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W. Macfarlane · SciRah

Researcher profile · Semantic Scholar

W. Macfarlane

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W. Macfarlane — researcher profile on SciRah

h-index: 20
Works: 63
Citations: 1,712

Most-cited papers

Glucose Stimulates Translocation of the Homeodomain Transcription Factor PDX1 from the Cytoplasm to the Nucleus in Pancreatic β-Cells*
W. Macfarlane, C. McKinnon, Zoë A. Felton-Edkins, H. Cragg +2 more
1999Journal of Biological Chemistry238 citations Open access
Semantic Scholar
The p38/Reactivating Kinase Mitogen-activated Protein Kinase Cascade Mediates the Activation of the Transcription Factor Insulin Upstream Factor 1 and Insulin Gene Transcription by High Glucose in Pancreatic β-Cells*
W. Macfarlane, Stuart B. Smith, R. James, A. Clifton +3 more
1997Journal of Biological Chemistry189 citations Open access
Semantic Scholar
Bacterial biofilm formation on indwelling urethral catheters
H. Pelling, J. Nzakizwanayo, S. Milo, E. Denham +4 more
2019Letters in Applied Microbiology152 citations Open access
Semantic Scholar
Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner.
W. Macfarlane, Martin L Read, M. Gilligan, I. Bujalska +1 more
1994Biochemical Journal150 citations Open access
Semantic Scholar
Escherichia coli Nissle 1917 enhances bioavailability of serotonin in gut tissues through modulation of synthesis and clearance
J. Nzakizwanayo, Cinzia Dedi, G. Standen, W. Macfarlane +2 more
2015Scientific Reports99 citations Open access
Semantic Scholar
Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells.
Hong Wu, W. Macfarlane, M. Tadayyon, J. Arch +2 more
1999Biochemical Journal83 citations Open access
Semantic Scholar
Glucose Regulates Islet Amyloid Polypeptide Gene Transcription in a PDX1- and Calcium-dependent Manner*
W. Macfarlane, S. C. Campbell, Lucy J. Elrick, Victoria Oates +6 more
2000Journal of Biological Chemistry81 citations Open access
Semantic Scholar
Engineering a Glucose-responsive Human Insulin-secreting Cell Line from Islets of Langerhans Isolated from a Patient with Persistent Hyperinsulinemic Hypoglycemia of Infancy*
W. Macfarlane, J. C. Chapman, R. M. Shepherd, Molly N. Hashmi +11 more
1999Journal of Biological Chemistry69 citations Open access
Semantic Scholar
Selenium stimulates pancreatic beta‐cell gene expression and enhances islet function
S. C. Campbell, A. Aldibbiat, C. Marriott, C. Landy +5 more
2008FEBS Letters68 citations Open access
Semantic Scholar
Characterisation of physico-mechanical properties and degradation potential of calcium alginate beads for use in embolisation
R. Forster, F. Thürmer, C. Wallrapp, A. Lloyd +4 more
2010Journal of materials science. Materials in medicine61 citations Open access
Semantic Scholar
Functional consequences of mutations in the MODY4 gene (IPF1) and coexistence with MODY3 mutations
J. Weng, W. Macfarlane, M. Lehto, H. Gu +5 more
2001Diabetologia61 citations Open access
Semantic Scholar
Impaired expression of transcription factor IUF1 in a pancreatic β‐cell line derived from a patient with persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis)
W. Macfarlane, H. Cragg, H. Docherty, Martin L Read +3 more
1997FEBS Letters51 citations Open access
Semantic Scholar
Comparison of DC Bead-irinotecan and DC Bead-topotecan drug eluting beads for use in locoregional drug delivery to treat pancreatic cancer
R. Forster, S. Small, Yi-Qing Tang, Clare L. Heaysman +5 more
2010Journal of materials science. Materials in medicine41 citations Open access
Semantic Scholar
Effects of rosiglitazone and metformin on pancreatic beta cell gene expression
H. Richardson, S. C. Campbell, Sa Smith, W. Macfarlane
2006Diabetologia39 citations Open access
Semantic Scholar
Preparation and characterisation of vandetanib‐eluting radiopaque beads for locoregional treatment of hepatic malignancies
Alice Hagan, G. Phillips, W. Macfarlane, A. Lloyd +2 more
2017European Journal of Pharmaceutical Sciences35 citations Open access
Semantic Scholar
Predicting pharmacokinetic behaviour of drug release from drug-eluting embolization beads using in vitro elution methods.
Alice Hagan, M. Caine, Cara Press, W. Macfarlane +8 more
2019European Journal of Pharmaceutical Sciences32 citations Open access
Semantic Scholar
Hypoxia as a target for drug combination therapy of liver cancer
C. Bowyer, A. Lewis, A. Lloyd, G. Phillips +1 more
2017Anti-Cancer Drugs30 citations Open access
Semantic Scholar
Disruption of Escherichia coli Nissle 1917 K5 Capsule Biosynthesis, through Loss of Distinct kfi genes, Modulates Interaction with Intestinal Epithelial Cells and Impact on Cell Health
J. Nzakizwanayo, Sandeep Kumar, L. Ogilvie, B. Patel +3 more
2015PLoS ONE26 citations Open access
Semantic Scholar
Transcriptional regulation of the IAPP gene in pancreatic beta-cells.
L. M. Shepherd, S. C. Campbell, W. Macfarlane
2004Biochimica et Biophysica Acta22 citations Open access
Semantic Scholar
Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y.
W. Macfarlane, R. O'Brien, P. D. Barnes, R. M. Shepherd +6 more
2000Diabetes22 citations Open access
Semantic Scholar
Development of a combination drug-eluting bead: towards enhanced efficacy for locoregional tumour therapies
R. Forster, Yi-Qing Tang, C. Bowyer, A. Lloyd +3 more
2012Anti-Cancer Drugs20 citations
Semantic Scholar
Nitric oxide stimulates insulin gene transcription in pancreatic β-cells
S. C. Campbell, H. Richardson, W. Ferris, C. S. Butler +1 more
200717 citations Open access
Semantic Scholar
Regulation of the pdx1 gene promoter in pancreatic beta-cells.
S. C. Campbell, W. Macfarlane
2002Biochemical and Biophysical Research Communications - BBRC15 citations
Semantic Scholar
Derepression of the smvA Efflux System Arises in Clinical Isolates of Proteus mirabilis and Reduces Susceptibility to Chlorhexidine and Other Biocides
H. Pelling, L. Bock, J. Nzakizwanayo, M. Wand +4 more
2019Antimicrobial Agents and Chemotherapy14 citations Open access
Semantic Scholar
Evidence for recognition of novel islet T cell antigens by granule‐specific T cell lines from new onset type 1 diabetic patients
T. Tree, D. O'Byrne, J. Tremble, W. Macfarlane +5 more
2000Clinical and Experimental Immunology14 citations Open access
Semantic Scholar
Carboxybetaine-modified succinylated chitosan-based beads encourage pancreatic β-cells (Min-6) to form islet-like spheroids under in vitro conditions
V. Perugini, M. Best, Sandeep Kumar, A. Guildford +4 more
2017Journal of materials science. Materials in medicine13 citations Open access
Semantic Scholar
Inability to process and store proinsulin in transdifferentiated pancreatic acinar cells lacking the regulated secretory pathway.
A. Aldibbiat, C. Marriott, K. Scougall, S. C. Campbell +3 more
2008Journal of Endocrinology11 citations Open access
Semantic Scholar
Cytotoxicity of radiosensitizers in multicell spheroids: combination treatment with hyperthermia.
R. Sutherland, W. Macfarlane
1978The British journal of cancer. Supplement11 citations
Semantic Scholar
Tumor Suppressor Pdcd4 Is a Major Transcript That Is Upregulated During In Vivo Pancreatic Islet Neogenesis and Is Expressed in Both Beta-Cell and Ductal Cell Lines
W. Ferris, C. Marriott, T. Ali, C. Landy +2 more
2011Pancreas9 citations Open access
Semantic Scholar
Nitric oxide stimulates insulin gene transcription in pancreatic beta-cells.
S. C. Campbell, H. Richardson, W. Ferris, C. S. Butler +1 more
2007Biochemical and Biophysical Research Communications - BBRC8 citations
Semantic Scholar
The role of tumour suppressor PDCD4 in beta cell death in hypoxia
Sandeep Kumar, C. Marriott, N. Alhasawi, A. Bone +1 more
2017PLoS ONE6 citations Open access
Semantic Scholar
Identification of mechanisms modulating chlorhexidine and octenidine susceptibility in Proteus mirabilis.
H. Pelling, V. Bennett, L. Bock, M. Wand +4 more
2024Journal of Applied Microbiology4 citations Open access
Semantic Scholar
35th Annual Meeting of the European Association for the Study of Diabetes
A. Melander, J. Olsson, G. Lindberg, A. Salzman +496 more
2016Diabetologia3 citations
Semantic Scholar
Pancreas Biology, Pathology, and Tissue Engineering
W. Macfarlane, A. Bone, M. Harrison
20093 citations
Semantic Scholar
Approaches to beta-cell regeneration and neogenesis
W. Macfarlane
20063 citations
Semantic Scholar
Glucocorticoid Administration and Brief Occlusion of the Main Pancreatic Duct Are Likely to Increase Islet Mass by a Similar Mechanism
W. Ferris, L. van der Merwe, S. C. Campbell, W. Macfarlane
2005Pancreas3 citations Open access
Semantic Scholar
A 3-Dimensional Coculture Model to Visualize and Monitor Interaction Between Pancreatic Cancer and Islet β Cells
Sandeep Kumar, D. Jach, W. Macfarlane, T. Crnogorac-Jurcevic
2021Pancreas2 citations
Semantic Scholar
In vitro and in vivo characterisation of a multiple tyrosine kinase inhibitor drug eluting bead
Alice Hagan, W. Macfarlane, A. Lloyd, G. Phillips +9 more
20162 citations
Semantic Scholar
Detection of insulin production by immunohistochemistry.
S. C. Campbell, W. Macfarlane
2003Methods in Molecular Medicine2 citations Open access
Semantic Scholar
Short Papers in Drug Delivery
Catherine M Sherwin, R. Broadbent, F. McCaffrey, D. Reith +6 more
20081 citations
Semantic Scholar
Rosiglitazone modulates multiple signalling pathways in pancreatic beta cells and protects beta cells from the detrimental effects of free fatty acids
C. Landy, T. Ali, R. Crawford, C. Marriott +3 more
20081 citations
Semantic Scholar
IUF1, A Nutrient Responsive Transcription Factor In The Pancreatic β-cells
W. Macfarlane, K. Docherty
19961 citations
Semantic Scholar
Physicochemical Evaluation and Insights into the Biological Efficacy of Vandetanib-Eluting Radiopaque Beads
Alice Hagan, Sami A Znati, Rebecca Carter, A. Westhorpe +5 more
1 citations
Semantic Scholar
Vandetanib-eluting radiopaque beads for chemoembolization: physicochemical evaluation and biological activity of vandetanib in hypoxia
Alice Hagan, Sami A Znati, R. Carter, A. Westhorpe +5 more
2021Anti-Cancer Drugs0 citations
Semantic Scholar
Protection of islet cells for transplantation therapy in Type 1 diabetes
N. Alhasawi, Sandeep Kumar, W. Macfarlane, C. Marriott +1 more
20140 citations
Semantic Scholar
Conditioning three-dimensional biomimetic scaffolds for the cultivation of transplantable beta cells
J. D. Bockhart, C. Marriott, W. Macfarlane, D. Cowieson
20140 citations
Semantic Scholar
Targeting HIF-1 and mTOR expression in hypoxic and normoxic liver cancer cells; towards optimal combination therapy for DEB-TACE
C. Bowyer, R. Forster, A. Lewis, A. Lloyd +2 more
20100 citations
Semantic Scholar
Imagining beta-cell lipotoxicity
T. Ali, C. Landy, C. Marriott, M. Harrison +1 more
20100 citations
Semantic Scholar
Abstracts of Diabetes UK's Annual Professional Conference 2009. March 11-13, 2009. Glasgow, United Kingdom.
T. Ali, C. Landy, C. Marriott, M. Harrison +1 more
2009Diabetic Medicine0 citations
Semantic Scholar
Mucin proteins form a key component of the extracellular matrix of three dimensional Min6 cell clusters
W. Macfarlane, M. Harrison, C. Marriott
20090 citations
Semantic Scholar

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