Researcher profile · Semantic Scholar

J. Morphy

h-index: 15
Works: 39
Citations: 829

Most-cited papers

Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
G. Pupo, F. Ibba, D. Ascough, A. C. Vicini +7 more
2018Science136 citations
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Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase.
P. Hill, A. Docherty, K. M. K. Bottomley, J. O'Connell +3 more
1995Biochemical Journal99 citations Open access
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General routes for the synthesis of mono, di and tri-n-substituted derivatives of cyclam
I. Helps, D. Parker, J. Morphy, J. Chapman
198965 citations
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Designing multi-target drugs
J. Morphy, C. Harris
201264 citations
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Synthesis of an array of amides by aluminium chloride assisted cleavage of resin-bound esters
D. Barn, J. Morphy, D. Rees
199658 citations
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Matrix Metalloproteinase Inhibitors: Current Status
J. Morphy, T. Millican, J. R. Porter
1995Current Medicinal Chemistry44 citations
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Antibody labelling with functionalised cyclam macrocycles
J. Morphy, D. Parker, R. Alexander, A. Bains +8 more
198834 citations
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Towards tumour targeting with copper-radiolabelled macrocycle–antibody conjugates: synthesis, antibody linkage, and complexation behaviour
J. Morphy, D. Parker, R. Kataky, M. Eaton +4 more
199030 citations
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Potent and selective inhibitors of gelatinase-A 2. carboxylic and phosphonic acid derivatives
J. Morphy, N. Beeley, Byron A. Boyce, J. Leonard +5 more
199429 citations
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Implementation of macrocycle conjugated antibodies for tumour-targetting
D. Parker, J. Morphy, K. Jankowski, Jonathan P. L. Cox
198928 citations Open access
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The dual role of thiourea in the thiotrifluoromethylation of alkenes
P. Ricci, Tanatorn Khotavivattana, Lukas Pfeifer, M. Médebielle +2 more
2016Chemical Science24 citations Open access
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Towards tumour targeting with copper-radiolabelled macrocycle–antibody conjugates
J. Morphy, D. Parker, R. Kataky, A. Harrison +4 more
198923 citations
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Linkers for solid-phase organic synthesis.
J. Morphy
1998Current opinion in drug discovery & development20 citations
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Chapter 10:The Challenges of Multi-Target Lead Optimization
J. Morphy
201219 citations
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Parallel synthesis and biological activity of a new class of high affinity and selective delta-opioid ligand.
David R. Barn, W. Caulfield, J. Cottney, K. McGurk +3 more
2001Bioorganic & Medicinal Chemistry18 citations
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ChEMBLSpace - a graphical explorer of the chemogenomic space covered by the ChEMBL database
N. Fechner, G. Papadatos, David A. Evans, J. Morphy +3 more
2013Bioinform.13 citations Open access
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Review Oncologic, Endocrine & Metabolic: Recent developments in matrix metalloproteinase inhibitors
J. R. Porter, T. Millican, J. Morphy
199513 citations
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Design and synthesis of a maximally diverse and druglike screening library using REM resin methodology.
D. Barn, W. Caulfield, P. Cowley, R. Dickins +5 more
2001Journal of combinatorial chemistry12 citations
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Fluorocarbon accelerated supported transformations (FAST) on REM resin
J. Morphy, Z. Rankovic, M. York
200112 citations
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Synthesis of novel analogues of the delta opioid ligand SNC-80 using REM resin.
J. Cottney, Z. Rankovic, J. Morphy
1999Bioorganic & Medicinal Chemistry Letters12 citations Open access
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Low dilution procedures in solid-phase organic synthesis: Diels-Alder and Heck reactions
J. Morphy, Z. Rankovic, M. York
200211 citations
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Optimization of reaction conditions for REM resin-bound quaternization reactions.
K. Cameron, J. Morphy, Z. Rankovic, M. York
2002Journal of combinatorial chemistry11 citations
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Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins.
M. Plater, Alison M. Murdoch, J. Morphy, Z. Rankovic +1 more
2000Journal of combinatorial chemistry11 citations
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Solid-phase synthesis of cyclic imides.
D. Barn, J. Morphy
1999Journal of combinatorial chemistry9 citations
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One-pot Hofmann elimination-transesterification/amidation reactions on REM resin using perfluorous solvents
J. Morphy, Z. Rankovic, M. York
20028 citations
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Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist.
Angus R. Brown, Michael Bosies, H. Cameron, J. K. Clark +34 more
2011Bioorganic & Medicinal Chemistry Letters7 citations Open access
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Chapter 8:Historical Strategies for Lead Generation
J. Morphy
20126 citations
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Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
S. Napier, Jeffrey J. Letourneau, N. Ansari, D. Auld +22 more
2011Bioorganic & Medicinal Chemistry Letters6 citations Open access
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Reagent concentration effects in the REM resin solid phase synthesis of tertiary amines
J. Morphy, Z. Rankovic, M. York
20035 citations
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Potent, selective inhibitors of human gelatinase and their potential in the treatment of tumour metastases
J. Morphy, T. S. Baker, N. Beeley, M. Birch +17 more
19941 citations
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General Routes for the Synthesis of Mono‐, Di‐ and Tri‐N‐Substituted Derivatives of Cyclam.
I. Helps, D. Parker, J. Morphy, J. Chapman
19891 citations
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Medicinal Chemistry Strategies to Prevent Compound Attrition
J. Morphy
20150 citations
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Identification and optimisation of novel sulfonamide, selective vasopressin V1B receptor antagonists.
James Baker, M. Bingham, R. Blackburn-Munro, Jia-Qiang Cai +10 more
2011Bioorganic & Medicinal Chemistry Letters0 citations Open access
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Isoquinoline derivatives as inhibitors 6-substituted-1 rock.
Steven Laats, J. Morphy, P. Ray, B. Sherborne
20070 citations
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Inhibition ofboneresorption invitro byselective inhibitors ofgelatinase andcollagenase
P. Hill, J. Docherty, K. Bottomley, J. Morphy +1 more
19950 citations
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Gelatinase inhibitors and tumour metastasis
A. Millican, T. S. Baker, N. Beeley, M. Birch +18 more
19950 citations
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Derives phosphono d'acides amines en tant qu'inhibiteurs de metalloproteases
N. R. A. Beeley, Thomas Andrew Millican, J. Morphy
19930 citations
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Towards Tumor Targeting with Copper-Radiolabeled Macrocycle-Antibody Conjugates: Synthesis, Antibody Linkage, and Complexation Behavior.
J. Morphy, D. Parker, R. Kataky, M. Eaton +4 more
19900 citations
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Functionalised macrocycles for tumour targeting
J. Morphy
19880 citations
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M. Eaton

×4

A. Harrison×4

A. Docherty×3

J. O'Connell×3

D. Barn×3

J. R. Porter×3

R. Alexander×3

R. Kataky×3