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A. Paschen · SciRah

Researcher profile · Semantic Scholar

A. Paschen

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A. Paschen — researcher profile on SciRah

h-index: 43
Works: 134
Citations: 6,211

Most-cited papers

Integrative molecular and clinical modeling of clinical outcomes to PD-1 blockade in metastatic melanoma patients
David Liu, B. Schilling, Derek Liu, A. Sucker +32 more
2019Nature Medicine848 citations Open access
Semantic Scholar
Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
A. Sucker, Fang Zhao, N. Pieper, Christina Heeke +19 more
2017Nature Communications232 citations Open access
Semantic Scholar
Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30.
Eva Schlecker, Nathalie Fiegler, A. Arnold, P. Altevogt +7 more
2014Cancer Research192 citations
Semantic Scholar
Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D.
A. Heinemann, Fang Zhao, S. Pechlivanis, J. Eberle +4 more
2012Cancer Research188 citations Open access
Semantic Scholar
Development of a rapid lateral flow immunoassay test for detection of exosomes previously enriched from cell culture medium and body fluids
Myriam Oliveira-Rodríguez, Sheila López-Cobo, H. Reyburn, A. Costa-García +6 more
2016Journal of Extracellular Vesicles152 citations Open access
Semantic Scholar
Genetic Evolution of T-cell Resistance in the Course of Melanoma Progression
A. Sucker, Fang Zhao, B. Real, Christina Heeke +15 more
2014Clinical Cancer Research150 citations Open access
Semantic Scholar
Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma
Cathrin Ritter, Kaiji Fan, A. Paschen, Sine Reker Hardrup +5 more
2017Scientific Reports131 citations Open access
Semantic Scholar
Vemurafenib reverses immunosuppression by myeloid derived suppressor cells
B. Schilling, A. Sucker, K. Griewank, Fang Zhao +5 more
2013International Journal of Cancer130 citations
Semantic Scholar
Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes
M. Bernal, F. Ruiz-Cabello, Á. Concha, A. Paschen +1 more
2012Cancer Immunology and Immunotherapy119 citations Open access
Semantic Scholar
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes
Jan H. Kessler, Selina Khan, U. Seifert, S. Le Gall +24 more
2011Nature Immunology116 citations Open access
Semantic Scholar
SF3B1 and BAP1 mutations in blue nevus-like melanoma
K. Griewank, Hansgeorg Müller, L. Jackett, M. Emberger +19 more
2017Modern Pathology94 citations Open access
Semantic Scholar
Elevated baseline serum PD-1 or PD-L1 predicts poor outcome of PD-1 inhibition therapy in metastatic melanoma.
S. Ugurel, D. Schadendorf, K. Horny, A. Sucker +12 more
2020Annals of Oncology87 citations Open access
Semantic Scholar
Frequent loss of heterozygosity in the β2-microglobulin region of chromosome 15 in primary human tumors
I. Maleno, N. Aptsiauri, T. Cabrera, A. Gallego +3 more
2011Immunogenetics85 citations
Semantic Scholar
Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function
Robert M. Petri, A. Hackel, Katrin Hahnel, C. Dumitru +5 more
2017Stem Cell Reports82 citations Open access
Semantic Scholar
NF1 mutations in conjunctival melanoma
S. L. Scholz, I. Cosgarea, D. Süsskind, R. Murali +13 more
2018British Journal of Cancer81 citations Open access
Semantic Scholar
Tumor CDKN2A-Associated JAK2 Loss and Susceptibility to Immunotherapy Resistance.
S. Horn, S. Leonardelli, A. Sucker, D. Schadendorf +2 more
2018Journal of the National Cancer Institute73 citations Open access
Semantic Scholar
Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
Phyllis F. Cheung, Jiajin Yang, Rui Fang, Arianna Borgers +31 more
2022Nature Communications72 citations Open access
Semantic Scholar
Immunoassays for scarce tumour-antigens in exosomes: detection of the human NKG2D-Ligand, MICA, in tetraspanin-containing nanovesicles from melanoma
Sheila López-Cobo, Carmen Campos-Silva, Amanda Moyano, Myriam Oliveira-Rodríguez +4 more
2018Journal of Nanobiotechnology72 citations Open access
Semantic Scholar
The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma.
B. Phung, M. Cieśla, Adriana Sanna, N. Guzzi +19 more
2019Cell Reports68 citations Open access
Semantic Scholar
Melanoma Lesions Independently Acquire T-cell Resistance during Metastatic Latency.
Fang Zhao, A. Sucker, S. Horn, Christina Heeke +13 more
2016Cancer Research67 citations Open access
Semantic Scholar
Exosome-dependent immune surveillance at the metastatic niche requires BAG6 and CBP/p300-dependent acetylation of p53
Maximiliane Schuldner, Bastian Dörsam, Olga Shatnyeva, K. Reiners +13 more
2019Theranostics61 citations Open access
Semantic Scholar
Activating cysteinyl leukotriene receptor 2 (CYSLTR2) mutations in blue nevi
Inga Möller, R. Murali, Hansgeorg Müller, T. Wiesner +14 more
2016Modern Pathology60 citations Open access
Semantic Scholar
Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma
R. Váraljai, L. Zimmer, Y. Al-Matary, Paulien Kaptein +26 more
2023Nature Cancer59 citations Open access
Semantic Scholar
Impaired NK cell recognition of vemurafenib-treated melanoma cells is overcome by simultaneous application of histone deacetylase inhibitors
Sheila López-Cobo, N. Pieper, Carmen Campos-Silva, E. García-Cuesta +3 more
2018Oncoimmunology55 citations Open access
Semantic Scholar
The proteasome immunosubunits, PA28 and ER‐aminopeptidase 1 protect melanoma cells from efficient MART‐126‐35‐specific T‐cell recognition
M. Keller, F. Ebstein, Elke Bürger, K. Textoris-Taube +16 more
2015European Journal of Immunology54 citations Open access
Semantic Scholar
MMP19 is upregulated during melanoma progression and increases invasion of melanoma cells
Matthias Müller, I. Beck, Judith Gadesmann, Nadine Karschuk +5 more
2010Modern Pathology54 citations Open access
Semantic Scholar
Differential influence of vemurafenib and dabrafenib on patients' lymphocytes despite similar clinical efficacy in melanoma.
B. Schilling, W. Sondermann, F. Zhao, K. Griewank +18 more
2014Annals of Oncology52 citations Open access
Semantic Scholar
Dacarbazine in melanoma: from a chemotherapeutic drug to an immunomodulating agent.
S. Ugurel, A. Paschen, J. Becker
2013Journal of Investigative Dermatology52 citations Open access
Semantic Scholar
Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma.
A. Roesch, A. Paschen, J. Landsberg, I. Helfrich +2 more
2016European Journal of Cancer49 citations
Semantic Scholar
Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy.
Lina Such, Fang Zhao, Derek Liu, Beatrice Thier +26 more
2020Journal of Clinical Investigation47 citations Open access
Semantic Scholar
Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma.
S. L. Scholz, Inga Möller, H. Reis, D. Süsskind +12 more
2017Investigative Ophthalmology and Visual Science43 citations Open access
Semantic Scholar
Clinical and genetic analysis of melanomas arising in acral sites
A. Zaremba, R. Murali, P. Jansen, Inga Möller +12 more
2019European Journal of Cancer38 citations Open access
Semantic Scholar
Evolution of melanoma cross-resistance to CD8+ T cells and MAPK inhibition in the course of BRAFi treatment
N. Pieper, A. Zaremba, S. Leonardelli, Franziska Noelle Harbers +14 more
2018Oncoimmunology36 citations Open access
Semantic Scholar
NF1-mutated melanomas reveal distinct clinical characteristics depending on tumor origin and respond favorably to immune-checkpoint inhibitors
C. M. Thielmann, Eleftheria Chorti, Johanna Matull, R. Murali +25 more
2021European Journal of Cancer35 citations Open access
Semantic Scholar
Immunological consequences of selective BRAF inhibitors in malignant melanoma
B. Schilling, A. Paschen
2013Oncoimmunology35 citations Open access
Semantic Scholar
HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model
Barbara Schrörs, Silke Lübcke, V. Lennerz, Martina Fatho +7 more
2017OncoTarget34 citations Open access
Semantic Scholar
Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection
A. Malyshkina, Elisabeth Littwitz-Salomon, K. Sutter, Gennadiy Zelinskyy +6 more
2017Scientific Reports32 citations Open access
Semantic Scholar
Expression of stress ligands of the immunoreceptor NKG2D in melanoma: regulation and clinical significance.
A. Paschen, Jolanthe Baingo, D. Schadendorf
2014European Journal of Cell Biology30 citations
Semantic Scholar
Circulating cell‐free messenger RNA enables non‐invasive pan‐tumour monitoring of melanoma therapy independent of the mutational genotype
L. Albrecht, Anna Höwner, K. Griewank, S. Lueong +12 more
2022Clinical and Translational Medicine29 citations Open access
Semantic Scholar
Arenavirus Induced CCL5 Expression Causes NK Cell-Mediated Melanoma Regression
H. Bhat, G. Zaun, T. Hamdan, Judith Lang +24 more
2020Frontiers in Immunology29 citations Open access
Semantic Scholar
Persister state-directed transitioning and vulnerability in melanoma
H. Chauvistré, B. Shannan, S. Daignault-Mill, R. Ju +32 more
2020Nature Communications29 citations Open access
Semantic Scholar
Frequent TERT Promoter Mutations in Ocular Surface Squamous Neoplasia.
S. L. Scholz, H. Thomasen, H. Reis, Inga Möller +11 more
2015Investigative Ophthalmology and Visual Science29 citations
Semantic Scholar
GNA14, GNA11, and GNAQ Mutations Are Frequent in Benign but Not Malignant Cutaneous Vascular Tumors
P. Jansen, Hansgeorg Müller, G. Lodde, A. Zaremba +12 more
2021Frontiers in Genetics28 citations Open access
Semantic Scholar
Direct RIG‐I activation in human NK cells induces TRAIL‐dependent cytotoxicity toward autologous melanoma cells
J. Daßler-Plenker, A. Paschen, Bastian Putschli, Stephanie Rattay +5 more
2019International Journal of Cancer28 citations Open access
Semantic Scholar
The predictive and prognostic significance of cell‐free DNA concentration in melanoma
R. Váraljai, S. El Ouali, S. Lueong, K. Wistuba-Hamprecht +10 more
2020Journal of the European Academy of Dermatology and Venereology27 citations Open access
Semantic Scholar
Exposure to Melan-A/MART-126-35 tumor epitope specific CD8+T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS)
F. Ebstein, M. Keller, A. Paschen, P. Walden +6 more
2016Scientific Reports26 citations Open access
Semantic Scholar
The Efficiency of Human Cytomegalovirus pp65495–503 CD8+ T Cell Epitope Generation Is Determined by the Balanced Activities of Cytosolic and Endoplasmic Reticulum-Resident Peptidases
S. Urban, K. Textoris-Taube, B. Reimann, Katharina Janek +15 more
2012Journal of Immunology26 citations
Semantic Scholar
Survivin blockade sensitizes rhabdomyosarcoma cells for lysis by fetal acetylcholine receptor-redirected T cells.
K. Simon-Keller, A. Paschen, A. Hombach, P. Ströbel +12 more
2013American Journal of Pathology24 citations Open access
Semantic Scholar
New developments in biomarkers for melanoma
K. Griewank, S. Ugurel, D. Schadendorf, A. Paschen
2013Current Opinion in Oncology22 citations
Semantic Scholar
Screening of Human Tumor Antigens for CD4+ T Cell Epitopes by Combination of HLA-Transgenic Mice, Recombinant Adenovirus and Antigen Peptide Libraries
W. Osen, Sabine Soltek, Ming-Xia Song, B. Leuchs +6 more
2010PLoS ONE18 citations Open access
Semantic Scholar

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D. Schadendorf×29
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A. Sucker×23
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K. Griewank×17
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B. Schilling×13
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E. Livingstone×9

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L. Zimmer — researcher profile on SciRah

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