A. Le

Most-cited papers

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B-cells
A. Le, A. Lane, M. Hamaker, Sminu Bose +13 more
2012Cell Metabolism1,086 citations Open access
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Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC
Wei Liu, A. Le, Chad N. Hancock, A. Lane +3 more
2012Proceedings of the National Academy of Sciences of the United States of America465 citations Open access
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Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.
Yan Xiang, Zachary E. Stine, Jin-Song Xia, Yunqi Lu +20 more
2015Journal of Clinical Investigation365 citations Open access
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Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step
A. Shestov, Xiao-Jing Liu, Ser Zheng, Ahmad A. Cluntun +7 more
2014eLife280 citations Open access
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Dysregulated metabolism contributes to oncogenesis
Matthew D. Hirschey, R. DeBerardinis, A. Diehl, J. Drew +21 more
2015Seminars in Cancer Biology275 citations Open access
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ED SUM: Triple-negative breast cancer is inhibited by depleting mitochondrial copper in mice.
L. Cui, Arvin M. Gouw, Edward L LaGory, Shenghao Guo +22 more
2020Nature Biotechnology267 citations Open access
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A Broad-Spectrum Integrative Design for Cancer Prevention and Therapy
K. Block, C. Gyllenhaal, Leroy Lowe, A. Amedei +176 more
2015Seminars in Cancer Biology249 citations Open access
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Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer
A. Elgogary, Qingguo Xu, Brad Poore, J. Alt +19 more
2016Proceedings of the National Academy of Sciences of the United States of America228 citations Open access
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Glutamine Metabolism in Cancer.
Ting Li, A. Le
2018Advances in Experimental Medicine and Biology215 citations
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Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness
Yi-Ze Li, T. Lih, S. Dhanasekaran, R. Mannan +64 more
2022Cancer Cell212 citations Open access
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Therapeutic targeting of cancer cell metabolism
C. Dang, M. Hamaker, P. Sun, A. Le +1 more
2011Journal of molecular medicine183 citations Open access
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Glucose Metabolism in Cancer: The Warburg Effect and Beyond
Sminu Bose, Cissy Zhang, A. Le
2021Advances in Experimental Medicine and Biology175 citations Open access
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Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 function
N. Rajeshkumar, Prasanta Dutta, S. Yabuuchi, R. D. de Wilde +9 more
2015Cancer Research152 citations Open access
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Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma.
R. Rais, A. Jančařík, L. Tenora, Michael T. Nedelcovych +13 more
2016Journal of Medicinal Chemistry125 citations
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Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer
Tu Nguyen, B. Kirsch, R. Asaka, Karim B. Nabi +23 more
2019Cell Reports101 citations Open access
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Glucose Metabolism in Cancer.
Sminu Bose, A. Le
2018Advances in Experimental Medicine and Biology101 citations
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Inhibition of the MYC-regulated glutaminase metabolic axis is an effective synthetic lethal approach for treating chemoresistant cancers
Yao-An Shen, Jiaxin Hong, R. Asaka, Asaka Shiho +16 more
2020Cancer Research83 citations Open access
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Kynurenines link chronic inflammation to functional decline and physical frailty
Reyhan M. Westbrook, Tae Chung, Jacqueline Lovett, C. Ward +12 more
2020JCI Insight80 citations Open access
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Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment
Marise R. Heerma van Voss, F. Vesuna, G. Bol, Junaid Afzal +17 more
2017Oncogene72 citations Open access
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The Heterogeneity of Lipid Metabolism in Cancer.
Joshua K Park, Nathan J. Coffey, Aaron Limoges, A. Le
2018Advances in Experimental Medicine and Biology67 citations
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Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment
Yao-An Shen, Chi-Long Chen, Yi-Hsuan Huang, Emily Evans +4 more
2021Current Opinion in Chemical Biology66 citations Open access
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Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold
S. C. Zimmermann, E. Wolf, A. Luu, A. Thomas +7 more
2016ACS Medicinal Chemistry Letters63 citations Open access
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The Limitless Applications of Single-Cell Metabolomics
Shenghao Guo, Cissy Zhang, A. Le
2021Current Opinion in Biotechnology61 citations Open access
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Metabolic Relationship Between Cancer-Associated Fibroblasts and Cancer Cells.
Christos Sazeides, A. Le
2021Advances in Experimental Medicine and Biology61 citations Open access
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Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer
Sunag Udupa, S. Nguyen, Giang Hoang, Tu Nguyen +15 more
2019Proteomics61 citations Open access
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Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors
Prasanta Dutta, A. Le, D. L. Vander Jagt, T. Tsukamoto +3 more
2013Cancer Research61 citations Open access
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Hepatocyte Growth Factor, a Determinant of Airspace Homeostasis in the Murine Lung
C. Calvi, M. Podowski, Armando Lopez-Mercado, Shana L. Metzger +10 more
2013PLoS Genetics59 citations Open access
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Conceptual Framework for Cutting the Pancreatic Cancer Fuel Supply
A. Le, N. Rajeshkumar, A. Maitra, C. Dang
2012Clinical Cancer Research59 citations Open access
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Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia–cell cycle dual reporter
A. Le, Zachary E. Stine, Christopher Nguyen, Junaid Afzal +10 more
2014Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
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A specialized metabolic pathway partitions citrate in hydroxyapatite to impact mineralization of bones and teeth
Naomi Dirckx, Qian Zhang, E. Chu, R. Tower +16 more
2022Proceedings of the National Academy of Sciences of the United States of America53 citations Open access
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Glutamine Metabolism in Cancer.
Ting Li, Christopher Copeland, A. Le
2021Advances in Experimental Medicine and Biology47 citations Open access
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Application of metabolomics technologies toward cancer prognosis and therapy.
Giang Hoang, Sunag Udupa, A. Le
2019International Review of Cell and Molecular Biology46 citations
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Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation
A. Walker, Anju Singh, E. Tully, Juhyung Woo +5 more
2018Free Radical Biology & Medicine44 citations Open access
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Metabolomics-Based Identification of Metabolic Dysfunction in Frailty.
Reyhan M. Westbrook, Cissy Zhang, Huan-Le Yang, Jing Tian +5 more
2021The journals of gerontology. Series A, Biological sciences and medical sciences43 citations Open access
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The Heterogeneity of Liver Cancer Metabolism.
J. Salazar, A. Le
2021Advances in Experimental Medicine and Biology42 citations Open access
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The Intratumoral Heterogeneity of Cancer Metabolism.
Karim B. Nabi, A. Le
2021Advances in Experimental Medicine and Biology40 citations Open access
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The Metabolic Interplay between Cancer and Other Diseases
A. Le, Sunag Udupa, Cissy Zhang
2019Trends in Cancer40 citations Open access
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Metabolic Reservoir Cycles in Cancer
Cissy Zhang, Addison Quinones, A. Le
2022Seminars in Cancer Biology37 citations Open access
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Targeting Metabolic Cross Talk Between Cancer Cells and Cancer-Associated Fibroblasts.
J. Jung, A. Le
2021Advances in Experimental Medicine and Biology36 citations Open access
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The Heterogeneity of Cancer Metabolism
A. Le
2018Advances in Experimental Medicine and Biology31 citations Open access
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The Heterogeneity of Breast Cancer Metabolism.
Jessica Tan, A. Le
2021Advances in Experimental Medicine and Biology30 citations Open access
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Studying Myc’s Role in Metabolism Regulation
A. Le, C. Dang
2013Methods in molecular biology27 citations Open access
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Regulation of Mitochondrial Fragmentation in Microvascular Endothelial Cells Isolated from the Su5416/Hypoxia model of Pulmonary Arterial Hypertension.
K. Suresh, Laura E. Servinsky, Hai-Yang Jiang, Z. Bigham +9 more
2019American Journal of Physiology - Lung cellular and Molecular Physiology26 citations Open access
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Different Tumor Microenvironments Lead to Different Metabolic Phenotypes.
M. J. Antonio, A. Le
2018Advances in Experimental Medicine and Biology26 citations
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Valsartan Nano-Filaments Alter Mitochondrial Energetics and Promote Faster Healing in Diabetic Rat Wounds
Lolita S Nidadavolu, David Stern, Ran Lin, Yu-Zhu Wang +16 more
2021Wound Repair and Regeneration22 citations Open access
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The Intricate Metabolism of Pancreatic Cancers.
F. Camêlo, A. Le
2021Advances in Experimental Medicine and Biology22 citations Open access
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The Multifaceted Glioblastoma: From Genomic Alterations to Metabolic Adaptations.
Addison Quinones, A. Le
2021Advances in Experimental Medicine and Biology22 citations Open access
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Diverse mitochondrial abnormalities in a new cellular model of TAFFAZZIN deficiency are remediated by cardiolipin-interacting small molecules
A. Anzmann, Olivia L. Sniezek, Alexandra Pado, V. Busa +8 more
2021Journal of Biological Chemistry22 citations Open access
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The Multifaceted Metabolism of Glioblastoma.
Addison Quinones, A. Le
2018Advances in Experimental Medicine and Biology22 citations
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Non-Hodgkin Lymphoma Metabolism.
B. Kirsch, Shu-Jyuan Chang, M. Betenbaugh, A. Le
2021Advances in Experimental Medicine and Biology21 citations Open access
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