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L. Quek · SciRah

Researcher profile · Semantic Scholar

L. Quek

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L. Quek — researcher profile on SciRah

h-index: 31
Works: 94
Citations: 3,585

Most-cited papers

AraGEM, a Genome-Scale Reconstruction of the Primary Metabolic Network in Arabidopsis1[W]
C. G. de Oliveira Dal'Molin, L. Quek, R. Palfreyman, S. Brumbley +1 more
2009Plant Physiology351 citations Open access
Semantic Scholar
Recon 2.2: from reconstruction to model of human metabolism
Neil Swainston, Kieran Smallbone, Hooman Hefzi, P. Dobson +21 more
2016Metabolomics290 citations Open access
Semantic Scholar
A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary (CHO) Cell Metabolism
Hooman Hefzi, Kok Siong Ang, Michael Hanscho, A. Bordbar +36 more
2016Cell Systems247 citations Open access
Semantic Scholar
C4GEM, a Genome-Scale Metabolic Model to Study C4 Plant Metabolism1[W][OA]
C. G. de Oliveira Dal'Molin, L. Quek, R. Palfreyman, S. Brumbley +1 more
2010Plant Physiology168 citations Open access
Semantic Scholar
Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption.
Verónica S. Martínez, Stefanie Dietmair, L. Quek, M. Hodson +2 more
2013Biotechnology and Bioengineering143 citations
Semantic Scholar
Low carbon fuels and commodity chemicals from waste gases – systematic approach to understand energy metabolism in a model acetogen
E. Marcellin, James Behrendorff, Shilpa Nagaraju, Sashini DeTissera +11 more
2016139 citations Open access
Semantic Scholar
AlgaGEM – a genome-scale metabolic reconstruction of algae based on the Chlamydomonas reinhardtii genome
Cristiana Gomes de Oliveira Dal'Molin, L. Quek, R. Palfreyman, L. Nielsen
2011BMC Genomics137 citations Open access
Semantic Scholar
Metabolic flux analysis in mammalian cell culture.
L. Quek, Stefanie Dietmair, J. Krömer, L. Nielsen
2010Metabolic Engineering137 citations
Semantic Scholar
A Multi-Omics Analysis of Recombinant Protein Production in Hek293 Cells
Stefanie Dietmair, M. Hodson, L. Quek, Nicholas E. Timmins +2 more
2012PLoS ONE120 citations Open access
Semantic Scholar
Metabolite profiling of CHO cells with different growth characteristics
Stefanie Dietmair, M. Hodson, L. Quek, Nicholas E. Timmins +4 more
2012Biotechnology and Bioengineering116 citations
Semantic Scholar
A multi-tissue genome-scale metabolic modeling framework for the analysis of whole plant systems
Cristiana Gomes de Oliveira Dal'Molin, L. Quek, P. Saa, L. Nielsen
2015Frontiers in Plant Science113 citations Open access
Semantic Scholar
Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease.
Timothy A. Couttas, N. Kain, Alexandra K Suchowerska, L. Quek +4 more
2016Neurobiology of Aging89 citations
Semantic Scholar
Epithelial-mesenchymal transition induction is associated with augmented glucose uptake and lactate production in pancreatic ductal adenocarcinoma
Menghan Liu, L. Quek, Ghazal Sultani, N. Turner
2016Cancer & Metabolism88 citations Open access
Semantic Scholar
Gut-derived acetate promotes B10 cells with antiinflammatory effects
C. Daïen, J. Tan, R. Audo, J. Mielle +18 more
2021JCI Insight79 citations Open access
Semantic Scholar
Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effect
Maria Buchsteiner, L. Quek, P. Gray, L. Nielsen
2018Biotechnology and Bioengineering75 citations
Semantic Scholar
Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism.
J. Krycer, K. Yugi, A. Hirayama, D. Fazakerley +17 more
2017Cell Reports67 citations Open access
Semantic Scholar
Lactate production is a prioritized feature of adipocyte metabolism
J. Krycer, L. Quek, D. Francis, D. Fazakerley +14 more
2019Journal of Biological Chemistry65 citations Open access
Semantic Scholar
C4GEM - Genome-Scale Metabolic Model to study C4 plant metabolism
C. G. de Oliveira Dal'Molin, L. Quek, R. Palfreyman, Stevens +2 more
201065 citations
Semantic Scholar
Dynamic metabolic flux analysis using B-splines to study the effects of temperature shift on CHO cell metabolism
Verónica S. Martínez, Maria Buchsteiner, P. Gray, L. Nielsen +1 more
2015Metabolic Engineering Communications64 citations Open access
Semantic Scholar
Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways
M. van Geldermalsen, L. Quek, N. Turner, Natasha Freidman +6 more
2018BMC Cancer62 citations Open access
Semantic Scholar
Reducing Recon 2 for steady-state flux analysis of HEK cell culture.
L. Quek, Stefanie Dietmair, Michael Hanscho, Verónica S. Martínez +2 more
2014Journal of Biotechnology62 citations
Semantic Scholar
Glutamine addiction promotes glucose oxidation in triple-negative breast cancer
L. Quek, M. van Geldermalsen, Yi F. Guan, K. Wahi +9 more
2022Oncogene57 citations Open access
Semantic Scholar
On the reconstruction of the Mus musculus genome-scale metabolic network model.
L. Quek, L. Nielsen
2008Genome informatics. International Conference on Genome Informatics56 citations
Semantic Scholar
Insulin signaling requires glucose to promote lipid anabolism in adipocytes
J. Krycer, L. Quek, D. Francis, Armella Zadoorian +20 more
2020Journal of Biological Chemistry53 citations Open access
Semantic Scholar
C 4 GEM , a Genome-Scale Metabolic Model to Study C 4 Plant Metabolism
C. G. de Oliveira Dal'Molin, L. Quek, R. Palfreyman, S. Brumbley +1 more
201050 citations
Semantic Scholar
ACSM1 and ACSM3 regulate fatty acid metabolism to support prostate cancer growth and constrain ferroptosis.
R. Shrestha, Zeyad D. Nassar, Adrienne R. Hanson, R. Iggo +14 more
2024Cancer Research45 citations Open access
Semantic Scholar
Metabolic Profiling and Flux Analysis of MEL-2 Human Embryonic Stem Cells during Exponential Growth at Physiological and Atmospheric Oxygen Concentrations
Jennifer Turner, L. Quek, D. Titmarsh, J. Krömer +4 more
2014PLoS ONE44 citations Open access
Semantic Scholar
Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production
Cuauhtémoc Licona-Cassani, E. Marcellin, L. Quek, Shana Jacob +1 more
2012Antonie van Leeuwenhoek38 citations
Semantic Scholar
A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth
Joanna L. Gillis, Josephine A. Hinneh, N. Ryan, Swati Irani +12 more
2020bioRxiv33 citations Open access
Semantic Scholar
Snail-Overexpression Induces Epithelial-mesenchymal Transition and Metabolic Reprogramming in Human Pancreatic Ductal Adenocarcinoma and Non-tumorigenic Ductal Cells
Menghan Liu, Sarah E. Hancock, Ghazal Sultani, Brendan P. Wilkins +4 more
2019Journal of Clinical Medicine33 citations Open access
Semantic Scholar
Network thermodynamic curation of human and yeast genome-scale metabolic models.
Verónica S. Martínez, L. Quek, L. Nielsen
2014Biophysical Journal33 citations Open access
Semantic Scholar
Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake.
Lewin Small, A. Brandon, L. Quek, J. Krycer +3 more
2018American Journal of Physiology. Endocrinology and Metabolism31 citations Open access
Semantic Scholar
Escherichia coli W shows fast, highly oxidative sucrose metabolism and low acetate formation
Yalun Arifin, Colin Archer, Sooa Lim, L. Quek +5 more
2014Applied Microbiology and Biotechnology30 citations
Semantic Scholar
Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin
L. Quek, J. Krycer, S. Ohno, K. Yugi +12 more
2020iScience27 citations Open access
Semantic Scholar
Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation
Lynn-Jee Kim, Timothy J. Chalmers, Romanthi Madawala, Greg C. Smith +8 more
2023FEBS Letters24 citations Open access
Semantic Scholar
Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer
C. Mah, A. Nguyen, Takuto Niijima, M. Helm +11 more
2024British Journal of Cancer23 citations Open access
Semantic Scholar
Fructose bisphosphatase 2 overexpression increases glucose uptake in skeletal muscle.
Ishita Bakshi, Eurwin Suryana, Lewin Small, L. Quek +3 more
2018Journal of Endocrinology23 citations Open access
Semantic Scholar
A depth-first search algorithm to compute elementary flux modes by linear programming
L. Quek, L. Nielsen
2014BMC Systems Biology22 citations Open access
Semantic Scholar
Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism
E. Filipe, Sipiththa Velayuthar, Ashleigh M. Philp, Max Nobis +49 more
2024Advancement of science21 citations Open access
Semantic Scholar
Kinetic Trans-omic Analysis Reveals Key Regulatory Mechanisms for Insulin-Regulated Glucose Metabolism in Adipocytes
S. Ohno, L. Quek, J. Krycer, K. Yugi +7 more
2020iScience20 citations Open access
Semantic Scholar
EXERCISE-INDUCED BENEFITS ON GLUCOSE HANDLING IN A MODEL OF DIET-INDUCED OBESITY ARE REDUCED BY CONCURRENT NICOTINAMIDE MONONUCLEOTIDE
Joseph G. Yu, D. R. Laybutt, Lynn-Jee Kim, L. Quek +3 more
2020bioRxiv18 citations Open access
Semantic Scholar
Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress
F. Byrne, Ellen M. Olzomer, Gabriella Marriott, L. Quek +21 more
2019Redox Biology17 citations Open access
Semantic Scholar
Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment
L. Quek, Menghan Liu, Sanket Joshi, N. Turner
2016Cancer & Metabolism15 citations Open access
Semantic Scholar
ON THE RECONSTRUCTION OF THE MUS MUSCULUS GENOME-SCALE METABOLIC NETWORK MODEL
L. Quek, L. Nielsen
200815 citations
Semantic Scholar
Nicotinamide riboside supplementation does not alter whole‐body or skeletal muscle metabolic responses to a single bout of endurance exercise
B. Stocks, Stephen P. Ashcroft, S. Joanisse, Linda C Dansereau +8 more
2021Journal of Physiology14 citations Open access
Semantic Scholar
Macropinocytosis mediates resistance to loss of glutamine transport in triple-negative breast cancer
K. Wahi, Natasha Freidman, Qian Wang, Michelle Devadason +9 more
2024bioRxiv13 citations Open access
Semantic Scholar
13C-fluxomics: A tool for measuring metabolic phenotypes
J. Krömer, L. Quek, L. Nielsen
200913 citations
Semantic Scholar
Nicotinamide mononucleotide (NMN) deamidation by the gut microbiome and evidence for indirect upregulation of the NAD+metabolome
Lynn-Jee Kim, Timothy J. Chalmers, Greg C. Smith, Abhirup Das +6 more
202012 citations Open access
Semantic Scholar
DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer
Xiao-Hong Zhao, M. Han, Qian-Qian Yan, Y. Yue +17 more
2025Cell Death and Disease11 citations Open access
Semantic Scholar
Insulin sensitivity is preserved in mice made obese by feeding a high starch diet
A. Brandon, Lewin Small, Tuong-Vi Nguyen, Eurwin Suryana +13 more
2022bioRxiv11 citations Open access
Semantic Scholar

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