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Chuan-Lai Shen · SciRah

Researcher profile · Semantic Scholar

Chuan-Lai Shen

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Chuan-Lai Shen — researcher profile on SciRah

h-index: 17
Works: 70
Citations: 779

Most-cited papers

Silk Fibroin and Sericin Differentially Potentiate the Paracrine and Regenerative Functions of Stem Cells Through Multiomics Analysis
Ya-Nan Zhang, Ren-Wang Sheng, Jia-Lin Chen, Hongmei Wang +12 more
2023Advances in Materials123 citations
Semantic Scholar
Hypermethylation of HLA class I gene is associated with HLA class I down-regulation in human gastric cancer.
Q. Ye, Yuqing Shen, X. Wang, J. Yang +3 more
2010Tissue Antigens65 citations
Semantic Scholar
Direct modulation of myelin-autoreactive CD4+ and CD8+ T cells in EAE mice by a tolerogenic nanoparticle co-carrying myelin peptide-loaded major histocompatibility complexes, CD47 and multiple regulatory molecules
Wei-ya Pei, Xin Wan, K. Shahzad, Lei Zhang +5 more
2018International Journal of Nanomedicine36 citations Open access
Semantic Scholar
Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8+ T cell responses in HLA-A transgenic mice
Xiaoxiao Jin, Yan Ding, Shi-Hui Sun, Xinyi Wang +14 more
2021Cellular & Molecular Immunology33 citations Open access
Semantic Scholar
Latex bead-based artificial antigen-presenting cells induce tumor-specific CTL responses in the native T-cell repertoires and inhibit tumor growth.
Chuan-Lai Shen, Kai Cheng, Shenwei Miao, Wei Wang +3 more
2013Immunology Letters30 citations
Semantic Scholar
On-target and direct modulation of alloreactive T cells by a nanoparticle carrying MHC alloantigen, regulatory molecules and CD47 in a murine model of alloskin transplantation
K. Shahzad, Xin Wan, Lei Zhang, Wei-ya Pei +4 more
2018Drug Delivery27 citations Open access
Semantic Scholar
Killer artificial antigen-presenting cells deplete alloantigen-specific T cells in a murine model of alloskin transplantation.
Chuan-Lai Shen, Yong He, Kai Cheng, Daoping Zhang +5 more
2011Immunology Letters26 citations
Semantic Scholar
Expression of the nonclassical HLA class I and MICA/B molecules in human hepatocellular carcinoma.
A.-Q. Chen, Y. Shen, M. Xia, L. Xu +6 more
2011Neoplasma (Bratislava)26 citations
Semantic Scholar
Dual FGFR and VEGFR inhibition synergistically restrain hexokinase 2-dependent lymphangiogenesis and immune escape in intrahepatic cholangiocarcinoma
Min Peng, Hui Li, Huan Cao, Ya-Mei Huang +3 more
2023Journal of gastroenterology25 citations Open access
Semantic Scholar
PEGylated and CD47-conjugated nanoellipsoidal artificial antigen-presenting cells minimize phagocytosis and augment anti-tumor T-cell responses
Shilong Song, Xiaoxiao Jin, Lei Zhang, Chenchen Zhao +4 more
2019International Journal of Nanomedicine25 citations Open access
Semantic Scholar
Paracrine release of IL-2 and anti-CTLA-4 enhances the ability of artificial polymer antigen-presenting cells to expand antigen-specific T cells and inhibit tumor growth in a mouse model
Lei Zhang, Limin Wang, K. Shahzad, Tao Xu +3 more
2017Cancer Immunology and Immunotherapy23 citations
Semantic Scholar
A Systematic Review of T Cell Epitopes Defined from the Proteome of Hepatitis B Virus
Yan-Dan Wu, Yan Ding, Chuan-Lai Shen
2022Vaccines21 citations Open access
Semantic Scholar
Effects of Adjuvants on the Immunogenicity and Efficacy of a Zika Virus Envelope Domain III Subunit Vaccine
Xinyi Wang, Wan-Bo Tai, Xiaolu Zhang, Yu-Sen Zhou +2 more
2019Vaccines20 citations Open access
Semantic Scholar
Mutations in ISDR of NS5A gene influence interferon efficacy in Chinese patients with chronic hepatitis C virus genotype 1b infection
Chuan-Lai Shen, Tingting Hu, Ling Shen, Lei Gao +2 more
2007Journal of Gastroenterology and Hepatology20 citations
Semantic Scholar
A systemic review of T-cell epitopes defined from the proteome of SARS-CoV-2
Xiaoxiao Jin, Xiaotao Liu, Chuan-Lai Shen
2022Virus Research18 citations Open access
Semantic Scholar
Design and Optimization of PLGA Particles to Deliver Immunomodulatory Drugs for the Prevention of Skin Allograft Rejection
K. Shahzad, M. Naeem, Lei Zhang, Xin Wan +5 more
2019Immunological Investigations18 citations
Semantic Scholar
Downregulation of HLA class I molecules in primary oral squamous cell carcinomas and cell lines.
Q. Tang, Jian-Qiong Zhang, B. Qi, Chuan-Lai Shen +1 more
2009Archives of Medical Research18 citations
Semantic Scholar
Exosomal Vaccine Loading T Cell Epitope Peptides of SARS-CoV-2 Induces Robust CD8+ T Cell Response in HLA-A Transgenic Mice
An‐Ran Shen, Xiao-xiao Jin, Tao-Tao Tang, Yan Ding +8 more
2022International Journal of Nanomedicine16 citations Open access
Semantic Scholar
Screening and Identification of HBV Epitopes Restricted by Multiple Prevalent HLA-A Allotypes
Yan Ding, Zining Zhou, Xingyu Li, Chen Zhao +7 more
2022Frontiers in Immunology15 citations Open access
Semantic Scholar
An Artificial Antigen-Presenting Cell Delivering 11 Immune Molecules Expands Tumor Antigen–Specific CTLs in Ex Vivo and In Vivo Murine Melanoma Models
Lei Zhang, Shilong Song, Xiaoxiao Jin, Xin Wan +4 more
2019Cancer immunology research15 citations
Semantic Scholar
A Tolerogenic Artificial APC Durably Ameliorates Experimental Autoimmune Encephalomyelitis by Directly and Selectively Modulating Myelin Peptide–Autoreactive CD4+ and CD8+ T Cells
Xin Wan, Wei-ya Pei, K. Shahzad, Lei Zhang +5 more
2018Journal of Immunology13 citations Open access
Semantic Scholar
A biodegradable killer microparticle to selectively deplete antigen-specific T cells in vitro and in vivo
Wei Wang, Kun Fang, Miao-Chen Li, Di Chang +5 more
2016OncoTarget13 citations Open access
Semantic Scholar
Cloning and expression of three peptide-linked β2-microglobulin molecules in Escherichia coli with an isocaudamer technique
F. Meng, Chuan-Lai Shen, Yong He, F. Miao +1 more
2009Biotechnology Letters13 citations
Semantic Scholar
Screening of Efficient Adjuvants for the RBD-Based Subunit Vaccine of SARS-CoV-2
Juan Shi, Yu Zhao, M. Peng, Suyue Zhu +3 more
2023Vaccines12 citations Open access
Semantic Scholar
Loss of heterozygosity at 6p21 underlying [corrected] HLA class I downregulation in Chinese primary esophageal squamous cell carcinomas.
Yi Yang, Jian-Qiong Zhang, F. Miao, J. Wei +3 more
2008Tissue Antigens12 citations
Semantic Scholar
Induction of tumor antigen-specific cytotoxic T cell responses in naïve mice by latex microspheres-based artificial antigen-presenting cell constructs.
Chuan-Lai Shen, Jian-Qiong Zhang, Lingzhi Xia, F. Meng +1 more
2007Cellular Immunology12 citations
Semantic Scholar
An Antigen-Presenting and Apoptosis-Inducing Polymer Microparticle Prolongs Alloskin Graft Survival by Selectively and Markedly Depleting Alloreactive CD8+ T Cells
Wei Wang, K. Shahzad, Miao-Chen Li, Ai-Feng Zhang +4 more
2017Frontiers in Immunology10 citations Open access
Semantic Scholar
Antigen-Specific Killer Polylactic-Co-Glycolic Acid (PLGA) Microspheres Can Prolong Alloskin Graft Survival in a Murine Model
Wei Wang, Kun Fang, Xiaobing Wang, Miao-Chen Li +5 more
2015Immunological Investigations8 citations
Semantic Scholar
Structural and functional characterization of peptide–β2m fused HLA-A2/MART127–35 complexes
Chuan-Lai Shen, Chien-Chung Chang, Jian-Qiong Zhang, Wei Guo +3 more
20068 citations
Semantic Scholar
Electrodeposition of F-doped hydroxyapatite-TiO2 coating on AZ31 magnesium alloy for enhancing corrosion protection and biocompatibility
Yuanyong Ouyang, Zihao Zhang, Wei Huang, Wenzhong Yang +4 more
2022Journal of Materials Science7 citations
Semantic Scholar
Routine evaluation of HBV-specific T cell reactivity in chronic hepatitis B using a broad-spectrum T-cell epitope peptide library and ELISpot assay
Yan-Dan Wu, Xiaotao Liu, Y. Mao, Ruixue Ji +8 more
2024Journal of Translational Medicine6 citations Open access
Semantic Scholar
The Use of Molecular Dynamics Simulation Method to Quantitatively Evaluate the Affinity between HBV Antigen T Cell Epitope Peptides and HLA-A Molecules
Xue-Yin Mei, Xingyu Li, Chen Zhao, Anna Liu +3 more
2022International Journal of Molecular Sciences6 citations Open access
Semantic Scholar
Computer-Based Immunoinformatic Analysis to Predict Candidate T-Cell Epitopes for SARS-CoV-2 Vaccine Design
Xue-Yin Mei, P. Gu, Chuan-Lai Shen, X. Lin +1 more
2022Frontiers in Immunology6 citations Open access
Semantic Scholar
Identification of HLA-A2 restricted epitopes of glypican-3 and induction of CTL responses in HLA-A2 transgenic mice
Xiaoxiao Jin, Xiaotao Liu, Zining Zhou, Yan Ding +3 more
2021Cancer Immunology and Immunotherapy6 citations Open access
Semantic Scholar
Inconsistence between number and function of autoreactive T cells in the course of experimental autoimmune encephalomyelitis
Xin Wan, Wei-ya Pei, Yiming Zhang, Lei Zhang +3 more
2018Immunological Investigations6 citations
Semantic Scholar
Frequency and reactivity of antigen-specific T cells were concurrently measured through the combination of artificial antigen-presenting cell, MACS and ELISPOT
Chuan-Lai Shen, Tao Xu, You Wu, Xiao'e Li +6 more
2017Scientific Reports6 citations Open access
Semantic Scholar
Receptor-Binding Domain Proteins of SARS-CoV-2 Variants Elicited Robust Antibody Responses Cross-Reacting with Wild-Type and Mutant Viruses in Mice
Juan Shi, Xiaoxiao Jin, Yan Ding, Xiaotao Liu +4 more
2021Vaccines5 citations Open access
Semantic Scholar
Cancer Immunotherapy: Theory and Application
Guo-Bing Chen, M. Bodogai, N. Tamehiro, Chuan-Lai Shen +1 more
2018Journal of Immunological Research5 citations Open access
Semantic Scholar
Selective downregulation of distinct circRNAs in the tissues and plasma of patients with primary hepatic carcinoma
Yan Ding, An-Ning Fang, Jia-Lai Yan, J. Duan +3 more
2019Oncology Letters3 citations Open access
Semantic Scholar
A Combination Strategy for Construction of Peptide-β2m-H-2Kb Single Chain with Overlap Extension PCR and One-Step Cloning.
Tao Xu, Xiao'e Li, You Wu, K. Shahzad +3 more
2016Journal of Microbiology and Biotechnology3 citations
Semantic Scholar
Characterization of MHC/peptide complexes refolded by a one-step ion-exchange chromatography.
Chuan-Lai Shen, Yong He, F. Meng, Kai Cheng +3 more
2011JIM - Journal of Immunological Methods3 citations
Semantic Scholar
Up-regulate HLA Class I Expression Following Hepatitis B Virus Transfection in a Hepatocellular Carcinoma Cell Line BEL7405
Lian-Hong Xu, Yuqing Shen, M. Xia, F. Miao +3 more
2010Immunological Investigations3 citations
Semantic Scholar
Structural and functional characterization of peptide-beta2m fused HLA-A2/MART1(27-35) complexes.
Chuan-Lai Shen, Chien-Chung Chang, Jian-Qiong Zhang, Wei Guo +3 more
2006Biochemical and Biophysical Research Communications - BBRC3 citations
Semantic Scholar
Predominant T-cell epitopes of SARS-CoV-2 restricted by multiple prevalent HLA-B and HLA-C allotypes in Northeast Asia
Yu Zhao, Min Peng, Cheng-Tao He, Min Li +7 more
2025Frontiers in Immunology2 citations Open access
Semantic Scholar
Large-scale screening of HIV-1 T-cell epitopes restricted by 12 prevalent HLA-A allotypes in Northeast Asia and universal detection of HIV-1-specific CD8+ T cells
Yan Ding, Jia-Lai Yan, Ling Huang, Jin-Hong Yu +3 more
2025Frontiers in Microbiology2 citations Open access
Semantic Scholar
Comparison of HBV-specific T cell reactivity across the pregnant, postpartum and non-pregnant women with chronic HBV infection
Genju Wang, Fangping Yue, Ziyue Zhang, Yan-Dan Wu +4 more
2024Frontiers in Immunology2 citations Open access
Semantic Scholar
Correction: A Tolerogenic Artificial APC Durably Ameliorates Experimental Autoimmune Encephalomyelitis by Directly and Selectively Modulating Myelin Peptide–Autoreactive CD4+ and CD8+ T Cells
Xin Wan, Wei-ya Pei, K. Shahzad, Lei Zhang +5 more
2019Journal of Immunology2 citations Open access
Semantic Scholar
Large‐Scale Screening of CD4+ T‐Cell Epitopes From SARS‐CoV‐2 Proteins and the Universal Detection of SARS‐CoV‐2 Specific T Cells for Northeast Asian Population
Yu Zhao, Cheng-Tao He, Min Peng, Min Li +8 more
2025Journal of Medical Virology1 citations
Semantic Scholar
jmbReview A Combination Strategy for Construction of Peptide-β 2 mH-2 K b Single Chain with Overlap Extension PCR and One-Step Cloning
Tao Xu, Xiao'e Li, You Wu, K. Shahzad +3 more
20161 citations
Semantic Scholar
A novel one-step strategy for the preparation of HLA/HBc18–27 and HLA/CEA694–702 complexes with ion exchange chromatography
F. Meng, Chuan-Lai Shen, F. Miao, Yong He +3 more
2010Biotechnology Letters1 citations
Semantic Scholar

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