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Joachim H. C. Orth · SciRah

Researcher profile · Semantic Scholar

Joachim H. C. Orth

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Joachim H. C. Orth — researcher profile on SciRah

h-index: 22
Works: 38
Citations: 1,168

Most-cited papers

Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation
Joachim H. C. Orth, I. Preuss, Ines Fester, A. Schlosser +2 more
2009Proceedings of the National Academy of Sciences of the United States of America112 citations Open access
Semantic Scholar
Cell-free synthesis and characterization of a novel cytotoxic pierisin-like protein from the cabbage butterfly Pieris rapae.
Joachim H. C. Orth, B. Schorch, S. Boundy, R. ffrench-Constant +2 more
2011Toxicon79 citations
Semantic Scholar
Pasteurella multocida Toxin-induced Activation of RhoA Is Mediated via Two Families of Gα Proteins, Gαq and Gα12/13*
Joachim H. C. Orth, Simona Lang, M. Taniguchi, K. Aktories
2005Journal of Biological Chemistry74 citations Open access
Semantic Scholar
Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure
S. Mayer, Ralf Gilsbach, Sebastian Preissl, Elsa Beatriz Monroy Ordonez +25 more
2015Circulation Research68 citations Open access
Semantic Scholar
A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins
T. Jank, X. Bogdanović, C. Wirth, Erik Haaf +8 more
2013Nature Structural &Molecular Biology64 citations
Semantic Scholar
Biological Activity of a C-Terminal Fragment ofPasteurella multocida Toxin
C. Busch, Joachim H. C. Orth, N. Djouder, K. Aktories
2001Infection and Immunity58 citations Open access
Semantic Scholar
The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes
Jan Castonguay, Joachim H. C. Orth, T. Müller, Faten Sleman +7 more
2017Scientific Reports51 citations Open access
Semantic Scholar
Granzyme A produces bioactive IL-1β through a nonapoptotic inflammasome-independent pathway.
D. Hildebrand, K. Bode, David Rieß, Daniela Cerny +8 more
2014Cell Reports48 citations Open access
Semantic Scholar
Activation of Gαi and Subsequent Uncoupling of Receptor-Gαi Signaling by Pasteurella multocida Toxin*
Joachim H. C. Orth, Ines Fester, I. Preuss, L. Agnoletto +2 more
2008Journal of Biological Chemistry43 citations Open access
Semantic Scholar
Pasteurella multocida toxin is a potent activator of anti‐apoptotic signalling pathways
I. Preuss, D. Hildebrand, Joachim H. C. Orth, K. Aktories +1 more
2010Cellular Microbiology42 citations Open access
Semantic Scholar
Modulation of Host Cell Gene Expression through Activation of STAT Transcription Factors by Pasteurella multocida Toxin*
Joachim H. C. Orth, K. Aktories, K. F. Kubatzky
2007Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Action of Pasteurella multocida Toxin Depends on the Helical Domain of Gαq*
Joachim H. C. Orth, Simona Lang, K. Aktories
2004Journal of Biological Chemistry39 citations Open access
Semantic Scholar
Substrate specificity of Pasteurella multocida toxin for α subunits of heterotrimeric G proteins
Joachim H. C. Orth, Ines Fester, P. Siegert, M. Weise +7 more
2013The FASEB Journal34 citations Open access
Semantic Scholar
Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins
T. Brink, V. Leiss, P. Siegert, Doris Jehle +8 more
2018PLoS Pathogens32 citations Open access
Semantic Scholar
Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles
A. Eisenhardt, Adrian Sprenger, M. Röring, Ricarda Herr +14 more
2016OncoTarget32 citations Open access
Semantic Scholar
His1205 and His1223 are essential for the activity of the mitogenic Pasteurella multocida toxin.
Joachim H. C. Orth, Dagmar Blöcker, K. Aktories
2003Biochemistry32 citations
Semantic Scholar
Pasteurella Multocida Toxin Prevents Osteoblast Differentiation by Transactivation of the MAP-Kinase Cascade via the Gαq/11 - p63RhoGEF - RhoA Axis
P. Siegert, G. Schmidt, P. Papatheodorou, T. Wieland +2 more
2013PLoS Pathogens30 citations Open access
Semantic Scholar
Molecular biology of Pasteurella multocida toxin.
Joachim H. C. Orth, K. Aktories
2012Current Topics in Microbiology and Immunology30 citations
Semantic Scholar
Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins.
I. Preuss, Barbara Kurig, B. Nürnberg, Joachim H. C. Orth +1 more
2009Cellular Signalling28 citations
Semantic Scholar
Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of G{alpha} proteins, G{alpha}q and G{alpha}12/13.
Joachim H. C. Orth, Simona Lang, M. Taniguchi, K. Aktories
2005Journal of Biological Chemistry27 citations
Semantic Scholar
Action of Pasteurella multocida toxin on Galpha(q) is persistent and independent of interaction with G-protein-coupled receptors.
Joachim H. C. Orth, Simona Lang, I. Preuss, G. Milligan +1 more
2007Cellular Signalling23 citations
Semantic Scholar
Pasteurella multocida toxin (PMT) activates RhoGTPases, induces actin polymerization and inhibits migration of human dendritic cells, but does not influence macropinocytosis.
Dagmar Blöcker, L. Berod, J. Fluhr, Joachim H. C. Orth +3 more
2006International Immunology22 citations Open access
Semantic Scholar
Pasteurella multocida Toxin Activates Various Heterotrimeric G Proteins by Deamidation
Joachim H. C. Orth, K. Aktories
2010Toxins21 citations Open access
Semantic Scholar
Toxin-induced RhoA Activity Mediates CCL1-triggered Signal Transducers and Activators of Transcription Protein Signaling*
Simone Reipschläger, K. F. Kubatzky, S. Taromi, M. Burger +3 more
2012Journal of Biological Chemistry20 citations Open access
Semantic Scholar
Pasteurella multocida Toxin as a Transporter of Non-Cell-Permeating Proteins
Stefan Bergmann, Doris Jehle, Carsten Schwan, Joachim H. C. Orth +1 more
2013Infection and Immunity17 citations Open access
Semantic Scholar
Noncanonical G-Protein-Dependent Modulation of Osteoclast Differentiation and Bone Resorption Mediated by Pasteurella multocida Toxin
J. Strack, Hannah Heni, R. Gilsbach, L. Hein +2 more
2014mBio15 citations Open access
Semantic Scholar
Genome wide CRISPR screen for Pasteurella multocida toxin (PMT) binding proteins reveals LDL Receptor Related Protein 1 (LRP1) as crucial cellular receptor
Julian Schöllkopf, T. Müller, Lena Hippchen, Teresa Müller +6 more
2022bioRxiv12 citations Open access
Semantic Scholar
Pasteurella multocida : molecular biology, toxins and infection
K. Aktories, Joachim H. C. Orth, B. Adler
201211 citations
Semantic Scholar
Pasteurella multocida toxin
Brenda A. Wilson, S. Bergmann, M. Ho, Joachim H. C. Orth
201510 citations
Semantic Scholar
A systemic Pasteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice
M. Weise, C. Vettel, Katharina Spiger, R. Gilsbach +5 more
2015Cellular Microbiology10 citations Open access
Semantic Scholar
Activation of Gq signaling by Pasteurella multocida toxin inhibits the osteoblastogenic-like actions of Activin A in C2C12 myoblasts, a cell model of fibrodysplasia ossificans progressiva.
Julia K. Ebner, G. König, E. Kostenis, P. Siegert +2 more
2019Bone9 citations
Semantic Scholar
Involvement of Osteocytes in the Action of Pasteurella multocida Toxin
Hannah Heni, Julia K. Ebner, G. Schmidt, K. Aktories +1 more
2018Toxins9 citations Open access
Semantic Scholar
Anion secretion evoked by Pasteurella multocida toxin across rat colon.
B. Hennig, Joachim H. C. Orth, K. Aktories, M. Diener
2008European Journal of Pharmacology9 citations
Semantic Scholar
From cosubstrate similarity to inhibitor diversity--inhibitors of ADP-ribosyltransferases from kinase inhibitor screening.
B. Maurer, Ulf Mathias, P. Papatheodorou, S. Shekfeh +6 more
2011Molecular Biosystems8 citations
Semantic Scholar
Pleiotropic role of Rac in mast cell activation revealed by a cell permeable Bordetella dermonecrotic fusion toxin.
Heidi Stratmann, Carsten Schwan, Joachim H. C. Orth, G. Schmidt +1 more
2010Cellular Signalling5 citations
Semantic Scholar
Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication
Stefan Carle, T. Brink, Joachim H. C. Orth, K. Aktories +1 more
2017Toxins4 citations Open access
Semantic Scholar
Substrate speciﬁcity of Pasteurella multocida toxin for (cid:1) subunits of heterotrimeric G proteins for
Joachim H. C. Orth, Ines Fester, P. Siegert, M. Weise +7 more
20130 citations
Semantic Scholar
Pasteurella multocida.(Preface).
Klaus Aktories, Joachim H. C. Orth, B. Adler
2012Current Topics in Microbiology and Immunology0 citations
Semantic Scholar

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