 more
2016Biochimie97 citations
Semantic Scholar
Post-GWAS in prostate cancer: from genetic association to biological contribution
S. Farashi, T. Kryza, J. Clements, J. Batra
2018Nature Reviews. Cancer88 citations Open access
Semantic Scholar
Remodelling of the tumour microenvironment by the kallikrein-related peptidases
Srilakshmi Srinivasan, T. Kryza, J. Batra, J. Clements
2022Nature Reviews. Cancer71 citations
Semantic Scholar
The CDCP1 Signaling Hub: A Target for Cancer Detection and Therapeutic Intervention
T. Khan, T. Kryza, Nicholas J. Lyons, Yao-Wu He +1 more
2021Cancer Research63 citations
Semantic Scholar
GelMA, Click-Chemistry Gelatin and Bioprinted Polyethylene Glycol-Based Hydrogels as 3D Ex Vivo Drug Testing Platforms for Patient-Derived Breast Cancer Organoids
N. Bock, F. Forouz, Luke Hipwood, Julien Clegg +10 more
2023Pharmaceutics59 citations Open access
Semantic Scholar
Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment
N. Bock, Ali Shokoohmand, T. Kryza, Joan Röhl +5 more
2019Bone Research47 citations Open access
Semantic Scholar
In vitro engineering of a bone metastases model allows for study of the effects of antiandrogen therapies in advanced prostate cancer
N. Bock, T. Kryza, Ali Shokoohmand, Joan Röhl +5 more
2021Science Advances43 citations Open access
Semantic Scholar
Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation
T. Khan, Mitchell A. Sullivan, J. Gunter, T. Kryza +3 more
2020Frontiers in Oncology43 citations Open access
Semantic Scholar
Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma
T. Kryza, T. Khan, S. Puttick, Chao Li +20 more
2020Theranostics31 citations Open access
Semantic Scholar
A Suite of Activity-Based Probes To Dissect the KLK Activome in Drug-Resistant Prostate Cancer
S. Lovell, Leran Zhang, T. Kryza, Anna Neodo +11 more
2021bioRxiv27 citations Open access
Semantic Scholar
Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer
Brittney S. Harrington, Yao-Wu He, T. Khan, S. Puttick +18 more
2020Theranostics26 citations Open access
Semantic Scholar
Kallikrein‐related peptidase 4 induces cancer‐associated fibroblast features in prostate‐derived stromal cells
T. Kryza, L. M. Silva, N. Bock, R. A. Fuhrman-Luck +8 more
2017Molecular Oncology24 citations Open access
Semantic Scholar
Integration of Two In-depth Quantitative Proteomics Approaches Determines the Kallikrein-related Peptidase 7 (KLK7) Degradome in Ovarian Cancer Cell Secretome*
L. M. Silva, T. Kryza, T. Stoll, C. Hoogland +7 more
2019Molecular & Cellular Proteomics23 citations Open access
Semantic Scholar
The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer
T. Kryza, N. Bock, S. Lovell, A. Rockstroh +15 more
2019Molecular Oncology21 citations Open access
Semantic Scholar
Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1
T. Kryza, T. Khan, S. Lovell, Brittney S. Harrington +11 more
2021Nature Chemical Biology20 citations Open access
Semantic Scholar
Reactive Oxygen Species as Mediators of Disease Progression and Therapeutic Response in Colorectal Cancer
N. Lyons, R. Giri, J. Begun, David A. Clark +4 more
2023Antioxidants and Redox Signaling18 citations
Semantic Scholar
MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by Protecting the Mucosal Epithelial Barrier
M. McGuckin, Julie M Davies, Pascal Felgner, K. Wong +12 more
2023Cellular and Molecular Gastroenterology and Hepatology18 citations Open access
Semantic Scholar
CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy
T. Khan, Nicholas J. Lyons, M. Gough, K. Kwah +13 more
2022Theranostics14 citations Open access
Semantic Scholar
A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer
Srilakshmi Srinivasan, T. Kryza, Nathalie Bock, Brian W C Tse +221 more
2024Nature Communications13 citations Open access
Semantic Scholar
Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells
Esha T. Shah, C. Molloy, M. Gough, T. Kryza +15 more
2024British Journal of Cancer12 citations Open access
Semantic Scholar
Disruption of Glycogen Utilization Markedly Improves the Efficacy of Carboplatin against Preclinical Models of Clear Cell Ovarian Carcinoma
T. Khan, Yao-Wu He, T. Kryza, Brittney S. Harrington +21 more
2020Cancers12 citations Open access
Semantic Scholar
Mass spectrometry-based determination of Kallikrein-related peptidase 7 (KLK7) cleavage preferences and subsite dependency
L. M. Silva, T. Stoll, T. Kryza, C. Stephens +5 more
2017Scientific Reports10 citations Open access
Semantic Scholar
Improved concordance of challenging human epidermal growth factor receptor 2 dual in‐situ hybridisation cases with the use of a digital image analysis algorithm in breast cancer
M. Gough, Cheng Liu, B. Srinivasan, L. Wilkinson +8 more
2023Histopathology9 citations Open access
Semantic Scholar
KLK4 Induces Anti-Tumor Effects in Human Xenograft Mouse Models of Orthotopic and Metastatic Prostate Cancer
B. Tse, T. Kryza, Mei-Chun Yeh, Ying-Jin Dong +8 more
2020Cancers6 citations Open access
Semantic Scholar
Preclinical Evaluation of a Fluorescent Probe Targeting Receptor CDCP1 for Identification of Ovarian Cancer.
Yao-Wu He, T. Khan, T. Kryza, Martina L. Jones +18 more
2021Molecular Pharmaceutics5 citations
Semantic Scholar
Receptor CDCP1 is a potential target for personalized imaging and treatment of poor outcome HER2+, triple negative and metastatic ER+/HER2- breast cancers.
M. Gough, K. Kwah, T. Khan, Saikat Ghosh +19 more
2025Clinical Cancer Research4 citations
Semantic Scholar
Preclinical Molecular PET-CT Imaging Targeting CDCP1 in Colorectal Cancer
T. Cuda, Yao-Wu He, T. Kryza, T. Khan +14 more
2021Contrast Media & Molecular Imaging4 citations Open access
Semantic Scholar
Pathogenic OTUD3 Mutations Predispose to Ulcerative Colitis Due to Barrier Dysfunction
R. Giri, Minyi Lee, G. Magor, A. Bergot +15 more
2025Cellular and Molecular Gastroenterology and Hepatology3 citations Open access
Semantic Scholar
Development of a CUB domain-containing protein 1 (CDCP1)-targeting antibody-drug conjugate for triple-negative and metastatic breast cancer.
M. Gough, K. Kwah, Yao-Wu He, C. Snell +2 more
2023Journal of Clinical Oncology2 citations
Semantic Scholar
Pathway Analysis of Genes Identified through Post-GWAS to Underpin Prostate Cancer Aetiology
S. Farashi, T. Kryza, J. Batra
2019Genes2 citations Open access
Semantic Scholar
Glycogen phosphorylase inhibition alongside taxol chemotherapy synergistically elicits ferroptotic cell death in clear cell ovarian and kidney cancers
T. Khan, T. Kryza, Yao-Wu He, J. Gunter +3 more
2023bioRxiv1 citations Open access
Semantic Scholar
Development of antibody-drug conjugates targeting the CDCP1 receptor for the treatment of Triple negative and metastatic breast cancer
M. Gough, K. Kwah, T. Khan, Y. He +5 more
2022European Journal of Cancer1 citations
Semantic Scholar
Abstract P4-07-26: Development of CDCP1-targeting antibody-drug conjugate for Triple negative and metastatic breast cancer
M. Gough, T. Khan, K. Kwah, Yao-Wu He +5 more
2023Cancer Research0 citations
Semantic Scholar
Unravelling the Role of Iroquois Homeobox 4 and its Interplay with Androgen Receptor in Prostate Cancer
Panchadsaram Janaththani, G. Tevž, Achala Fernando, Adil Malik +9 more
2023Research Square0 citations Open access
Semantic Scholar
Biochemical activity induced by a germline variation in KLK3 (PSA) associates with cellular function and clinical outcome in prostate cancer
Srilakshmi Srinivasan, T. Kryza, N. Bock, B. Tse +62 more
2023Research Square0 citations Open access
Semantic Scholar
HER2 in situ hybridization testing in breast cancer: Applying algorithm-assisted assessment to reduce interobserver variability in difficult cases.
M. Gough, Cheng Liu, B. Srinivasan, L. Wilkinson +7 more
2023Journal of Clinical Oncology0 citations Open access
Semantic Scholar
EP-368 Intraoperative identification of colorectal cancer lesions using indocyanine green labelled antibodies in preclinical murine models
Nicholas J. Lyons, J. Hooper, David A. Clark, A. Riddell +1 more
2022British Journal of Surgery0 citations
Semantic Scholar
EP-369 Examining EphA2 expression in Colorectal Cancer
Nicholas J. Lyons, J. Hooper, T. Kryza, David A. Clark +1 more
2022British Journal of Surgery0 citations
Semantic Scholar
100: EXOME SEQUENCING OF A FAMILY WITH A SEVERE COLITIS PHENOTYPE IDENTIFIES A RARE MISSENSE MUTATION IN A NOVEL IBD GENE
R. Giri, Robert J. Gordon, G. Magor, Yao-Wu He +10 more
2022Gastroenterology0 citations
Semantic Scholar
Substrate-biased activity-based probes identify the urokinase-plasminogen axis as a master regulator of metastatic signaling by orphan membrane receptor CDCP1
T. Kryza, T. Khan, S. Lovell, Brittney S. Harrington +11 more
20200 citations Open access
Semantic Scholar
A GWAS identified functional variation in PSA (KLK3) gene that confers lower risk is also associated with more aggressive disease and lower survival in men with prostate cancer
Srilakshmi Srinivasan, T. Kryza, N. Bock, C. Stephens +17 more
2019Oncology Abstracts0 citations
Semantic Scholar
"Theranostics": radioimmunodetection and radioimmunotherapy for metastatic colorectal cancer
T. Cuda, J. Hooper, S. Puttick, Yao-Wu He +2 more
20190 citations
Semantic Scholar
Title: Integration of two in-depth quantitative proteomics approaches determines the kallikrein- related peptidase 7 (KLK7) degradome in ovarian cancer cell secretome. Authors and affiliations:
L. M. Silva, T. Kryza, T. Stoll, C. Hoogland +8 more
20180 citations
Semantic Scholar
Modulation of protease expression in prostate cancer cells after androgen deprivation
T. Kryza, G. Tevž, S. McPherson, M. Lehman +2 more
20150 citations
Semantic Scholar
Kallikrein-related peptidase 4 induces tumour microenvironment alterations that support tumour growth
R. A. Fuhrman-Luck, T. Kryza, M. L. Hastie, T. Stoll +8 more
20150 citations
Semantic Scholar

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