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N. Ito · SciRah

Researcher profile · Semantic Scholar

N. Ito

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N. Ito — researcher profile on SciRah

h-index: 25
Works: 156
Citations: 3,338

Most-cited papers

Selective inhibition of the kinase DYRK1A by targeting its folding process
I. Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto +11 more
2016Nature Communications81 citations Open access
Semantic Scholar
CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses.
M. Yamamoto, H. Onogi, I. Kii, Suguru Yoshida +7 more
2014Journal of Clinical Investigation68 citations Open access
Semantic Scholar
Structural Dynamics of the PET-Degrading Cutinase-like Enzyme from Saccharomonospora viridis AHK190 in Substrate-Bound States Elucidates the Ca2+-Driven Catalytic Cycle.
N. Numoto, N. Kamiya, G. Bekker, Y. Yamagami +6 more
2018Biochemistry61 citations
Semantic Scholar
Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice
Satoshi Morooka, Mitsuteru Hoshina, I. Kii, T. Okabe +16 more
2015Molecular Pharmacology52 citations
Semantic Scholar
CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP
Chizuru Akatsu, Kenro Shinagawa, N. Numoto, Zhihong Liu +7 more
2016Journal of Experimental Medicine46 citations Open access
Semantic Scholar
Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives
H. Masuno, T. Ikura, D. Morizono, I. Orita +3 more
2013Journal of Lipid Research37 citations Open access
Semantic Scholar
HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology
Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma +17 more
2021Communications Biology32 citations Open access
Semantic Scholar
CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice
N. Matsubara, A. Imamura, Tatsuya Yonemizu, Chizuru Akatsu +14 more
2018Frontiers in Immunology32 citations Open access
Semantic Scholar
Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis.
So Masaki, I. Kii, Yuto Sumida, Tomoe Kato-Sumida +7 more
2015Bioorganic & Medicinal Chemistry28 citations Open access
Semantic Scholar
Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands.
M. Nakabayashi, Yoshito Tsukahara, Yukiko Iwasaki-Miyamoto, Mika Mihori-Shimazaki +8 more
2013Journal of Medicinal Chemistry27 citations
Semantic Scholar
Structural basis of mutants of PET‐degrading enzyme from Saccharomonospora viridis AHK190 with high activity and thermal stability
Miho Emori, N. Numoto, A. Senga, G. Bekker +5 more
2020Proteins: Structure, Function, and Bioinformatics26 citations
Semantic Scholar
Combination of triple bond and adamantane ring on the vitamin D side chain produced partial agonists for vitamin D receptor.
T. Kudo, Michiyasu Ishizawa, K. Maekawa, M. Nakabayashi +7 more
2014Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins*
S. Inaba, N. Numoto, Shu-hei Ogawa, H. Morii +4 more
2016Journal of Biological Chemistry21 citations Open access
Semantic Scholar
High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28
Kunitake Higo, T. Ikura, M. Oda, H. Morii +3 more
2013PLoS ONE21 citations Open access
Semantic Scholar
Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists.
Harue Sasaki, H. Masuno, Haru Kawasaki, A. Yoshihara +9 more
2020Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Butyl pocket formation in the vitamin D receptor strongly affects the agonistic or antagonistic behavior of ligands.
N. Yoshimoto, Yuta Sakamaki, Minoru Haeta, A. Kato +5 more
2012Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Peptidyl-prolyl isomerase activity of FK506 binding protein 12 prevents tau peptide from aggregating.
T. Ikura, N. Ito
2013Protein engineering, design & selection : PEDS19 citations
Semantic Scholar
Structural and functional properties of Grb2 SH2 dimer in CD28 binding
Y. Hosoe, N. Numoto, S. Inaba, Shu-hei Ogawa +4 more
2019Biophysics and Physicobiology17 citations Open access
Semantic Scholar
Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists
A. Yoshihara, Haru Kawasaki, H. Masuno, Koki Takada +8 more
2022Biomolecules16 citations Open access
Semantic Scholar
Multiple structural states of Ca2+ regulated PET hydrolase, Cut190, and its correlation with activity and stability.
A. Senga, N. Numoto, M. Yamashita, A. Iida +3 more
2020Journal of Biochemistry (Tokyo)14 citations
Semantic Scholar
Tau aggregation and seeding analyses of two novel MAPT variants found in patients with motor neuron disease and progressive parkinsonism.
S. Nakayama, S. Shimonaka, M. Elahi, Kenya Nishioka +11 more
2019Neurobiology of Aging14 citations
Semantic Scholar
A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides.
Amin Alborzian Deh Sheikh, S. Gomaa, Xue-Xin Li, M. Routledge +9 more
2020Journal of Autoimmunity13 citations
Semantic Scholar
Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries
Tomomi Imamura, Kyota Fujita, K. Tagawa, T. Ikura +14 more
2016Scientific Reports12 citations Open access
Semantic Scholar
Structural and biophysical analysis of sero-specific immune responses using epitope grafted Dengue ED3 mutants.
M. Kulkarni, Monirul M. Islam, N. Numoto, M. Elahi +3 more
2015Biochimica et Biophysica Acta12 citations
Semantic Scholar
Effects of DNA binding of the zinc finger and linkers for domain fusion on the catalytic activity of sequence-specific chimeric recombinases determined by a facile fluorescent system.
Wataru Nomura, A. Masuda, K. Ohba, Arisa Urabe +4 more
2012Biochemistry12 citations
Semantic Scholar
Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.
M. Iiyama, N. Numoto, Shu-hei Ogawa, M. Kuroda +4 more
2020Molecular Immunology11 citations
Semantic Scholar
Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds.
Y. Watarai, Michiyasu Ishizawa, T. Ikura, Flavia C. Zacconi +6 more
2015Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Hepta-Histidine Inhibits Tau Aggregation.
Kanoh Kondo, T. Ikura, Hikari Tanaka, Kyota Fujita +10 more
2021ACS Chemical Neuroscience10 citations
Semantic Scholar
Modeling and experimental assessment of a buried Leu-Ile mutation in dengue envelope domain III.
M. Kulkarni, N. Numoto, N. Ito, Y. Kuroda
2016Biochemical and Biophysical Research Communications - BBRC10 citations
Semantic Scholar
Crystal Structure of the Vitamin D Receptor Ligand-Binding Domain with Lithocholic Acids.
T. Ikura, N. Ito
2016Vitamins and hormones10 citations
Semantic Scholar
Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity.
Y. Anami, Yuta Sakamaki, T. Itoh, Y. Inaba +4 more
2015Bioorganic & Medicinal Chemistry10 citations Open access
Semantic Scholar
Development of novel lithocholic acid derivatives as vitamin D receptor agonists.
H. Masuno, Yuko Kazui, Aya Tanatani, S. Fujii +5 more
2019Bioorganic & Medicinal Chemistry9 citations Open access
Semantic Scholar
Three-dimensional structure of a high affinity anti-(4-hydroxy-3-nitrophenyl)acetyl antibody possessing a glycine residue at position 95 of the heavy chain.
A. Nishiguchi, N. Numoto, N. Ito, T. Azuma +1 more
2019Molecular Immunology9 citations
Semantic Scholar
25 S-Adamantyl-23-yne-26,27-dinor-1α,25-dihydroxyvitamin D3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex.
R. Otero, Michiyasu Ishizawa, N. Numoto, T. Ikura +5 more
2018Journal of Medicinal Chemistry9 citations Open access
Semantic Scholar
The trans isomer of Tau peptide is prone to aggregate, and the WW domain of Pin1 drastically decreases its aggregation
T. Ikura, N. Tochio, Ryosuke Kawasaki, M. Matsuzaki +5 more
2018FEBS Letters8 citations Open access
Semantic Scholar
Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα)
Y. Miyashita, N. Numoto, S. Arulmozhiraja, S. Nakano +9 more
2018FEBS Letters6 citations Open access
Semantic Scholar
Crystal structure of PET-degrading cutinase Cut190 S176A/S226P/R228S mutant in monoethyl succinate bound state
N. Numoto, N. Kamiya, G. Bekker, Y. Yamagami +6 more
20185 citations
Semantic Scholar
Biophysical Reviews Special Issue call: Computational biophysics and structural biology of proteins—A Special Issue in honor of Prof. Haruki Nakamura’s 70th birthday
G. Basu, Damien Hall, N. Ito
2022Biophysical Reviews3 citations Open access
Semantic Scholar
Computational biophysics and structural biology of proteins—a Special Issue in honor of Prof. Haruki Nakamura’s 70th birthday
Damien Hall, G. Basu, N. Ito
2022Biophysical Reviews3 citations Open access
Semantic Scholar
Coarse snapshots of oxygen-dissociation intermediates of a giant hemoglobin elucidated by determining the oxygen saturation in individual subunits in the crystalline state
N. Numoto, Y. Kawano, H. Okumura, S. Baba +3 more
2021IUCrJ3 citations Open access
Semantic Scholar
Mutational effects of Cys113 on structural dynamics of Pin1
T. Ikura, Y. Yonezawa, N. Ito
2019Biophysics and Physicobiology3 citations Open access
Semantic Scholar
Structural basis of the broad substrate tolerance of the antibody 7B9-catalyzed hydrolysis of p-nitrobenzyl esters.
N. Miyamoto, Miho Yoshimura, Yuji Okubo, Kayo Suzuki-Nagata +3 more
2017Bioorganic & Medicinal Chemistry3 citations
Semantic Scholar
Structural Analysis of Hen Egg Lysozyme Refolded after Denaturation at Acidic pH
M. Oda, Tomoki Sano, Y. Kamatari, Y. Abe +2 more
2022The Protein Journal2 citations
Semantic Scholar
Structural and functional properties of Grb2 SH2 dimer in CD28 binding.
Y. Hosoe, N. Numoto, S. Inaba, Shu-hei Ogawa +4 more
20192 citations
Semantic Scholar
Partial oxygen-dissociation of crystalline giant hemoglobin
N. Numoto, Taro Nakagawa, A. Kita, N. Ito +2 more
20141 citations Open access
Semantic Scholar
High-index and high-transparent glass for AR/MR devices
S. Konoshita, Koichi Yabuuchi, S. Fujita, T. Murata +6 more
2023AR, VR, MR0 citations
Semantic Scholar
Vitamin D3 receptor/lithochoric acid derivative complex
H. Masuno, N. Numoto, H. Kagechika, N. Ito
20210 citations
Semantic Scholar
Open form of PET-degrading cutinase Cut190 with thermostability-improving mutations of S226P/R228S/Q138A/D250C-E296C/Q123H/N202H and S176A inactivation
M. Emori, N. Numoto, A. Senga, G. Bekker +4 more
20210 citations
Semantic Scholar
Closed form of PET-degrading cutinase Cut190 with thermostability-improving mutations of S226P/R228S/Q138A/D250C-E296C/Q123H/N202H
M. Emori, N. Numoto, A. Senga, G. Bekker +4 more
20210 citations
Semantic Scholar
Varying the Directionality of Protein Catalysts for Aldol and Retro‐Aldol Reactions
Toshifumi Fujioka, N. Numoto, Hiroyuki Akama, Kola Shilpa +7 more
2021ChemBioChem0 citations Open access
Semantic Scholar

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