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S. Howell · SciRah

Researcher profile · Semantic Scholar

S. Howell

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S. Howell — researcher profile on SciRah

h-index: 37
Works: 197
Citations: 6,273

Most-cited papers

Capivasertib in Hormone Receptor–Positive Advanced Breast Cancer
N. Turner, M. Oliveira, S. Howell, F. Dalenc +19 more
2023New England Journal of Medicine585 citations Open access
Semantic Scholar
Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive breast cancer (FAKTION): a multicentre, randomised, controlled, phase 2 trial
Robert Jones, A. Casbard, M. Carucci, Catrin Cox +12 more
2020The Lancet Oncology174 citations Open access
Semantic Scholar
Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
R. Eyre, D. Alférez, A. Santiago-Gómez, Katherine Spence +14 more
2019Nature Communications134 citations Open access
Semantic Scholar
Polygenic risk scores and breast cancer risk prediction
E. Roberts, S. Howell, D. G. Evans
2023Breast108 citations Open access
Semantic Scholar
Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial
S. Howell, A. Casbard, M. Carucci, K. Ingarfield +13 more
2022The Lancet Oncology76 citations Open access
Semantic Scholar
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
K. Bach, S. Pensa, Marija Zarocsinceva, K. Kania +12 more
2021Nature Communications68 citations Open access
Semantic Scholar
Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib
R. Coombes, S. Howell, S. Lord, L. Kenny +19 more
2023Nature Communications65 citations Open access
Semantic Scholar
Breast cancer in neurofibromatosis 1: survival and risk of contralateral breast cancer in a five country cohort study
D. Evans, R. Kallionpää, M. Clementi, E. Trevisson +9 more
2019Genetics in Medicine53 citations Open access
Semantic Scholar
Breast cancer risk stratification in women of screening age: Incremental effects of adding mammographic density, polygenic risk, and a gene panel.
D. Evans, E. V. van Veen, E. Harkness, A. Brentnall +10 more
2022Genetics in Medicine50 citations Open access
Semantic Scholar
Breast Cancer Risk Assessment and Primary Prevention Advice in Primary Care: A Systematic Review of Provider Attitudes and Routine Behaviours
S. Bellhouse, R. Hawkes, S. Howell, Louise Gorman +1 more
2021Cancers46 citations Open access
Semantic Scholar
The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells
D. Alférez, B. Simões, S. Howell, R. Clarke
2018Current Stem Cell Reports39 citations Open access
Semantic Scholar
Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer
B. Simões, A. Santiago-Gómez, Chiara Chiodo, Tiago Moreira +15 more
2020Oncogene36 citations Open access
Semantic Scholar
Capivasertib (AZD5363) plus fulvestrant versus placebo plus fulvestrant after relapse or progression on an aromatase inhibitor in metastatic ER-positive breast cancer (FAKTION): A randomized, double-blind, placebo-controlled, phase II trial.
Robert Jones, M. Carucci, A. Casbard, R. Butler +9 more
2019Journal of Clinical Oncology34 citations
Semantic Scholar
The Angelina Jolie effect: Contralateral risk-reducing mastectomy trends in patients at increased risk of breast cancer
N. Basu, J. Hodson, Shaunak Chatterjee, A. Gandhi +12 more
2021Scientific Reports33 citations Open access
Semantic Scholar
Abstract GS3-04: GS3-04 Capivasertib and fulvestrant for patients with aromatase inhibitor-resistant hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: results from the Phase III CAPItello-291 trial
N. Turner, M. Oliveira, S. Howell, F. Dalenc +15 more
2023Cancer Research31 citations
Semantic Scholar
Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH+ Breast Cancer Stem Cells
Aida Sarmiento-Castro, E. Caamano-Gutierrez, A. Sims, Nathan J. Hull +10 more
2020Stem Cell Reports30 citations Open access
Semantic Scholar
Oestradiol measurement during fulvestrant treatment for breast cancer
L. Owen, P. Monaghan, A. Armstrong, B. Keevil +3 more
2019British Journal of Cancer30 citations Open access
Semantic Scholar
PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer
A. Santiago-Gómez, Thomas Kedward, B. Simões, I. Dragoni +7 more
2019bioRxiv30 citations Open access
Semantic Scholar
The effectiveness of home versus community-based weight control programmes initiated soon after breast cancer diagnosis: a randomised controlled trial
M. Harvie, M. Pegington, Debbie McMullan, N. Bundred +10 more
2019British Journal of Cancer29 citations Open access
Semantic Scholar
Uptake and efficacy of bilateral risk reducing surgery in unaffected female BRCA1 and BRCA2 carriers
Ruta Marcinkute, E. Woodward, A. Gandhi, S. Howell +13 more
2021Journal of Medical Genetics27 citations Open access
Semantic Scholar
Uptake of bilateral-risk-reducing-mastectomy: Prospective analysis of 7195 women at high-risk of breast cancer
D. Evans, A. Gandhi, J. Wisely, T. Clancy +9 more
2021Breast27 citations Open access
Semantic Scholar
Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
Thomas E. Bartlett, I. Evans, Allison Jones, James E. Barrett +19 more
2022Genome Medicine26 citations Open access
Semantic Scholar
Predictors of weight gain in a cohort of premenopausal early breast cancer patients receiving chemotherapy.
A. Gandhi, E. Copson, D. Eccles, L. Durcan +7 more
2019Breast24 citations Open access
Semantic Scholar
Quantifying the effects of risk-stratified breast cancer screening when delivered in real time as routine practice versus usual screening: the BC-Predict non-randomised controlled study (NCT04359420)
D. Evans, L. McWilliams, S. Astley, A. Brentnall +24 more
2023British Journal of Cancer21 citations Open access
Semantic Scholar
“I don’t know what I’m feeling for”: young women’s beliefs about breast cancer risk and experiences of breast awareness
Sarah Hindmarch, Louise S. Gorman, R. Hawkes, S. Howell +1 more
2023BMC Women's Health21 citations Open access
Semantic Scholar
Randomised controlled trial of intermittent vs continuous energy restriction during chemotherapy for early breast cancer
M. Harvie, M. Pegington, S. Howell, N. Bundred +14 more
2021British Journal of Cancer21 citations Open access
Semantic Scholar
Palbociclib and endocrine therapy in heavily pretreated hormone receptor-positive HER2-negative advanced breast cancer: the UK Compassionate Access Programme experience
N. Battisti, B. Kingston, J. King, A. Denton +16 more
2019Breast Cancer Research and Treatment20 citations
Semantic Scholar
Incorporating progesterone receptor expression into the PREDICT breast prognostic model
Isabelle Grootes, R. Keeman, F. Blows, R. Milne +99 more
2022European Journal of Cancer19 citations Open access
Semantic Scholar
Implementing Risk-Stratified Breast Screening in England: An Agenda Setting Meeting
L. McWilliams, D. Evans, K. Payne, Fiona Harrison +3 more
2022Cancers19 citations Open access
Semantic Scholar
350TiP A phase III trial of capivasertib and fulvestrant versus placebo and fulvestrant in patients with HR+/HER2− breast cancer (CAPItello-291)
N. Turner, S. Howell, K. Jhaveri, H. Gomez +10 more
202019 citations Open access
Semantic Scholar
Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock
J. Barrett, Chiara M. S. Herzog, Y. Kim, Thomas E. Bartlett +11 more
2022Genome Biology18 citations Open access
Semantic Scholar
Breast cancer incidence and early diagnosis in a family history risk and prevention clinic: 33-year experience in 14,311 women
D. Evans, S. Howell, A. Gandhi, E. V. van Veen +11 more
2021Breast Cancer Research and Treatment17 citations Open access
Semantic Scholar
The Impact of Morbidity and Disability on Attendance at Organized Breast Cancer–Screening Programs: A Systematic Review and Meta-Analysis
L. McWilliams, Samantha Groves, S. Howell, D. French
2022Cancer Epidemiology, Biomarkers and Prevention15 citations Open access
Semantic Scholar
Clinical utility of testing for PALB2 and CHEK2 c.1100delC in breast and ovarian cancer
E. Woodward, E. V. van Veen, C. Forde, E. Harkness +12 more
2021Genetics in Medicine14 citations Open access
Semantic Scholar
CDK4/6 inhibitors versus weekly paclitaxel for treatment of ER+/HER2- advanced breast cancer with impending or established visceral crisis
R. Behrouzi, A. Armstrong, S. Howell
2023Breast Cancer Research and Treatment13 citations Open access
Semantic Scholar
CApecitabine plus Radium-223 (Xofigo™) in breast cancer patients with BONe metastases (CARBON): study protocol for a phase IB/IIA randomised controlled trial
R. Coleman, Janet E. Brown, E. Rathbone, L. Flanagan +8 more
2020Trials13 citations Open access
Semantic Scholar
Optimising the delivery of breast cancer risk assessment for women aged 30–39 years: A qualitative study of women’s views
Sarah Hindmarch, Louise S. Gorman, R. Hawkes, S. Howell +1 more
2023Women's Health11 citations Open access
Semantic Scholar
Fulvestrant plus capivasertib versus fulvestrant plus placebo after relapse or progression on an aromatase inhibitor in metastatic, estrogen receptor–positive breast cancer (FAKTION): Overall survival and updated progression-free survival data with enhanced biomarker analysis.
Robert Jones, A. Casbard, M. Carucci, Kate Ingarfield-Herbert +13 more
2022Journal of Clinical Oncology11 citations
Semantic Scholar
A phase IB and randomised phase IIA trial of CApecitabine plus Radium-223 (Xofigo™) in breast cancer patients with BONe metastases: CARBON trial results
M. Winter, R. Coleman, J. Kendall, C. Palmieri +12 more
2022Journal of Bone Oncology11 citations Open access
Semantic Scholar
265P Study of samuraciclib (CT7001), a first-in-class, oral, selective inhibitor of CDK7, in combination with fulvestrant in patients with advanced hormone receptor positive HER2 negative breast cancer (HR+BC)
S. Howell, M. Krebs, S. Lord, L. Kenny +16 more
2021Annals of Oncology11 citations Open access
Semantic Scholar
Final results of the STEM trial: SFX-01 in the treatment and evaluation of ER+ Her2- metastatic breast cancer (mBC)
S. Howell, M. Campone, J. Cortes, F. Duhoux +3 more
2019Annals of Oncology11 citations Open access
Semantic Scholar
Artificial Intelligence for Image-Based Breast Cancer Risk Prediction Using Attention
Stepan Romanov, S. Howell, E. Harkness, M. Bydder +4 more
2023Medical Imaging10 citations Open access
Semantic Scholar
Breast density prediction from low and standard dose mammograms using deep learning: effect of image resolution and model training approach on prediction quality
Steven Squires, E. Harkness, Alistair Mackenzie, D. Evans +2 more
2023medRxiv8 citations Open access
Semantic Scholar
266P MEN1611, a PI3K inhibitor, combined with trastuzumab (T) ± fulvestrant (F) for HER2+/PIK3CA mutant (mut) advanced or metastatic (a/m) breast cancer (BC): Safety and efficacy results from the ongoing phase Ib study (B-PRECISE-01)
M. Piccart, M. Borrego, H. Arkenau, S. Escrivá-de-Romaní +16 more
2021Annals of Oncology8 citations Open access
Semantic Scholar
Automatic density prediction in low dose mammography
Steven Squires, Georgia V. Ionescu, E. Harkness, Alistair Mackenzie +4 more
2020Other Conferences8 citations Open access
Semantic Scholar
Estimating the Cost of 3 Risk Prediction Strategies for Potential Use in the United Kingdom National Breast Screening Program
S. Wright, M. Eden, Helen Ruane, H. Byers +6 more
2023MDM Policy & Practice7 citations Open access
Semantic Scholar
Differential involvement of germline pathogenic variants in breast cancer genes between DCIS and low-grade invasive cancers
D. Evans, S. Sithambaram, E. V. van Veen, G. Burghel +12 more
2022Journal of Medical Genetics7 citations Open access
Semantic Scholar
Gene Panel Testing for Breast Cancer Reveals Differential Effect of Prior BRCA1/2 Probability
D. G. Evans, E. V. van Veen, E. Woodward, E. Harkness +8 more
2021Cancers7 citations Open access
Semantic Scholar
Extended gene panel testing in lobular breast cancer
E. V. van Veen, D. Evans, E. Harkness, H. Byers +9 more
2021Familial Cancer7 citations Open access
Semantic Scholar
Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors
B. Simões, Bertram Kohler, R. Clarke, J. Stringer +6 more
2018Therapeutic Advances in Medical Oncology7 citations Open access
Semantic Scholar

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