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Irene N. Lee · SciRah

Researcher profile · Semantic Scholar

Irene N. Lee

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Irene N. Lee — researcher profile on SciRah

h-index: 25
Works: 61
Citations: 2,010

Most-cited papers

An implantable biofuel cell for a live insect.
Michelle A. Rasmussen, R. Ritzmann, Irene N. Lee, A. Pollack +1 more
2012Journal of the American Chemical Society250 citations
Semantic Scholar
DNA and RNA Binding by the Mitochondrial Lon Protease Is Regulated by Nucleotide and Protein Substrate*
Tong Liu, Bin Lu, Irene N. Lee, G. Ondrovičová +2 more
2004Journal of Biological Chemistry167 citations Open access
Semantic Scholar
Multitasking in the mitochondrion by the ATP-dependent Lon protease
S. Venkatesh, Jae Lee, Kamlendra Singh, Irene N. Lee +1 more
2011Biochimica et Biophysica Acta159 citations Open access
Semantic Scholar
CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease.
Kevin A. Strauss, R. N. Jinks, E. Puffenberger, S. Venkatesh +18 more
2015American Journal of Human Genetics151 citations Open access
Semantic Scholar
Functional mechanics of the ATP-dependent Lon protease- lessons from endogenous protein and synthetic peptide substrates.
Irene N. Lee, C. Suzuki
2008Biochimica et Biophysica Acta122 citations Open access
Semantic Scholar
The ATP-dependent Lon protease of Mus musculus is a DNA-binding protein that is functionally conserved between yeast and mammals.
Bin Lu, Tong Liu, Juan A. Crosby, Jennifer A. Thomas-Wohlever +2 more
2003Gene84 citations
Semantic Scholar
Regulation of Pyruvate Dehydrogenase Kinase 4 in the Heart through Degradation by the Lon Protease in Response to Mitochondrial Substrate Availability*
C. Crewe, Christopher M. Schafer, Irene N. Lee, M. Kinter +1 more
2016Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Towards the control of intracellular protein turnover: mitochondrial Lon protease inhibitors versus proteasome inhibitors.
A. Bayot, N. Basse, Irene N. Lee, M. Gareil +4 more
2008Biochimie55 citations
Semantic Scholar
Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease.
Hilary Frase, J. Hudak, Irene N. Lee
2006Biochemistry51 citations Open access
Semantic Scholar
Wireless Communication by an Autonomous Self-Powered Cyborg Insect
Jamie Schwefel, R. Ritzmann, Irene N. Lee, A. Pollack +5 more
201348 citations Open access
Semantic Scholar
The use of nonnatural nucleotides to probe the contributions of shape complementarity and pi-electron surface area during DNA polymerization.
Xuemei Zhang, Irene N. Lee, A. Berdis
2005Biochemistry47 citations
Semantic Scholar
Kinetic characterization of the peptidase activity of Escherichia coli Lon reveals the mechanistic similarities in ATP-dependent hydrolysis of peptide and protein substrates.
Jennifer A. Thomas-Wohlever, Irene N. Lee
2002Biochemistry45 citations
Semantic Scholar
Hydrophobicity, shape, and pi-electron contributions during translesion DNA synthesis.
Xuemei Zhang, Irene N. Lee, Xiang Zhou, A. Berdis
2006Journal of the American Chemical Society44 citations
Semantic Scholar
Dysfunction of mitochondrial Lon protease and identification of oxidized protein in mouse brain following exposure to MPTP: Implications for Parkinson disease
A. Bulteau, Natalia P. Mena, F. Auchère, Irene N. Lee +4 more
2017Free Radical Biology & Medicine39 citations Open access
Semantic Scholar
Resolving individual steps in the operation of ATP-dependent proteolytic molecular machines: from conformational changes to substrate translocation and processivity.
S. Licht, Irene N. Lee
2008Biochemistry39 citations
Semantic Scholar
Gold-Containing Indoles as Anti-Cancer Agents that Potentiate the Cytotoxic Effects of Ionizing Radiation
Sandra N. Craig, Lei Gao, Irene N. Lee, Thomas Gray +1 more
2012Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Evaluating the contributions of desolvation and base-stacking during translesion DNA synthesis.
Xuemei Zhang, Irene N. Lee, A. Berdis
2004Organic and biomolecular chemistry38 citations
Semantic Scholar
N-Terminal peptidic boronic acids selectively inhibit human ClpXP.
Kenneth Knott, Jennifer Fishovitz, S. B. Thorpe, Irene N. Lee +1 more
2010Organic and biomolecular chemistry32 citations
Semantic Scholar
Non-Natural Nucleotides as Probes for the Mechanism and Fidelity of DNA Polymerases
Irene N. Lee, A. Berdis
2009Biochimica et Biophysica Acta31 citations Open access
Semantic Scholar
Identification of a region in the N-terminus of Escherichia coli Lon that affects ATPase, substrate translocation and proteolytic activity.
Iteen Cheng, Natalie Mikita, Jennifer Fishovitz, Hilary Frase +2 more
2012Journal of Molecular Biology28 citations
Semantic Scholar
Rational attempts to optimize non-natural nucleotides for selective incorporation opposite an abasic site.
Xuemei Zhang, Alison C. Donnelly, Irene N. Lee, A. Berdis
2006Biochemistry28 citations
Semantic Scholar
Correlation of an adenine-specific conformational change with the ATP-dependent peptidase activity of Escherichia coli Lon.
J. Patterson, Diana P. Vineyard, Jennifer A. Thomas-Wohlever, R. Behshad +2 more
2004Biochemistry27 citations
Semantic Scholar
Adenosine Triphosphate-Dependent Degradation of a Fluorescent λ N Substrate Mimic by Lon Protease
Irene N. Lee, A. Berdis
200127 citations Open access
Semantic Scholar
Peptidyl boronates inhibit Salmonella enterica serovar Typhimurium Lon protease by a competitive ATP-dependent mechanism.
Hilary Frase, Irene N. Lee
2007Biochemistry26 citations
Semantic Scholar
Optimization of non-natural nucleotides for selective incorporation opposite damaged DNA.
Diana P. Vineyard, Xuemei Zhang, Alison C. Donnelly, Irene N. Lee +1 more
2007Organic and biomolecular chemistry26 citations
Semantic Scholar
Monitoring the timing of ATP hydrolysis with activation of peptide cleavage in Escherichia coli Lon by transient kinetics.
Diana P. Vineyard, Jessica Patterson-Ward, A. Berdis, Irene N. Lee
2005Biochemistry26 citations
Semantic Scholar
A potential chemotherapeutic strategy for the selective inhibition of promutagenic DNA synthesis by nonnatural nucleotides.
Xuemei Zhang, Irene N. Lee, A. Berdis
2005Biochemistry24 citations
Semantic Scholar
A Non-Natural Nucleoside with Combined Therapeutic and Diagnostic Activities Against Leukemia
Edward A. Motea, Irene N. Lee, A. Berdis
2012ACS Chemical Biology22 citations Open access
Semantic Scholar
Quantifying the energetic contributions of desolvation and π-electron density during translesion DNA synthesis
Edward A. Motea, Irene N. Lee, A. Berdis
2010Nucleic Acids Research22 citations Open access
Semantic Scholar
The Mechanism and Dynamics of Translesion DNA Synthesis Catalyzed by the Escherichia coli Klenow fragment
Asim Sheriff, Edward A. Motea, Irene N. Lee, A. Berdis
2008Biochemistry21 citations Open access
Semantic Scholar
Enhancing the "A-rule" of translesion DNA synthesis: promutagenic DNA synthesis using modified nucleoside triphosphates.
Babho Devadoss, Irene N. Lee, A. Berdis
2007Biochemistry20 citations
Semantic Scholar
Processive degradation of unstructured protein by Escherichia coli Lon occurs via the slow, sequential delivery of multiple scissile sites followed by rapid and synchronized peptide bond cleavage events.
Natalie Mikita, Iteen Cheng, Jennifer Fishovitz, Jonathan T B Huang +1 more
2013Biochemistry19 citations
Semantic Scholar
UTILIZATION OF SYNTHETIC PEPTIDES TO EVALUATE THE IMPORTANCE OF SUBSTRATE INTERACTION AT THE PROTEOLYTIC SITE OF ESCHERICHIA COLI LON PROTEASE
Jessica Patterson-Ward, J. Tedesco, J. Hudak, Jennifer Fishovitz +4 more
2009Biochimica et Biophysica Acta19 citations Open access
Semantic Scholar
Single-turnover kinetic experiments confirm the existence of high- and low-affinity ATPase sites in Escherichia coli Lon protease.
Diana P. Vineyard, Jessica Patterson-Ward, Irene N. Lee
2006Biochemistry18 citations Open access
Semantic Scholar
Active-site directed chemical tools for profiling mitochondrial Lon protease
Jennifer Fishovitz, Min Li, Hilary Frase, J. Hudak +5 more
2011ACS Chemical Biology17 citations Open access
Semantic Scholar
Recent developments in the mechanistic enzymology of the ATP-dependent Lon protease from Escherichia coli: highlights from kinetic studies.
Irene N. Lee, A. Berdis, C. Suzuki
2006Molecular Biosystems17 citations Open access
Semantic Scholar
Detection and characterization of two ATP-dependent conformational changes in proteolytically inactive Escherichia coli Lon mutants by stopped flow kinetic techniques.
Jessica Patterson-Ward, Jonathan T B Huang, Irene N. Lee
2007Biochemistry16 citations Open access
Semantic Scholar
Replication of a Universal Nucleobase Provides Unique Insight into the Role of Entropy During DNA Polymerization and Pyrophosphorolysis
Xuemei Zhang, Edward A. Motea, Irene N. Lee, A. Berdis
2010Biochemistry13 citations Open access
Semantic Scholar
Effect of solvent on diffusion: probing with nonpolar solutes.
T. Chan, Irene N. Lee, K. S. Chan
2014Journal of Physical Chemistry B12 citations Open access
Semantic Scholar
Insights into the Roles of Desolvation and π‐Electron Interactions during DNA Polymerization
Edward A. Motea, Irene N. Lee, Anthony J. Berdis
2013ChemBioChem12 citations
Semantic Scholar
Bifunctional trehalose anode incorporating two covalently linked enzymes acting in series.
Michelle A. Rasmussen, R. West, J. Burgess, Irene N. Lee +1 more
2011Analytical Chemistry12 citations
Semantic Scholar
Development of a ‘clickable’ non-natural nucleotide to visualize the replication of non-instructional DNA lesions
Edward A. Motea, Irene N. Lee, A. Berdis
2011Nucleic Acids Research11 citations Open access
Semantic Scholar
Is a thymine dimer replicated via a transient abasic site intermediate? A comparative study using non-natural nucleotides.
Babho Devadoss, Irene N. Lee, A. Berdis
2007Biochemistry8 citations
Semantic Scholar
Fluorescent Analysis of Translesion DNA Synthesis by Using a Novel, Non‐natural Nucleotide Analogue
Irene N. Lee, A. Berdis
2006ChemBioChem8 citations
Semantic Scholar
Transient kinetic experiments demonstrate the existence of a unique catalytic enzyme form in the peptide-stimulated ATPase mechanism of Escherichia coli Lon protease.
Diana P. Vineyard, Xuemei Zhang, Irene N. Lee
2006Biochemistry7 citations
Semantic Scholar
Development and characterization of a non-natural nucleoside that displays anticancer activity against solid tumors.
J. Golden, Edward A. Motea, Xuemei Zhang, Jung-Suk Choi +4 more
2013ACS Chemical Biology6 citations
Semantic Scholar
Utilization of positional isotope exchange experiments to evaluate reversibility of ATP hydrolysis catalyzed by Escherichia coli Lon protease.
Jennifer Thomas, Jennifer Fishovitz, Irene N. Lee
2010Biochemistry and cell biology = Biochimie et biologie cellulaire5 citations
Semantic Scholar
Utilization of Mechanistic Enzymology to Evaluate the Significance of ADP Binding to Human Lon Protease
Jennifer Fishovitz, Z. Sha, Sujatha Chilakala, Iteen Cheng +2 more
2017Frontiers in Molecular Biosciences4 citations Open access
Semantic Scholar
A structure and function relationship study to identify the impact of the R721G mutation in the human mitochondrial lon protease
Z. Sha, M. Montano, Kristy Rochon, Jason A. Mears +5 more
2021Archives of Biochemistry and Biophysics3 citations Open access
Semantic Scholar
Inactivation of bovine plasma amine oxidase by 1,1,1-trihalo-3-aminopropanes.
Jisook Kim, Irene N. Lee
2017Bioorganic chemistry (Print)3 citations
Semantic Scholar

Frequent co-authors

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A. Berdis×21
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A. Berdis — researcher profile on SciRah
Xuemei Zhang×9
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Xuemei Zhang — researcher profile on SciRah
C. Suzuki×7
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C. Suzuki — researcher profile on SciRah
Jennifer Fishovitz×7
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Jennifer Fishovitz — researcher profile on SciRah

Edward A. Motea

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Edward A. Motea — researcher profile on SciRah

Hilary Frase×5

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Hilary Frase — researcher profile on SciRah

Diana P. Vineyard×5

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Diana P. Vineyard — researcher profile on SciRah

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Iteen Cheng — researcher profile on SciRah

Natalie Mikita×4

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Natalie Mikita — researcher profile on SciRah

Jessica Patterson-Ward×4

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Jessica Patterson-Ward — researcher profile on SciRah

Michelle A. Rasmussen×3

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Michelle A. Rasmussen — researcher profile on SciRah

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D. Scherson — researcher profile on SciRah