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Ben Lehner · SciRah

Researcher profile · Semantic Scholar

Ben Lehner

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Ben Lehner — researcher profile on SciRah

h-index: 58
Works: 131
Citations: 13K

Most-cited papers

3D structure of individual mammalian genomes studied by single cell Hi-C
T. Stevens, D. Lando, S. Basu, Liam P. Atkinson +19 more
2017Nature758 citations Open access
Semantic Scholar
Chromatin organization is a major influence on regional mutation rates in human cancer cells
Benjamin Schuster-Böckler, Ben Lehner
2012Nature652 citations Open access
Semantic Scholar
Synonymous mutations frequently act as driver mutations in human cancers.
F. Supek, B. Miñana, J. Valcárcel, T. Gabaldón +1 more
2014Cell551 citations Open access
Semantic Scholar
The rules and impact of nonsense-mediated mRNA decay in human cancers
R. Lindeboom, F. Supek, Ben Lehner
2016Nature Genetics484 citations Open access
Semantic Scholar
Intergenerational and transgenerational epigenetic inheritance in animals
M. F. Perez, Ben Lehner
2019Nature Cell Biology453 citations
Semantic Scholar
Transgenerational transmission of environmental information in C. elegans
A. Klosin, Eduard Casas, Cristina Hidalgo-Carcedo, Tanya Vavouri +1 more
2017Science358 citations
Semantic Scholar
Differential DNA mismatch repair underlies mutation rate variation across the human genome
F. Supek, Ben Lehner
2015Nature350 citations Open access
Semantic Scholar
Molecular mechanisms of epistasis within and between genes.
Ben Lehner
2011Trends in Genetics327 citations
Semantic Scholar
A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression
B. Bolognesi, Nieves Lorenzo Gotor, R. Dhar, D. Cirillo +3 more
2016Cell Reports283 citations Open access
Semantic Scholar
The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
R. Lindeboom, M. Vermeulen, Ben Lehner, F. Supek
2019Nature Genetics255 citations Open access
Semantic Scholar
The Causes and Consequences of Genetic Interactions (Epistasis).
Júlia Domingo, Pablo Baeza-Centurión, Ben Lehner
2019Annual review of genomics and human genetics (Print)244 citations
Semantic Scholar
Genotype to phenotype: lessons from model organisms for human genetics
Ben Lehner
2013Nature reviews genetics232 citations Open access
Semantic Scholar
Mapping the energetic and allosteric landscapes of protein binding domains
André J. Faure, Júlia Domingo, Jörn M. Schmiedel, Cristina Hidalgo-Carcedo +2 more
2022Nature223 citations
Semantic Scholar
To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases.
F. Supek, Ben Lehner, R. Lindeboom
2020Trends in Genetics215 citations Open access
Semantic Scholar
Predicting mutation outcome from early stochastic variation in genetic interaction partners
A. Burga, M. Casanueva, Ben Lehner
2011Nature195 citations
Semantic Scholar
Clustered Mutation Signatures Reveal that Error-Prone DNA Repair Targets Mutations to Active Genes.
F. Supek, Ben Lehner
2017Cell192 citations Open access
Semantic Scholar
Fitness Trade-Offs and Environmentally Induced Mutation Buffering in Isogenic C. elegans
M. Casanueva, A. Burga, Ben Lehner
2012Science151 citations
Semantic Scholar
The mutational landscape of a prion-like domain
B. Bolognesi, André J. Faure, Mireia Seuma, Joern M Schmiedel +2 more
2019Nature Communications149 citations Open access
Semantic Scholar
MUFFINN: cancer gene discovery via network analysis of somatic mutation data
A-Ra Cho, J. Shim, Eiru Kim, F. Supek +2 more
2016Genome Biology147 citations Open access
Semantic Scholar
Human epidermal stem cell function is regulated by circadian oscillations.
Peggy Janich, Kiana Toufighi, G. Solanas, N. Luis +4 more
2013Cell Stem Cell143 citations Open access
Semantic Scholar
The energetic and allosteric landscape for KRAS inhibition
Chen-Chun Weng, André J. Faure, Albert Escobedo, Ben Lehner
2022bioRxiv140 citations Open access
Semantic Scholar
Human genes with CpG island promoters have a distinct transcription-associated chromatin organization
Tanya Vavouri, Ben Lehner
2012Genome Biology134 citations Open access
Semantic Scholar
Determining protein structures using deep mutagenesis
Jörn M. Schmiedel, Ben Lehner
2019Nature Genetics133 citations Open access
Semantic Scholar
The genetic landscape of a physical interaction
G. Diss, Ben Lehner
2018eLife131 citations Open access
Semantic Scholar
The effects of genetic variation on gene expression dynamics during development
M. Francesconi, Ben Lehner
2013Nature126 citations Open access
Semantic Scholar
Pairwise and higher order genetic interactions during the evolution of a tRNA
Júlia Domingo, G. Diss, Ben Lehner
2018Nature119 citations Open access
Semantic Scholar
Vitellogenins - Yolk Gene Function and Regulation in Caenorhabditis elegans
M. F. Perez, Ben Lehner
2019Frontiers in Physiology114 citations Open access
Semantic Scholar
Combinatorial Genetics Reveals a Scaling Law for the Effects of Mutations on Splicing.
Pablo Baeza-Centurión, B. Miñana, Jörn M. Schmiedel, J. Valcárcel +1 more
2019Cell114 citations Open access
Semantic Scholar
Maternal age generates phenotypic variation in C. elegans
M. F. Perez, M. Francesconi, Cristina Hidalgo-Carcedo, Ben Lehner
2017Nature101 citations Open access
Semantic Scholar
Conflict between Noise and Plasticity in Yeast
Ben Lehner
2010PLoS Genetics100 citations Open access
Semantic Scholar
Chromatin Organization in Sperm May Be the Major Functional Consequence of Base Composition Variation in the Human Genome
Tanya Vavouri, Ben Lehner
2011PLoS Genetics93 citations Open access
Semantic Scholar
Predicting genetic modifier loci using functional gene networks.
Insuk Lee, Ben Lehner, Tanya Vavouri, Junha Shin +2 more
2010Genome Research93 citations Open access
Semantic Scholar
DiMSum: an error model and pipeline for analyzing deep mutational scanning data and diagnosing common experimental pathologies
André J. Faure, Jörn M. Schmiedel, Pablo Baeza-Centurión, Ben Lehner
2020Genome Biology91 citations Open access
Semantic Scholar
Genes Confer Similar Robustness to Environmental, Stochastic, and Genetic Perturbations in Yeast
Ben Lehner
2010PLoS ONE91 citations Open access
Semantic Scholar
Systematic Analysis of the Determinants of Gene Expression Noise in Embryonic Stem Cells.
André J. Faure, Jörn M. Schmiedel, Ben Lehner
2017Cell Systems84 citations Open access
Semantic Scholar
Scales and mechanisms of somatic mutation rate variation across the human genome.
F. Supek, Ben Lehner
2019DNA Repair80 citations Open access
Semantic Scholar
Mechanisms, timescales and principles of trans-generational epigenetic inheritance in animals.
A. Klosin, Ben Lehner
2016Current Opinion in Genetics and Development80 citations
Semantic Scholar
Predicting phenotypic variation in yeast from individual genome sequences
Rob Jelier, Jennifer I. Semple, Rosa Garcı́a-Verdugo, Ben Lehner
2011Nature Genetics77 citations
Semantic Scholar
Rapid selection of transgenic C. elegans using antibiotic resistance
Jennifer I. Semple, Rosa Garcı́a-Verdugo, Ben Lehner
2010Nature Methods73 citations
Semantic Scholar
Cancer type-dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types
Solip Park, Ben Lehner
2015Molecular Systems Biology63 citations Open access
Semantic Scholar
An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation
Mireia Seuma, Ben Lehner, B. Bolognesi
2022bioRxiv57 citations Open access
Semantic Scholar
Beyond genotype to phenotype: why the phenotype of an individual cannot always be predicted from their genome sequence and the environment that they experience
A. Burga, Ben Lehner
2012The FEBS Journal56 citations Open access
Semantic Scholar
Reaching the limit
B. Bolognesi, Ben Lehner
2018eLife53 citations Open access
Semantic Scholar
Slow growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage
D. van Dijk, R. Dhar, A. Missarova, L. Espinar +3 more
2015Nature Communications53 citations Open access
Semantic Scholar
Inferring gene function from evolutionary change in signatures of translation efficiency
A. Kriško, Tea Copić, T. Gabaldón, Ben Lehner +1 more
2014Genome Biology52 citations Open access
Semantic Scholar
The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer’s disease mutations
Mireia Seuma, André J. Faure, Marta Badia, Ben Lehner +1 more
2020bioRxiv51 citations Open access
Semantic Scholar
Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming
M. Francesconi, B. D. Di Stefano, Clara Berenguer, L. de Andrés-Aguayo +9 more
2019eLife51 citations Open access
Semantic Scholar
Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits
Solip Park, F. Supek, Ben Lehner
2018Nature Communications51 citations Open access
Semantic Scholar
Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise
Jörn M. Schmiedel, Lucas B. Carey, Ben Lehner
2019Nature Communications42 citations Open access
Semantic Scholar
Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours
A. Avgustinova, Aikaterini Symeonidi, A. Castellanos, Uxue Urdiroz-Urricelqui +7 more
2018Nature Cell Biology42 citations
Semantic Scholar

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