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M. Takakura · SciRah

Researcher profile · Semantic Scholar

M. Takakura

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M. Takakura — researcher profile on SciRah

h-index: 39
Works: 91
Citations: 6,279

Most-cited papers

Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells.
M. Takakura, S. Kyo, Taro Kanaya, H. Hirano +3 more
1999Cancer Research571 citations
Semantic Scholar
Estrogen activates telomerase.
S. Kyo, M. Takakura, Taro Kanaya, Wang Zhuo +4 more
1999Cancer Research532 citations
Semantic Scholar
Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).
S. Kyo, M. Takakura, T. Taira, Taro Kanaya +4 more
2000Nucleic Acids Research521 citations Open access
Semantic Scholar
Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers
S. Kyo, M. Takakura, T. Fujiwara, M. Inoue
2008Cancer Science367 citations Open access
Semantic Scholar
Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer.
M. Takakura, S. Kyo, Taro Kanaya, Masaaki Tanaka +1 more
1998Cancer Research322 citations
Semantic Scholar
Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.
Taro Kanaya, S. Kyo, K. Hamada, M. Takakura +3 more
2000Clinical Cancer Research252 citations
Semantic Scholar
Telomerase activity in human endometrium.
Satoru Kyo, M. Takakura, Takafumi Kohama, Masaki Inoue
1997Cancer Research232 citations
Semantic Scholar
Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers.
Jian Gu, S. Kagawa, M. Takakura, S. Kyo +3 more
2000Cancer Research205 citations
Semantic Scholar
Telomerase activation by histone deacetylase inhibitor in normal cells.
M. Takakura, Satoru Kyo, Yoshihiro Sowa, Zhuo Wang +4 more
2001Nucleic Acids Research165 citations Open access
Semantic Scholar
High Twist expression is involved in infiltrative endometrial cancer and affects patient survival.
S. Kyo, Junko Sakaguchi, S. Ohno, Yasunari Mizumoto +7 more
2006Human Pathology161 citations
Semantic Scholar
Expression of human telomerase subunits and correlation with telomerase activity in urothelial cancer.
H. Ito, Satoru Kyo, Taro Kanaya, M. Takakura +2 more
1998Clinical Cancer Research151 citations
Semantic Scholar
Bone marrow-derived cells from male donors can compose endometrial glands in female transplant recipients.
Tomomi Ikoma, S. Kyo, Yoshiko Maida, S. Ozaki +3 more
2009American Journal of Obstetrics and Gynecology140 citations
Semantic Scholar
Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter.
T. Komata, Y. Kondo, T. Kanzawa, S. Hirohata +11 more
2001Cancer Research137 citations
Semantic Scholar
Human telomerase reverse transcriptase as a critical determinant of telomerase activity in normal and malignant endometrial tissues
S. Kyo, Taro Kanaya, M. Takakura, Masaaki Tanaka +1 more
1999International Journal of Cancer131 citations Open access
Semantic Scholar
Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway.
Zhuo Wang, Satoru Kyo, M. Takakura, Masaaki Tanaka +7 more
2000Cancer Research121 citations
Semantic Scholar
hTERT is a critical determinant of telomerase activity in renal‐cell carcinoma
Taro Kanaya, S. Kyo, M. Takakura, H. Ito +2 more
1998International Journal of Cancer119 citations Open access
Semantic Scholar
Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT
Kohtaro Fujimoto, S. Kyo, M. Takakura, Taro Kanaya +4 more
2000Nucleic Acids Res.116 citations Open access
Semantic Scholar
Function of AP-1 in Transcription of the Telomerase Reverse Transcriptase Gene (TERT) in Human and Mouse Cells
M. Takakura, S. Kyo, M. Inoue, W. Wright +1 more
2005Molecular and Cellular Biology115 citations Open access
Semantic Scholar
A Novel Telomerase-Specific Gene Therapy: Gene Transfer of Caspase-8 Utilizing the Human Telomerase Catalytic Subunit Gene Promoter
S. Koga, Satoshi Hirohata, Y. Kondo, T. Komata +4 more
2000Human Gene Therapy107 citations
Semantic Scholar
Expression of human telomerase subunits in ovarian malignant, borderline and benign tumors
S. Kyo, Taro Kanaya, M. Takakura, Masaaki Tanaka +3 more
1999International Journal of Cancer101 citations Open access
Semantic Scholar
Expression of telomerase activity in human endometrium is localized to epithelial glandular cells and regulated in a menstrual phase-dependent manner correlated with cell proliferation.
Masaaki Tanaka, Satoru Kyo, M. Takakura, Taro Kanaya +5 more
1998American Journal of Pathology86 citations Open access
Semantic Scholar
Detection of human telomerase reverse transcriptase messenger RNA in voided urine samples as a useful diagnostic tool for bladder cancer.
Hideaki Ito, Satoru Kyo, Taro Kanaya, M. Takakura +3 more
1998Clinical Cancer Research78 citations
Semantic Scholar
A case of cervical cancer with aggressive tumor growth: possible autocrine growth stimulation by G-CSF and Il-6.
Satoru Kyo, Taro Kanaya, M. Takakura, Masaki Inoue
2000Gynecologic Oncology75 citations
Semantic Scholar
Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis
Yasunari Mizumoto, S. Kyo, N. Mori, Junko Sakaguchi +5 more
2007Cancer Science73 citations Open access
Semantic Scholar
Prognostic impact of CD133 expression as a tumor-initiating cell marker in endometrial cancer.
Mitsuhiro Nakamura, S. Kyo, Bo Zhang, Xiu-Zhi Zhang +7 more
2010Human Pathology67 citations
Semantic Scholar
Expression of telomerase activity in human chorion.
Satoru Kyo, M. Takakura, Masaaki Tanaka, Taro Kanaya +6 more
1997Biochemical and Biophysical Research Communications - BBRC67 citations
Semantic Scholar
Application of telomerase assay for the screening of cervical lesions.
Satoru Kyo, M. Takakura, H. Ishikawa, T. Sasagawa +3 more
1997Cancer Research66 citations
Semantic Scholar
Intraperitoneal administration of telomerase-specific oncolytic adenovirus sensitizes ovarian cancer cells to cisplatin and affects survival in a xenograft model with peritoneal dissemination
M. Takakura, Mitsuhiro Nakamura, S. Kyo, M. Hashimoto +6 more
2009Cancer Gene Therapy64 citations Open access
Semantic Scholar
Caspase-8 Gene Therapy Using the Human Telomerase Reverse Transcriptase Promoter for Malignant Glioma Cells
T. Komata, Y. Kondo, T. Kanzawa, Hideaki Ito +9 more
2002Human Gene Therapy58 citations
Semantic Scholar
Telomerase activity in cervical cancer is quantitatively distinct from that in its precursor lesions
S. Kyo, M. Takakura, Masaaki Tanaka, Taro Kanaya +1 more
1998International Journal of Cancer56 citations
Semantic Scholar
Creation of immortalised epithelial cells from ovarian endometrioma
Yukiko Bono, Satoru Kyo, M. Takakura, Yoshiko Maida +5 more
2012British Journal of Cancer54 citations Open access
Semantic Scholar
Tamoxifen regulates human telomerase reverse transcriptase (hTERT) gene expression differently in breast and endometrial cancer cells
Zhuo Wang, S. Kyo, Yoshiko Maida, M. Takakura +8 more
2002Oncogene51 citations Open access
Semantic Scholar
2-5A antisense therapy directed against human telomerase RNA inhibits telomerase activity and induces apoptosis without telomere impairment in cervical cancer cells
N. Yatabe, S. Kyo, S. Kondo, Taro Kanaya +6 more
2002Cancer Gene Therapy46 citations Open access
Semantic Scholar
Demethylating reagent 5-azacytidine inhibits telomerase activity in human prostate cancer cells through transcriptional repression of hTERT.
Y. Kitagawa, Satoru Kyo, M. Takakura, Taro Kanaya +3 more
2000Clinical Cancer Research46 citations
Semantic Scholar
FADD gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter to restrict induction of apoptosis to tumors in vitro and in vivo.
S. Koga, Satoshi Hirohata, Y. Kondo, T. Komata +4 more
2001Anticancer Research43 citations
Semantic Scholar
Forkhead Transcription Factor FOXO1 is a Direct Target of Progestin to Inhibit Endometrial Epithelial Cell Growth
S. Kyo, Junko Sakaguchi, T. Kiyono, Y. Shimizu +8 more
2010Clinical Cancer Research42 citations Open access
Semantic Scholar
Single type infection of human papillomavirus as a cause for high-grade cervical intraepithelial neoplasia and invasive cancer in Japan
J. Sakamoto, S. Kamiura, Kaori Okayama, Mitsuaki Okodo +7 more
2018Papillomavirus Research41 citations Open access
Semantic Scholar
Exosomal transfer of functional small RNAs mediates cancer‐stroma communication in human endometrium
Yoshiko Maida, M. Takakura, T. Nishiuchi, T. Yoshimoto +1 more
2015Cancer Medicine41 citations Open access
Semantic Scholar
A novel treatment of human malignant gliomas in vitro and in vivo: FADD gene transfer under the control of the human telomerase reverse transcriptase gene promoter.
T. Komata, S. Koga, Satoshi Hirohata, M. Takakura +5 more
2001International Journal of Oncology39 citations
Semantic Scholar
Concomitant activation of AKT with extracellular‐regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss
N. Mori, S. Kyo, Junko Sakaguchi, Yasunari Mizumoto +5 more
2007Cancer Science34 citations Open access
Semantic Scholar
Association of mismatch repair deficiency with PTEN frameshift mutations in endometrial cancers and the precursors in a Japanese population.
Taro Kanaya, S. Kyo, Junko Sakaguchi, Yoshiko Maida +5 more
2005American Journal of Clinical Pathology33 citations
Semantic Scholar
Creation of tumorigenic human endometrial epithelial cells with intact chromosomes by introducing defined genetic elements
Yasunari Mizumoto, Satoru Kyo, S. Ohno, M. Hashimoto +6 more
2006Oncogene32 citations Open access
Semantic Scholar
Activation of NF-κB Is a Novel Target of KRAS-Induced Endometrial Carcinogenesis
Yasunari Mizumoto, S. Kyo, T. Kiyono, M. Takakura +6 more
2011Clinical Cancer Research31 citations Open access
Semantic Scholar
Quantitative differences in telomerase activity among malignant, premalignant, and benign ovarian lesions.
Satoru Kyo, M. Takakura, M. Tanaka, K. Murakami +3 more
1998Clinical Cancer Research31 citations
Semantic Scholar
Molecular characterization of CD133+ cancer stem-like cells in endometrial cancer.
Mitsuhiro Nakamura, Xiu-Zhi Zhang, Yasunari Mizumoto, Yoshiko Maida +3 more
2014International Journal of Oncology30 citations Open access
Semantic Scholar
The PRB-dependent FOXO1/IGFBP-1 axis is essential for progestin to inhibit endometrial epithelial growth.
Mitsuhiro Nakamura, M. Takakura, Reina Fujii, Yoshiko Maida +5 more
2013Cancer Letters29 citations
Semantic Scholar
Role of menin in the regulation of telomerase activity in normal and cancer cells.
M. Hashimoto, S. Kyo, X. Hua, H. Tahara +8 more
2008International Journal of Oncology29 citations Open access
Semantic Scholar
Detection of circulating tumor cells in cervical cancer using a conditionally replicative adenovirus targeting telomerase‐positive cells
M. Takakura, Takeo Matsumoto, Mitsuhiro Nakamura, Yasunari Mizumoto +17 more
2017Cancer Science27 citations Open access
Semantic Scholar
The prevalence of VAIN, CIN, and related HPV genotypes in Japanese women with abnormal cytology
Shi-Tai Zhang, Mayumi Saito, S. Yamada, J. Sakamoto +3 more
2020Journal of Medical Virology25 citations
Semantic Scholar
Expression of HER-2 affects patient survival and paclitaxel sensitivity in endometrial cancer
N. Mori, S. Kyo, Mitsuhiro Nakamura, M. Hashimoto +6 more
2010British Journal of Cancer25 citations Open access
Semantic Scholar

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S. Kyo×34
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S. Kyo — researcher profile on SciRah
M. Inoue×30
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Taro Kanaya×19
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Yoshiko Maida×19
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Yasunari Mizumoto

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Mitsuhiro Nakamura×15

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Satoru Kyo — researcher profile on SciRah

Masaki Inoue×13

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Masaaki Tanaka×10

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Masaaki Tanaka — researcher profile on SciRah

M. Hashimoto×9

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Junko Sakaguchi×7

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