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E. Gerhardt · SciRah

Researcher profile · Semantic Scholar

E. Gerhardt

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E. Gerhardt — researcher profile on SciRah

h-index: 31
Works: 58
Citations: 3,419

Most-cited papers

Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation
Diana F. Lázaro, E. Rodrigues, R. Langohr, Hedieh Shahpasandzadeh +13 more
2014PLoS Genetics228 citations Open access
Semantic Scholar
Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis.
R. Linker, De-Hyung Lee, S. Demir, S. Wiese +7 more
2010Brain : a journal of neurology209 citations Open access
Semantic Scholar
Protection by Synergistic Effects of Adenovirus-Mediated X-Chromosome-Linked Inhibitor of Apoptosis and Glial Cell Line-Derived Neurotrophic Factor Gene Transfer in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease
O. Eberhardt, R. Coelln, S. Kügler, J. Lindenau +10 more
2000Journal of Neuroscience205 citations Open access
Semantic Scholar
Tau deletion promotes brain insulin resistance
Elodie Marciniak, A. Leboucher, Emilie Caron, T. Ahmed +23 more
2017Journal of Experimental Medicine187 citations Open access
Semantic Scholar
Neuron-specific expression of therapeutic proteins: evaluation of different cellular promoters in recombinant adenoviral vectors.
S. Kügler, L. Meyn, H. Holzmüller, E. Gerhardt +3 more
2001Molecular and cellular neurosciences187 citations
Semantic Scholar
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
R. M. de Oliveira, Hugo Vicente Miranda, Laetitia Francelle, Raquel Pinho +21 more
2017PLoS Biology183 citations Open access
Semantic Scholar
Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage
I. Paiva, Raquel Pinho, M. A. Pavlou, M. Hennion +10 more
2017Human Molecular Genetics168 citations Open access
Semantic Scholar
Nuclear localization and phosphorylation modulate pathological effects of alpha‐synuclein
Raquel Pinho, I. Paiva, K. G. Jerčić, L. Fonseca-Ornelas +22 more
2018Human Molecular Genetics164 citations Open access
Semantic Scholar
Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells
Lma Oliveira, LJ Falomir-Lockhart, MG Botelho, K.-H. Lin +9 more
2015Cell Death and Disease152 citations Open access
Semantic Scholar
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.
Frank P. Marx, C. Holzmann, K. Strauss, Lei Li +13 more
2003Human Molecular Genetics152 citations
Semantic Scholar
The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity
E. Butler, Aaron Voigt, A. Lutz, J. P. Toegel +6 more
2012PLoS Genetics136 citations Open access
Semantic Scholar
Membrane binding, internalization, and sorting of alpha-synuclein in the cell
C. Masaracchia, Marilena Hnida, E. Gerhardt, Tomás Lopes da Fonseca +7 more
2018Acta Neuropathologica Communications90 citations Open access
Semantic Scholar
Mutant huntingtin alters Tau phosphorylation and subcellular distribution.
D. Blum, F. Herrera, Laetitia Francelle, T. Mendes +8 more
2015Human Molecular Genetics90 citations Open access
Semantic Scholar
Cascade of caspase activation in potassium-deprived cerebellar granule neurons: targets for treatment with peptide and protein inhibitors of apoptosis.
E. Gerhardt, S. Kügler, M. Leist, C. Beier +6 more
2001Molecular and cellular neurosciences88 citations Open access
Semantic Scholar
Synucleinopathies: Where we are and where we need to go
I. C. Brás, Antonio Dominguez-Meijide, E. Gerhardt, D. Koss +5 more
2020Journal of Neurochemistry84 citations Open access
Semantic Scholar
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity
Anna Villar-Piqué, Tomás Lopes da Fonseca, Ricardo Sant'Anna, E. Szegö +14 more
2016Proceedings of the National Academy of Sciences of the United States of America81 citations Open access
Semantic Scholar
Potential synergistic protection of retinal ganglion cells from axotomy-induced apoptosis by adenoviral administration of glial cell line-derived neurotrophic factor and X-chromosome-linked inhibitor of apoptosis.
Guido Straten, C. Schmeer, A. Kretz, E. Gerhardt +5 more
2002Neurobiology of Disease71 citations Open access
Semantic Scholar
Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1
Aline de Araújo Brasil, M. D. C. de Carvalho, E. Gerhardt, D. D. Queiroz +3 more
2019Proceedings of the National Academy of Sciences of the United States of America66 citations Open access
Semantic Scholar
FasL (CD95L/APO-1L) Resistance of Neurons Mediated by Phosphatidylinositol 3-Kinase-Akt/Protein Kinase B-Dependent Expression of Lifeguard/Neuronal Membrane Protein 35
C. Beier, J. Wischhusen, M. Gleichmann, E. Gerhardt +8 more
2005Journal of Neuroscience65 citations Open access
Semantic Scholar
Intracellular acidification by inhibition of the Na+/H+-exchanger leads to caspase-independent death of cerebellar granule neurons resembling paraptosis
D. Schneider, E. Gerhardt, J. Bock, Marguerite Müller +3 more
2004Cell Death and Differentiation64 citations
Semantic Scholar
Chemotherapy‐induced cell death in primary cerebellar granule neurons but not in astrocytes: in vitro paradigm of differential neurotoxicity
A. Wick, W. Wick, J. Hirrlinger, E. Gerhardt +4 more
2004Journal of Neurochemistry62 citations
Semantic Scholar
Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.
É. Szegő, Antonio Dominguez-Meijide, E. Gerhardt, Annekatrin König +15 more
2019Cell Reports57 citations Open access
Semantic Scholar
Fas/CD95 Regulatory Protein Faim2 Is Neuroprotective after Transient Brain Ischemia
A. Reich, C. Spering, K. Gertz, C. Harms +12 more
2011Journal of Neuroscience57 citations Open access
Semantic Scholar
Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice
E. Gerhardt, Simone Graber, É. Szegő, N. Moisoi +3 more
2011PLoS ONE50 citations Open access
Semantic Scholar
LRRK2 Promotes Tau Accumulation, Aggregation and Release
P. Guerreiro, E. Gerhardt, Tomás Lopes da Fonseca, M. Bähr +2 more
2015Molecular Neurobiology43 citations Open access
Semantic Scholar
Gene Expression Differences in Peripheral Blood of Parkinson’s Disease Patients with Distinct Progression Profiles
Raquel Pinho, L. Guedes, Lilach Soreq, P. P. Lobo +15 more
2016PLoS ONE40 citations Open access
Semantic Scholar
Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway.
É. Szegő, E. Gerhardt, T. Outeiro
2017Neurobiology of Aging35 citations Open access
Semantic Scholar
Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity.
S. Tenreiro, R. Rosado-Ramos, E. Gerhardt, F. Favretto +6 more
2016Human Molecular Genetics34 citations Open access
Semantic Scholar
HMGB1 and RAGE in skeletal muscle inflammation: Implications for protein accumulation in inclusion body myositis.
Ingrid E. Muth, J. Zschüntzsch, Konstanze Kleinschnitz, A. Wrede +7 more
2015Experimental Neurology33 citations
Semantic Scholar
Rapidly Signal‐enhanced Metabolites for Atomic Scale Monitoring of Living Cells with Magnetic Resonance
Yong-Hong Ding, S. Korchak, S. Mamone, A. Jagtap +11 more
2022Chemistry–Methods32 citations Open access
Semantic Scholar
Emergence of brain‐derived neurotrophic factor‐induced postsynaptic potentiation of NMDA currents during the postnatal maturation of the Kölliker–Fuse nucleus of rat
Miriam Kron, Julia Reuter, E. Gerhardt, T. Manzke +2 more
2008Journal of Physiology32 citations Open access
Semantic Scholar
Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models
A. A. Brasil, Rayne S. S. Magalhães, M. D. C. de Carvalho, I. Paiva +4 more
2017Molecular Neurobiology31 citations Open access
Semantic Scholar
Aggregate formation and toxicity by wild‐type and R621C synphilin‐1 in the nigrostriatal system of mice using adenoviral vectors
A. Krenz, B. Falkenburger, E. Gerhardt, Anja Drinkut +1 more
2009Journal of Neurochemistry29 citations Open access
Semantic Scholar
Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice.
É. Szegő, E. Gerhardt, T. Outeiro, P. Kermer
2011Journal of Neurological Sciences26 citations
Semantic Scholar
A30P α-synuclein impairs dopaminergic fiber regeneration and interacts with L-DOPA replacement in MPTP-treated mice.
É. Szegő, E. Gerhardt, P. Kermer, J. Schulz
2012Neurobiology of Disease24 citations Open access
Semantic Scholar
LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?
T. Outeiro, K. Harvey, Antonio Dominguez-Meijide, E. Gerhardt
2019Biochemical Society Transactions19 citations Open access
Semantic Scholar
Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation
L. Torres-Garcia, Joana M. Domingues, E. Brandi, C. Haikal +8 more
2022Scientific Reports18 citations Open access
Semantic Scholar
Ectosomes and exosomes modulate neuronal spontaneous activity.
I. C. Brás, M. Khani, D. Riedel, I. Parfentev +5 more
2022Journal of Proteomics16 citations Open access
Semantic Scholar
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
R. M. de Oliveira, Hugo Vicente Miranda, Laetitia Francelle, Raquel Pinho +21 more
2017PLoS Biology16 citations Open access
Semantic Scholar
Apoptosis: its relevance to Parkinson's disease
J. Schulz, E. Gerhardt
2001Clinical Neuroscience Research15 citations
Semantic Scholar
α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway
Marina I. Oliveira da Silva, M. Santejo, Isaac W Babcock, Ana Magalhães +11 more
2024Cell Death and Disease14 citations Open access
Semantic Scholar
Inhibition of 26S proteasome activity by α‐synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1
Dajana Galka, Tariq T. Ali, A. Bast, Marie Niederleithinger +7 more
2024Aging Cell14 citations Open access
Semantic Scholar
miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy
Mary Xylaki, I. Paiva, Mohammed Al-Azzani, E. Gerhardt +7 more
2023Journal of Parkinson's Disease11 citations Open access
Semantic Scholar
Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity
I. C. Brás, M. Khani, Eftychia Vasili, Wiebke Möbius +8 more
2022Journal of Parkinson's Disease11 citations Open access
Semantic Scholar
Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic.
K. Hassanzadeh, Castrese Morrone, K. Akhtari, E. Gerhardt +3 more
2022Mechanisms of Ageing and Development10 citations Open access
Semantic Scholar
SUMOylation modulates mitochondrial dynamics in an in vitro rotenone model of Parkinson's disease.
E. S. Soares, L. Y. Queiroz, E. Gerhardt, R. D. S. Prediger +2 more
2024Molecular and cellular neurosciences5 citations Open access
Semantic Scholar
Ectosomes and exosomes are distinct proteomic entities that modulate spontaneous activity in neuronal cells
I. C. Brás, M. Khani, D. Riedel, I. Parfentev +5 more
2021bioRxiv4 citations Open access
Semantic Scholar
Cofilin pathology is a new player on α-synuclein-induced spine impairment in models of hippocampal synucleinopathy
Marina I. Oliveira da Silva, M. Santejo, IW Babcock, A. Magalhães +8 more
2021bioRxiv4 citations Open access
Semantic Scholar
Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells
I. C. Brás, M. Khani, Eftychia Vasili, W. Möbius +8 more
2021bioRxiv3 citations Open access
Semantic Scholar
A water-soluble manganese(II) octanediaoate/phenanthroline complex acts as an antioxidant and attenuates alpha-synuclein toxicity.
D. D. Queiroz, T. Ribeiro, J. M. Gonçalves, L. Mattos +10 more
2021Biochimica et Biophysica Acta - Molecular Basis of Disease2 citations Open access
Semantic Scholar

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