N. Bonagas

Most-cited papers

1. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

   N. Gustafsson, K. Farnegardh, N. Bonagas, A. Ninou +17 more

   2018Nature Communications120 citations Open access

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2. Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

   N. Bonagas, N. Gustafsson, M. Henriksson, Petra Marttila +64 more

   2022Nature Cancer84 citations Open access

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3. Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.

   R. Gustafsson, A. Jemth, N. Gustafsson, K. Farnegardh +11 more

   2017Cancer Research82 citations Open access

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4. Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

   A. Green, Petra Marttila, N. Kiweler, Christina Chalkiadaki +30 more

   2023Nature Metabolism55 citations Open access

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5. The one‐carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation

   Petra Marttila, N. Bonagas, Christina Chalkiadaki, Hannah Stigsdotter +11 more

   2024Molecular Oncology4 citations Open access

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6. Abstract B109: MTHFD1/2 inhibitor TH9619 targets the DNA damage response and causes cancer-specific folate trapping with an unprecedented therapeutic window

   Petra Martilla, A. Green, N. Kiweler, Christina Chalkiadaki +18 more

   2023Molecular Cancer Therapeutics0 citations

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7. Crystal structure of human mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase (MTHFD2) in complex with LY345899 and cofactors

   R. Gustafsson, A. Jemth, N. G. Sheppard, K. Farnegardh +11 more

   20160 citations

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