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N. Enzan · SciRah

Researcher profile · Semantic Scholar

N. Enzan

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N. Enzan — researcher profile on SciRah

h-index: 15
Works: 76
Citations: 846

Most-cited papers

Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury
H. Miyamoto, M. Ikeda, Tomomi Ide, T. Tadokoro +11 more
2022JACC: Basic to Translational Science135 citations Open access
Semantic Scholar
Clinical Characteristics and Outcomes of Hospitalized Patients With Heart Failure From the Large-Scale Japanese Registry Of Acute Decompensated Heart Failure (JROADHF).
Tomomi Ide, Hidetaka Kaku, S. Matsushima, T. Tohyama +10 more
2021Circulation Journal125 citations Open access
Semantic Scholar
ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts
N. Enzan, S. Matsushima, S. Ikeda, Kosuke Okabe +16 more
2023Circulation Research91 citations Open access
Semantic Scholar
Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway
S. Ikeda, S. Matsushima, Kosuke Okabe, M. Ikeda +9 more
2019Scientific Reports53 citations Open access
Semantic Scholar
Machine learning‐based model for predicting 1 year mortality of hospitalized patients with heart failure
T. Tohyama, Tomomi Ide, M. Ikeda, Hidetaka Kaku +6 more
2021ESC Heart Failure41 citations Open access
Semantic Scholar
DPP (Dipeptidyl Peptidase)-4 Inhibitor Attenuates Ang II (Angiotensin II)–Induced Cardiac Hypertrophy via GLP (Glucagon-Like Peptide)-1–Dependent Suppression of Nox (Nicotinamide Adenine Dinucleotide Phosphate Oxidase) 4-HDAC (Histone Deacetylase) 4 Pathway
Kosuke Okabe, S. Matsushima, S. Ikeda, M. Ikeda +9 more
2020HYPERTENSION38 citations
Semantic Scholar
Prevalence, characteristics and cardiovascular and non‐cardiovascular outcomes in patients with heart failure with supra‐normal ejection fraction: Insight from the JROADHF study
Yu Horiuchi, M. Asami, Tomomi Ide, K. Yahagi +9 more
2023European Journal of Heart Failure33 citations
Semantic Scholar
Beneficial Effects of Dipeptidyl Peptidase-4 Inhibitors on Heart Failure With Preserved Ejection Fraction and Diabetes
N. Enzan, S. Matsushima, Hidetaka Kaku, T. Tohyama +3 more
2023JACC: Asia32 citations Open access
Semantic Scholar
Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure
T. Furihata, S. Takada, N. Kakutani, S. Maekawa +15 more
2021Communications Biology31 citations Open access
Semantic Scholar
GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway.
Akihito Ishikita, S. Matsushima, S. Ikeda, Kosuke Okabe +11 more
2021iScience26 citations Open access
Semantic Scholar
Efficacy of Early Catheter Ablation for Atrial Fibrillation After Admission for Heart Failure.
K. Sakamoto, T. Tohyama, Tomomi Ide, Y. Mukai +8 more
2023JACC Clinical Electrophysiology21 citations Open access
Semantic Scholar
Spironolactone use is associated with improved outcomes in heart failure with mid‐range ejection fraction
N. Enzan, S. Matsushima, Tomomi Ide, Hidetaka Kaku +3 more
2020ESC Heart Failure20 citations Open access
Semantic Scholar
Long-Term Outcomes of Heart Failure Patients With Preserved, Mildly Reduced, and Reduced Ejection Fraction
Takuya Nagata, Tomomi Ide, T. Tohyama, Hidetaka Kaku +5 more
2023JACC: Asia17 citations Open access
Semantic Scholar
Frailty Scale Captures Multidimensional Vulnerability and Predicts Mortality in Heart Failure.
T. Nakade, Yudai Fujimoto, Y. Singh, Y. Akama +12 more
2025Journal of the American College of Cardiology15 citations
Semantic Scholar
A higher resting heart rate is associated with cardiovascular event risk in patients with type 2 diabetes mellitus without known cardiovascular disease
S. Ikeda, Keisuke Shinohara, N. Enzan, S. Matsushima +6 more
2023Hypertension Research15 citations
Semantic Scholar
Beta‐Blocker Use Is Associated With Prevention of Left Ventricular Remodeling in Recovered Dilated Cardiomyopathy
N. Enzan, S. Matsushima, Tomomi Ide, Hidetaka Kaku +4 more
2021Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease15 citations Open access
Semantic Scholar
Propensity-Matched Study of Early Cardiac Rehabilitation in Patients With Acute Decompensated Heart Failure
N. Enzan, S. Matsushima, Hidetaka Kaku, T. Tohyama +7 more
2023Circulation: Heart Failure13 citations Open access
Semantic Scholar
Beta-blocker use is associated with prevention of left ventricular remodeling in recovered dilated cardiomyopathy
N. Enzan, S. Matsushima, Tomomi Ide, Hidetaka Kaku +2 more
2020European Heart Journal13 citations Open access
Semantic Scholar
IFN-γ-STAT1-ERK Pathway Mediates Protective Effects of Invariant Natural Killer T Cells Against Doxorubicin-Induced Cardiomyocyte Death
Masashi Sada, S. Matsushima, M. Ikeda, S. Ikeda +12 more
2023JACC: Basic to Translational Science11 citations Open access
Semantic Scholar
Left atrial involvement of cardiac sarcoidosis manifesting as left atrial re-entrant tachycardia.
N. Enzan, Kisho Ohtani, Kazuhiro Nagaoka, I. Sakamoto +1 more
2019European Heart Journal-Cardiovascular Imaging11 citations
Semantic Scholar
The Use of Angiotensin-Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Is Associated with the Recovered Ejection Fraction in Patients with Dilated Cardiomyopathy.
N. Enzan, S. Matsushima, Tomomi Ide, Hidetaka Kaku +4 more
2021International Heart Journal9 citations Open access
Semantic Scholar
Clinical Characteristics and Contemporary Management of Patients With Cardiomyopathies in Japan ― Report From a National Registry of Clinical Personal Records ―
N. Enzan, S. Matsushima, Tomomi Ide, Hidetaka Kaku +4 more
2021Circulation Reports9 citations Open access
Semantic Scholar
Management and outcomes of heart failure hospitalization among older adults in the United States and Japan
Benjamin A. Bates, N. Enzan, T. Tohyama, Poonam Gandhi +4 more
2024ESC Heart Failure8 citations Open access
Semantic Scholar
Hyperoxemia is Associated With Poor Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Rescued by Extracorporeal Cardiopulmonary Resuscitation: Insight From the Nationwide Multicenter Observational JAAM-OHCA (Japan Association for Acute Medicine) Registry.
Masaaki Nishihara, K. Hiasa, N. Enzan, K. Ichimura +6 more
2022Journal of Emergency Medicine8 citations Open access
Semantic Scholar
Atrial fibrillation type and long-term clinical outcomes in hospitalized patients with heart failure: insight from JROADHF.
Y. Hamatani, N. Enzan, M. Iguchi, T. Yoshizawa +7 more
2024European Heart Journal - Quality of Care and Clinical Outcomes7 citations
Semantic Scholar
The use of angiotensin II receptor blocker is associated with greater recovery of cardiac function than angiotensin‐converting enzyme inhibitor in dilated cardiomyopathy
N. Enzan, S. Matsushima, Tomomi Ide, T. Tohyama +3 more
2022ESC Heart Failure7 citations Open access
Semantic Scholar
Delayed administration of epinephrine is associated with worse neurological outcomes in patients with out-of-hospital cardiac arrest and initial pulseless electrical activity: insight from the nationwide multicentre observational JAAM-OHCA (Japan Association for Acute Medicine) registry
N. Enzan, Ken-ichi Hiasa, K. Ichimura, Masaaki Nishihara +6 more
2022European heart journal. Acute cardiovascular care6 citations Open access
Semantic Scholar
Efficacy of intensive lipid-lowering therapy with statins stratified by blood pressure levels in patients with type 2 diabetes mellitus and retinopathy: Insight from the EMPATHY study
Keisuke Shinohara, S. Ikeda, N. Enzan, S. Matsushima +6 more
2021Hypertension Research6 citations
Semantic Scholar
Serial measurement of B-type natriuretic peptide and future cardiovascular events in patients with type 2 diabetes mellitus without known cardiovascular disease.
S. Ikeda, Keisuke Shinohara, N. Enzan, S. Matsushima +6 more
2022International Journal of Cardiology5 citations Open access
Semantic Scholar
Sex Differences in Time-Dependent Changes in B-Type Natriuretic Peptide in Hypertrophic Cardiomyopathy
N. Enzan, S. Matsushima, Tomomi Ide, Hidetaka Kaku +4 more
2021Circulation Reports4 citations Open access
Semantic Scholar
Regional Variation in the Clinical Practice and Prognosis in Patients With Heart Failure With Reduced Ejection Fraction in Japan - A Report From the Japanese Registry of Acute Decompensated Heart Failure (JROADHF).
Yu Sato, A. Yoshihisa, Tomomi Ide, T. Tohyama +4 more
2023Circulation Journal3 citations Open access
Semantic Scholar
Beta-blockers are associated with reverse remodeling in patients with dilated cardiomyopathy and mid-range ejection fraction
N. Enzan, S. Matsushima, Tomomi Ide, T. Tohyama +3 more
2021American Heart Journal Plus: Cardiology Research and Practice3 citations Open access
Semantic Scholar
Effectiveness of statin intensive therapy in type 2 diabetes mellitus with high visit-to-visit blood pressure variability
S. Ikeda, Keisuke Shinohara, N. Enzan, S. Matsushima +6 more
2021Journal of Hypertension3 citations
Semantic Scholar
Cyclin dependent kinase 1 (CDK1) positively regulates cardiac hypertrophy and fibrosis via TGF-beta pathway
Taishi Yamamoto, S. Matsushima, Kosuke Okabe, S. Ikeda +6 more
20203 citations Open access
Semantic Scholar
Prognostic impact of moderate to severe anemia associated with renal dysfunction in patients with heart failure
E. Noda, S. Matsushima, Toru Hashimoto, Y. Tsutsui +10 more
2025Scientific Reports2 citations Open access
Semantic Scholar
Long-term prognostic impact of in-hospital serum albumin concentration changes in patients hospitalised for heart failure
Keiko Fukino, S. Miyata, T. Ide, S. Matsushima +4 more
2025Open Heart2 citations Open access
Semantic Scholar
Artificial intelligence-based analysis of payment system data can predict one-year mortality of hospitalized patients with heart failure
T. Tohyama, K. Funakoshi, Hidetaka Kaku, N. Enzan +5 more
2020European Heart Journal2 citations
Semantic Scholar
P6283Downregulation of Tim44 exacerbates oxidative stress-induced ROS production and cardiomyocytes death by reducing mitochondrial SOD2
S. Ikeda, S. Matsushima, Kosuke Okabe, Ayako Ishikita +8 more
2019European Heart Journal2 citations
Semantic Scholar
Electrocardiographic Left Ventricular Hypertrophy Is Independently Associated With Better Long-Term Outcomes in Dilated Cardiomyopathy Patients
S. Matsushima, Hidetaka Kaku, N. Enzan, Tomomi Ide +3 more
2019Circulation Reports2 citations Open access
Semantic Scholar
Goreisan attenuates cardiac hypertrophy and diastolic dysfunction in heart failure with preserved ejection fraction induced by HFD/L-NAME via regulation of ICAT-β-catenin/ERK axis
Yoko Shojima Isayama, S. Matsushima, Keisuke Shinohara, Koichi Isayama +17 more
2025Hypertension Research1 citations Open access
Semantic Scholar
Evaluation of the A2B Score for Prediction of Survival in Patients With Heart Failure in a Nationwide Cohort in Japan
Atsushi Kyodo, Yasuki Nakada, M. Nogi, K. Nogi +8 more
2024Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease1 citations Open access
Semantic Scholar
The nationwide registry of hospitalized heart failure patients in Japan: Japanese Registry Of Acute Decompensated Heart Failure (JROADHF)
Tomomi Ide, Hidetaka Kaku, S. Matsushima, T. Tohyama +9 more
20201 citations Open access
Semantic Scholar
Implications of albuminuria for subsequent renal function decline and renal outcomes in patients hospitalized for worsening heart failure: insights from the JROADHF-NEXT registry
Y. Singh, T. Ide, K. Kida, S. Matsushima +11 more
2026European Journal of Heart Failure0 citations
Semantic Scholar
Implications of urinary albumin-to-creatinine ratio for subsequent kidney function decline and kidney-related outcomes in patients hospitalized for worsening heart failure: Insights from the JROADHF-NEXT registry.
Y. Akama, Y. Singh, T. Nakade, Yudai Fujimoto +16 more
2026Journal of Cardiac Failure0 citations
Semantic Scholar
Prognostic utility of the kansas city cardiomyopathy questionnaire across cognitive function levels in older patients with heart failure: insights from the JROADHF-NEXT registry
T. Nakade, T. Ide, K. Kida, S. Matsushima +11 more
2026European Journal of Heart Failure0 citations
Semantic Scholar
Temporal comparison of clinical practice and outcomes in heart failure: the JROADHF and JROADHF-NEXT studies.
T. Tohyama, M. Ikeda, Tatsuya Watanabe, N. Enzan +16 more
2026European Heart Journal0 citations
Semantic Scholar
26-A-14923-ACC PROGNOSTIC VALUE OF THE KANSAS CITY CARDIOMYOPATHY QUESTIONNAIRE OVERALL SUMMARY SCORE IN OLDER PATIENTS WITH HEART FAILURE: AN INSIGHT FROM THE JROADHF-NEXT
T. Nakade, Yudai Fujimoto, Y. Akama, T. Ide +9 more
2026JACC0 citations
Semantic Scholar
Prognostic Impact of a Simple GDMT Score on Clinical Outcomes and Cardiac Reverse Remodelling in Patients with ADHF: Insights from the JROADHF-Next Registry
R. Matsukawa, Y. Mukai, Yudai Fujimoto, Y. Matsue +12 more
2026CJC Open0 citations Open access
Semantic Scholar
Inhibition of CDK1 attenuates cardiac remodeling via suppression of fibroblast-derived TGF-β1.
Taishi Yamamoto, S. Matsushima, E. Noda, Kosuke Okabe +18 more
2026Journal of Molecular and Cellular Cardiology0 citations Open access
Semantic Scholar
Prognostic value of fractures in hospitalized patients with heart failure: insights from the JROADHF-NEXT registry
Y. Singh, T. Nakade, Y. Fujimoto, T. Ide +11 more
2026European Journal of Heart Failure0 citations
Semantic Scholar

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S. Matsushima×41
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S. Matsushima — researcher profile on SciRah
Tomomi Ide×27
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Tomomi Ide — researcher profile on SciRah
T. Tohyama×25
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M. Ikeda×20
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M. Ikeda — researcher profile on SciRah

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Hidetaka Kaku×16

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