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Rainer Lehtonen · SciRah

Researcher profile · Semantic Scholar

Rainer Lehtonen

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Rainer Lehtonen — researcher profile on SciRah

h-index: 35
Works: 111
Citations: 6,480

Most-cited papers

Pituitary Adenoma Predisposition Caused by Germline Mutations in the AIP Gene
O. Vierimaa, M. Georgitsi, Rainer Lehtonen, P. Vahteristo +12 more
2006Science591 citations
Semantic Scholar
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling
S. Tuupanen, M. Turunen, Rainer Lehtonen, Outi K. Hallikas +19 more
2009Nature Genetics534 citations
Semantic Scholar
The Glanville fritillary genome retains an ancient karyotype and reveals selective chromosomal fusions in Lepidoptera
Virpi Ahola, Rainer Lehtonen, P. Somervuo, L. Salmela +43 more
2014Nature Communications224 citations Open access
Semantic Scholar
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance
Elina A. Pietilä, J. Gonzalez-Molina, L. Moyano-Galceran, S. Jamalzadeh +16 more
2021Nature Communications160 citations Open access
Semantic Scholar
Lep-MAP: fast and accurate linkage map construction for large SNP datasets
P. Rastas, L. Paulin, I. Hanski, Rainer Lehtonen +1 more
2013Bioinform.125 citations Open access
Semantic Scholar
Analysis of fumarate hydratase mutations in a population‐based series of early onset uterine leiomyosarcoma patients
Sanna K. Ylisaukko-oja, M. Kiuru, Heli J. Lehtonen, Rainer Lehtonen +4 more
2006International Journal of Cancer97 citations Open access
Semantic Scholar
A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients
M. Tumiati, S. Hietanen, J. Hynninen, Elina A. Pietilä +15 more
2018Clinical Cancer Research96 citations Open access
Semantic Scholar
Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin lymphoma.
S. Saarinen, M. Aavikko, K. Aittomäki, V. Launonen +15 more
2011Blood90 citations Open access
Semantic Scholar
Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma
D. Berta, Heli Kuisma, Niko Välimäki, Maritta Räisänen +23 more
2021Nature85 citations
Semantic Scholar
Mutations in the Circadian Gene CLOCK in Colorectal Cancer
P. Alhopuro, Mikael Björklund, H. Sammalkorpi, M. Turunen +18 more
2010Molecular Cancer Research85 citations Open access
Semantic Scholar
Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans
Eevi Kaasinen, O. Kuismin, K. Rajamäki, H. Ristolainen +31 more
2019Nature Communications81 citations Open access
Semantic Scholar
Genomic profile of pseudomyxoma peritonei analyzed using next‐generation sequencing and immunohistochemistry
P. Nummela, L. Saarinen, A. Thiel, P. Järvinen +6 more
2015International Journal of Cancer78 citations Open access
Semantic Scholar
High genetic load in an old isolated butterfly population
A. L. K. Mattila, Anne Duplouy, Malla Kirjokangas, Rainer Lehtonen +2 more
2012Proceedings of the National Academy of Sciences of the United States of America77 citations Open access
Semantic Scholar
Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability
Niko Välimäki, Heli Kuisma, Annukka Pasanen, O. Heikinheimo +14 more
2018eLife70 citations Open access
Semantic Scholar
Predictable allele frequency changes due to habitat fragmentation in the Glanville fritillary butterfly
Toby Fountain, M. Nieminen, J. Siren, S. C. Wong +2 more
2016Proceedings of the National Academy of Sciences of the United States of America70 citations Open access
Semantic Scholar
Prevalence of Germline PTEN, BMPR1A, SMAD4, STK11, and ENG Mutations in Patients with Moderate-Load Colorectal Polyps
J. Ngeow, B. Heald, L. Rybicki, M. Orloff +12 more
2013Gastroenterology68 citations Open access
Semantic Scholar
SNP Design from 454 Sequencing of Podosphaera plantaginis Transcriptome Reveals a Genetically Diverse Pathogen Metapopulation with High Levels of Mixed-Genotype Infection
C. Tollenaere, H. Susi, Jussi Nokso-Koivisto, Patrik Koskinen +6 more
2012PLoS ONE66 citations Open access
Semantic Scholar
Plastic larval development in a butterfly has complex environmental and genetic causes and consequences for population dynamics.
M. Saastamoinen, Suvi Ikonen, S. C. Wong, Rainer Lehtonen +1 more
2013Journal of Animal Ecology57 citations
Semantic Scholar
Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1).
Eevi Kaasinen, K. Aittomäki, M. Eronen, P. Vahteristo +5 more
2010Human Molecular Genetics53 citations
Semantic Scholar
Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer
S. Saarinen, P. Vahteristo, Rainer Lehtonen, K. Aittomäki +3 more
2012Familial Cancer52 citations
Semantic Scholar
Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene
J. Känsäkoski, J. Jääskeläinen, T. Jääskeläinen, J. Tommiska +7 more
2016Scientific Reports51 citations Open access
Semantic Scholar
Background mutation frequency in microsatellite-unstable colorectal cancer.
H. Sammalkorpi, P. Alhopuro, Rainer Lehtonen, J. Tuimala +5 more
2007Cancer Research49 citations Open access
Semantic Scholar
BMPR2 mutation in a patient with pulmonary arterial hypertension and suspected hereditary hemorrhagic telangiectasia
C. Rigelsky, Constance Jennings, Rainer Lehtonen, Omar A. Minai +2 more
2008American Journal of Medical Genetics. Part A48 citations
Semantic Scholar
Prospective Longitudinal ctDNA Workflow Reveals Clinically Actionable Alterations in Ovarian Cancer
J. Oikkonen, Kaiyang Zhang, Liina Salminen, Ingrid Schulman +11 more
2019JCO Precision Oncology39 citations Open access
Semantic Scholar
Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma
S. K. Ylisaukko-oja, C. Cybulski, Rainer Lehtonen, M. Kiuru +9 more
2006European Journal of Human Genetics38 citations
Semantic Scholar
SePIA: RNA and small RNA sequence processing, integration, and analysis
Katherine Icay, Ping Chen, Alejandra Cervera, Ville Rantanen +2 more
2016BioData Mining37 citations Open access
Semantic Scholar
Mathematical Modeling Predicts Response to Chemotherapy and Drug Combinations in Ovarian Cancer.
Emilia Kozłowska, A. Färkkilä, Tuulia Vallius, O. Carpén +6 more
2018Cancer Research36 citations Open access
Semantic Scholar
Identification of Prognostic Groups in High-Grade Serous Ovarian Cancer Treated with Platinum-Taxane Chemotherapy.
Ping Chen, K. Huhtinen, Katja Kaipio, P. Mikkonen +8 more
2015Cancer Research35 citations Open access
Semantic Scholar
MicroRNAs regulate key cell survival pathways and mediate chemosensitivity during progression of diffuse large B-cell lymphoma
S. Leivonen, Katherine Icay, Kirsi Jäntti, Ilari Sirén +12 more
2017Blood Cancer Journal34 citations Open access
Semantic Scholar
Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditary leiomyomatosis and renal cell cancer
Taru A. Koski, Heli J. Lehtonen, K. Jee, S. Ninomiya +15 more
2009Genes, Chromosomes and Cancer34 citations
Semantic Scholar
Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer.
T. Ahvenainen, Heli J. Lehtonen, Rainer Lehtonen, P. Vahteristo +18 more
2008Cancer Genetics and Cytogenetics34 citations
Semantic Scholar
Flight‐induced changes in gene expression in the Glanville fritillary butterfly
J. Kvist, A. L. K. Mattila, P. Somervuo, Virpi Ahola +12 more
2015Molecular Ecology31 citations
Semantic Scholar
No evidence for a genetic modifier for renal cell cancer risk in HLRCC syndrome
P. Vahteristo, Taru A. Koski, Laura Näätsaari, M. Kiuru +17 more
2010Familial Cancer31 citations
Semantic Scholar
PRISM: recovering cell-type-specific expression profiles from individual composite RNA-seq samples
Antti Häkkinen, Kaiyang Zhang, A. Alkodsi, N. Andersson +12 more
2021Bioinform.27 citations Open access
Semantic Scholar
EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis
A. Kokko, P. Laiho, Rainer Lehtonen, Sanna Korja +8 more
2006BMC Cancer27 citations Open access
Semantic Scholar
Distinct subtypes of diffuse large B-cell lymphoma defined by hypermutated genes
A. Alkodsi, Alejandra Cervera, Kaiyang Zhang, R. Louhimo +7 more
2019Leukemia25 citations
Semantic Scholar
Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma
L. Meriranta, A. Pasanen, R. Louhimo, Alejandra Cervera +10 more
2017Haematologica25 citations Open access
Semantic Scholar
Anagrelide for Gastrointestinal Stromal Tumor
Olli-Pekka Pulkka, Y. Gebreyohannes, A. Wozniak, J. Mpindi +16 more
2018Clinical Cancer Research24 citations Open access
Semantic Scholar
Alternative splicing discriminates molecular subtypes and has prognostic impact in diffuse large B-cell lymphoma
S. Leivonen, M. Taskinen, Alejandra Cervera, M. Karjalainen-Lindsberg +5 more
2017Blood Cancer Journal22 citations Open access
Semantic Scholar
Phenotypic plasticity in thermal tolerance in the Glanville fritillary butterfly.
Shi-Qi Luo, Swee Chong Wong, Chongren Xu, I. Hanski +2 more
2014Journal of Thermal Biology22 citations
Semantic Scholar
Nationwide Registry-Based Analysis of Cancer Clustering Detects Strong Familial Occurrence of Kaposi Sarcoma
Eevi Kaasinen, M. Aavikko, P. Vahteristo, T. Patama +10 more
2013PLoS ONE22 citations Open access
Semantic Scholar
Multiple components of PKA and TGF-β pathways are mutated in pseudomyxoma peritonei
L. Saarinen, P. Nummela, A. Thiel, Rainer Lehtonen +6 more
2017PLoS ONE19 citations Open access
Semantic Scholar
Effects of ambient and preceding temperatures and metabolic genes on flight metabolism in the Glanville fritillary butterfly
S. C. Wong, A. Oksanen, A. L. K. Mattila, Rainer Lehtonen +2 more
2016Journal of insect physiology19 citations Open access
Semantic Scholar
Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers.
T. Hienonen, H. Sammalkorpi, S. Enholm, P. Alhopuro +13 more
2005Cancer Research18 citations Open access
Semantic Scholar
Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling‐path microarray CGH and mutation analysis of known genes in this region
S. Vanharanta, Noel C. Wortham, C. Langford, M. El-Bahrawy +6 more
2007Genes, Chromosomes and Cancer17 citations
Semantic Scholar
Open Source Infrastructure for Health Care Data Integration and Machine Learning Analyses.
V. Isoviita, Liina Salminen, Jimmy Azar, Rainer Lehtonen +7 more
2019JCO Clinical Cancer Informatics15 citations
Semantic Scholar
Data integration to prioritize drugs using genomics and curated data
R. Louhimo, M. Laakso, D. Belitškin, Juha Klefström +2 more
2016BioData Mining14 citations Open access
Semantic Scholar
Identification of sample-specific regulations using integrative network level analysis
Cheng-Yu Liu, R. Louhimo, M. Laakso, Rainer Lehtonen +1 more
2015BMC Cancer13 citations Open access
Semantic Scholar
Deciphering cancer genomes with GenomeSpy: a grammar-based visualization toolkit
Kari Lavikka, J. Oikkonen, Yilin Li, T. Muranen +9 more
2023bioRxiv9 citations Open access
Semantic Scholar
Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high‐grade serous ovarian cancer
F. Deng, Maren Laasik, Liina Salminen, Lauri Lapatto +6 more
2023Basic & Clinical Pharmacology & Toxicology8 citations Open access
Semantic Scholar

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