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T. Michalak · SciRah

Researcher profile · Semantic Scholar

T. Michalak

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T. Michalak — researcher profile on SciRah

h-index: 26
Works: 132
Citations: 2,519

Most-cited papers

Hepatitis C Virus Persistence after Spontaneous or Treatment-Induced Resolution of Hepatitis C
T. Pham, S. MacParland, Patricia M. Mulrooney, H. Cooksley +2 more
2004Journal of Virology330 citations Open access
Semantic Scholar
Immune cell subsets and their gene expression profiles from human PBMC isolated by Vacutainer Cell Preparation Tube (CPT™) and standard density gradient
C. P. Corkum, Danielle P. Ings, Christopher Burgess, S. Karwowska +2 more
2015BMC Immunology172 citations Open access
Semantic Scholar
Intrahepatic Expression of Genes Affiliated with Innate and Adaptive Immune Responses Immediately after Invasion and during Acute Infection with Woodchuck Hepadnavirus
C. Guy, P. M. Mulrooney-Cousins, N. D. Churchill, T. Michalak
2008Journal of Virology82 citations Open access
Semantic Scholar
Persistent occult hepatitis B virus infection: experimental findings and clinical implications.
P. M. Mulrooney-Cousins, T. Michalak
2007World Journal of Gastroenterology79 citations Open access
Semantic Scholar
Low doses of hepadnavirus induce infection of the lymphatic system that does not engage the liver.
T. Michalak, Patricia M. Mulrooney, C. Coffin
2004Journal of Virology77 citations Open access
Semantic Scholar
Hepatitis C Virus Infection of Human T Lymphocytes Is Mediated by CD5
Mohammed A. Sarhan, T. Pham, Annie Y. Chen, T. Michalak
2012Journal of Virology73 citations Open access
Semantic Scholar
Posttranscriptional Inhibition of Class I Major Histocompatibility Complex Presentation on Hepatocytes and Lymphoid Cells in Chronic Woodchuck Hepatitis Virus Infection
T. Michalak, P. Hodgson, N. D. Churchill
2000Journal of Virology69 citations Open access
Semantic Scholar
Mitogen-induced upregulation of hepatitis C virus expression in human lymphoid cells.
T. Pham, S. MacParland, C. Coffin, Samuel S. Lee +2 more
2005Journal of General Virology67 citations Open access
Semantic Scholar
In Vitro and In Vivo Infectivity and Pathogenicity of the Lymphoid Cell-Derived Woodchuck Hepatitis Virus
Yuan-Yee Lew, T. Michalak
2001Journal of Virology58 citations Open access
Semantic Scholar
De novo infection and propagation of wild-type Hepatitis C virus in human T lymphocytes in vitro.
S. MacParland, T. Pham, S. Gujar, T. Michalak
2006Journal of General Virology53 citations Open access
Semantic Scholar
Occult persistence and lymphotropism of hepatitis C virus infection.
T. Pham, T. Michalak
2008World Journal of Gastroenterology50 citations Open access
Semantic Scholar
Reactivation of hepatitis B after liver transplantation: Current knowledge, molecular mechanisms and implications in management
R. Chauhan, S. Lingala, C. Gadiparthi, Nivedita Lahiri +4 more
2018World Journal of Hepatology48 citations Open access
Semantic Scholar
Hepatitis C virus upregulates B-cell receptor signaling: a novel mechanism for HCV-associated B-cell lymphoproliferative disorders
B. Dai, Annie Y. Chen, Christopher P. Corkum, Raymond J. Peroutka +14 more
2015Oncogene46 citations Open access
Semantic Scholar
Low Doses of Hepadnavirus Induce Infection of the Lymphatic System That Does Not Engage the Liver
T. Michalak, Patricia M. Mulrooney, C. Coffin
2004Journal of Virology40 citations Open access
Semantic Scholar
Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor
Clifford S. Guy, Sherri L. Rankin, T. Michalak
2011Hepatology36 citations Open access
Semantic Scholar
Antibody‐directed complement‐mediated cytotoxicity to hepatocytes from patients with chronic hepatitis B
T. Michalak, Johnson Y. N. Lau, B. McFarlane, GraemeJ.M. Alexander +2 more
1995Clinical and Experimental Immunology35 citations Open access
Semantic Scholar
Bicistronic Woodchuck Hepatitis Virus Core and Gamma Interferon DNA Vaccine Can Protect from Hepatitis but Does Not Elicit Sterilizing Antiviral Immunity
Jinguo Wang, S. Gujar, L. Cova, T. Michalak
2006Journal of Virology34 citations Open access
Semantic Scholar
Detection of hepatitis B and woodchuck hepatitis viral DNA in plasma and mononuclear cells from heparinized blood by the polymerase chain reaction.
I. Pardoe, T. Michalak
1995Journal of Virological Methods33 citations
Semantic Scholar
Quantitative Detection of Hepadnavirus-Infected Lymphoid Cells by In Situ PCR Combined with Flow Cytometry: Implications for the Study of Occult Virus Persistence
Patricia M. Mulrooney, T. Michalak
2003Journal of Virology29 citations Open access
Semantic Scholar
Hepadna virus nucleocapsid and surface antigens and the antigen-specific antibodies associated with hepatocyte plasma membranes in experimental woodchuck acute hepatitis.
T. Michalak, B. Lin, N. D. Churchill, P. Dzwonkowski +1 more
1990Laboratory investigation; a journal of technical methods and pathology29 citations
Semantic Scholar
Immunology of hepatitis B virus
T. Michalak
200427 citations
Semantic Scholar
Epidemiologic and clinical features of chronic hepatitis B virus infection in 8 Canadian provinces: a descriptive study by the Canadian HBV Network.
C. Coffin, A. Ramji, C. Cooper, D. Miles +23 more
2019CMAJ Open26 citations Open access
Semantic Scholar
Primary Seronegative but Molecularly Evident Hepadnaviral Infection Engages Liver and Induces Hepatocarcinoma in the Woodchuck Model of Hepatitis B
P. M. Mulrooney-Cousins, R. Chauhan, N. D. Churchill, T. Michalak
2014PLoS Pathogens26 citations Open access
Semantic Scholar
Primary Occult Hepadnavirus Infection Induces Virus-Specific T-Cell and Aberrant Cytokine Responses in the Absence of Antiviral Antibody Reactivity in the Woodchuck Model of Hepatitis B Virus Infection
S. Gujar, T. Michalak
2009Journal of Virology26 citations Open access
Semantic Scholar
Profound Antiviral Effect of Oral Administration of MIV-210 on Chronic Hepadnaviral Infection in a Woodchuck Model of Hepatitis B
T. Michalak, Hong Zhang, N. D. Churchill, T. Larsson +2 more
2009Antimicrobial Agents and Chemotherapy26 citations Open access
Semantic Scholar
Flow Cytometric Quantification of T Cell Proliferation and Division Kinetics in Woodchuck Model of Hepatitis B
S. Gujar, T. Michalak
2005Immunological Investigations26 citations
Semantic Scholar
A monoclonal antibody to the endothelium of rat brain microvessels.
T. Michalak, F. P. White, A. Gard, G. Dutton
1986Brain Research26 citations
Semantic Scholar
Occult hepatitis C virus infection and its relevance in clinical practice.
T. Pham, T. Michalak
2011Journal of Clinical and Experimental Hepatology25 citations Open access
Semantic Scholar
Molecular diagnosis of occult HCV and HBV infections
T. Michalak, T. Pham, P. M. Mulrooney-Cousins
200725 citations
Semantic Scholar
Diverse Virus and Host-Dependent Mechanisms Influence the Systemic and Intrahepatic Immune Responses in the Woodchuck Model of Hepatitis B
T. Michalak
2020Frontiers in Immunology24 citations Open access
Semantic Scholar
Differential Expression of Woodchuck Toll-Like Receptors 1–10 in Distinct Forms of Infection and Stages of Hepatitis in Experimental Hepatitis B Virus Infection
John B. Williams, Alena Hüppner, P. M. Mulrooney-Cousins, T. Michalak
2018Frontiers in Microbiology22 citations Open access
Semantic Scholar
Identification of woodchuck class I MHC antigens using monoclonal antibodies.
T. Michalak, N. D. Churchill, D. Codner, S. Drover +1 more
1995Tissue Antigens22 citations
Semantic Scholar
Hepadnaviral Lymphotropism and Its Relevance to HBV Persistence and Pathogenesis
C. Coffin, P. M. Mulrooney-Cousins, T. Michalak
2021Frontiers in Microbiology21 citations Open access
Semantic Scholar
Differential Expression of Candidate Virus Receptors in Human T Lymphocytes Prone or Resistant to Infection with Patient-Derived Hepatitis C Virus
Mohammed A. Sarhan, Annie Y. Chen, T. Michalak
2013PLoS ONE21 citations Open access
Semantic Scholar
Persistence of Hepatitis C Virus during and after Otherwise Clinically Successful Treatment of Chronic Hepatitis C with Standard Pegylated Interferon α-2b and Ribavirin Therapy
Annie Y. Chen, M. Zeremski, R. Chauhan, I. Jacobson +2 more
2013PLoS ONE21 citations Open access
Semantic Scholar
Comparison of biological activity of recombinant woodchuck interferon gamma and tumor necrosis factor alpha produced in baculovirus and Escherichia coli expression systems.
J. Wang, T. Michalak
2005Cytokine21 citations
Semantic Scholar
Nanoparticle Uptake in a Spontaneous and Immunocompetent Woodchuck Liver Cancer Model.
Lewis Y. Liu, Xue-Zhong Ma, Ben Ouyang, Danielle P. Ings +25 more
2020ACS Nano20 citations Open access
Semantic Scholar
Authentic Patient-Derived Hepatitis C Virus Infects and Productively Replicates in Primary CD4+ and CD8+ T Lymphocytes In Vitro
G. Skardasi, Annie Y. Chen, T. Michalak
2017Journal of Virology20 citations Open access
Semantic Scholar
Asymptomatic Hepadnaviral Persistence and Its Consequences in the Woodchuck Model of Occult Hepatitis B Virus Infection
P. M. Mulrooney-Cousins, T. Michalak
2015Journal of Clinical and Translational Hepatology20 citations Open access
Semantic Scholar
Repeated Passage of Wild-Type Woodchuck Hepatitis Virus in Lymphoid Cells Does Not Generate Cell Type-Specific Variants or Alter Virus Infectivity
P. M. Mulrooney-Cousins, T. Michalak
2008Journal of Virology20 citations Open access
Semantic Scholar
Inhibition by Woodchuck Hepatitis Virus of Class I Major Histocompatibility Complex Presentation on Hepatocytes Is Mediated by Virus Envelope Pre-S2 Protein and Can Be Reversed by Treatment with Gamma Interferon
Jinguo Wang, T. Michalak
2006Journal of Virology20 citations Open access
Semantic Scholar
Persistence of Hepatitis C Virus Traces after Spontaneous Resolution of Hepatitis C
Annie Y. Chen, M. Hoare, A. Shankar, M. Allison +2 more
2015PLoS ONE18 citations Open access
Semantic Scholar
Repeated Exposure to Trace Amounts of Woodchuck Hepadnavirus Induces Molecularly Evident Infection and Virus-Specific T Cell Response in the Absence of Serological Infection Markers and Hepatitis
S. Gujar, P. M. Mulrooney-Cousins, T. Michalak
2012Journal of Virology18 citations Open access
Semantic Scholar
Aberrant Lymphocyte Activation Precedes Delayed Virus-Specific T-Cell Response after both Primary Infection and Secondary Exposure to Hepadnavirus in the Woodchuck Model of Hepatitis B Virus Infection
S. Gujar, Adam K M Jenkins, C. Guy, Jinguo Wang +1 more
2008Journal of Virology18 citations Open access
Semantic Scholar
Patient-derived hepatitis C virus and JFH-1 clones differ in their ability to infect human hepatoma cells and lymphocytes.
Mohammed A. Sarhan, Annie Y. Chen, R. Russell, T. Michalak
2012Journal of General Virology17 citations Open access
Semantic Scholar
Retrotransposon elements among initial sites of hepatitis B virus integration into human genome in the HepG2-NTCP cell infection model.
R. Chauhan, Yoshimi Shimizu, K. Watashi, T. Wakita +2 more
2019Cancer Genetics16 citations
Semantic Scholar
Early viraemia clearance during antiviral therapy of chronic hepatitis C improves dendritic cell functions.
I. Pachiadakis, S. Chokshi, H. Cooksley, D. Farmakiotis +4 more
2009Clinical Immunology16 citations
Semantic Scholar
Woodchuck hepatitis virus hepatocyte culture models.
N. D. Churchill, T. Michalak
2004Methods in Molecular Medicine15 citations
Semantic Scholar
Earliest hepatitis B virus-hepatocyte genome integration: sites, mechanism, and significance in carcinogenesis
R. Chauhan, T. Michalak
2021Hepatoma Research14 citations Open access
Semantic Scholar
Characterization of the binding sites for glutaraldehyde-polymerized albumin on purified woodchuck hepatocyte plasma membranes.
T. Michalak, Gordon T. Bolger
1989Gastroenterology14 citations Open access
Semantic Scholar

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P. M. Mulrooney-Cousins×9
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P. M. Mulrooney-Cousins — researcher profile on SciRah
Annie Y. Chen×8
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Annie Y. Chen — researcher profile on SciRah
T. Pham×7
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T. Pham — researcher profile on SciRah
N. D. Churchill×7
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S. Gujar — researcher profile on SciRah

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C. Coffin — researcher profile on SciRah

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Patricia M. Mulrooney×4

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Patricia M. Mulrooney — researcher profile on SciRah

S. MacParland×3

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S. MacParland — researcher profile on SciRah

Mohammed A. Sarhan×3

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H. Cooksley — researcher profile on SciRah